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All Journal Jurnal Kesehatan Lingkungan indonesia Jurnal Ilmu Dasar Jurnal Natur Indonesia e-Journal Pustaka Kesehatan Althea Medical Journal Indonesian Journal of Urology Journal of Agromedicine and Medical Sciences MNJ (Malang Neurology Journal) Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Majalah Kedokteran Andalas ISM (Intisari Sains Medis) : Jurnal Kedokteran Journal of Health Sciences Medica Hospitalia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Berkala Penelitian Hayati JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Makara Journal of Health Research Jember Medical Journal (JMJ)
Heni Fatmawati
Department Of Radiology, Faculty Of Medicine, Universitas Jember, Jember, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Dentistry Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health

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Pengaruh Likopen terhadap Penurunan Aktivitas Mitogen-Activated Protein Kinase (MAPK) dan Ekspresi Endothelin-1 (ET-1) pada Kultur Huvecs yang Dipapar Leptin Fatmawati, Heni; Satuman, Satuman; Rudijanto, Ahmad; Indra, Muhammad Rasjad
Jurnal Natur Indonesia Vol 13, No 2 (2011)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (75.081 KB) | DOI: 10.31258/jnat.13.2.162-167

Abstract

The effect of obesity on vascular function is mediated by hormon leptin. Leptin has been proved to increaseoxidative stress in endothelial cell. The previous study has proven that leptin caused the endothelial dysfunction asa step of the atherogenesis. Lycopene, an antioxidant, is presumed having the ability to block the atherogenesismechanism, which is stimulated a proinflamatory cytokine and adhesion molecules by MAPK and transcriptionfactor ET-1. Therefore, the aim of this research was to prove and to determine whether lycopene could decreasethe MAPK and ET-1 expression in Human Umbillical Vein Endothelial Cells (HUVECs) culture induced by 500 ng/mlleptin. In vitro study used primary culture of the HUVECs were devided in to 7 groups, there were (1) 0 ng/ml leptinand 0 ìM lycopene, (2) induced by 500 ng/ml leptin for 12 hours, (3) induced by leptin and lycopene with concentration10; 25; 40; 55 and 75 ìM for 12 hours. Then the identification of MAPK was applied by using imunocytochemistrycompared with ELISA procedure on cell endothel culture lysate and ET-1 expression was measured by using RTPCR. It was showed that lycopene 10-25 ìM decreased MAPK and ET-1 expression significantly in HUVECs cultureinduced by leptin 500 ng/ml. Leptin was increased ERK1/2 MAPK and ET-1 expression in HUVECs culture and candecrease by lycopene. Optimum dose of lycopene is 10-25 ìM.
RELATION OF TOTAL CHOLESTEROL TO PROSTATE VOLUME AND INTRAVESICAL PROSTATIC PROTRUSION IN BENIGN PROSTATIC HYPERPLASIA PATIENTS Made Devi Desyana Arisandi; Wahyudi, Septa Surya; Fatmawati, Heni
Indonesian Journal of Urology Vol 28 No 2 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i2.675

Abstract

Objective: To determine the relationship between total cholesterol, prostate volume, and intravesical prostatic protrusion in patients with benign prostatic hyperplasia. Material & Methods: This study used a cross-sectional method, carried out at the Paru and Bina Sehat Hospital in Jember. The sample in this study was BPH patients who met the inclusion criteria taken through medical record data from October 2019 to January 2020 Results: Samples on this study amounted to 33 patients. In this study, there was a difference between normal and high cholesterol with prostate volume in BPH patients (p = 0.00) and there was a significant relationship between cholesterol and prostate volume with strong correlation strength (p = 0.00 and r = 0.751) while the difference between high and normal cholesterol with IPP obtained insignificant results (p = 0.211) and the correlation between cholesterol and IPP obtained an insignificant relation with weak correlation strength (p = 0.217 and r = 0.221). Conclusion: There is a significant relationship between total cholesterol and prostate volume and a significant difference in prostate volume between normal and high total cholesterol in BPH patients, while there is no significant result between total cholesterol and intravesical prostatic protrusion in BPH patients.
Analisis Histopatologi Pembuluh Darah Tikus Berdasarkan Jarak Luka Masuk Pasca Paparan Listrik Annisa Sarfina Djunaedy; Ulfa Elfiah; Heni Fatmawati
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 2 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v2i2.1237

