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All Journal Diponegoro Law Journal Journal of Agromedicine and Medical Sciences Pharmascience Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Journal of Health Promotion and Behavior Buletin Poltanesa Jurnal Industri Pariwisata Jurnal Rekonstruksi dan Estetik Jember Medical Journal (JMJ) International Journal of Health and Information System (IJHIS) Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Folia Medica Indonesiana Jurnal Veteriner
Laksmi Indreswari
Anatomi, Universitas Jember
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary

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MODULASI AKTIVITAS CIPROFLOXACIN TERHADAP Pseudomonas aeruginosa OLEH N-ASETILSISTEIN DAN VITAMIN C Agustina, Dini; Indreswari, Laksmi; Tristianti, Farmitalia Nisa; El Milla, Kardiana Izza; Hermansyah, Bagus; Wahyudi, Septa Surya; Firdaus, Jauhar
Syifa'Medika Vol 11, No 1 (2020): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v11i1.2389

Abstract

Pseudomonas aeruginosa merupakan salah satu bakteri penyebab infeksi yang sulit diobati dengan terapi obat tunggal karena tingkat keberhasilan yang rendah serta kecenderungan menjadi resisten selama pemberian obat tunggal. Salah satu antibiotik yang digunakan adalah ciprofloxacin. Untuk meningkatkan sensitivitas P. aeruginosa terhadap ciprofloxacin, kombinasi N-asetilsistein atau vitamin C mungkin diperlukan. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi antara N- asetilsistein dan ciprofloxacin serta antara vitamin C dan ciprofloxacin terhadap pertumbuhan P. aeruginosa. Penelitian ini menggunakan uji difusi cakram yang berisi kombinasi konsentrasi ciprofloxacin konstan 1mg/ml dengan N-asetilsistein dalam berbagai konsentrasi 1,25mg/ml, 2,5mg/ml, 5mg/ml, 10mg/ml, dan 20mg/ml dan vitamin C dengan 2,5 mg/ml; 5 mg/ml; 10 mg/ml; 20 mg/ml; dan konsentrasi 40 mg/ml. Dalam kombinasi antara N-asetilsistein dan ciprofloxacin, peningkatan sensitivitas P. aeruginosa terjadi pada konsentrasi 10ml/mg pada kombinasi obat, dan dalam kombinasi antara vitamin C dan ciprofloxacin, peningkatan sensitivitas P. aeruginosa terjadi pada konsentrasi 2, 5 ml/mg pada kombinasi obat di atas kontrol positif. Regresi logaritmik mengungkapkan konsentrasi minimal N- asetilsistein dan vitamin C masing-masing adalah 9,593 mg/ml dan 1,9 mg/ml dapat meningkatkan sensitivitas P. aeruginosa pada ciprofloxacin. Dapat disimpulkan bahwa N-asetilsistein dan vitamin C meningkatkan aktivitas ciprofloxacin untuk menghambat pertumbuhan P. aeruginosa in vitro.
The Effect of Red Spinach Extract (Amaranthus tricolor L.) on Serum Malondialdehyde of Male Rattus Novergicus Fracture Model Aris Prasetyo; Ahmad Baihaqi; Laksmi Indreswari
Journal of Agromedicine and Medical Sciences Vol 6 No 2 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i2.6838

