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All Journal Majalah Patologi Indonesia Jurnal MedScientiae
Angeline, Reni
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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HUBUNGAN PENGETAHUAN DAN SIKAP TERHADAP PERILAKU SISWA SMP-SMA X TANGERANG TERHADAP ROKOK SEBAGAI FAKTOR RISIKO PENYEBAB KANKER PARU Angeline, Reni; Wijaya, Hertiawan; Ruchika, Ruchika; Christina, Shintia
Jurnal MedScientiae Vol 3 No 2 (2024): August
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3274

Abstract

Lung cancer is the first cancer for men and the third for women based on cancer globally. Based on RISKESDAS, there is an increase in the prevalence of smokers every year in junior high and high school. This is because teenagers think smoking makes it easier for them to socialize. The purpose of this study was to determine the relationship between knowledge and attitudes towards the behavior of students of SMP and SMA X Tangerang towards smoking as a risk factor for lung cancer. This type of research uses analytic methods with a cross sectional approach. The sample used was 88 respondents with a simple random sampling technique. Data collection using a questionnaire and data analysis using Spearman. The results showed that there was a relationship between the level of knowledge and behavior with a value of p = 0.012 (p = <0.05). Likewise the relationship between attitude and behavior, there is a significant relationship with a value of p = 0.000 (p = <0.05). It was concluded that there was a significant relationship between knowledge and attitudes towards the behavior of students of SMP and SMA X Tangerang towards smoking as a risk factor for lung cancer.
Efektivitas Terapi Target Sorafenib dalam Penanganan Hepatocellular Carcinoma: Literature Review Dharma, Herbert; Purnamawati; Angeline, Reni
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3141

Abstract

Liver cancer is the sixth most common cancer and the third leading cause of death in the world. The main cause of liver cancer is the Hepatitis B or Hepatitis C virus which causes patient to experience chronic liver disease which can worsen and develop into liver cancer. Sorafenib targeted therapy can be used to treat patients with advanced liver cancer. This drug can suppress tumor cell proliferation and inhibit tumor angiogenesis. This study aims to determine the benefits of targeted therapy in treating Hepatocellular Carcinoma. The method used in this study is by searching for articles in electronic databases via the internet using Google Scholar and Pubmed. The results showed that the combination of sorafenib targeted therapy with conventional therapy, such as TACE and radiofrequency ablation, could significantly increase survival rates and time to progression. In conclusion, sorafenib targeted therapy when combined with conventional therapy has higher benefits and effectiveness compared to other therapies. The disadvantage of sorafenib targeted therapy is that it can cause many side effects for the patients.
Characteristics and Histopathological Features of Breast Tumor Patients at RSUD dr. Chasbullah Abdulmadjid Bekasi City 2019-2023 Angeline, Reni; Husseynia Muharrani; Shintia Christina; Freciyana Boedijono
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3501

Abstract

Globocan data for 2020 in the world, breast cancer cases are in first place with 2,261,419 cases, the death rate is in fifth place with 684,994 people. In Indonesia, in 2020 breast cancer ranks first. In the 2020 Bekasi City health profile data, there were 92 cases (4.8%) of breast lumps/tumors, compared to 2019 was 6.37%, but when compared to 2018, there was an increase in cases of 4.18%. The aim of this study was to find out information on the characteristics and histopathological features of breast tumor patients at RSUD dr. Chasbullah Abdulmadjid Bekasi City in 2019-2023. This research is a descriptive study with a cross-sectional method, using secondary data from anatomical pathology archives. In the study, a total of 488 cases of benign and malignant breast tumors were found, consisting of: 176 cases in 2019, 97 cases in 2020, 77 cases in 2021, 69 cases in 2022, and 69 cases in 2023. Description of tumor incidence Most benign breasts at the age of 20-29 years, location of upper lateral quadrant tumors, clinical diagnosis of benign breast tumors and histopathological type of mammary fibroadenoma. Meanwhile, the description of the incidence of malignant breast tumors is highest at age > 50 years, location of the upper lateral quadrant tumor, clinical diagnosis and histopathological type of invasive ductal carcinoma.
Gambaran Klinis dan Histopatologi Karsinoma Prostat di Salah Satu RS Swasta Jakarta Barat Tahun 2021-2023 Firman Kevin Gratio Nainggolan; Christina, Shintia; Boedijono, Freciyana; Angeline, Reni
Jurnal MedScientiae Vol 4 No 1 (2025): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i1.3588

