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Aria, Mimi
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Agriculture, Biological Sciences & Forestry Economics, Econometrics & Finance Engineering Languange, Linguistic, Communication & Media Social Sciences

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Anti-Inflamatory Activity Evaluation of Sungkai Leaf Ethanol Extract (Peronema Canescens Jack) Using the Red Blood Cell Membrane Stabilization Method Aria, Mimi; Nessa, Nessa; Ilona, Sandra; Lestari, Wahyu
Jurnal Riset Multidisiplin dan Inovasi Teknologi Том 3 № 01 (2025): Jurnal Riset Multidisiplin dan Inovasi Teknologi
Publisher : PT. Riset Press International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59653/jimat.v3i01.1473

Abstract

Research has been carried out on the anti-inflammatory activity test of the ethanol extract of Sungkai leaf (Peronema canescens Jack) with the red blood cell membrane stabilization method. Purpose of study was to determine the anti-inflammatory activity the effect of the concentration of ethanol extract of sungkai leaves. Anti-inflammatory activity can be determined by measuring stability red blood cells, looking at absorbance of  decomposition of hemoglobin so that the percentage of stability is obtained. Variations in the concentration of the test solution made were 4 variations in concentration, namely 15, 30, 60 and 120 ppm. The extract's ability to reduce inflammation. was then compared standard ibuprofen. Based on the study's findings, the percentage of erythrocyte membrane stability of sungkai leaf extract sequentially with concentrations of 15, 30, 60 and 120 ppm was 2.24%, 32.61%, 37.72%, 44.31%, while the comparison (ibuprofen) The percentage of erythrocyte membrane stability, respectively, with concentrations of 15, 30, 60 and 120 ppm were 24.1%, 36.2%, 49.4%, 63.4% and control 0.98%. The data from study were analyzed using one-way ANOVA which was followed by Duncan test. From this research is isconcluded The activity that reduces inflammation of the ethanolic extract of the sungkai leaf variation of the concentration regarding ethanolic extract of sungkai leaf (Peronema canescens Jack) gave an influence on the anti-inflammatory activity with an increase in the proportion of the stability of the red blood cell membrane following The rise in the concentration of the ethanol extractf the sungkai leaf.
Cost-Effectiveness Analysis of Antibiotic Use in Patients with Chronic Obstructive Pulmonary Desease (COPD) Pameswari, Puspa; Aria, Mimi; Zuhriah, Aminah
Jurnal Riset Multidisiplin dan Inovasi Teknologi Том 3 № 01 (2025): Jurnal Riset Multidisiplin dan Inovasi Teknologi
Publisher : PT. Riset Press International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59653/jimat.v3i01.1474

Abstract

Chronic obstructive pulmonary disease (COPD) is a disease with airway limitations that are not completely reversible due to harmful substances or gases. The most common cause of acute exacerbations of COPD is bacterial infection, so treatment that can be done is to use antibiotics. Ineffective drug therapy will affect the effectiveness and costs incurred by patients. The purpose of this study is to find out how cost-effective and antibiotic treatment are in patients with acute exacerbations of COPD. This study uses an observational descriptive method with retrospective data collection based on medical record data and the cost of using antibiotics for Chronic Obstructive Pulmonary Disease (COPD) acute exacerbations of hospitalization at hospitals. Dr. M. Djamil Padang in 2019-2021. The calculation result with the lowest CER was the combination of levofloxacin and ceftriaxone of Rp. 323.6 and an outcome value of 100%. It can be concluded that the most effective use of antibiotic therapy models in COPD patients with acute exacerbations is the combination of levofloxacin and ceftriaxone.
Co-Authors Ilona, Sandra Nessa Nessa Pameswari, Puspa Wahyu Lestari Zuhriah, Aminah