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GRANUL EFFERVESCENT KOMBINASI BUNGA TELANG (Clitoria ternatea) DAN JERUK KALAMANSI (Citrus microcarpa) SEBAGAI ALTERNATIF MINUMAN KESEHATAN Putri, Nurwigya Mohamad; Slamet, Nangsih Sulastri; Wicita, Prisca Safriani; Imran, Arlan K
Journal of Experimental and Clinical Pharmacy (JECP) Vol 1, No 1 (2021): Februari, 2021
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v1i1.196

Bunga telang (Clitoria ternatea) adalah tanaman yang memiliki potensi farmakologis sebagai antioksidan, antimikroba, antiparasit, anti-inflamasi, antikanker, antihistamin. Jeruk kalamansi (Citrus microcarpa) merupakan tanaman yang sangat kaya akan mineral dan vitamin C sehingga sangat baik digunakan untuk bahan baku minuman kesehatan. Sediaan granul effervescent adalah hasil dari gabungan senyawa asam dan basa yang bila ditambahkan dengan air (H2O) akan bereaksi melepaskan karbon dioksida (CO2), sehingga efek ini akan menghasilkan buih pada sediaan. Tujuan dari penelitian ini adalah untuk memanfaatkan bunga telang dan jeruk kalamansiÂ sebagai bahan aktif dan untuk menghasilkan sediaan granul effervescent sebagai alternatif minuman kesehatan. Ekstrak bunga telang diperoleh dari metode ekstraksi sederhana dengan cara diblender menggunakan air (1:3). Sari jeruk kalamansi diperoleh dari perasan buahjeruk kalamansi. Hasil penelitian menunjukkan bahwa sediaan granul effervescent kombinasi bunga telang dan jeruk kalamansi ini memiliki warna granul putih keunguan dan larutan biru muda bening serta memiliki bau dan rasa kombinasi bunga telang dan jeruk kalamansi, waktu dispersi yang memenuhi persyaratan waktu larut yakni 1 menit 4 detik dan indeks kompresibilitas 13,3%. Berdasarkan penilaian panelis dari parameter tekstur, warna, aroma dan rasa menunjukkan rata-rata 4,3 denganÂ kategori suka.Kata Kunci : Bunga telang, Jeruk kalamansi, Granul effervescent

Aplikasi Xanthan Gum Dalam Sistem Penghantaran Obat PRISCA SAFRIANI WICITA
Farmaka Vol 15, No 3 (2017): Farmaka
Publisher : Fakultas Farmasi, Universitas Padjadjaran

ABSTRAKDalam proses penemuan terapi farmasetis yang baru, teknologi formulasi sediaan farmasi dan sistem penghantaran obat memegang peranan penting Hal ini yang mendorong semakin berkembangnya sistem penghantaran obat terutama dari segi formulasi untuk mengoptimalkan penggunaan zat tambahan sehingga memperoleh suatu sediaan obat dengan sistem penghantaran yang baik dan memenuhi efek terapi. Beberapa tahun terakhir penggunaan polimer untuk sistem penghantaran obat menjadi perhatian beberapa peneliti. Salah satunya adalah xanthan gum. Xanthan gum memberikan hasil positif sebagai media penghantaran obat terutama untuk pelepasan obat terkontrol (untuk tujuan penghantaran obat pada usus besar) serta memiliki banyak fungsi diantaranya sebagai matriks/film tablet, coating, penghantaran obat floating, bukal, transdermal, topikal dan sebagai hidrogel.Kata kunci : Xanthan gum, polimer, sistem penghantaran obat

Tingkat Pengetahuan, Sikap dan Rasionalitas Swamedikasi pada Masa Pandemi di Kota Gorontalo Vyani Kamba; Prisca Safriani Wicita; Insyira Fadliana Basri; Pratiwi Y Ishak
Jurnal Surya Medika (JSM) Vol 8 No 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i2.3248

