Garuda - Garba Rujukan Digital

Hubungan Imunoekspresi p53 Mutan dan Derajat Histopatologi pada Karsinoma Ovarium Serosum Pamelia Mayorita; RZ Nizar; Aswiyanti Asri
Majalah Patologi Indonesia Vol 28 No 1 (2019): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (593.836 KB)

Latar belakangKarsinoma ovarium serosum adalah keganasan organ reproduksi wanita yang paling sering mematikankarena bersifat sangat progresif. Berdasarkan temuan terbaru, WHO membagi karsinoma ovariumserosum menjadi karsinoma serosum derajat tinggi dan rendah. Gen p53 berperan dalam patogenesismolekuler karsinoma ovarium serosum khususnya pada derajat tinggi. Mutasi p53 pada karsinoma ovariumserosum diduga berperan pada progresivitas tumor dan berhubungan dengan derajat histopatologikkarsinoma serosum. Penelitian ini bertujuan untuk menganalisis hubungan ekspresi p53 mutant danderajat histopatologik pada karsinoma ovarium serosum.MetodePenelitian ini adalah studi komparatif potong lintang analitik dengan populasi kasus karsinoma serosumovarium, yang didiagnosis di Laboratorium Patologi Anatomik di Sumatera Barat tahun 2013-2015.Berdasarkan kriteria World Health Organization (WHO) 2014, didapatkan 32 kasus yang direview derajathistopatologik. Selektif blok parafin dipisahkan dan diwarnai dengan antibodi monoklonal p53 (Clone EP9;Biocare).Ekspresi p53 dibagi menjadi ekspresi positif dan negatif. Hubungan antara ekspresi p53 danderajat histopatologik dianalisis dengan uji chi-square (p<0,05).HasilKasus karsinoma ovarium serosum memiliki rentang usia 29-67 tahun, dengan usia rata-rata 49,50 untukderajat tinggi dan 45,44 untuk derajat rendah. Ekspresi p53 menunjukkan hasil positif pada 12 kasuskarsinoma serosum derajat tinggi (75%) dan 4 kasus derajat rendah (25%). Terdapat hubungan bermaknaantara ekspresi p53 dengan derajat histopatologik karsinoma serosum ovarium (p=0,013).KesimpulanEkspresi p53 mutan berhubungan dengan derajat histopatologik karsinoma serosum ovarium

HUBUNGAN EKSPRESI Ki-67 DENGAN KARAKTERISTIK HISTOPATOLOGIK PADA KANKER PAYUDARA TRIPEL NEGATIF Aswiyanti Asri; Pamelia Mayorita; Daan Khambri
Majalah Kedokteran Andalas Vol 38, No 3 (2015): Published in December 2015
Publisher : Faculty of Medicine, Universitas Andalas

Kanker payudara triple negative mempunyai prognosis paling buruk. Ki-67, derajat diferensiasi dan invasi limfovaskular (LVI) adalah parameter prognostik patomolekuler, dimana Ki-67 juga dipakai sebagai prediktor respon terapi. Penelitian ini bertujuan untuk mengetahui hubungan derajat diferensiasi dan LVI dengan ekspresi Ki-67 pada kanker payudara tripel negatif. Sembilan belas kasus kanker payudara tripel negatif dikumpulkan dan direview ulang derajat diferensiasi dan LVI. Hasil pemeriksaan Ki-67 dikelompokkan dimana ≤10 % sampai 29 % ekspresi rendah-sedang; dan >30% ekspresi tinggi. Hubungan antara ekspresi Ki-67 dengan derajat diferensiasi dan invasi limfovaskular dianalisis menggunakan Chi Square. Dari 19 kasus kanker payudara tripel negatif, 52,6 % kasus mempunyai derajat diferensiasi tinggi dan sisanya derajat diferensiasi rendah. Invasi limfovaskular ditemukan positif pada 68,4% kasus. Ekspresi Ki-67 yang tinggi hanya ditemukan pada 1 kasus. Uji statistik antara ekspresi Ki-67 dengan derajat diferensiasi maupun dengan invasi limfovaskular tidak ditemukan hubungan yang bermakna. Tidak ditemukan korelasi antara ekspresi Ki-67 dengan derajat diferensiasi dan invasi limfovaskular pada kanker payudara tripel negatif.

