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All Journal MNJ (Malang Neurology Journal) Universa Medicina Jember Medical Journal (JMJ)
Habibi, Ali
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Parasite immunomodulatory role in reducing the prevalence of COVID-19 in endemic regions Hermansyah, Bagus; Agustina, Dini; Zulaikha, Siti; Habibi, Ali
Universa Medicina Vol. 41 No. 1 (2022)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2022.v41.90-99

Abstract

Nearly 35 million cases and one million deaths over the nine months of the COVID-19 pandemic have been reported worldwide. Africa and some countries with endemic parasitic infections had a low incidence of COVID-19. By contrast, the United States and several European countries, having a non-endemicity of parasitic infections, recorded a high incidence of COVID-19. Some parasites have an immunomodulatory mechanism that can induce an immune tolerance state in the infected persons by balancing pro-inflammatory and anti-inflammatory responses. Emerging reports also stated that COVID-19 and helminth co-infections may have more hidden outcomes than predictable ones. Hence, the aim of this literature review is to show and identify that an increase in the number of regulatory immune cells due to the immunomodulatory role of a pre-existing parasitic infection could reduce the risk of COVID-19. This study explored the existing literature to determine the role of parasitic infections in modulating the immune response and possibly reduce the risk of COVID-19 infection in endemic countries. The mechanism of immunomodulation by parasites is the increased numbers of Treg cells, M2 macrophages, eosinophils, the Th2 cytokines IL-4 and IL-5, and the pro-inflammatory downregulation of IFN λ, TNF α, and IL-6, which play an essential role in inducing cytokine storms in COVID-19 infection. This condition will probably occur in an individual with parasitic infection in a community with limited facilities and infrastructure to treat parasitic infections, particularly in developing countries. To conclude, in endemic areas, the immunomodulatory effect of parasitic infection to reduce the risk of COVID-19 cases/deaths is a possibility if the host is immunocompetent. Herein, the current knowledge on the immunomodulatory role of COVID-19 and helminth co-infections will be discussed.
Extraction of Air Gun Pellet in Lung Base Thoracic Vertebrae Region with Lateral Extracavitary Approach: A Case Report Adji, Novan Krisno; Putri, Komang Yunita Wiryaning; Indreswari, Laksmi; Nugraha, Muhammad Yuda; Habibi, Ali
Jember Medical Journal Vol. 2 No. 2 (2023)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jembermedicaljournal.v2i2.452

Abstract

Thoracic gunshot injuries are associated with significant morbidity and mortality, but fatal accidents from air guns are rare. Surgery in this area is challenging, especially if the gun pellet penetrates the visceral organ like the lung. In this case, we present a case of an 18-year-old male who came to the emergency department with an air gunshot (pellet) that penetrated the chest and settled in the lung base. After being shot by an air gun, the patient came with pain in the right back and weakness in both lower extremities. Based on the radiological examination, metallic corpus allienum measuring ± 0.8 x 0.7 cm has shown at the lung base as high as the Thoracic 12 vertebrae, 9.5 cm right lung laceration, right hemothorax, and emphysema subcutis on the right inferior side of hemithorax. The patient planned surgery to extract the corpus allienum through a lateral extra cavitary approach to expose the lungs at the level of the Th10-12 vertebrae. The lateral extra cavitary approach can be an alternative, less invasive method to extract foreign body lung base in front of vertebrae thoracic region.
EFFICACY OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION AS UPPER EXTREMITY MOTOR REHABILITATION THERAPY AFTER STROKE: A SYSTEMATIC REVIEW Purwandhono, Azham; Adji, Novan Krisno; Abrori, Cholis; Fatmawati, Heni; Habibi, Ali
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.12

Abstract

Background: The most frequent impairment following a stroke is the hemiparesis of the opposite-side upper extremity. Repetitive Transcranial Magnetic Stimulation (rTMS) is popular in research studies on upper extremity motor rehabilitation after stroke. Information regarding the onset of therapy, duration of therapy, and the type of rTMS in post-stroke upper extremity motor rehabilitation therapy is still spread in various journals, therefore researchers are interested in making this systematic review. Objective: This study aimed to assess the efficacy of rTMS for upper extremity motor rehabilitation after stroke, and had specific aims to compare different treatment timings and durations, as well as evaluating the effectiveness of high-frequency versus low-frequency rTMS. Methods: Literature search was conducted with multiple electronic databases, such as PubMed, ScienceDirect, Cochrane Library, and LinkSpringer. The boolean operator method will be used for the keywords and the synonyms were searched using the Medical Subject Heading (MeSH) database. Critical appraisal and Risk of biases were assessed for each study using The Joanna Briggs Institute (JBI) Critical Appraisal Tools. Data analysis in this systematic review are using descriptive analysis. Results: The included studies consisted of two types of rTMS with varying onset and duration of the therapy. The duration of rTMS therapy consists of 5-18 sessions. In the Upper Extremity Fugl-Meyer Assessment (UE-FMA) based study, High-Frequency (HF) rTMS had significant overall results when compared to sham, whereas Low-Frequency (LF) rTMS therapy still showed contradictory results. HF-rTMS therapy can be performed in acute, subacute, and chronic stroke phases. The duration of HF-rTMS therapy can be done with 5 or 10 sessions, but it still needs further research in order to determine the number of sessions that have the best efficacy. Conclusion: This study show HF-rTMS has better efficacy compared to LF-rTMS for upper extremity motor rehabilitation therapy after stroke.
Co-Authors Adji, Novan Krisno Azham Purwandhono Bagus Hermansyah Cholis Abrori, Cholis Dini Agustina Heni Fatmawati Laksmi Indreswari Nugraha, Muhammad Yuda Putri, Komang Yunita Wiryaning Siti Zulaikha