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RZ Nizar
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Hubungan Ekspresi BRAF V600E dengan Varian Histopatologik dan Infiltrasi Limfosit pada Papillary Thyroid Carcinoma (PTC) Dutia Gestin; RZ Nizar; Aswiyanti Asri; Husna Yetti
Majalah Patologi Indonesia Vol 30 No 2 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (372.975 KB) | DOI: 10.55816/mpi.v30i2.473

Abstract

BackgroundPapillary thyroid carcinoma is the most common endocrine gland malignancy that has the highest incidence rate of 60-80%. In papillarythyroid carcinoma BRAF V600E mutation plays an important role in carcinogenesis. BRAF V600E is a RAS-regulated-serine-threoninekinase and activator of the MAPK pathway cascade that functions to regulate cell proliferation, differentiation and survival. BRAFV600E mutations in PTC is associated with a high incidence of recurrence and reduced survival. The purpose of this study is to lookat the relationship of BRAF V600E expression with histopathological variants and lymphocyte infiltration in PTC.MethodsThis research was a retrospective observational cross sectional study with 40 cases of papillary thyroid carcinoma which werediagnosed in 4 Pathology Anatomy Laboratory in West Sumatera. Samples were obtained from paraffin blocks of tissue from surgeryand were reevaluated for histopathological variant and lymphocyte infiltration. Expression of BRAF V600E in tumor cell were analyzedusing immunohistochemistry staining. Bivariate statistical analysis of Chi-Square were used and p value <0,05 were consideredsignificance.ResultsPositive BRAF V600E expression was found in 24 case (60%). Positive BRAF V600E expression was mostly found in classic PTC(50%). Papillary thyroid carcinoma with lymphocyte infiltration mostly found with negative BRAF V600E expression (79.2%). Statisticalanalysis showed no significant correlation between BRAF V600E with histopathological variant (p=0.74) and no significancecorrelation between BRAF V600E expression with lymphocyte infiltration (p=0.12).ConclusionThe conclusion is BRAF V600E expression has no correlation with histological variants in papillary thyroid carcinoma and no significantcorrelation of BRAF V600E expression with lymphocyte infiltration.
Hubungan Imunoekspresi p53 Mutan dan Derajat Histopatologi pada Karsinoma Ovarium Serosum Pamelia Mayorita; RZ Nizar; Aswiyanti Asri
Majalah Patologi Indonesia Vol 28 No 1 (2019): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (593.836 KB)

