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All Journal Jurnal Ilmu Kefarmasian Indonesia Journal of Experimental and Clinical Pharmacy (JECP) Jurnal Info Kesehatan
Husain, Fadli
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Efek Ekstrak Etanol 70% Herba Akar Kucing (Acalypha indica L.) dalam Menurunkan Kadar Gula Darah Mencit (Mus musculus) Jantan yang diinduksi Aloksan Nihe, Nur Fauziyah S.; Hartati, Hartati; Nur, Moh. Usman; Husain, Fadli
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 1 (2024): February 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i1.914

Abstract

Tanaman akar kucing (Acalypha indica L.) merupakan tanaman yang biasanya digunakan oleh masyarakat untuk mengatasi penyakit diabetes. Tanaman ini memiliki kandungan senyawa flavonoid dan alkaloid yang diduga memiliki efek terhadap penurunan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui konsentrasi ekstrak etanol herba akar kucing yang efektif dalam menurunkan kadar gula darah pada mencit (Mus musculus) jantan setelah diinduksi aloksan. Penelitian ini merupakan penelitian berjenis eksperimental laboratorium dengan kelompok perlakuan dosis yang berbeda yaitu F1 (5 mg), F2 (10 mg), dan F3 (15 mg) dan sebagai kontrol positif (K+) digunakan obat glibenklamid dan dilakukan pengukuran kadar gula darah menggunakan glukometer terhadap mencit jantan. Hasil penelitian menunjukkan penurunan kadar gula darah terjadi pada mencit yang telah diberikan ekstrak etanol herba akar kucing setelah 7 hari pengamatan dengan selisih penurunan yaitu F1 41 mg/dl (33,06%), F2 57 mg/dl (45,72%), F3 64 mg/dl (57,06%). Hasil uji One Way Anova menggunakan SPSS 25.0 menunjukkan bahwa terdapat perbedaan yang signifikan diantara 4 perlakuan tersebut dengan control positif. Kesimpulannnya bahwa semua konsentrasi ekstrak etanol herba akar kucing memiliki kemampuan dalam menurunkan kadar gula darah pada mencit dengan konsentrasi yang paling efektif adalah kelompok F3 15 mg (57,06%).The Acalypha indica L. is a plant that is usually used by people to treat diabetes. This plant contains flavonoid and alkaloid compounds, which are thought to have an effect on reducing blood glucose levels. This study aims to determine the concentration of the ethanol extract of the Acalypha indica herb that is effective in reducing blood sugar levels in male mice (Mus musculus) after being induced by alloxan. This research is a laboratory experimental type study with different dose treatment groups, namely F1 (5 mg), F2 (10 mg), and F3 (15 mg), and as a positive control (K+), the drug glibenclamide was used, and blood sugar levels were measured using a glucometer against male mice. The results showed that a decrease in blood sugar levels occurred in mice that had been given an ethanol extract of Acalypha indica herb after 7 days of observation, with a difference in the decrease, namely F1 41 mg/dl (33.06%), F2 57 mg/dl (45.72%), and F3 64 mg/dl (57.06%). The results of the one-way ANOVA test using SPSS 25.0 showed that there were significant differences between the four treatments and the positive control. The conclusion was that all concentrations of Acalypha indica herb ethanol extract had the ability to reduce blood sugar levels in mice, with the most effective concentration being the F3 15 mg group (57.06%).
Analisis Pengelolaan Obat di Instalasi Farmasi Dinas Kesehatan Kabupaten/Kota Se-Provinsi Gorontalo Periode Tahun 2018 dan 2019 Husain, Fadli; Kamba, Vyani; Zulfiayu, Zulfiayu; Imran, Arlan K
Journal of Experimental and Clinical Pharmacy (JECP) Vol 2, No 1 (2022): February 2022
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v2i1.352