Changes in people's lifestyles tend to pay less attention to health, and the development of diseases in the community is also unavoidable, especially during the current Covid-19 pandemic. The development of this disease encourages people to look for alternative treatments that are cost-effective and therapeutically effective. In this regard, self-medication or self-medication is an alternative that is taken by the community. Community efforts to treat themselves are known as self-medication or self-medication. This study aims to determine the knowledge, attitudes, and rationality of self-medication in the community in Gorontalo City with a descriptive cross-sectional design method. The sample in this study were people who did self-medication and met the inclusion criteria, namely aged 18-60 years and willing to be respondents as many as 80. The level of knowledge related to self-medication of the people of Gorontalo City is 43.8% in the good category, self-medication attitude in a good category is 55%, and rationality is 65%. There is a significant relationship between respondents' knowledge level and self-medication attitude, with a p-value of 0.001.

Tingkat Pengetahuan, Sikap dan Rasionalitas Swamedikasi pada Masa Pandemi di Kota Gorontalo: Patient Knowledge, Attitude and Rationality of Self-Medicatio During Pandemic in Gorontalo City Vyani Kamba; Prisca Safriani Wicita; Insyira Fadliana Basri; Pratiwi Y Ishak
Jurnal Surya Medika (JSM) Vol. 8 No. 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i2.3248

Changes in people's lifestyles tend to pay less attention to health, and the development of diseases in the community is also unavoidable, especially during the current Covid-19 pandemic. The development of this disease encourages people to look for alternative treatments that are cost-effective and therapeutically effective. In this regard, self-medication or self-medication is an alternative that is taken by the community. Community efforts to treat themselves are known as self-medication or self-medication. This study aims to determine the knowledge, attitudes, and rationality of self-medication in the community in Gorontalo City with a descriptive cross-sectional design method. The sample in this study were people who did self-medication and met the inclusion criteria, namely aged 18-60 years and willing to be respondents as many as 80. The level of knowledge related to self-medication of the people of Gorontalo City is 43.8% in the good category, self-medication attitude in a good category is 55%, and rationality is 65%. There is a significant relationship between respondents' knowledge level and self-medication attitude, with a p-value of 0.001.

THE EFFECT OF SAFE COSMETIC COUNSELINGTO KNOWLEDGE AND ATTITUDE OF STUDENTS OF STATE SENIOR HIGH SCHOOL 3 GORONTALO Prisca Safriani Wicita
International Interdisciplinary Conference on Sustainable Development Goals Vol 2 No 1 (2019): Proceedings of International Interdisciplinary Conference on Sustainable Developm
Publisher : LP2M Universitas Bina Mandiri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.923 KB)

Cosmetics are materials or preparations intended to be used on the outside of the human body (epidermis, hair, nails, lips and external genital organs) or teeth and oral mucous membranes primarily to cleanse, fragrance, change the appearance and / or improve body odor or protect or maintain the body in good condition Cosmetics is one product that is used routinely and continuously by the public. Therefore, in the selection of cosmetics required a vigilance of the components contained therein, especially those containing additives. Negative reactions caused not only affect the skin tissue but also affect the tissue system and other important organs. The lack of understanding and the lack of optimal socialization about safe cosmetics are the main factors, in this case, therefore one of the efforts that can be done to increase adolescent knowledge is to conduct counseling activities. Department of Pharmacy of the Polytechnic of the Ministry of Health Gorontalo in collaboration with IAI Gorontalo City, conducting counseling for students of State Senior High School 3 Gorontalo. The purpose of this activity is to see the effect of counseling on improving the knowledge and attitudes of students of State Senior High School 3 Gorontalo about safe cosmetics. This research with pre-experiment design uses a pretest-posttest design model that is analyzed by the Wilcoxon sign test. The results of the analysis of differences in mean knowledge and attitudes of students showed results, there were significant differences in the knowledge and attitudes of students where the value of p <0.0001 (p <0.05) and based on the value of the proportion of knowledge before counseling and after counseling there was an increase in the number and percentage where the value of p <0.0001 (p <0.05), but based on the results of the analysis for the proportion of attitudes there was no significant difference in the attitudes of students p = 0.163 (p> 0.05). Overall, these results indicate that counseling can bring changes in knowledge and attitudes towards students of State Senior High School 3 Gorontalo so that it is expected to be able to improve health problems such as skin diseases, especially those related to the use of illegal cosmetics