Abstract

Prostate carcinoma is a type of cancer that occurs in the prostate gland in men. Globally, in 2022, 14,2% of prostate cancer cases were recorded in the male population. In the Indonesian male population, there were 7,0% of prostate cancer cases. This study aims to determine the clinical and histopathological features of prostate carcinoma patients at one of Jakarta Barat private hospital in 2021–2023..This study is a descriptive study with a retrospective approach at one of private hospital in West Jakarta. Determination of sample size using consecutive sampling technique with a sample size of 79 samples. The most cases of carcinoma were recorded in 2021 with 35 samples (44,3%). In this study, there were 36 cases in the age range >70–80 years (45,6%). The most common clinical complaint was LUTS with 54 samples (68,4%). The most common sampling technique was TRUS-biopsy with 35 samples (44,3%). The results of histopathological examination were dominated by acinar adenocarcinoma with 72 samples (91,1%). A total of 27 samples were Gleason Class Group 5 (34,2%). The incidence of prostate carcinoma at one of Jakarta Barat private hospital in 2021-2023 was 79 samples with the most common complaint being LUTS. The most common incidents occurred in the age range of >70-80 years. The most frequently used method of sampling was TRUS-biopsy with acinar adenocarcinoma being the most common histopathological result found and Gleason Grade Group 5 dominating in this study.
Hubungan Pola Makan dengan Penyakit Kanker Kolorektal Mansyur, Firman Riscky; Angeline, Reni; Christina, Shintia; Kertadjaya, Wiwi
Jurnal MedScientiae Vol 4 No 2 (2025): August
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i2.3741

Abstract

Cancer is the second leading cause of death globally. Colorectal cancer is one of the most common cancers worldwide. Referring to GLOBOCAN data, in general colorectal cancer is the third highest incidence of cancer after lung cancer and breast cancer. This is attributed to the diet that affects colorectal cancer. Most colorectal cancer are still closely related to genetics. In addition to genetic factors, food intake factors also closely related to colorectal cancer. Current research shows colorectal cancer occurs due to genetic mutations and inflammatory bowel disease. This literature review uses a Literature review design using a search method with a library of research articles or journals through PubMed and other journal sources. The results of the literature review are associated with dietary pattern that affect colorectal cancer, red mead intake is related to the growth of colorectal cancer, while high fiber food can help reduce the risk of colorectal cancer.
Deteksi Mikrometastasis pada Bulky Kelenjar Getah Bening Karsinoma Serviks Stadium IA-IIB Menggunakan Sitokeratin AE1/AE3 Angeline, Reni; Tjahjadi, Hartono; Wuyung, Puspita Eka
Majalah Patologi Indonesia Vol. 29 No. 3, September 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i3.441

Abstract

BackgroundCervical uterine carcinoma is a primary malignant disease of the uterine cervix. The presence or absence of metastasis in lymphnodes does not alter the stage but affects recurrence, survival, and therapy. Immunohistochemistry stains of the AE1/AE3cytokeratin can assist in the diagnosis and determine the small focus of carcinoma metastasis. In this study, we analyzedimmunohistochemistry cytokeratin AE1/AE3 could determine micrometastasis in bulky lymph nodes negative.MethodsThis study used cross-sectional design. The sample consisted of 52 cases of stage IA-IIB cervical carcinoma performed by radicalhysterectomy and lymphadenectomy accompanied by negative bulky lymph nodes at the Department of Anatomical PathologyFaculty of Medicine University of Indonesia/Cipto Mangunkusumo Hospital (FKUI/RSCM) from January 2011 to June 2017. Allcases stained by immunohistochemistry cytokeratin AE1/AE3.ResultsBulky Lymph Nodes Cervical Carcinoma stage IA-IIB, histopathologic diagnose of non keratinized squamous cell carcinoma,moderate differentiation degree, no lymphovascular invasion and deepest invasion >5.0 mm. Immunohistochemistry staining ofAE1/AE3 cytokeratin showed no micrometastasis in all cases.ConclusionThe immunohistochemistry staining of AE1/AE3 cytokeratin used in Bulky Lymph Nodes Cervical Carcinoma stage IA-IIB could notdetected micrometastasis in all cases.
LITERATURE REVIEW : TARGET TEKANAN DARAH PADA PASIEN STROKE ISKEMIK DAN HEMORAGIK Tosi, Roswita Sisilia; Suparto, Suparto; Angeline, Reni
Jurnal MedScientiae Vol 2 No 3 (2023): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i3.2973