Abstract

Instalasi farmasi sering menghadapi permasalahan pada tahap seleksi, perencanaan dan pengadaan. Pengelolaan obat yang buruk menyebabkan tingkat ketersediaan obat menjadi berkurang, terjadi kekosongan obat, banyaknya obat yang menumpuk karena tidak sesuainya perencanaan obat, serta banyaknya obat yang kadaluwarsa/rusak akibat sistem distribusi yang kurang baik sehingga dapat berdampak kepada inefisiensi penggunaan anggaran/biaya obat di tingkat Kabupaten/Kota. Penelitian ini menggunakan rancangan deskriptif dengan pengambilan data secara retrospektif dan concurent. Penelitian ini dilaksanakan di Instalasi Farmasi Kab. Kota se-Provinsi Gorontalo. Alat ukur penelitian ini adalah daftar pertanyaan berdasarkan indikator standar yang telah ditetapkan sesuai pedoman yang digunakan untuk monitoring dan evaluasi pengelolaan obat kabupaten/kota, serta melakukan wawancara langsung kepada penanggung jawab Instalasi Farmasi setempat. Hasil penelitian didapatkan bahwa; alokasi dana pengadaan obat tahun 2018 > 2 Miliar rupiah dan tahun 2019 1,7 Miliar - 4,3 Miliar rupiah. Terdapat 50% Kabupaten/kota yang sudah memiliki Tim Perencanaan Obat Terpadu (TPOT) di lingkungan Dinas Kesehatan. Biaya obat perkapita bila menggunakan standar WHO 1 US$ perkapita maka 80% Kabupaten/Kota sudah sesuai bahkan melampaui, hanya 1 kabupaten yang dibawah standar WHO. Terdapat 83% Kabupaten/kota yang kesesuaian item obat dengan DOEN diatas 80% dan seluruh  Kabupaten Kota mempunyai kesesuaian FORNAS lebih dari 80%.Pharmaceutical installations often face problems at the selection, planning, and procurement stages. Poor drug management causes decreasing the level of drug availability, drug vacancies, overstock of drugsdue to inappropriate drug planning, and expired/damaged drugs due to a poor distribution system can have an impact on inefficiency in the use of drug budgets/costs at the Regency/City. This study used a descriptive design with retrospective and concurrent. This research was conducted at the Pharmacy Installation at the Regency/City in Gorontalo Province. The measuring instrument for this research is a list of questions based on standard indicators that have been set according to the guidelines used for monitoring and evaluating regency/citydrug management and conducting direct interviews with the PIC of the local Pharmacy Installation. The results of the study found that; the allocation of funds for drug procurement in 2018 was more than 2 billion rupiah and in 2019 was 1.7 billion - 4.3 billion rupiah. There are 50% of regencies/cities already have an Integrated Drug Planning Team (TPOT) within the Health Office. Drug costs per capita when using the WHO standard of US$ 1 per capita, 80% of districts/cities comply and even exceed, only 1 district is below the WHO standard. There are 83% of regencies/cities whose conformity of drug items with DOEN is above 80% and all regencies/cities have FORNAS conformity of more than 80%.
The effectiveness of butterfly pea hydrogel film (Clitoria Ternatea) with chitosan and poly-vinyl-alcohol based as diabetic wound healing Wicita, Prisca Safriani; Daud, Rizka Puji Astuti; Sapiun, Zulfiayu; Yahya, Cindy; Wantaa, Nurunnisa; Mohamad, Fihrina; Imran, Arlan K.; Hartati, Hartati; Husain, Fadli
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1483

Abstract

Butterfly pea possesses antioxidant activities with IC50 470 μg/ml of wound healing acceleration quality. Hydrogel for diabetic wound healing due to its physical characteristic that binds water, aside from its qualities that wets the surface and bio-compatibility in the body. This study aimed to identify effectivity test of hydrogel film preparation with butterfly pea (clitoria ternatea l.) Water extract for diabetic wound healing, employing true experimental method which involves 12 rats divided into 4 groups. The control group was treated without the Hydrogel (HET) or HET0 on hyperglycemic rats, HET1 (2%), HET2 (5%), and HET3 (7.5%). The findings revealed wounds treated with HET0 was healed in 9 days with 11.13 mm of diameter (100%), HET1 was healed in 6 days with 15.22 mm of diameter (100%), HET2 that was healed in 4 days with 11.29 mm of diameter (100%), and HET3 that was healed in 8 days with 9.05 mm of diameter (100%). It was concluded that the effectivity test revealed that the best formula is HET2 (5%) healed in 4 days with 11.29 mm of diameter in 100%.
Antibacterial Activity Test of Etanol Extract of Black Sea Cucumber (Holothuria atra) against the Bacteria Staphylococcus aureus and Escherichia coli Husain, Fadli; Padja, Tegar Abdiyanto; Slamet, Nangsih Sulastri; Nur, Moh. Usman; Yunus, Fitriah Ayu Magfirah; Abubakar, Fadlun; Polontalo, Febriyanti
JURNAL INFO KESEHATAN Vol 23 No 1 (2025): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol23.Iss1.1337

Abstract

Black Sea cucumber (Holothuria atra) contain chemical compounds that has antibacterial activity. One of the bacteria that is pathogenic to humans and at risk of death are Staphylococcus aureus and Eschericia coli. The purpose of this study is to ascertain whether black sea cucumber ethanol extract in Pataomeme waters has antibacterial activity against the microorganisms E. coli and S. aureus. The type of research used is quantitative research with quasi laboratory experiments. Antibacterial activity test using disc diffusion method. Black Sea cucumber extract was made in 3 concentrations, consisted of 7.5%, 10% and 12.5%. The results showed that black sea cucumber extract has antibacterial activity seen through the inhibition zone formed. The maximum inhibition zone is at a concentration of 12.5% sea cucumber extract, which is 28.59 mm against S. aureus bacteria and 21.02 mm against E. coli bacteria. According to our results, sea cucumber may be a suitable marine source of antibacterial substances. To ascertain its potential use in other areas of medicine, more in vivo research must be conducted.
Co-Authors Abubakar, Fadlun Daud, Rizka Puji Astuti Febriyanti Polontalo Fihrina Mohamad Hartati Hartati Imran, Arlan K Nihe, Nur Fauziyah S. Nur, Moh. Usman Padja, Tegar Abdiyanto PRISCA SAFRIANI WICITA Sapiun, Zulfiayu Vyani Kamba Wantaa, Nurunnisa Yahya, Cindy Yunus, Fitriah Ayu Magfirah