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Gambaran Klinis dan Histopatologi Karsinoma Prostat di Salah Satu RS Swasta Jakarta Barat Tahun 2021-2023 Firman Kevin Gratio Nainggolan; Christina, Shintia; Boedijono, Freciyana; Angeline, Reni
Jurnal MedScientiae Vol 4 No 1 (2025): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i1.3588

Abstract

Prostate carcinoma is a type of cancer that occurs in the prostate gland in men. Globally, in 2022, 14,2% of prostate cancer cases were recorded in the male population. In the Indonesian male population, there were 7,0% of prostate cancer cases. This study aims to determine the clinical and histopathological features of prostate carcinoma patients at one of Jakarta Barat private hospital in 2021–2023..This study is a descriptive study with a retrospective approach at one of private hospital in West Jakarta. Determination of sample size using consecutive sampling technique with a sample size of 79 samples. The most cases of carcinoma were recorded in 2021 with 35 samples (44,3%). In this study, there were 36 cases in the age range >70–80 years (45,6%). The most common clinical complaint was LUTS with 54 samples (68,4%). The most common sampling technique was TRUS-biopsy with 35 samples (44,3%). The results of histopathological examination were dominated by acinar adenocarcinoma with 72 samples (91,1%). A total of 27 samples were Gleason Class Group 5 (34,2%). The incidence of prostate carcinoma at one of Jakarta Barat private hospital in 2021-2023 was 79 samples with the most common complaint being LUTS. The most common incidents occurred in the age range of >70-80 years. The most frequently used method of sampling was TRUS-biopsy with acinar adenocarcinoma being the most common histopathological result found and Gleason Grade Group 5 dominating in this study.
Gambaran Klinis dan Histopatologi Karsinoma Urotelial di Salah Satu RS Swasta Jakarta Barat Tahun 2021-2023 Andri Lesmana; Christina, Shintia; Indarto, Fanny; Boedijono, Freciyana
Jurnal MedScientiae Vol 4 No 3 (2025): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i3.3597

Abstract

Urothelial carcinoma is a type of cancer that can occur in organs lined with urothelial cells, specifically in the urinary tract. Globally, in 2022, bladder cancer accounted for 3% of all cancer cases. Objective to determine the clinical and histopathological characteristics of urothelial carcinoma patients at a private hospital in West Jakarta from 2021 to 2023. This study is a descriptive study with a retrospective approach conducted at a private hospital in West Jakarta. The sample size was determined using the consecutive sampling technique, resulting in a total of 40 samples. The highest number of urothelial carcinoma cases was recorded in 2021, with 21 cases (52.5%). In this study, 14 cases (35.0%) were found in the 60-69 age group. The most common clinical complaint was gross hematuria, observed in 34 samples (85.0%). Histopathological examination showed that the most frequent pathological stage was pT1, found in 14 samples (35.0%), while the most common pathological grading was high grade, observed in 29 samples (72.5%). The incidence of urothelial carcinoma at a private hospital in West Jakarta from 2021 to 2023 was 40 cases, with gross hematuria being the most common clinical complaint. The highest incidence was in the 60-69 age group. The most frequent pathological stage was pT1, and the most common pathological grading was high grade.
Ekspresi Programmed Death Ligand-1 (PD-L1) pada Seminoma Testis sebagai Potensi Faktor Prognostik Boedijono, Freciyana; Tanurahardja, Budiana; Kodariah, Ria
Majalah Patologi Indonesia Vol. 29 No. 3, September 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i3.448

Abstract

BackgroundThe prognosis of testicular seminoma cases which failed to be cured with conventional therapy is poor. Several recurrent eventsafter chemotherapy were also found. PD-L1 is expressed in various types of malignancy and tumor infiltrating lymphocytes (TILs)and its role is known as a prognostic factor. This study was conducted to determine the role of PD-L1 expression seminoma indetermining overall survival (OS) and progression free survival (PFS).MethodsThis is a retrospective cohort study with survival analysis. Clinical data were obtained from medical record in RSUPN CiptoMangunkusumo since January 2011-December 2016 and observed for 2 years. Histopathological data were obtained fromAnatomical Pathology Department and PD-L1 immunohistochemical staining were performed.ResultsA significant correlation between PD-L1 expression in tumor cells with 2-year OS (p=0.023) and PFS (p=0.002) in testicularseminoma was found. No significant correlation between PD-L1 expression in TILs with 2-year OS (p=0.235) and PFS (p=0.111).We also found significant correlations between PD-L1 expression of tumor cells and TILs with PFS (p=0.019). A significantcorrelation between stage with 2-year OS (p=0.010) and PFS (p=0.000) and lymph node metastases with 2-year OS (p=0.010) andPFS (p=0.000).ConclusionPD-L1 expression of testicular seminoma cells were significantly correlated with OS and PFS. There were no statistically significantassociations between PD-L1 expression in TILs with OS and PFS.