Abstract

Electrical injury merupakan suatu kerusakan pada jaringan atau organ tubuh akibat adanya aliran arus listrik yang melewati tubuh. Pembuluh darah merupakan salah satu jaringan yang mengalami kerusakan ketika terjadi electrical injury. Salah satu kerusakan pada pembuluh darah adalah adanya trombus yang dapat mengganggu aliran darah sehingga menyebabkan  tatalaksana electric injury menjadi kurang baik. Tujuan umum dari penelitian ini adalah menganalisis histopatologi pembuluh darah tikus berdasarkan jarak luka masuk pasca paparan listrik. Jenis penelitian yang digunakan adalah penelitian eksperimental sebenarnya dengan  rancangan post test only control group design. Penelitian ini menggunakan 25 ekor tikus wistar yang dibagi menjadi lima kelompok. Perlakuan yang diberikan berupa paparan listrik sebesar 140 V selama 17 detik. Kelompok kontrol merupakan kelompok yang tidak diberi paparan listrik, kelompok H0 diterminasi pada hari ke-0 pasca paparan listrik, kelompok  H3 diterminasi pada hari ke-3 pasca paparan listrik, kelompok H7 diterminasi pada hari ke-7 pasca paparan listrik, kelompok H10 diterminasi pada hari ke-10 pasca paparan listrik. Pada penelitian ini, hal yang diamati yaitu persentase trombus pada arteri saphena dekstra berdasaran jarak dari luka masuk. Hipotesis diterima apabila hasil analisis data menggunakan One Way Anova atau Kruskall Wallis menghasilkan p<0.05. Secara garis besar, pada hasil penelitian didapatkan bahwa bahwa persentase trombus semakin berkurang ketika semakin jauh dari luka masuk, kecuali pada kelompok H7. Selain itu, hasil penelitian  menunjukkan bahwa secara garis besar persentase trombus  bertambah  seiring berjalannya waktu dan menurun pada waktu tertentu. Namun, pada penelitian ini didapatkan bahwa tidak terdapat perbedaan yang signifikan secara statistik pada gambaran histopatologi pembuluh darah, khususnya trombus pasca paparan listrik berdasarkan jarak luka masuk di hari ke-0, ke-3, ke-7, dan ke-10.
Sensitivitas Dan Spesifisitas Mdct Angiografi Dalam Mendiagnosis Aneurisma Intrakranial Antonius Gunawan S; Heni Fatmawati
Medica Hospitalia : Journal of Clinical Medicine Vol. 4 No. 2 (2017): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (238.047 KB) | DOI: 10.36408/mhjcm.v4i2.320

