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All Journal Majalah Patologi Indonesia Jurnal RSMH Palembang Jurnal Mediasas : Media Ilmu Syari'ah dan Ahwal Al-Syakhsiyyah
Pratama, Eka Putra
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Dentistry Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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The Roles of Extracellular Matrix in Breast Carcinoma: A Narrative Literature Review Pratama, Eka Putra; Citra Dewi
Jurnal RSMH Palembang Vol. 3 No. 1 (2022): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/jrp.v3i1.27

Abstract

The extracellular matrix is a complex and highly dynamic molecular network and serves to provide biochemical signals in the process of development, invasion, and metastasis of breast cancer. There are several proteins that contribute to the structure and function of the extracellular matrix, including collagen, laminin, glycosaminoglycans, and proteoglycans. Alterations of the extracellular matrix in breast cancer are not only limited to the composition of the extracellular matrix but also remodeling enzymes such as matrix metalloproteinase (MMP), cathepsin, urokinase plasminogen activator (uPA), lysyl oxidase (LOX) and heparanase. The extracellular matrix can increase breast cancer progressivity and resistance to treatment, so it is important to know its role because it can be a targeted therapy in the future.
Dinamika Pengaturan Pencatatan Perkawinan di Indonesia Pasca Permendagri No. 9 Tahun 2016 Pratama, Eka Putra; Nanang, Shifa Anindita; Sulistiani, Siska Lis
Jurnal Mediasas: Media Ilmu Syari'ah dan Ahwal Al-Syakhsiyyah Vol. 5 No. 2 (2022): Jurnal Mediasas: Media Ilmu Syariah dan Ahwal Al-Syakhsiyyah
Publisher : Islamic Family Law Department, STAI Syekh Abdur Rauf Aceh Singkil, Indonesia

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This study aims to determine the changes in the rules relating to marriage registration in Indonesia based on applicable laws such as the Marriage Law No. 1 of 1974 and Islamic law, especially after the Minister of Home Affairs Regulation No. 6 of 2019. This study uses a normative juridical research method using primary and secondary legal data sources and types such as laws and regulations on marriage, compilations of Islamic law, and other relevant articles, then collected using the literature study method and analyzed through descriptive methods. qualitative. The results of this study indicate that marriage registration is still based on Law no. 1 of 1974, as for the Minister of Home Affairs No. 6 of 2016 only to regulate population administration with unregistered status for marriages that are not registered in the KUA or Civil Registry (;) Penelitian ini bertujuan untuk mengetahui perubahan aturan berkaitan pencatatan perkawinan di Indonesia berdasarkan hukum yang berlaku seperti UU Perkawinan No.1 Tahun 1974 dan hukum Islam khususnya setelah adanya Permendagri No. 6 Tahun 2019. Penelitian ini menggunakan metode penelitian yuridis normatif dengan menggunakan sumber dan jenis data hukum primer dan sekunder seperti peraturan perundang-undangan tentang perkawinan, kompilasi hukum Islam, dan artikel lainnya yang relevan, kemudian dikumpulkan dengan metode studi literatur dan dianalisis melalui metode deskriptif kualitatif. Hasil penelitian ini menunjukkan bahwa pencatatan perkawinan tetap didasarkan pada UU No. 1 Tahun 1974, adapun dengan adanya permendagri No.6 Tahun 2016 hanya menertibkan secara administrasi kependudukan dengan status tidak tercatat bagi perkawinan yang tidak tercatata di KUA ataupun Catatan Sipil
Mastitis Granulomatosa: Sebuah Tantangan Diagnosis Dewi, Citra; Amalia, Ella; Kurniawati, Nyiayu Fauziah; Maria Ulfa,, Maria Ulfa,; Pratama, Eka Putra; Murti, Krisna
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.492

Abstract

BackgroundGranulomatous mastitis (GM) is often found in reproductive-age women. These patients are treated by the administration ofantituberculosis drugs. It is difficult to determine the exact cause of GM cytologically and histopathologically. Various etiologies i.e.,tuberculosis, sarcoidosis, foreign bodies and immunological diseases may provide granulomatous inflammation features in thetissue. High-sensitivity tests such as PCR can help to detect the presence of Mycobacterium tuberculosis (MT) as one of possibleetiologic agent. Accurate diagnosis will improve the treatment quality thus a better quality of life. The aim of this study was todetermine whether the granulomatous mastitis patients who referred to the Department of Anatomic Pathology Faculty of MedicineUniversitas Sriwijaya/Dr. Moh. Hoesin Palembang Hospital were caused by MT.MethodsA descriptive observational study was performed. Thirty paraffin blocks of GM patients during the period of 1st October 2018 to 29thSeptember 2020 were collected. DNAs were extracted from tissue scrapings of the slides. Then, PCR analysis was conducted usinga specific primer IS6110 with around 200 bp PCR product.ResultsThe mean age of the patients was 40.8 years (range: 23-67 years). There were six samples (20%) of GM produced the expectedamplicon. However, only three of six samples morphologically consistent with tuberculosis.ConclusionGranulomatous inflammatory reactions in the breast are not only caused by tuberculosis. Further study is needed to determine theexact cause of this lesion. Despite high costs, PCR examination may become an alternative approach in determining the etiology ofGM.
Co-Authors Citra Dewi Citra Dewi Ella Amalia, Ella Krisna Murti Maria Ulfa,, Maria Ulfa, Nanang, Shifa Anindita Nyiayu Fauziah Kurniawati Siska Lis Sulistiani