Abstract

Fracture is a musculoskeletal injury with a high incidence rate. The healing process of fracture is disturbed by the oxidative stress, because of imbalance quantity of Reactive Oxygen Species (ROS) and antioxidant capacity in the body that neutralizes it. Antioxidants in red spinach have the potential to suppress the level of oxidative stress. The study aimed to determinate the effect of red spinach ethanolic extract on decreasing oxidative stress by measuring malonaldialdehyde (MDA) concentration in fracture healing process. The study used thirty rats and divided into five groups; negative control group, positive control group,and three treatment groups of red spinach ethanolic extract in a dose of 35,4 mg/150gBB, 70,8 mg/150gBB, and 141,6 mg/150gBB manually fractured on right femur under anaesthesia and immobilized by leucodur plaster. Each group was treated orally respectively one week. The result of One Way Anova showed a significance of 0,000 (p<0,05) in which there was a significant difference in serum MDA levels between the treatment groups and the control groups. The result of LSD test between P1 group and P3 group showed significantly different in which decreased serum MDA levels were consistent with increasing doses of red spinach ethanolic extract. The study concluded that red spinach ethanolic extract had a positive effect on supression of oxidative stress in fracture healing process. Keywords: Red spinach ethanolic extract, fracture healing process, MDA, ROS
Potential of Cocoa Extract (Theobroma cacao) in Inhibiting Erythrocyte Damage Induced by Physalia utriculus Venom Adinningtyas Intansari; Al Munawir; Laksmi Indreswari
Journal of Agromedicine and Medical Sciences Vol 6 No 3 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i3.9661

Abstract

Physalia utriculus is one of the invertebrate marine biota that is often found in Indonesia. Some symptoms of venoming due to jellyfish stings cause pain, itching, and hemolysis. In Indonesia, 13 cases of jellyfish stings were reported in 2005-2009 with three people dying in Java, Bali, and Bangka. Cocoa beans (Theobroma cacao L.) contain fat, carbohydrates, proteins, and polyphenol compounds that are useful as antioxidants. Polyphenols in the form of epicathechins, catechins, and procyanidins serve to provide protection to hemolysis. The purpose of this study was to determine the potential of ethanol extract of cacao (Theobroma cacao L.) in inhibiting the damage of erythrocyte induced by Physalia utriculus in vitro. This study used 28 samples of erythrocytes divided into seven groups, namely the normal control group, negative controls, and treatment with cocoa ethanol extract 0.2%, 0.1%, 0.04%, and 0.02%. Each subsequent group induced venom Physalia utriculus. The results showed that the average speed of erythrocyte lysis in the treatment group by giving cocoa ethanol extract 0.2%, 0.1%, 0.04%, and 0.02% respectively (seconds ± standard deviation) was 858,25 ± 94,44; 1.000,5 ± 159,93; 678,5 ± 19,71; and 1.006 ± 159,50. The mean speed of erythrocyte lysis in the negative control group was 1,025 ± 164.63 and the positive control group with the administration of N-Acetylcystein can last up to one hour after administration of venoms. Test for normality and homogeneity shows that data is normally distributed and homogeneous. One Way Annova analysis shows the significance value of p <0.05, then a post hoc analysis test was performed with the Bonferoni method to find out the differences in significance in each group. In this study it can be concluded that the administration of cocoa ethanol extract has no potential to inhibit erythrocyte damage that has been venomed by Physalia utriculus in vitro. Keywords: Physalia utriculus, cacao, erythrocyte damage
Tetraciclyne Resistance Eschericia coli Isolated From Broiler Chicken Meat Anisa Rizca Putri; Enny Suswati; Laksmi Indreswari
Journal of Agromedicine and Medical Sciences Vol 4 No 1 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i1.6402

Abstract

Antibiotic resistance is a serious health problem that have ben uneffective therapy. The cause of antibiotic resistance 80% comes from food of animal origin such as Broiler Chicken. E. coli contamination in antibiotic resistant chicken has been shown to transfer genetic factors between bacteria in the human intestinal system. Almost all broiler breeders use commercial feed containing tetracycline antibiotics. The use of antibiotics in the feed mixture is one of the risk factors for resistance. The aim of this study was to get an information of antibiotic resistance E. coli which isolated from broiler meat. Identification test of E. coli used two phase, presumtive test and confirmed test. Sensitivity test for E. coli to antibiotic by disc diffusion Kirby Bauer method. This study used 6 sample of upper thigh broiler meat, the antibiotic use tetracycline. The data were analyzed descriptively. The results of this study show that from 6 isolate sample, there are 4 isolate identificated as E. coli and 2 isolate show resistance to the tetracycline antibiotic. The conclusion of this study showed resistance has occurred on 50% sample.
The Effect of Zumba Exercise to Women's Waist Hip Ratio Laksmi Indreswari; Yunita Dewi Anggraeni; Rena Normasari
Journal of Agromedicine and Medical Sciences Vol 6 No 2 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i2.17449

