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All Journal Indonesian Journal of Obstetrics & Gynecology Science Asian Journal of Health Research Indonesian Journal of Cancer Medical and Health Journal
Gita Nawangtantrini
Division of Pathology Anatomy, Department Pathology Anatomy Margono Soekarjo General Hospital/ Faculty of Medicine, Jendral Soedirman University
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Prevalensi Mioma Uteri dengan Koeksistensi Hiperplasia Endometrium Nadya Hasna Rasyida Da; Aditiyono Aditiyono; Gita Nawangtantrini
Indonesian Journal of Obstetrics & Gynecology Science Volume 5 Nomor 1 Maret 2022
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v5n1.316

Abstract

Tujuan: Penelitian ini dilakukan untuk mengetahui prevalensi mioma uteri dengan koeksistensi hiperplasia endometrium pada RSUD Margono Soekarjo Purwokerto dalam rentang 2017−2019.Metode: Penelitian ini menggunakan desain observational cross-sectional yang dilakukan di Pusat Onkologi di RSUD Margono Soekarjo Purwokerto. Sumber data adalah hasil pemeriksaan mikroskopis pada laboratorium Patologi Anatomi dari pasien yang dilakukan histerektomi dengan teknik total sampling pada rentang waktu tahun 2017-2019. Data kemudian dicatat hasil pengolahan data univariat dan ditampilkan dalam bentuk tabel.Hasil: Dari 389 partisipan yang diteliti, terdapat 306 (78.7%) pasien terdiagnosa dengan mioma uteri tanpa hiperplasia endometrium dan 83 (21.3%) pasien dengan diagnosa mioma uteri disertai dengan koeksistensi hiperplasia endometrium. Dari 83 sampel pasien dengan koeksistensi hiperplasia endometrium, didapatkan 49 (59.0%) sampel memiliki gambaran hiperplasia simpleks non atipik, 14 sampel (16.9%) memiliki gambaran hiperplasia kompleks non atipik, 6 (7.2%) sampel dengan gambaran hiperplasia simpleks atipik dan 14 (16.9%) dengan gambaran hiperplasia kompleks atipik.Kesimpulan: Mioma uteri banyak terjadi pada usia perimenopause karena ketidak seimbangan hormone antara estrogen dan progesterone. Mioma uteri dapat terjadi dengan atau tanpa koeksistensi dengan patologi lainnya, seperti hiperplasia endometrium, adenomyosis ataupun polip. Hiperplasia endometrium sering terjadi sebagai patologi sekunder, dengan prevalensi terbanyak adalah hiperplasia endometrium simpleks non atipik.The Prevalence of Uterine Fibroid with Endometrial Hyperplasia CoexistenceAbstractObjective: This study was conducted to determine the prevalence of uterine fibroids with the coexistence of endometrial hyperplasia at RSUD Margono Soekarjo Purwokerto in the period of 2017−2019.Methods: This study used an observational cross-sectional design, conducted at the Oncology Center of RSUD Margono Soekarjo Purwokerto. The data used are the results of microscopic examinations of patients who underwent hysterectomy in the Anatomical Pathology laboratory with total sampling technique in the period of 2017-2019.Results: Of the 389 participants studied, there were 306 (78.7%) patients diagnosed with uterine fibroids without endometrial hyperplasia and 83 (21.3%) patients with uterine fibroids with the coexistence of endometrial hyperplasia. From the 83 samples of patients with coexistence of endometrial hyperplasia, 49 (59.0%) samples had simple hyperplasia without atypia, 14 (16.9%) had complex hyperplasia without atypia, 6 (7.2%) had simple atypical hyperplasia and 14 ( 16.9%) with complex atypical hyperplasia.Conclusion: Uterine fibroids often occur at perimenopausal age due to hormonal imbalance of estrogen and progesterone. Uterine fibroids may occur with or without coexistence of other pathologies, such as endometrial hyperplasia, adenomyosis or polyps. Endometrial hyperplasia often occurs as a secondary pathology, with the highest prevalence being simplex  hyperplasia without atypia.Key words: uterine fibroid, endometrial hyperplasia, perimopause
A Rare Clinical Entity of Krukenberg Tumor: A Case Report in Margono Soekarjo Hospital of Purwokerto Aditya Eka Octavian; M Yamsun; Gita Nawangtantrini
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.931

Abstract

Introduction: Krukenberg Tumor is an ovarian tumor that originated from other organ metastases such as gastric, colorectal, pylorus, appendix, colorectal, or breasts. This study aims to report an incidence of a Krukenberg tumor found in a-36year- old woman who has finished her therapy at Margono Soekarjo Hospital.Case Presentation: This case reports the incidence of a Krukenberg tumor found in a-36-year old woman with the main complaint of a burning sensation in her stomach and the existence of a mass in the right and under the Arcus Costae. The patient underwent metastasectomy and biopsy. Histopathological examinations show that the features of Krukenberg tumor originated from a gaster. The patient then underwent chemotherapy for 6 cycles, radiotherapy 20 times, and some evaluation. This case had been observed for 12 months since the first time the patient came to the hospital.Conclusions: Krukenberg tumor is a rare tumor of the ovary which is characterized by poor prognosis. This case depicts the finding of Krukenberg tumor with gastric clinical features. The combination of metastasectomy and chemotherapy can be done in such a case to improve patient survival rates.
EFFECT OF GIVING GARLIC ON URIC ACID LEVELS OF HYPERURISEMIC WHITE RATS (Rattus norvegicus) Fajar Wahyu Pribadi; Afifah Afifah; Gita Nawangtantrini
Medical and Health Journal Vol 2 No 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (424.031 KB) | DOI: 10.20884/1.mhj.2023.2.2.8340