PEMBERDAYAAN KELOMPOK DASAWISMA MELALUI PEMANFAATAN TOGA BERBASIS IPTEK DAN APLIKASI TEMUAN ILMIAH Fihrina Mohamad; Prisca Safriani Wicita; Ysrafil Ysrafil; Denny Indra Setiawan
JMM (Jurnal Masyarakat Mandiri) Vol 7, No 2 (2023): April
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v7i2.12918

Abstrak: Kelurahan Ipilo merupakan salah satu kelurahan di Kota Gorontalo yang umumnya masih memiliki pekarangan yang luas untuk pemanfaatan TOGA. Berdasarkan pengamatan, beberapa ibu rumah tangga telah menanam TOGA, namun belum memahami manfaat TOGA secara ilmiah dan belum memahami cara penggunaan TOGA. Oleh karena itu, permasalahan yang muncul adalah kecenderungan masyarakat untuk memilih obat tradisional masih rendah dibandingkan dengan obat sintetik, yang diketahui jika obat sintetik dikonsumsi dalam jangka panjang memiliki efek samping yang sangat berpengaruh terhadap status kesehatan. Pengabdian masyarakat ini bertujuan untuk memberikan pelatihan dan pendampingan kepada masyarakat sejumlah 30 peserta yang terdiri atas kelompok Dasawisma dan anggota PKK di kelurahan Ipilo Kota Gorontalo ¬untuk mengoptimalkan TOGA. Kegiatan ini dilakukan dalam 3 tahap. Tahap pertama; Edukasi berupa penyuluhan dan demonstrasi, tahap kedua; monitoring dan evaluasi, tahap ketiga; Tindak lanjut hasil monev berupa pendampingan dan fasilitasi kepada anggota Dasa Wisma, kader dan Kelompok UP2K PKK Kel. Ipilo dalam pembuatan produk herbal serta praktek nyata kewirausahaan melalui kegiatan bazar. Hasil kegiatan pengabdian kepada masyarakat ini antara lain (1) adanya peningkatan pemahaman masyarakat kelurahan Ipilo mengenai khasiat ilmiah TOGA berdasarkan hasil pre-test (86%) dan post-test (99%); (2) adanya peningkatan kepercayaan penggunaan obat tradisional dibandingkan dengan obat sintetik dalam pengobatan sendiri berdasarkan hasil monitoring dan evaluasi baik secara langsung maupun melalui Whatsapp Group "Keluarga Herbal Sehat"; (3) adanya peningkatan keterampilan masyarakat dalam berinovasi untuk mengolah TOGA menjadi produk yang bernilai ekonomis, berupa produk makanan berbahan tanaman obat (daun ceri) yaitu puding susu ceri dan minuman susu jagung ceri; dan (4) adanya fasilitasi bagi masyarakat untuk mendapatkan sertifikat Keamanan Pangan. Abstract: Ipilo Village is one of the villages in Gorontalo City which generally still has a large yard for the use of TOGA. Based on observations, several housewives have planted TOGA, but do not understand the benefits of TOGA scientifically and do not understand how to use TOGA. Therefore, the problem that arises is that the tendency of people to choose traditional medicines is still low compared to synthetic drugs, which is known if synthetic drugs are consumed in the long term it has side effects that greatly affect health status. This community service aims to provide training and assistance to the community, especially the Dasawisma group and PKK members in Ipilo Village to optimize TOGA. This activity is carried out in 3 stages. The first stage; Education in the form of counseling and demonstrations, the second stage; monitoring and evaluation, third stage; The follow-up to the results of the monev was in the form of mentoring and facilitation to Dasa Wisma members, cadres and the UP2K PKK Group Kel. Ipilo in the manufacture of herbal products as well as the real practice of entrepreneurship through bazaar activities. The results of this community service activity include (1) an increase in the understanding of the Ipilo village community regarding the scientific efficacy of TOGA based on the results of pre-test (86%) and post-test (99%); (2) there is an increase in trust in the use of traditional medicines compared to synthetic drugs in self-medication based on the results of monitoring and evaluation both directly and through the Whatsapp Group "Healthy Herbal Family"; (3) there is an increase in community skills in innovating to process TOGA into products that have economic value, in the form of food products made from medicinal plants (cherry leaves), namely cherry milk pudding and cherry corn milk drink; and (4) facilitation for the community to obtain a Food Safety certificate.

