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Saputra, Muhammad Furqon Novryan
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Chemical Engineering, Chemistry & Bioengineering Chemistry

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The Role of Macrocyclic Compounds as Supramolecular Drug Delivery Systems: A-Review Saputra, Muhammad Furqon Novryan; Nursofia, Yesi; Tarigan, Indra Lasmana
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.41724

Abstract

In recent decades, significant advances in the development of drug delivery systems have unlocked new possibilities for enhancing therapeutic efficacy. Among the diverse range of innovative materials, macrocyclic-based supramolecular systems have emerged as promising platforms due to their unique physicochemical properties. Macrocyclic compounds such as cyclodextrins and cucurbiturils exhibit a remarkable ability to form stable inclusion complexes with various drug molecules, thereby improving their solubility, chemical stability, bioavailability, and pharmacokinetic profiles. This review highlights the design principles, synthetic strategies, and mechanisms of action underlying macrocyclic drug carriers, with particular emphasis on their responsiveness to environmental stimuli such as pH, temperature, and biomolecular triggers. Recent findings demonstrate that macrocyclic systems can significantly enhance drug loading efficiency, targeted delivery, and cellular uptake, while minimizing systemic toxicity. These advances underscore the potential of macrocyclic supramolecules as foundational elements for the development of next-generation drug delivery systems that are more precise, effective, and adaptable to personalized therapeutic needs.
Isolasi Proses Bioaktif Ekstrak Metanol Daun Putat (Planchonia valida) sebagai Antioksidan Farid, Faizar; Br Sembiring, Vera Lorensya; Nelson, Nelson; Saputra, Muhammad Furqon Novryan; Putri, Silvi Ayudiah; Tarigan, Indra Lasmana; Latief, Madyawati
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41634

Abstract

Putat leaves (Planchonia valida) are a plant that is traditionally used by people in the Tanjung Lanjut areas, Jambi as fresh vegetables, and as a traditional medicine to treat skin diseases and restore health. This identifies that the putat plant contains chemical compounds that have the potential to have antioxidant activity. Extraction was carried out using n-hexane and ethyl acetate solvents using multistage maceration. Next, phytochemical screening and antioxidant activity tests are carried out to obtain information about fractions that can potentially proceed to the isolation stage. In the maceration process, an extract percentage was obtained with a yield value of 1.39%. Next, isolation was carried out using vacuum liquid chromatography. The isolates obtained were then characterized using UV-Vis and FT-IR spectrophotometer instruments. The isolate obtained was in the form of a wet solid, and if seen through characterization, it belonged to the class of steroid compounds; it was suspected to be an ergosterol compound. Antioxidants are known to have the ability to inhibit and reduce the presence of free radicals in the human body. In this study, antioxidant activity was tested using the DPPH (2,2-diphenyl-1-picrihidazil) method on F1 isolates. The F1 isolate obtained was proven to have antioxidant activity with a value of 99.2265 ppm, which is classified in the strong antioxidant activity range.
Co-Authors Br Sembiring, Vera Lorensya Faizar Farid Indra Lasmana Tarigan Madyawati Latief Nelson Nelson Nursofia, Yesi Putri, Silvi Ayudiah