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HUBUNGAN USIA DAN JUMLAH PARITAS DENGAN TIPE KARSINOMA ENDOMETRIUM DI RSUD PROF. DR. MARGONO SOEKARJO Nusa, Arifah Pelangi; Nawangtantrini, Gita; Aditiyono, Aditiyono; Novrial, Dody; Yamsum, M
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.8741

Background: Endometrial cancer ranks 15th with the highest number of new cases in 2020 in the world. There are still differences in research results regarding the relationship between age and number of parities with endometrial carcinome. Aim: To determine the relationship between age and parity with type of endometrial carcinoma at RSUD Prof. Dr. Margono Soekarjo. Method: This research is an observational analytic study with a cross sectional study. The sampling technique uses total sampling. Total subjects were 129 endometrial carcinoma patients at RSUD Prof. Dr. Margono Soekarjo in 2017-2022. The data taken is secondary data from the medical records. The variable age and number of parities are the data listed in the medical record document. Data were analyzed using the chi-square statistical test. Result: The total sample obtained was 129 patients. The most common age was found at the age of 51-60 years (41.1%) and the least at the age of <40 years (7.8%). The highest number of parities found was parity ≥2 (55.8%) and the least was parity 1 (15.5%). The results of the chi-square statistical test for age with endometrial carcinoma type showed a value of p = 0.159 (p>0.05). Based on the results of the analysis, there was no significant relationship between age and the type of endometrial cancer. The results of the chi-square statistical test for the number of endometrial carcinoma types showed a value of p = 0.02 (p <0.05). Based on the results of the analysis, it showed that there was a significant relationship between the number of parities and the type of endometrial cancer. Conclusion: There was no significant relationship between age and the type of endometrial carcinome and there was a significant relationship between the number of parities and the type of endometrial carcinome at RSUD Prof. Dr. Margono Soekarjo.

Neutrophil-lymphocyte Ration Difference in Squamous Cell Carcinoma and Adenocarcinoma of Cervical Cancer Sinaga, Rislefia Amadina; Aditiyono, Aditiyono; Kurniadi, Andi
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 3 November 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i3.732

Introduction: Cervical cancer is the most commonly found malignancy in female reproductive system. There are two most found types of this cancer based on histopathologic finding, adenocarcinoma and squamous cell carcinoma (SCC). Each type has different outcome, especially in later stages. Neutrophil-lymphocyte ratio (NLR) is an indicator that can pinpoint the inflammation severity level, hence able to predict outcome and prognosis in malignancy, including cervical cancer.Objective: This study aimed to determine the difference of NLR in both types of cervical cancer Methods: This study used retrospective analytic observational with cross-sectional design. Data was sampled from Prof. dr. Margono Soekarjo General Regional Hospital medical record from patients diagnosed with cervical cancer of both types during January to December 2022. Mann-Whitney test was performed to determine the difference of NLR value between both types of cervical cancer. Result: Between January and December 2022, 68 patients were diagnosed with cervical cancer. Of these, 37 (54.41%) had squamous cell carcinoma (SCC) and 31 (45.59%) had adenocarcinoma. The neutrophil-to-lymphocyte ratio (NLR) ranged from 1.55 to 25.99 in SCC patients, with a mean value of [insert mean value here]. For adenocarcinoma patients, the NLR ranged from 1.32 to 11.99. Conclusion: Neutrophil-lymphocyte ratio can’t differentiate squamous cell carcinoma and adenocarcinoma of cervival cancer.Perbedaan Rasio Neutrofil Limfosit pada Kanker Serviks Tipe Karsinoma Sel Skuamosa dan Tipe AdenokarsinomaAbstrakPendahuluan: Kanker serviks merupakan keganasan yang paling banyak ditemukan pada sistem reproduksi wanita. Berdasarkan temuan histopatologi, terdapat dua jenis kanker serviks yang paling banyak ditemukan, yaitu adenokarsinoma dan karsinoma sel skuamosa (SCC). Setiap jenis memiliki hasil yang berbeda, terutama pada tahap selanjutnya. Rasio neutrofil-limfosit (NLR) merupakan salah satu indikator yang dapat digunakan untuk mengetahui tingkat keparahan inflamasi sehingga dapat memprediksi outcome dan prognosis pada suatu keganasan, termasuk kanker serviks.Tujuan: Penelitian ini bertujuan untuk mengetahui perbedaan NLR pada kedua jenis kanker serviks Metode: Penelitian ini menggunakan metode observasional analitik retrospektif dengan desain cross-sectional. Data diambil dari rekam medis RSUD Prof. dr. Margono Soekarjo mengenai pasien yang terdiagnosis kanker serviks kedua jenis tersebut selama bulan Januari hingga Desember 2022. Uji Mann-Whitney dilakukan untuk mengetahui perbedaan nilai NLR antara kedua jenis kanker serviks tersebut. Hasil: Antara Januari dan Desember 2022, terdapat 68 pasien yang terdiagnosis kanker serviks. Dari jumlah tersebut, 37 (54,41%) menderita karsinoma sel skuamosa (SCC) dan 31 (45,59%) menderita adenokarsinoma. Rasio neutrofil terhadap limfosit (NLR) berkisar antara 1,55 hingga 25,99 pada pasien SCC, dengan nilai rata-rata [masukkan nilai rata-rata di sini]. Untuk pasien adenokarsinoma, NLR berkisar antara 1,32 hingga 11,99. Kesimpulan: Rasio neutrofil-limfosit tidak dapat membedakan karsinoma sel skuamosa dan adenokarsinoma kanker serviks.Kata kunci: Adenokarsinoma, Kanker Serviks, Rasio Neutrofil-Limfosit,