Abstract

Hiperurisemia adalah kondisi dimana kadar asam urat dalam tubuh melebihi batas normal akibat peningkatan sintesis purin yang berlebih dalam tubuh karena pola makan tidak sehat, proses pengeluaran asam urat dari dalam tubuh mengalami gangguan atau kombinasi dari keduanya. Bawang hitam mengandung s-alyl cistein (SAC), tetrahydro-β-carbolines, alkaloid, dan flavonoid yang diduga menghambat kerja dari enzim xanthine oksidase sehingga dapat menurunkan asam urat. Tujuan jangka pendek penelitian ini untuk mengetahui efek bawang hitam terhadap kadar asam urat tikus putih hiperurisemik. Tujuan jangka panjang yang ingin dicapai yaitu pemanfaatan bawang hitam untuk pencegahan dan atau mengatasi dampak negatif hiperurisemia. Tikus dikelompokkan menjadi lima kelompok yaitu kontrol control positif (A), kelompok allopurinol (B), kelompok bawang hitam dosis 240mg (C), 480mg (D) dan 960mg (E). Induksi hiperurisemia dilakukan dengan injeksi kalium oksonat dan penambahan otak sapi selama 14 hari, dilanjutkan bersama dengan pemberian perlakuan. Hasil rata-rata asam urat pada masing- masing kelompok adalah A: 15,02 ± 0.71, B: 6,45 ± 0,13, C: 8,46 ± 0,12, D: 7,64 ± 0,14, E: 7,55 ± 0,55. Data dianalisis menggunakan One Way ANOVA dilanjutkan Post Hoc LSD. Kesimpulan pemberian bawang hitam berbagai dosis dapat menurunkan kadar asam urat pada tikus hiperurisemia.
Hepatotoxicity Oral Administration of Flavonoids Rich Extract from Phaleria Macrocarpha in Mice Siskanita Fitriana; Sri Andarini; Sutrisno Sutrisno; Gita Nawangtantrini; Maharani Maharani
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.109

Abstract

Introduction : Herbal medications are increasingly being used to treat a wide range of illnesses. Phaleria macrocarpa, often known as the crown of the gods, is a plant rich in flavonoids that is frequently used in herbal therapy. The goal of this study was to see what effect a flavonoid-rich extract from phaleria macrocarpa has on the livers of mice. Material and Methode : This study used adult female mice aged 6-8 weeks and weighing 20-30 gr as experimental animals, which were divided into four groups: the control group was given distilled water, group 2 was given a flavonoid dose of 500 mg/kg/day, group 3 was given a flavonoid dose of 1000 mg/kg/day, and group 4 was given a flavonoid dose of 2000 mg/kg/day. The flavonoid-rich extract of Phaleria macrocarpa was administered for 28 days. On the 29th day, the mice were necropsied, followed by surgery and examination of the mice's livers. Result : The flavonoid-rich extract of phaleria macrocarpa at a dose of 500 mg/kg body weight/day resulted in no changes in the weight or histological structure of the liver (p>0.05). Hydropic degeneration and necrosis were observed in the group administered the flavonoid-rich extract of phaleria macrocarpa at doses of 1000 and 2000 mg/kg body weight/day. Conclusion : The administration of a flavonoid-rich extract from Phaleria macrocarpa at a level of 500 mg/kg body weight/day caused no harm in the liver of mice. The use of more than 500 mg/kg body weight/day over an extended period of time has hazardous effects and is not recommended.
HUBUNGAN USIA DAN JUMLAH PARITAS DENGAN TIPE KARSINOMA ENDOMETRIUM DI RSUD PROF. DR. MARGONO SOEKARJO Nusa, Arifah Pelangi; Nawangtantrini, Gita; Aditiyono, Aditiyono; Novrial, Dody; Yamsum, M
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.8741

Abstract

Background: Endometrial cancer ranks 15th with the highest number of new cases in 2020 in the world. There are still differences in research results regarding the relationship between age and number of parities with endometrial carcinome. Aim: To determine the relationship between age and parity with type of endometrial carcinoma at RSUD Prof. Dr. Margono Soekarjo. Method: This research is an observational analytic study with a cross sectional study. The sampling technique uses total sampling. Total subjects were 129 endometrial carcinoma patients at RSUD Prof. Dr. Margono Soekarjo in 2017-2022. The data taken is secondary data from the medical records. The variable age and number of parities are the data listed in the medical record document. Data were analyzed using the chi-square statistical test. Result: The total sample obtained was 129 patients. The most common age was found at the age of 51-60 years (41.1%) and the least at the age of <40 years (7.8%). The highest number of parities found was parity ≥2 (55.8%) and the least was parity 1 (15.5%). The results of the chi-square statistical test for age with endometrial carcinoma type showed a value of p = 0.159 (p>0.05). Based on the results of the analysis, there was no significant relationship between age and the type of endometrial cancer. The results of the chi-square statistical test for the number of endometrial carcinoma types showed a value of p = 0.02 (p <0.05). Based on the results of the analysis, it showed that there was a significant relationship between the number of parities and the type of endometrial cancer. Conclusion: There was no significant relationship between age and the type of endometrial carcinome and there was a significant relationship between the number of parities and the type of endometrial carcinome at RSUD Prof. Dr. Margono Soekarjo.
Co-Authors Aditiyono Aditiyono Aditiyono, Aditiyono Aditya Eka Octavian Dody Novrial, Dody Fajar Wahyu Pribadi M Yamsun Maharani Maharani Muhammad Afif Nadya Hasna Rasyida Da Nusa, Arifah Pelangi Siskanita Fitriana Sri Andarini Sutrisno Sutrisno Yamsum, M