Abstract

Latar belakang: Deteksi yang cepat untuk menemukan ruptur aneurisma intrakranial (AI) sangat penting karena ruptur AI menyebabkan perdarahan subarahnoid (PSA) spontan yang merupakan kegawatan medis dan menyebabkan kematian atau kecacatan berat. Multidetector computed tomography angiography (MDCTA), sebagai alat diagnostik non invasif, telah digunakan secara luas dalam imaging pembuluh darah otak. Tujuan: mengetahui kemampuan sensitivitas dan spesifisitas MDCTA untuk mendeteksi lokasi dan ukuran aneurisma intrakranial. Metode: Studi cross-sectional pada pasien dengan dugaan aneurisma intrakranial yang telah dilakukan pemeriksaan MDCTA dan Digital Substraction Angiography (DSA) dari data rekam medik di RSUP Dr. Kariadi Semarang mulai Oktober 2012 – November 2015. Pengambilan sampel dilakukan dengan consecutive sampling. Dua orang dokter spesialis radiologi yang independen mengevaluasi hasil MDCTA dan DSA untuk menentukan lokasi dan ukuran aneurisma. Analisis statistik menggunakan sensitivitas dan spesifisitas. Hasil: Penderita aneurisma intrakranial terbanyak berusia 40-60 tahun 73,7%, perempuan 78,9% dan 52,6% berukuran 3-7 mm serta 80,5% berlokasi di sirkulasi anterior. Sensitivitas MDCTA dalam mendeteksi aneurisma baik yang berukuran kurang dari 3 mm, 3-7 mm dan lebih dari 7 mm pada penelitian ini adalah 100, 100, 100 %, sedangkan nilai spesifisitas adalah 100, 100 dan 93,3%. Kesimpulan: Penggunaan MDCTA untuk mendiagnosis aneurisma intrakranial mempunyai sensitivitas dan spesifisitas tinggi sehingga dapat menjadi pilihan pertama dalam tehnik imaging. Kata kunci: Aneurisma intrakranial, MDCTA, sensitivitas, spesifisitas
Pengaruh Ekstrak Air Ubi Jalar Ungu (Ipomoea batatas L.,) terhadap Jumlah Endhotelial Progenitor Cell (EPC) pada Tikus Wistar Diabetes Melitus Cynthia Parasetiayu Ariesty; Sugiyanta Sugiyanta; Heni Fatmawati
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes melitus adalah penyakit metabolik dengan karakteristik hiperglikemia yang terjadi karena kelainan sekresi insulin, kerja insulin, atau keduanya. Hiperglikemia menjadi faktor penentu dalam perkembangan disfungsi endotel dan penurunan kemampuan pembentukan pembuluh darah baru. Proses pembentukan pembuluh darah baru dihasilkan dari proliferasi endotel setempat dan peran dari Endhotelial Progenitor Cell (EPC) yang dapat dicegah dengan pemberian antioksidan. Salah satu tanaman yang mengandung antioksidan adalah ubi jalar ungu. Dalam penelitian ini, 25 ekor tikus dibagi menjadi 5 kelompok, yaitu 2 kelompok kontrol dan 3 kelompok perlakuan. Pemberian ekstrak dilakukan selama 14 hari melalui cara sonde dengan dosis 1,4 cc/ekor/hari, 3,5 cc/ekor/hari dan 5,6 cc/ekor/hari untuk P1, P2 dan P3. Penghitungan jumlah EPC tikus dilakukan dengan flowcytometry, selanjutnya data dianalisis dengan analisis Oneway ANOVA. Meskipun tidak berbeda secara signifikan, jumlah EPC pada tikus yang diinduksi ekstrak ubi jalar ungu lebih tinggi dibandingkan dengan kelompok tikus diabetik tanpa perlakuan). Dapat disimpulkan bahwa pemberian ekstrak air ubi jalar ungu dengan berbagai dosis tidak menunjukkan adanya perbedaan nyata terhadap kadar EPC tikus yang diinduksi diabetes mellitus.   Kata Kunci: Antioksidan, Diabetes melitus, EPC, Ubi Jalar Ungu
The Role Of Lycopene to Nuclear Factor Kappa Beta (Nf-κB) Activities and Intracellular Cell Adhesion Molecule-1 (Icam-1) Expressions on Leptin-Induced Endothelial Cell Heni Fatmawati; S Satuman; Endang SW; A Rudijanto; M Rasjad Indra
Jurnal ILMU DASAR Vol 11 No 2 (2010)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.881 KB)