The Relationship between Maternal Characteristics and Neonatal Outcomes of Premature Rupture of Membranes Yulius, Will Hans; Aditiyono, Aditiyono; Pramatirta, Akhmad Yogi; Salima, Siti
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 3 November 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i3.682

Introduction: Premature rupture of the membranes occurs when the amniotic membrane bursts before 37 weeks of gestation. Preterm labour is the primary cause of perinatal and neonatal death, with premature membrane rupture accounting for 40% of cases. This study aimed to investigate the relationship between the incidence of premature rupture of membranes (PROM) with maternal characteristics and neonatal outcomes.Method: This study was carried out through medical record analysis in premature rupture of membrane patients at the Regional General Hospital Prof. Dr. Margono Soekarjo for the period July 2022 to March 2023 using descriptive and analytical methods with a cross-sectional study design. Results: Among 139 patients with PROM, the majority of patients are less than 35 years old, multipara, term birth, and education level below junior high school. For neonatal outcomes, both infants with PROM and without PROM, the majority were born with normal weight, first and fifth-minute APGAR without asphyxia, and male. The results found a significant relationship between gestational age, maternal education level, birth weight, and neonatal APGAR scores on the incidence of PROM.Conclusions: premature rupture of membrane significantly impact neonatal outcome including birth weight, first-minute APGAR, and fifth-minute APGAR.Hubungan Karakteristik Maternal dan Luaran Neonatus Kasus Ketuban Pecah DiniAbstrakPendahuluan: Ketuban pecah dini terjadi ketika selaput ketuban pecah sebelum usia kehamilan 37 minggu. Persalinan prematur adalah penyebab utama kematian perinatal dan neonatal dengan ketuban pecah dini mencapai 40% kasus. Penelitian ini bertujuan untuk mengetahui hubungan antara kejadian ketuban pecah dini dan karakteristik ibu dan luaran neonatal.Metode: Penelitian ini dilakukan melalui analisis rekam medis pada pasien ketuban pecah dini di Rumah Sakit Umum Daerah Prof. Margono Soekarjo periode Juli 2022 hingga Maret 2023. Metode yang digunakan untuk penelitian ini adalah metode deskriptif dan analitik dengan desain studi cross-sectional.Hasil: Dari 139 pasien ketuban pecah dini, mayoritas pasien berusia kurang dari 35 tahun, multipara, lahir cukup bulan, dan tingkat pendidikan di bawah SMP. Untuk luaran neonatal, baik bayi dengan ketuban pecah dini, maupun tanpa ketuban pecah dini, mayoritas lahir dengan berat badan normal, APGAR menit pertama dan kelima tanpa asfiksia, dan berjenis kelamin laki-laki. Hasil penelitian menemukan adanya hubungan yang signifikan antara usia kehamilan, tingkat pendidikan ibu, berat badan lahir, dan skor APGAR neonatus terhadap kejadian ketuban pecah dini.Kesimpulan: ketuban pecah dini berdampak signifikan terhadap luaran neonatal termasuk berat badan lahir, APGAR menit pertama, dan APGAR menit kelima..Kata kunci: ketuban pecah dini, karakteristik maternal, luaran neonatus, study analitik

