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All Journal Pendidikan Kewarganegaraan The Indonesian Biomedical Journal Buana Pendidikan: Jurnal Fakultas Keguruan dan Ilmu Pendidikan Unipa Surabaya JURNAL KOULUTUS Jurnal Pendidikan Kewarganegaraan Adjektiva: Educational Languages and Literature Studies
MUTMAINNAH, FITRI
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Arts Humanities Biochemistry, Genetics & Molecular Biology Education Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Public Health Social Sciences Other

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Bioscrew of Green Mussel (Perna viridis) Shells-derived Hydroxyapatite, Polylactic Acid and Polycaprolactone Increases Procollagen 1 Intact N-Terminal Propeptide and Alkaline Phosphatase in Rabbit Model with Bone Defect Aprisia, Kartika Dwi; Nugroho, Eriawan Agung; Hendrianingtyas, Meita; Novriansyah, Robin; Nindita, Yora; Tjandra, Kevin Christian; Respati, Danendra Rakha Putra; Mutmainnah, Fitri; Sandra, Ferry
The Indonesian Biomedical Journal Vol 17, No 6 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i6.3795

Abstract

BACKGROUND: Hydroxyapatite (HA) is essential for bone regeneration and healing. Green mussel (Perna viridis) shell is a potential choice for preparing HA because they are abundant, widely available, have a smaller particle size, and have a higher HA content. Rather than using HA in powder or granule form, bioscrew has been fabricated as a composite of green mussel shell-derived HA, polylactid acid and polycaprolactone. However, its dynamic bone healing process has not been clearly disclosed, therefore Procollagen 1 Intact N-Terminal Propeptide (P1NP) and bone Alkaline Phosphatase (ALP) were investigated.METHODS: Male New Zealand white rabbits (Oryctolagus cuniculus) were used as animal model. The rabbits were anesthetized and prepared for surgery. A standardized defect was created in the metaphyseal region. For the treatment group, the defect was filled with a bioscrew implant, whereas the control group did not receive any implant. At week-2, -4 and -6 post-surgery, about 3 mL of blood was collected from rabbits' marginal ear vein to collect blood serum. The serum was used to quantify P1NP and ALP levels using Enzyme-linked Immunosorbent Assay (ELISA). Data of P1NP and ALP levels were then statistical analyzed.RESULTS: P1NP level of the treatment group was significantly (p<0.05) higher than the one of control group since the first monitor, at week-2. At the next monitor (week 4 and 6), P1NP levels of the treatment group were also significantly (p<0.05) higher than the ones of control group. In accordance with the P1NP results, the ALP level of the treatment group was significantly (p<0.05) higher than the one of control group.CONCLUSION: Since bioscrew of green mussel shell-derived HA, PCL and PLA could increase the PINP associated early matrix synthesis, and ALP associated with later-stage mineralization, it can be concluded that bioscrew of green mussel shell-derived HA, PCL and PLA can be a promising material to promote bone repair.KEYWORDS: bone, HA, green mussel, bioscrew, P1NP, ALP, PCL, PLA
Co-Authors Aprisia, Kartika Dwi Derana, Ganes Tegar Eriawan Agung Nugroho, Eriawan Agung Ferry Sandra Imam Suhaimi, Imam Meita Hendrianingtyas Novriansyah, Robin Prayetno, Dimas Purnomo, Panji Respati, Danendra Rakha Putra Safitri, Della Nor Sholehah, Inatus Sugara, Harry Tjandra, Kevin Christian Widianto Widianto Yora Nindita