Abstract

There is adipocytokine dysregulation on obesity such as amplified leptin, and reduced adiponectin at serum levels . Leptin has been proved to increase oxidative stress in endothelial cell. The adipocyte functions as an important secretory organ via nuclear factor-κ B (NF-κB) releasing a number of bioactive molecules such as leptin. Lycopene, an antioxidant, is presumed having the ability to block the atherogenesis mechanism, which is stimulated a proinflamatory cytokine and adhesion molecules ICAM-1 by NF-κB. Therefore, the aim of this research was to prove and to determine whether lycopene could decrease the NF-κBandICAM-1 expressionin Human Umbillical Vein Endothelial Cells (HUVECs) culture induced by 500 ng/mL leptin. In vitro study used primary culture of the HUVECs were devided in to 7 groups, there were (1) 0 ng/mL leptin and 0 μM lycopene, (2) induced by 500 ng/mL leptin for 12 hours, (3) induced by leptin and lycopene with concentration 10; 25; 40; 55 and 75 μM for 12 hours. Then the identification of NF-κB was applied by using imunocytochemistry compared with ELISA procedure on cell endothel culture lysate and ICAM-1 expression was measured by using RT PCR. It was showed that lycopene 25 μM decreased NF-κB level and ICAM-1 expression significantly in Human Umbillical Vein Endothelial Cells (HUVECs) culture induced by leptin 500 ng/mL.Leptin was increased NF-κB and ICAM-1 expression in HUVECs culture and was decreased by lycopene. Optimum dose of lycopene is 25 μM.
Effect of Soyflour (Glycine max L.) Hepatoprotector Activity on Liver MDA Level in Male Wistar Rat Induced by Diazinon Sofi Aliyatul Himah; Desie Dwi Wisudanti; Heni Fatmawati
Journal of Agromedicine and Medical Sciences Vol 4 No 1 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i1.6857

Abstract

Diazinon is metabolized in liver becomes diazoxon, an active metabolite form that can cause free radical raisingthat leads to lipid peroxidation. The result of lipid peroxidation is MDA. Soyflour has higher isoflavones than theother processed food of Glycine max L.This isoflavones donate its electron and hydrogen atom in lipidperoxidation so it can block the lipid peroxidation. The aim of this experiment is to investigate the effect of soyflour on MDA hepar level increase of male wistar rat induced by diazinon. The sample are divided into 5 groupswhich are Kn, K(-) group induced by diazinon 40mg/kgBW, K1, K2, K3 group given with soy flour 10%, 15%, and20% orally, then induced by diazinon 40 mg/kgBW. MDA liver measured on the day 34th with MDA-TBAmethode which has pink colour and measured by spectrofotometer. Average of liver MDA levels is Kn 6,35μg/mL; K(-) 9,23 μg/mL; K1 8,85 μg/mL; K2 7,88 μg/mL; K3 7,04 μg/mL. One way ANOVA and Post hoc LSDshowed significantly different (p<0,05). Pearson correlation showed strong negative correlation. Keywords: Diazinon, Diazoxon, MDA, Soyflour, Glycine max L., antioxidant
The Effect of Purple Sweet Potato Extract on The Circulating Endothelial Cell (CEC) levels in Rat Model of Diabetes Emilia Puspita Sari; Edi Junaidi; Heni Fatmawati
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5070

Abstract

Diabetes mellitus is a metabolic disease with impaired metabolism of carbohydrates, fats and proteins are characterized by hiperglycemia caused by insufficiency of insulin secretion and insulin resistance. Diabetes mellitus is the leading cause of death in Indonesia, especially in developing countries. Most (90%) classified as type 2 diabetes mellitus and 10% of type 1 diabetes mellitus. In DM, increased oxidative stres. DM oxidative stres due to the increase of free radicals in the body. Oxidative stres can lead to irreversible endothelial injury that would lead to the loss of endothelial cells characterized by the expression of CD 146. Ipomoea batatas L. anthocyanin-containing compound is an antioxidant that can reduce free radicals and reduce oxidative cell damage caused by free radicals. From the analysis of the data obtained Ipomoea batatas L. mempuyai influence on the content of the CEC of 42.5%.
Comparison Profile of Nutrition Status in Stage V Chronic Kidney Disease Patients Hemodialyzing Using New and Reuse Dialyzer Yuli Hermansyah; Ika Aulia Kurniasari; Heni Fatmawati
Journal of Agromedicine and Medical Sciences Vol 5 No 2 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i2.9613