Abstract

Latar belakangKarsinoma ovarium serosum adalah keganasan organ reproduksi wanita yang paling sering mematikankarena bersifat sangat progresif. Berdasarkan temuan terbaru, WHO membagi karsinoma ovariumserosum menjadi karsinoma serosum derajat tinggi dan rendah. Gen p53 berperan dalam patogenesismolekuler karsinoma ovarium serosum khususnya pada derajat tinggi. Mutasi p53 pada karsinoma ovariumserosum diduga berperan pada progresivitas tumor dan berhubungan dengan derajat histopatologikkarsinoma serosum. Penelitian ini bertujuan untuk menganalisis hubungan ekspresi p53 mutant danderajat histopatologik pada karsinoma ovarium serosum.MetodePenelitian ini adalah studi komparatif potong lintang analitik dengan populasi kasus karsinoma serosumovarium, yang didiagnosis di Laboratorium Patologi Anatomik di Sumatera Barat tahun 2013-2015.Berdasarkan kriteria World Health Organization (WHO) 2014, didapatkan 32 kasus yang direview derajathistopatologik. Selektif blok parafin dipisahkan dan diwarnai dengan antibodi monoklonal p53 (Clone EP9;Biocare).Ekspresi p53 dibagi menjadi ekspresi positif dan negatif. Hubungan antara ekspresi p53 danderajat histopatologik dianalisis dengan uji chi-square (p<0,05).HasilKasus karsinoma ovarium serosum memiliki rentang usia 29-67 tahun, dengan usia rata-rata 49,50 untukderajat tinggi dan 45,44 untuk derajat rendah. Ekspresi p53 menunjukkan hasil positif pada 12 kasuskarsinoma serosum derajat tinggi (75%) dan 4 kasus derajat rendah (25%). Terdapat hubungan bermaknaantara ekspresi p53 dengan derajat histopatologik karsinoma serosum ovarium (p=0,013).KesimpulanEkspresi p53 mutan berhubungan dengan derajat histopatologik karsinoma serosum ovarium
Hubungan Imunoekspresi p53 Mutan dan Derajat Histopatologi pada Karsinoma Ovarium Serosum Pamelia Mayorita; RZ Nizar; Aswiyanti Asri
Majalah Patologi Indonesia Vol. 28 No. 1, Januari 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakangKarsinoma ovarium serosum adalah keganasan organ reproduksi wanita yang paling sering mematikankarena bersifat sangat progresif. Berdasarkan temuan terbaru, WHO membagi karsinoma ovariumserosum menjadi karsinoma serosum derajat tinggi dan rendah. Gen p53 berperan dalam patogenesismolekuler karsinoma ovarium serosum khususnya pada derajat tinggi. Mutasi p53 pada karsinoma ovariumserosum diduga berperan pada progresivitas tumor dan berhubungan dengan derajat histopatologikkarsinoma serosum. Penelitian ini bertujuan untuk menganalisis hubungan ekspresi p53 mutant danderajat histopatologik pada karsinoma ovarium serosum.MetodePenelitian ini adalah studi komparatif potong lintang analitik dengan populasi kasus karsinoma serosumovarium, yang didiagnosis di Laboratorium Patologi Anatomik di Sumatera Barat tahun 2013-2015.Berdasarkan kriteria World Health Organization (WHO) 2014, didapatkan 32 kasus yang direview derajathistopatologik. Selektif blok parafin dipisahkan dan diwarnai dengan antibodi monoklonal p53 (Clone EP9;Biocare).Ekspresi p53 dibagi menjadi ekspresi positif dan negatif. Hubungan antara ekspresi p53 danderajat histopatologik dianalisis dengan uji chi-square (p<0,05).HasilKasus karsinoma ovarium serosum memiliki rentang usia 29-67 tahun, dengan usia rata-rata 49,50 untukderajat tinggi dan 45,44 untuk derajat rendah. Ekspresi p53 menunjukkan hasil positif pada 12 kasuskarsinoma serosum derajat tinggi (75%) dan 4 kasus derajat rendah (25%). Terdapat hubungan bermaknaantara ekspresi p53 dengan derajat histopatologik karsinoma serosum ovarium (p=0,013).KesimpulanEkspresi p53 mutan berhubungan dengan derajat histopatologik karsinoma serosum ovarium
Hubungan Ekspresi BRAF V600E dengan Varian Histopatologik dan Infiltrasi Limfosit pada Papillary Thyroid Carcinoma (PTC) Dutia Gestin; RZ Nizar; Aswiyanti Asri; Husna Yetti
Majalah Patologi Indonesia Vol. 30 No. 2, Mei 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i2.473

Abstract

BackgroundPapillary thyroid carcinoma is the most common endocrine gland malignancy that has the highest incidence rate of 60-80%. In papillarythyroid carcinoma BRAF V600E mutation plays an important role in carcinogenesis. BRAF V600E is a RAS-regulated-serine-threoninekinase and activator of the MAPK pathway cascade that functions to regulate cell proliferation, differentiation and survival. BRAFV600E mutations in PTC is associated with a high incidence of recurrence and reduced survival. The purpose of this study is to lookat the relationship of BRAF V600E expression with histopathological variants and lymphocyte infiltration in PTC.MethodsThis research was a retrospective observational cross sectional study with 40 cases of papillary thyroid carcinoma which werediagnosed in 4 Pathology Anatomy Laboratory in West Sumatera. Samples were obtained from paraffin blocks of tissue from surgeryand were reevaluated for histopathological variant and lymphocyte infiltration. Expression of BRAF V600E in tumor cell were analyzedusing immunohistochemistry staining. Bivariate statistical analysis of Chi-Square were used and p value <0,05 were consideredsignificance.ResultsPositive BRAF V600E expression was found in 24 case (60%). Positive BRAF V600E expression was mostly found in classic PTC(50%). Papillary thyroid carcinoma with lymphocyte infiltration mostly found with negative BRAF V600E expression (79.2%). Statisticalanalysis showed no significant correlation between BRAF V600E with histopathological variant (p=0.74) and no significancecorrelation between BRAF V600E expression with lymphocyte infiltration (p=0.12).ConclusionThe conclusion is BRAF V600E expression has no correlation with histological variants in papillary thyroid carcinoma and no significantcorrelation of BRAF V600E expression with lymphocyte infiltration.
Co-Authors Aswiyanti Asri Aswiyanti Asri Dutia Gestin Husna Yetti Pamelia Mayorita