UJI AKTIVITAS ANTIBAKTERI SEDIAAN PEEL OFF MASK EKSTRAK ETANOL DAUN KELOR Pratiwi Ishak; Fihrina Mohamad; Prisca Safriani Wicita; Nangsih Sulastri Slamet; Arlan K. Imran
JURNAL KATALISATOR Vol. 7 No. 1 (2022): Jurnal Katalisator Volume 7 Nomor 1, April 2022
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Propionibacterium acnes is one of the bacteria that trigger acne. A popular face mask preparation today for acne skin care is the peel off Mask. The purpose of this study was to formulate ethanol extract of moringa leaves (Moringa oleifera L.) become a Peel Off mask preparation and see the antibacterial activity of the preparation against Propionibacterium acnes. This research method is quasi experimental, formulated Peel Off Mask preparation with variation of ethanol extract of moringa leaves F1 (10%), F2 (15%) and F3 (20%), then physical test (organoleptic test with hedonic scale 1-5, pH test, irritation test, spreadability test, dry time test) and antibacterial activity test with diffusion method. Data analysis of antibacterial activity test results using one way ANOVA test. The results showed organoleptic test, pH test, irritation test and drying time test F1-F3 all meet the standard. Antibacterial activity test has the greatest power is F1 17.17 mm. The result of one way anova test between F3 treatment with positive control 2 (peel Off mask Brand x®) obtained significance value (0.01) <(0.05), which means F3 has a significant difference to KP2. Conclusion; preparation peel Off Mask ethanol extract of Moringa leaves F3 is the best formula physically and has the greatest antibacterial activity of 17.17 mm (strong) against Propionibacterium acnes.

SUPLEMENTASI SARI DAUN KELOR (Moringa oleifera L.) MENURUNKAN BILANGAN PEROKSIDA DAN ASAM LEMAK BEBAS VCO Nangsih Sulastri Slamet; Ghaitsa Zahira Sopha Yusuf; Fadli Husain; Fihrina Mohamad; Prisca Safriani Wicita; Zulfiayu; Fitriah Ayu Maghfirah Yunus
JURNAL KATALISATOR Vol. 8 No. 1 (2023): Jurnal Katalisator Volume 8 No. 1, April 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Syarat VCO menurut SNI 7381:2008 yaitu memiliki nilai bilangan peroksida dan kadar asam lemak bebas yang rendah. Permasalahan VCO yang beredar saat ini yaitu pada parameter organoleptik khususnya pada aroma bau tengik yang mempengaruhi kualitas dan penyimpanan. Sehingga untuk mengatasi hal tersebut diperlukan antioksidan alami. Daun kelor merupakan tanaman yang berpotensi sebagai antioksidan alami, sehingga berpotensi dalam menurunkan bilangan peroksida dan asal lemak bebas pada VCO.Penelitian ini bertujuan mengetahui nilai bilangan peroksida dan asam lemak bebas pada VCO yang disuplementasi dengan sari daun kelor (Moringa oleifera L.) menggunakan metode fermentasi.Penelitian ini merupakan penelitian quasi eksperimen mengunakan rancangan acak lengkap (RAL) dengan 4 formulasi dengan variasi volume penambahan sari daun kelor F1 (0 mL); F2 (50 mL); F3 (100 mL) dan F4 (150 mL). Bilangan peroksida dan asam lemak bebas dianalisis menggunakan metode titrimetri. Analisis data menggunakan uji Kruskal Wallis dan dilanjutkan dengan uji Mann Whitney.Hasil Penelitian: penambahan sari daun kelor dapat menurunkan bilangan peroksida dan asam lemak bebas pada VCO yang dihasilkan. Bilangan peroksida terukur pada F1, F2, F3 dan F4 berturut-turut adalah 5,76; 3,33; 2,42 dan 1,82 meq/kg, sedangkan kadar asam lemak bebas terukur berturut-turut sebesar 0,4; 0,36; 0,31 dan 0,2 %.Kesimpulan: Semakin besar volume sari daun kelor yang ditambahkan maka nilai bilangan peroksida dan kadar asam lemak bebas pada VCO semakin rendah.