Abstract

Burn wound healing process consists of three phases of inflammation, proliferation and remodelling. The number of fibroblasts has increased during the proliferation phase. Oxidative stress in burn may disrupt proliferation through TGF-β inhibition, result in decreased number of fibroblasts and poor burn wound healing. Genistein in edamame seeds has anti-inflammatory, antibacterial and antioxidant properties. Edamame contains vitamins A, C, and E which is also have antioxidant properties. Edamame has been suggested to protect burn wound healing from oxidative stress. This study aimed to understand the effectiveness of edamame seed (Glycine max L. Merril) ethanolic extract (ED) to fibroblast count in second degree burn wound healing. This is true experimental research with post test only control group design. The sample of this research was 24 rat models of second degree burn which was made by attaching hot metal (60 ° C) for 5 seconds on the shaved back of the rats. The sample was divided into 6 groups with topical treatment, among others: positive control group (silver sulfadiazine), negative control group (Na CMC 0.5%), group with ED 20%, ED 40%, ED 60%, and ED 80%. Treatment was given for 15 days and skin sample was taken on the 16th day. Observation of the number of fibroblasts was done by taking pictures of histhologic preparations in Hematoxylin and Eosin staining under 400x magnification of light microscope. In one way ANOVA test, significance value of 0.011 (p≤0,05) indicated that there was at least a significant difference between 2 groups. LSD’s post hoc analysis showed that there was a significant difference in the group ED 20, 40, and 60% compared with negative control. Keyword: burn wound healing, vegetable soybean, genistein, fibroblast count, silver sulfadiazine
The Effectivity of Extracts Soybean on Increasing Concentration of RBP (Retinol binding protein) in White Rat (Rattus norvegicus) Kwashiorkor Model Rizsa Aulia Danesty; Heni Fatmawati; Angga Mardro Raharjo
Journal of Agromedicine and Medical Sciences Vol 3 No 1 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i1.4095

Abstract

Kwashiorkor is a disease caused by a deficiency of protein in terms of both quality and quantity. Kwashiorkor cause dysfunction in various organ systems. The purpose of this study was to determine the role of soy in increasing serum RBP levels in rat models of kwashiorkor. The liver is a vital organ for protein synthesis, one RBP. The liver is particularly vulnerable to the effects of kwashiorkor. The method used is the mice given low-protein diet for 30 days and then given extract of soybean meal for 30 days subsequent serum RBP levels were evaluated using ELISA method. The results showed that the soy extract can increase the levels of RBP in mice models of kwashiorkor. Keywords: RBP, soybean extracts and kwashiorkor 
Co-Authors A Rudijanto Adji, Novan Krisno Adrian Wibisono Ahmad Rudijanto Al Munawir Ali Santosa Alvin Candra Ancah Caesarina Novi Marchianti Angga Mardro Raharjo Annisa Sarfina Djunaedy Antonius G Santoso Antonius Gunawan S Azham Purwandhono Azham Purwandhono Bagus Hermansyah Brillian Adexa Yudinda Cahyana, Nugraha Wahyu Candra Bumi Celly Afifah Pramono Cholis Abrori, Cholis Cynthia Parasetiayu Ariesty Desie Dwi Wisudanti Diana Chusna Mufida Dion Krismashogi Dharmawan Dita Diana Parti Edi Junaidi Elly Nurus Sakinah, Elly Nurus Emilia Puspita Sari Endang SW Erma Sulistyaningsih Ghani Silahudin Habibi, Ali Hendiadi, Bagus Sedya I Nyoman Semita Ida Srisurani Wiji Astuti Ika Aulia Kurniasari Ika Rahmawati Sutejo Irawan Fajar Kusuma Jauhar Firdaus Jauhar Firdaus Lailatul Maghfiroh M Rasjad Indra Made Devi Desyana Arisandi Muhamad Hasan Muhammad Afiful Jauhani Muhammad Rasjad Indra Ni Made Trismarani Sultradewi Kesuma Nindya Shinta Rumastika Nugraha Wahyu Cahyana Pattipeilohy, Florence Putri, Komang Yunita Wiryaning Putu Ayu Laksmi Lestari Rifaldy Nabiel Erisadana Rizsa Aulia Danesty S Satuman Sabila, Selma Naf’an Santoso, Antonius G Satuman Satuman septa surya wahyudi, septa surya Sofi Aliyatul Himah Sugiyanta Sugiyanta Ulfa Elfiah Wiryaning Putri, Komang Yunita Wiwien Sugih Utami Yehuda Tri Nugroho Supranoto Yoga Setyo Yuli Hermansyah Yunita Armiyanti Zahirah, Mutiara Zhafirah Rana Labibah