Abstract

Abdominal obesity is a global public health problem. The high prevalence of abdominal obesity triggers an increase in morbidity and mortality in chronic diseases such as diabetes mellitus, cardiovascular, and cancer. One of the causes of the high prevalence of abdominal obesity is the lack of physical activity. Prevention efforts are needed through the identification of risk factors such as measurement of waist hip ratios. The respondents of this study were divided into two groups: 28 respondents who did zumba exercise for four weeks and 28 control respondents. The statistical test performed was a paired t-test comparison test. The results of this study indicate the value of t-count > t-table value (7.184 > 2.052) and the significance of 0.000 < 0.05. These results indicate that there is a decrease in the waist hip ratio after doing zumba exercise for four weeks.
Effect of Vitamin C to Malondialdehyde (MDA) Level in Medical Students Jember University with Psychological Stress Rahmad Adi Prasetyo; Laksmi Indreswari; Aris Prasetyo
Journal of Agromedicine and Medical Sciences Vol 4 No 2 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i2.6423

Abstract

Medical students may to receive excessive psychological stressors during their education. The response of stress experienced by the body can activate the sympathetic neuron pathways and complex system hypothalamic pituitary-adrenal (HPA) axis. This can lead to a state of oxidative stress in the body through an increase of metabolism, mitochondrial oxidation, neutrophil activity, glycolysis and lipolysis processes. The level of malondialdehyde (MDA) is the most frequently used parameter for assessing oxidative stress conditions in the body. Vitamin C is an antioxidant that can neutralize the effects of free radicals through electron transfer mechanisms. This study aims to determine the effect of vitamin C on MDA levels in medical students of Jember University who experienced psychological stress. This is clinical test study with Quasi Experimental approach that used Pretest - Posttest Control Group Design with 32 sample of medical students Jember University who experienced psychological stress. The level of psychological stress was determined through questionnaire of Depression Anxiety Stress Scale (DASS) version Damanic Indonesian while the examination of MDA levels by the TBARs test. The result of T test analysis between MDA level at pretest and posttest is p= 0,000. It shows that there is effect of vitamin C consumption to the malondialdehyde (MDA) level in medical students Jember University with psychological stress. Keywords: Psychological stress, Malondialdehyde, Vitamin C
The Correlation between Noise in Workplace and Sleep Quality in Workers at PT. Muroco Jember Wood Processing Factory Lathifa Rusyda Gani; Dwita Aryadina Rachmawati; Laksmi Indreswari; Alif Mardijana; Yudha Nurdian
Journal of Agromedicine and Medical Sciences Vol 4 No 2 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i2.6790

Abstract

Noise is a problem that can’t be resolved properly until now because it is one of the factors that sometimes is neglected from the work environment, so it can be a serious threat to the health of workers. The production tools and engines in the factory as the result of technology development produce a sound that can cause noise and interfere with health. Noise can also cause a variety of other disorders such as physiological, psychological, and communication disorders. Psychological disorders can include discomfort, lack of concentration, insomnia, and irritability. Sleep disorders can be associated with 13% of occupational hazards. Workers who have sleep disorders have a 1.62 times higher risk of experiencing work accidents compared with workers who do not have sleep disorders. The aim of this study is to determine the correlation between noise in workplace and sleep quality in workers at PT. Muroco Jember wood processing factory. This is an analytical observational study with cross sectional study design using workers of the factory who meet inclusion and exclusion criteria. Noise in the workplace was measured with sound level meter and sleep quality of the workers was measured with Pittsburgh Sleep Quality Index Questionnaire. Spearman correlation test result between these variables is p= 0,899. That result indicates that there is no significant correlation between noise in workplace and sleep quality in workers at PT. Muroco Jember wood processing factory. Keywords: Noise, Sleep Quality, Worker
Analysis of Personal Protective Equipments Pesticides Usage Effects on Health Complaints of Farmers in Pringgondani Village Sumberjambe District Jember Regency BJ Azmy As'ady; Supangat Supangat; Laksmi Indreswari
Journal of Agromedicine and Medical Sciences Vol 5 No 1 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i1.7901