Correlation of Histological Type, Stage, Age, and Prognosis in Uterine Cervical Cancer at Margono Soekardjo Hospital Purwokerto from January – December 2024 Tambunan, Eka Maranatha; Permadi, Wiryawan; Aditiyono, Aditiyono; Grazielle, Grazielle
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.1007

Objective: To evaluate the correlation of histological subtype, stage, age, and prognosis in cervical cancer patients treated at Prof. Dr. Margono Soekarjo Hospital, Purwokerto.Methods: This is a retrospective descriptive cohort study conducted using medical records. Data on cervical cancer staging, age, and histopathological subtype were collected from all patients meeting the inclusion criteria. Statistical analysis was performed, and associations were examined using chi-square tests. The data used in the study were obtained from the medical records of patients at the research site from January to December 2024.Result: Of 582 patients identified, 245 met the inclusion criteria. Squamous cell carcinoma (SCC) accounted for 147 cases, and adenocarcinoma (AC) for 98. Most patients were aged >50 years old and diagnosed at stage II. SCC was most common at stage II, while AC was most frequently found at stage III. Statistical analysis revealed a significant but weak association between age, stage, prognosis, and histological subtype.Conclusion: There was a significant weak correlation of histological subtype and age, stage, and prognosis in cervical cancer.Korelasi Tipe Histologis, Stadium, Usia, dan Prognosis pada Kanker Uterin Serviks di Rumah Sakit Margono Soekardjo pada Januari – Desember 2024AbstrakTujuan: Penelitian ini bertujuan untuk mengetahui korelasi antara subtipe histologis, stadium, usia, dan prognosis kanker serviks uteri pada pasien yang diobati di RSUD Prof. Dr. Soekarjo Margono, Purwokerto, dalam rentang waktu Januari – Desember 2024Metode: Studi ini merupakan studi retrospektif deskriptif kohort dengan data dari rekam medis. Data yang diambil adalah stadium kanker, usia, dan subtipe histopatologis dan didapatkan dari semua pasien yang memenuhi kriteria inklusi. Analisis statistik dilakukan serta asosiasi diuji dengan uji Chi-Square. Data yang digunakan dalam penelitian diperoleh dari rekam medis pasien di RSUD Margono Soekardjo, Purwokerto pada bulan Januari hingga Desember 2024Hasil: Dari 582 pasien, sebanyak 245 pasien memenuhi kriteria inklusi. Karsinoma sel skuamosa (SCC) ditemukan pada 147 kasus, sedangkan adenokarsinoma (AC) pada 98 kasus. Sebagian besar pasien berusia >50 tahun dan didiagnosis pada stadium II. SCC paling banyak ditemukan pada stadium II, sementara AC didapatkan paling banyak pada stadium III. Analisis statistik menunjukkan adanya hubungan bermakna dengan korelasi lemah antara usia, stadium, dan prognosis dengan tipe histologis.Kesimpulan: Terdapat korelasi signifikan antara subtipe histologis dan usia, stadium, serta prognosis kanker serviks.Kata kunci: Kanker serviks; prognosis; subtipe histologis; stadium; usia

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