Diagnosis dan Tatalaksana Limfoma Non Hodgkin Tipe Sel B Sinonasal Tri Aryati Octavia; Dolly Irfandy; Bestari Jaka Budiman; Pamelia Mayorita
Majalah Kedokteran Andalas Vol 46, No 6 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p1103-1117.2023

Pendahuluan: Limfoma Non Hodgkin (LNH) sinonasal merupakan tumor ganas ekstranodal yang jarang terjadi. Lokasi paling sering adalah sinus maksilaris, sinus ethmoid dan rongga hidung. Diagnosis pasti imfoma ditegakkan berdasarkan hasil pemeriksaan histopatologi dan imunohistokimia. Tatalaksana kasus berdasarkan stadium dengan menggunakan stagging Ann Arbor. Laporan Kasus: Dilaporkan satu kasus LNH sinonasal pada laki–laki usia 56 tahun dengan keluhan hidung kanan tersumbat dan keluar darah dari hidung kanan. Pemeriksaan kavum nasal dekstra ditemukan adanya massa yang memenuhi kavum nasal disertai sekret mukopurulen. Kemudian dilakukan tindakan medial maksiektomi dengan pendekatan endoskopik dan didapatkan hasil histopatologi limfoma maligna tipe sel sedang serta imunohistokimia (IHK) dengan hasil limfoma maligna tipe sel B. Kesimpulan: Dilaporkan satu kasus LNH sinonasal pada laki–laki usia 56 tahun dengan keluhan hidung kanan tersumbat dan keluar darah dari hidung kanan. Pemeriksaan kavum nasal dekstra ditemukan adanya massa yang memenuhi kavum nasal disertai sekret mukopurulen. Kemudian dilakukan tindakan medial maksiektomi dengan pendekatan endoskopik dan didapatkan hasil histopatologi limfoma maligna tipe sel sedang serta imunohistokimia (IHK) dengan hasil limfoma maligna tipe sel B.Kata kunci: Limfoma Non Hodgkin sinonasal, Limfoma tipe Sel B, Kemoterapi.

Malignant Lesion on Intraoperative Frozen Section with Histopathology Feature Alveolar Soft Part Sarcoma: A Case Report Wildanur, Sri; Aswiyanti Asri; Pamelia Mayorita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 6 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i6.1003

Background: Alveolar soft part sarcoma (ASPS) are slow-growing inert soft tissue masses, but fast-growing masses are also reported. Because the cancer tissue is rich in blood vessels, distant metastasis is easy to occur through the blood tract, and lung metastasis is the most common. The diagnosis of ASPS should be combined with histopathology examination because of its rarity and often misdiagnosed, especially in unusual sites. Case presentation: A 22-year-old female came to the oncology surgery polyclinic at Dr. M. Djamil General Hospital Padang with a chief complaint of a lump in her left thigh since 1 year ago and has been getting enlarged in the last 6 months. The lump has been painful for the last 2 months. Upon an intraoperative frozen section examination, it was concluded that the lesion was malignant. Then, the tissue was prepared from formalin fixed paraffin embedded (FFPE), and the lesion was diagnosed as alveolar soft part sarcoma. Conclusion: In the case of ASPS, surgical management has an important role. The goal of the intraoperative frozen section of this patient is to determine whether the lesion is benign or malignant. There is a need for histological examination, collaboration, and optimal communication between pathologists and surgeons to avoid limitations and pitfalls examination.

ATYPICAL MICROGLANDULAR ADENOSIS MIMICKING INVASIVE TUBULAR CARCINOMA, A RARE CHALLENGING DIAGNOSIS Hera Novianti; Fitri Nur Handriyani; Aswiyanti Asri; Yenita Yenita; Noza Hilbertina; Pamelia Mayorita; Yessy Setiawati; Zulda Musyarifah; Meta Zulyati Oktora; Maisyah Nelzima
Nusantara Hasana Journal Vol. 4 No. 7 (2024): Nusantara Hasana Journal, December 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i7.1297

Background: Microglandular adenosis (MGA) is a rare breast lesion that poses diagnostic challenges due to its resemblance to invasive carcinoma, particularly invasive tubular carcinoma (ITC). Atypical MGA is of clinical concern because of its potential for malignant transformation. Accurate diagnosis relies on histopathological examination and immunohistochemical (IHC) analysis. Case Presentation: A 34-year-old woman presented with a painless lump in her left breast. Intraoperative frozen section analysis revealed small glandular structures with histological features mimicking ITC. Definitive diagnosis required further evaluation. Immunohistochemical analysis demonstrated S100 positivity, consistent with glandular differentiation, and negative p63 staining, indicating the absence of a myoepithelial layer. These findings, in the absence of definitive stromal invasion, supported a diagnosis of atypical MGA. Complete surgical excision was performed to ensure negative margins and exclude associated malignancy. Discussion: This case highlights the diagnostic complexity of atypical MGA, particularly in young patients. Frozen section analysis alone often fails to distinguish MGA from invasive carcinoma due to overlapping histological features. IHC markers, such as S100 and p63, are critical for differentiation. S100 positivity confirms glandular origin, while p63 negativity indicates the lack of a myoepithelial layer, distinguishing MGA from benign proliferative lesions. Accurate diagnosis is essential to avoid overtreatment, such as unnecessary chemotherapy or radical surgery, while ensuring appropriate management to mitigate malignant potential. Conclusion: This report underscores the importance of combining frozen section and IHC findings for rare breast lesions like atypical MGA. Increased awareness and careful evaluation are essential to achieve timely and precise diagnosis, enabling optimal surgical management and long-term outcomes.