Abstract

Jember is one of the districts in East Java Province with the majority of its population working as farmers. Pringgondani Village Farmers in Jember use pesticides when farming. Pesticides contain harmful chemicals. Use of PPE (Personal Protective Equipments) can protect farmers when mixing and spraying pesticides. This study aims to analyze correlation between PPE pesticides usage and health complaints of farmers in Pringgondani Village Sumberjambe District Jember Regency. Cross sectional surveys were conducted on 50 samples. Data were collected by interview using questionnaire. Data were analyzed by chi square test to know correlation between PPE pesticides use (protective clothing, head protection, mask, gloves and boots) and health complaints (headache, increased fatigue, itching and nausea). Chi square test result showed significance 0,043 (p <0,05) where there was a correlation between head protector use and health complaint of respondent with contingency coefficient (r) equal to 0,318. The conclusion is that there is a correlation between the head protection use and health complaints of farmers in Pringgondani Village Sumberjambe District Jember Regency with sufficient correlation. Keywords: PPE, pesticides, health complaints, Farmers, Pringgondani, Jember
Analisis Penggunaan Jumlah Bahan Aktif Pestisida dan Banyaknya Keluhan Masalah Kesehatan Pada Petani di Wilayah Agroindustri Jember Kristianningrum Dian Sofiana; Laksmi Indreswari; Jauhar Firdaus; Aris Prasetyo; Pulong wijang Pralampita; Supangat Supangat
Poltanesa Vol 23 No 1 (2022): Juni 2022
Publisher : P2M Politeknik Pertanian Negeri Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.333 KB) | DOI: 10.51967/tanesa.v23i1.1209

Abstract

Pestisida dapat menyebabkan masalah kesehatan baik akut ataupun kronik. Latar belakang dari penelitian ini adalah Penggunaan pestisida di kawasan agroindustri Jember yang tidak dapat dihindari.. Paparan pestisida pada petani Jember, baik paparan langsung ataupun tidak langsung, diduga menjadi salah satu penyebab munculnya masalah kesehatan.. Keterkaitan antar penggunaan bahan aktif pestisida dan masalah kesehatan pada petani di wilayah agroindustri jember perlu diteliti. Penelitian ini bertujuan untuk menganalisis penggunaan jumlah bahan aktif pestisida dengan banyaknya masalah kesehatan pada petani di wilayah Agroindustri Jember. Penelitian ini menggunakan metode deskriptif observational dengan pendekatan cross-sectional. Populasi yang diambil adalah petani yang berada di kabupaten jember yang diwakili oleh 11 kecamatan. Besar sampel berjumlah 84 orang yang diambil dengan accidental sampling. Variabel yang diambil adalah jenis pestisida, jumlah bahan aktif yang dipakai, keluhan masalah kesehatan, Analisis menggunakan analisis unvaried dan bivariate menggunakan Chi square tes dengan p <0,05. Penggunaan bahan aktif yang digunakan selama penyemprotan mayoritas 1 bahan aktif 51,19% .Keluhan masalah kesehatan sebesar 52,38% dengan keluhan terbanyak adalah pusing sebesar 29,76%.Hasil Analisis jumlah bahan aktif saat penyemprotan dengan banyaknya keluhan kesehatan dengan menggunakan Chi Square tes, p= 0,009 dengan nilai p<0,05. Dari penelitian ini didapatkan ada hubungan penggunaan bahan aktif residu pestisida dengan keluhan masalah kesehatan pada petani di Jember. Petani yang terpapar kebanyakan tidak merasakan keluhan kesehatan.
PENYELENGGARAAN PEMULIHAN KORBAN KDRT KHUSUS PEREMPUAN DAN ANAK DI WILAYAH KOTA SEMARANG Murniati, Yunita; Purwanti, Ani; Indreswari, Tri Laksmi
Diponegoro Law Journal Vol 12, No 4 (2023): Volume 12 Nomor 4, Tahun 2023
Publisher : Program Studi S1 Ilmu Hukum, Fakultas Hukum, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dlj.2023.39539

