Article Per Year (5 Year)
p-Index From 2021 - 2026
0.562
P-Index
This Author published in this journals
All Journal Journal Pharmaceutical Science and Application (JPSA)
Suardiana, I Kadek
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
ANTIBACTERIAL ACTIVITY TEST OF FENNEL LEAVES AND STEMS (Foeniculum vulgare Mill.) AGAINST BACTERIA Cutibacterium acnes AND Staphylococcus epidermidis Yanti, Ni Luh Putu Kris Monika; Dasilva, Madahlena Isaura; Andreani, Putu Ririn; Suardiana, I Kadek
Journal Pharmaceutical Science and Application Vol. 7 No. 2 (2025): Journal Pharmaceutical Science and Application
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2025.v07.i02.p02

Abstract

Background: Acne vulgaris is a common skin problem that often affects adolescents and young adults, caused by the bacteria Cutibacterium acnes and Staphylococcus epidermidis. The use of synthetic antibiotics for acne treatment can lead to resistance; therefore, it is necessary to develop alternative natural ingredients that can act as a companion or complementary therapy, such as fennel plants (Foeniculum vulgare Mill.). Objective: To identify and compare the antibacterial activity of ethanol extracts of fennel leaves and stems against C.acnes and S.epidermidis. Methods: Extraction is carried out by maceration using 96% ethanol. Antibacterial tests were carried out in vitro using disc diffusion methods with concentrations of 50%, 75%, and 100%. Tetracycline 1% is used as a positive control, and DMSO 10% as a negative control. Results: Extracts of fennel leaves and stems exhibited antibacterial activity. The diameter of the inhibition zone increased with increasing extract concentration, with the leaves extract showing greater antibacterial activity than the stems extract. Conclusion: The results of the antibacterial activity test showed that ethanol extracts of leaves and fennel stems were able to inhibit the growth of C. acnes and S. epidermidis, with an average inhibition zone of leaf extract that was more optimal than that of stems.
EFFECT OF EXTRACTION METHODS ON TOTAL FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY POTENTIAL OF ETHANOL EXTRACT OF GALING-GALING LEAVES (Cayratia trifolia (L.) Domin) Suardiana, I Kadek; Putra, A.A. Gede Rai Yadnya; Sari, Pande Made Nova Armita
Journal Pharmaceutical Science and Application Vol. 7 No. 1 (2025): Journal Pharmaceutical Science and Application
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2025.v07.i01.p02

Abstract

Background: Antioxidants play a key role in the prevention and treatment of various diseases. Flavonoids, a class of secondary metabolites, are known for their strong antioxidant properties. Cayratia trifolia (L.) Domin is an Indonesian endemic plant with medicinal potential, particularly as a natural antioxidant source. The extraction process is a critical step in isolating bioactive compounds and must be optimized to maximize flavonoid content and antioxidant activity. Objective: This study aims to evaluate the effect of different extraction methods— maceration, sonication, and Soxhlet extraction—on the total flavonoid content and antioxidant activity of ethanolic extracts of C. trifolia (L.) Domin leaves. Methods: This experimental study used three extraction techniques: maceration, sonication, and Soxhlet extraction. Total flavonoid content was determined using UV-Vis spectrophotometry and expressed as mg quercetin equivalent per gram of extract (mg QE/g extract). Antioxidant activity was measured using the DPPH free radical scavenging assay and expressed as IC₅₀ (ppm). Statistical analysis was conducted using one-way ANOVA with a 95% confidence level. Results: The sonication method yielded the highest total flavonoid content (41.82 ± 0.011 mg QE/g extract) and the strongest antioxidant activity (IC₅₀ = 66.523 ± 0.449 ppm), followed by Soxhlet extraction (35.78 ± 0.01 mg QE/g; IC₅₀ = 84.217 ± 0.565 ppm), and maceration (18.48 ± 0.01 mg QE/g; IC₅₀ = 94.579 ± 1.12 ppm). Statistical analysis showed that the extraction method significantly affected both total flavonoid content and antioxidant activity (P < 0.05). Conclusion: The extraction method significantly influences the yield of total flavonoids and antioxidant activity in C. trifolia ethanolic leaf extracts. Sonication was found to be the most effective method, suggesting its potential use in optimizing the recovery of antioxidant compounds from plant materials. Keywords: Antioxidant Activity; Cayratia trifolia (L.) Domin; DPPH; Extraction methods; Total Flavonoid Contents.
THE ROLE OF PHARMACOECONOMICS IN DETERMINING TREATMENT SELECTION IN INDONESIA: A SCOPING REVIEW Amalia, Adinda; Suardiana, I Kadek
Journal Pharmaceutical Science and Application Vol. 7 No. 1 (2025): Journal Pharmaceutical Science and Application
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2025.v07.i01.p05

Abstract

Background: Pharmacoeconomic analysis is a crucial tool for assessing the economic impact of alternative drug therapies, especially amid rising healthcare costs in Indonesia. It evaluates whether the benefits of a treatment justify the additional costs, supporting pharmacists in selecting effective and cost-efficient therapies that enhance patient quality of life. Four main types of pharmacoeconomic studies are commonly used: Cost Effectiveness Analysis (CEA), Cost Minimization Analysis (CMA), Cost Utility Analysis (CUA), and Cost Benefit Analysis (CBA). Objective: This review aims to provide an overview of pharmacoeconomic studies that can serve as a reference for pharmacists in Indonesia in selecting appropriate treatments, focusing on literature from national journals published within the last 10 years. Methods: A literature review was conducted using primary data from national research publications accessed via Google Scholar. Inclusion criteria were studies involving pharmacoeconomic evaluations related to therapy selection, published from 2015 onward in national journals. Studies examined include those covering drug utilization patterns, cost estimation, and alignment with the national formulary. Results: CEA and CUA are the most frequently applied pharmacoeconomic methods in Indonesia, particularly for evaluating antihypertensive, antiinfective, and cardiovascular drugs. These methods offer valuable insights that help pharmacists determine clinically effective and economically viable treatment options. Conclusion: Pharmacoeconomic studies are essential in supporting pharmacists in balancing treatment efficacy with cost considerations. Their application is particularly important in the context of the National Health Insurance (JKN), where informed decisions are needed to ensure cost-effective, sustainable healthcare delivery.   Keywords: Cost Benefit Analysis; Cost Effectiveness Analysis; Cost Minimization Analysis; Cost Utility Analysis; Pharmacoeconomics.
Co-Authors Amalia, Adinda Andreani, Putu Ririn Dasilva, Madahlena Isaura Putra, A.A. Gede Rai Yadnya Sari, Pande Made Nova Armita Yanti, Ni Luh Putu Kris Monika