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Nursofia, Yesi
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Chemical Engineering, Chemistry & Bioengineering Chemistry

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The Role of Macrocyclic Compounds as Supramolecular Drug Delivery Systems: A-Review Saputra, Muhammad Furqon Novryan; Nursofia, Yesi; Tarigan, Indra Lasmana
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.41724

Abstract

In recent decades, significant advances in the development of drug delivery systems have unlocked new possibilities for enhancing therapeutic efficacy. Among the diverse range of innovative materials, macrocyclic-based supramolecular systems have emerged as promising platforms due to their unique physicochemical properties. Macrocyclic compounds such as cyclodextrins and cucurbiturils exhibit a remarkable ability to form stable inclusion complexes with various drug molecules, thereby improving their solubility, chemical stability, bioavailability, and pharmacokinetic profiles. This review highlights the design principles, synthetic strategies, and mechanisms of action underlying macrocyclic drug carriers, with particular emphasis on their responsiveness to environmental stimuli such as pH, temperature, and biomolecular triggers. Recent findings demonstrate that macrocyclic systems can significantly enhance drug loading efficiency, targeted delivery, and cellular uptake, while minimizing systemic toxicity. These advances underscore the potential of macrocyclic supramolecules as foundational elements for the development of next-generation drug delivery systems that are more precise, effective, and adaptable to personalized therapeutic needs.
pengaruh efikasi diri dan kemandirian belajar peserta didik terhadap prestasi belajar kimia kelas X SMA Negeri 15 Pekanbaru Rahmawati, Ayu; Anwar, Lenny; Rasmiwetti, Rasmiwetti; Nursofia, Yesi
Chempublish Journal Vol. 8 No. 1 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i1.32867

Abstract

Self-efficacy and learning independence are important factors in improving chemistry learning achievement and these factors must be mastered by students. This study aims to determine the effect of self-efficacy and learning independence on chemistry learning achievement partially or simultaneously. This type of research is a survey-research with a quantitative approach. The data collection methods for this study are questionnaires and documentation. The self-efficacy and learning independence questionnaires used were 21 questions after being validated. The questionnaires were distributed to all samples of 119 students taken using the simple random sampling technique. Documentation was used to collect data on chemistry learning achievement scores. Data analysis used in this study was multiple linear regression analysis. The results of the study showed (1) There is a positive and significant effect of self-efficacy partially on chemistry learning achievement, (2) there is a positive and significant effect of learning independence on learning achievement, (3) There is a positive and significant effect between self-efficacy and learning independence simultaneously on chemistry learning achievement.
Co-Authors AYU RAHMAWATI Indra Lasmana Tarigan Lenny Anwar Rasmiwetti Rasmiwetti, Rasmiwetti Saputra, Muhammad Furqon Novryan