PENINGKATAN KELARUTAN SIMVASTATIN MELALUI PENAMBAHAN BAHAN PENGOMPLEKS SULFANILAMID Arlan Imran; Prisca Safriani Wicita; Zulfiayu Sapiun
JURNAL KATALISATOR Vol. 8 No. 1 (2023): Jurnal Katalisator Volume 8 No. 1, April 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Simvastatin is a drug used to lower cholesterol levels in the blood. The mechanism of action of simvastatin is by inhibiting the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which competitively inhibits the cholesterol biosynthesis process in the body. Simvastatin is included in the class II BCS (Biopharmaceutics Classification System) drug, which has low water solubility and high permeability. The low solubility of simvastatin in water will affect its bioavailability in the body, which result in a therapeutic effect that is not achieved. Drug complexation is a method used to determine the solubility of a compound by adding a complexing agent. Complexing materials that are often used in other research are materials that do not have therapeutic activity such as cyclodextrin, but ini this study used complexing material from anti-microbial drug class by utilizing the reaction of glucoronide formation in the glucoronic acid structure of sulfanilamide. This research is a quantitative research with a laboratory experimental trial method which aims to see the effect of adding sulfanilamide complexing agents at various concentrations (25 ppm, 50 ppm, 75 ppm, and 100 ppm) on the solubility level of simvastatin using the acid-base titration method. The dissolved simvastatin concentration values for F1, F2, F3, F4, and F5 were 0.261 ± 0.087, respectively; 0.348 ± 0.151; 0.416 ± 0.195; 0.444 ± 0.163; 0.539 ± 0.118. The results obtained showed that the higher concentration of the sulfanilamide complexing agent added, the greater solubility of simvastatin.

Utilization Of Butterfly Pea Instant Powder as an Antihypertension Health Drink in Dungaliyo Village, Gorontalo District Prisca Safriani Wicita; Arlan K. Imran; Fitriah Ayu Magfirah Yunus
ABDIMAS: Jurnal Pengabdian Masyarakat Vol. 6 No. 3 (2023): ABDIMAS UMTAS: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM Universitas Muhammadiyah Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35568/abdimas.v6i3.3464

Hypertension is a state of systolic blood pressure ≥140 mmHg and diastolic ≥90 mmHg. This non-communicable disease has become a problem in the world because of its increasing prevalence and its association with cardiovascular disease, stroke and kidney disease. Gorontalo Regency is a district with the highest number of hypertension sufferers and based on research data, one of the survey data for hypertension sufferers is in the Dungaliyo Village area. This community service aims to apply research results related to the use of natural ingredients in the form of butterfly pea flower (Clitoria ternatea L.) which has many benefits, one of which is antihypertensive activity. The application was realized in the form of distribution of butterfly pea flower instant powder and training for cadres/community groups related to the procedure for making butterfly pea flower instant powder. This is to increase the level of health and skills of the people of Gorontalo in general as well as the awareness of cadres/community groups where the community service is carried out in particular. This community service activity has been carried out in accordance with the objectives and methods planned in 3 (three) stages. Stage 1; Coordination with the Head of Dungaliyo village, Stage 2; Pretest understanding of hypertension and butterfly pea flowers, measurement of blood pressure and dissemination of the use of butterfly pea powder as an antihypertensive health drink, Stage 3; Socialization of butterfly pea flower cultivation, distribution of seeds, measurement of blood pressure and Posttest. This community service activity obtained the results of an evaluation of community understanding which increased from 50% to 90% and a decrease in blood pressure with the percentage of people with high blood pressure from 25% to 20 %.

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