Abstract

Stroke is a disease that can cause disability and even death. The highest incidence of stroke occurs in China. There is impaired cerebral function in stroke. Stroke is divided into 2 types, namely ischemic stroke and hemorrhagic stroke. Hypertension is a risk factor that is often found. Target blood pressure in stroke patients is part of stroke management. This study method is a literature review that uses the method of searching articles in databases such as Google Scholar Engine, Pubmed, and ProQuest which are then analyzed as many as 13 of the 1,455 journals obtained. The results showed that hemorrhagic stroke patients with systolic blood pressure ≥160 mmHg had a higher mortality rate within 90 days. Patients with a target systolic blood pressure of <140 mmHg can reduce the risk of progressive intracerebral hemorrhage and improve patient functional outcomes. An intensive fall in systolic blood pressure <120 mm Hg is associated with an increase in ischemic lesions and acute neurologic damage. Systolic blood pressure ≥ 160 mmHg can worsen the patient's condition symptomatically within 2 hours after thrombolysis compared to systolic blood pressure <140 mmHg which gives better functional results and reduced mortality in ischemic stroke patients.
Background: Sunlight is useful in the formation of provitamin D, which is useful for increasing the body's immunity. But besides these benefits, there are also negative effects of excess sun exposure, one of which can cause skin cancer. This incident can Winata, Alyandini Saraswati; Angeline, Reni; Deviana, Deviana; Christina, Shintia
Jurnal MedScientiae Vol 2 No 3 (2023): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i3.3037

Abstract

Sunlight is useful in the formation of provitamin D, which is useful for increasing the body's immunity. But besides these benefits, there are also negative effects of excess sun exposure, one of which can cause skin cancer. This incident can be prevented by using sunscreen regularly and correctly. However, it was found that only a third of adults use sunscreen every day. Therefore, this study was conducted to determine the relationship between knowledge and attitudes toward the behavior of Ukrida Faculty of Medicine students when using sunscreen to prevent skin cancer. The method used in this research uses descriptive-analytic research with a cross-sectional approach. The population used in this study were Ukrida Faculty of Medicine students in 2019, totaling 155 people. With a total sample of 123 respondents who met the inclusion and exclusion criteria. Data collection was done using a questionnaire. The results of this study indicate that there is a relationship between knowledge of behavior with a value of p = 0.027 (< 0.05) and a relationship between attitudes towards behavior with a value of p = 0.000 (< 0.05). Based on the results of the study, it was concluded that there was a significant relationship between knowledge and attitudes toward the behavior of 2019 Ukrida Faculty of Medicine students in using sunscreen to prevent skin cancer. However, most of the respondents did not reapply sunscreen every 2 hours.
Co-Authors Boedijono, Freciyana Deviana, Deviana Dharma, Herbert Firman Kevin Gratio Nainggolan Freciyana Boedijono Husseynia Muharrani Kertadjaya, Wiwi Mansyur, Firman Riscky Purnamawati Puspita Eka Wuyung Ruchika, Ruchika Shintia Christina Shintia Christina Suparto Suparto Tjahjadi, Hartono Tosi, Roswita Sisilia Wijaya, Hertiawan Winata, Alyandini Saraswati