Abstract

Kasus Kekerasan Dalam Rumah Tangga (KDRT) merupakan jenis kekerasan yang paling banyak terjadi diantara jenis kekerasan lainnya di Indonesia, termasuk di Kota Semarang. Data Dinas Pemberdayaan Perempuan dan Perlindungan Anak Kota Semarang mengungkapkan bahwa sepanjang tahun 2022 lalu dari total keseluruhan laporan kasus kekerasan yang masuk, 50% diantaranya merupakan laporan atas terjadinya kasus KDRT. Terjadinya KDRT tersebut menimbulkan kerugian diantaranya kerugian immaterill. Salah satu kerugian immateriil yang dialami korban KDRT adalah menurunnya kemampuan sosial. Kemampuan sosial yang menurun tersebut menghambat korban KDRT dalam melakukan aktivitas sehari-hari. Terkait dengan hal tersebut, maka menjadi suatu hal yang penting untuk korban KDRT mendapatkan keadilan atas kondisinya dengan adanya pemenuhan hak atas pemulihan dan rehabilitasi sosial bagi korban KDRT. Pemenuhan hak tersebut dalam konsep negara hukum seperti Indonesia, tentunya dilandasi oleh hukum tertulis yang berlaku.  Berdasarkan hasil penelitian diketahui bahwa hak atas pemulihan dan rehabilitasi sosial telah diatur dan dijamin dalam Pancasila, Undang-Undang Dasar Negara Republik Indonesia Tahun 1945, Undang-Undang Nomor 23 Tahun 2004 tentang Penghapusan Kekerasan Dalam Rumah Tangga hingga dalam Peraturan Walikota Kota Semarang Nomor 60 Tahun 2008 tentang Organisasi dan Tata Kerja Unit Pelaksana Teknis Dinas Panti Rehabilitasi Sosial Kota Semarang.
Co-Authors Adinningtyas Intansari Adji, Novan Krisno Ahmad Baihaqi Al Munawir Alif Mardijana Ancah Caesarina Novi Marchianti Ani Purwanti Anisa Rizca Putri Aris Prasetyo Aris Prasetyo Bagus Hermansyah Baladraf, Thabed Tholib BJ Azmy As'ady Cholis Abrori, Cholis Desie Dwi Wisudanti Dicky Setiawan Dika Pangestu, Yusufa Dini Agustina Dwita Aryadina Rachmawati El Milla, Kardiana Izza ENNY SUSWATI F P H, Fransiska Nooril Habibi, Ali Hairrudin Hairrudin Handoko, Adelia Ida Bagus Suryaningrat Jauhar Firdaus Kristianningrum Dian Sofiana Lathifa Rusyda Gani Laylatul Fitriah Mukarromah Luh Putu Ratna Sundari M.S. Irham Rozaq Murniati, Yunita Nadie Fatimatuzzahro Nugraha, Muhammad Yuda Pipiet Wulandari Pralampita, Pulong Wijang Pranata, Dadin Gilang Prasetyo, Aris Purnomo, Farah Fadhila Nasywa Putri, Komang Yunita Wiryaning Rahmad Adi Prasetyo Rena Normasari Rendra Chriestedy Prasetya Rofifah, Salma Putri Rokhani Rokhani Rozaq, M.S. Irham Rusdianto, Andrew Setiawan Safitri, Raghda Gita Sampurna, Hadi septa surya wahyudi, septa surya Setia, Bagus Sofiana, Kristianingrum Dian Supangat Supangat Supangat Supangat Suryono Suryono Tristianti, Farmitalia Nisa Ulfa Elfiah Winda Amilia Wiwien Sugih Utami Yunita Armiyanti Yunita Dewi Anggraeni