Background: The Covid-19 pandemic caused great stress, especially for health workers which resulted in moderate or severe symptoms of depression, anxiety, insomnia, and more serious stress. Gender is very influential, given the differences in biological and social roles between men and women. Gender differences between men and women allow for variations in strategies in responding to mental health to increase awareness and self-management, so as to avoid mental health problems during the Covid-19 pandemic.Subjects and Method: Meta-analysis was performed by searching articles from Google Scholar, PubMed, Scopus, Springer Link, and health-related databases. The keywords used in the article search were "health workers" AND "covid-19" AND "mental health". The inclusion of the criteria in this study is a full-text article, from 2019-2021, with a study design cross-sectional. The article analysis was carried out using RevMan 5.3. Results: There were 5 articles analyzed, the results showed no significant difference between gender and mental health responses among health workers during the Covid-19 pandemic (aOR= 1.12; 95% CI= 0.59-2.13; p=0.01).Conclusion: Not significant between primary studies regarding gender differences in mental health responses to health workers during the Covid-19 pandemic. Keywords: health workers, covid-19, mental healthCorrespondence: Riyesti Hero Fresna, Purwantoro Special Educational School. Wonogiri Regency, Central Java 57695. E-mail: riyestiherofresna01@gmail.com. Mobile +6281227831443.Journal of Health Policy and Management (2021), 06(02): 130-138https://doi.org/10.26911/thejhpm.2021.06.02.05