CASE REPORT MALIGNANT GLOMUS TUMOR: A RARE CASE Pamelia Mayorita; Mustika Sari; Zulda Musyarifah; Hera Novianti; Yessy Setiawati; Meta Zulyati Oktora
Nusantara Hasana Journal Vol. 4 No. 8 (2025): Nusantara Hasana Journal, January 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i8.1309

Background: Glomus tumor is a rare mesenchymal neoplasm that accounts for less than 2% of all soft tissue tumors and 1.5% of extremity neoplasms. Malignant glomus tumors are exceptionally rare, comprising only 1-2.9% of all glomus tumors, and are often associated with significant diagnostic and therapeutic challenges. Case Presentation: We report a case of a 62-year-old male presenting with a painful lump on his left thumb, progressively enlarging over six months. Clinical examination revealed a 3x2x1 cm subungual mass with positive cold sensitivity and pin love tests. The patient underwent amputation, and histopathological analysis showed a proliferation of round-to-oval and spindle cells with nuclear atypia, frequent mitotic figures (>5/50 HPF), and atypical mitoses, consistent with malignant glomus tumor grade 2. Surgical margins and bone were free of tumor infiltration. Conclusion: This case highlights the importance of clinical-pathological correlation in diagnosing malignant glomus tumors, which remain a diagnostic challenge due to their rarity. Complete surgical excision with negative margins remains the gold standard for treatment, ensuring favorable outcomes and minimizing recurrence risk.

Collecting Duct Carcinoma in the Kidneys: A Rare Case Report Aini, Julpa Nurul; Noza Hilbertina; Pamelia Mayorita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 7 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i7.1023

Background: Collecting duct carcinoma (CDC) is one of the rare pathological subtypes of renal cell carcinoma, with high malignancy and poor prognosis. Pathological examination is the gold standard in confirming the diagnosis of CDC. CDC is described as a tumor that has a tubulopapillary architecture and forms a hobnail pattern along the glandular tube. Case presentation: A 56-year-old woman with the main complaint of a lump in the right abdomen for 1.5 months before entering the hospital. The lump in the stomach is getting bigger, complaints are accompanied by intermittent pain, nausea, vomiting, body feeling weak, and decreased appetite. The patient then underwent a CT-Scan examination of the abdomen and concluded that fluid/water was found next to the right kidney, and a hypodense lesion appeared in segment 6 of the right lobe of the liver. Histopathological examination of large tissue shows pieces of kidney tissue with a connective tissue capsule on the outside containing glomeruli and tubules lined by cuboidal epithelium as well as a proliferation of tumor cells that grow infiltratively in the connective tissue stroma which is partly desmoplastic and fatty tissue between the glomeruli and tubules. Tumor cells are arranged to form tubulopapillary and tubulocystic structures. These cells with pleomorphic nuclei, some hyperchromatic, some vesicular, coarse chromatin, clear nuclei, and atypical mitoses can be found and tumor cell embolism in the blood vessels and perineural invasion can be seen. There were spots and clusters of lymphocytes and plasma cells as well as areas of bleeding and necrosis. Conclusion: The patient was diagnosed with collecting duct carcinoma (CDC).

Malignant Lesion on Intraoperative Frozen Section with Histopathology Feature Alveolar Soft Part Sarcoma: A Case Report Wildanur, Sri; Aswiyanti Asri; Pamelia Mayorita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 6 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i6.1003

Background: Alveolar soft part sarcoma (ASPS) are slow-growing inert soft tissue masses, but fast-growing masses are also reported. Because the cancer tissue is rich in blood vessels, distant metastasis is easy to occur through the blood tract, and lung metastasis is the most common. The diagnosis of ASPS should be combined with histopathology examination because of its rarity and often misdiagnosed, especially in unusual sites. Case presentation: A 22-year-old female came to the oncology surgery polyclinic at Dr. M. Djamil General Hospital Padang with a chief complaint of a lump in her left thigh since 1 year ago and has been getting enlarged in the last 6 months. The lump has been painful for the last 2 months. Upon an intraoperative frozen section examination, it was concluded that the lesion was malignant. Then, the tissue was prepared from formalin fixed paraffin embedded (FFPE), and the lesion was diagnosed as alveolar soft part sarcoma. Conclusion: In the case of ASPS, surgical management has an important role. The goal of the intraoperative frozen section of this patient is to determine whether the lesion is benign or malignant. There is a need for histological examination, collaboration, and optimal communication between pathologists and surgeons to avoid limitations and pitfalls examination.

Collecting Duct Carcinoma in the Kidneys: A Rare Case Report Aini, Julpa Nurul; Noza Hilbertina; Pamelia Mayorita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 7 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i7.1023

Background: Collecting duct carcinoma (CDC) is one of the rare pathological subtypes of renal cell carcinoma, with high malignancy and poor prognosis. Pathological examination is the gold standard in confirming the diagnosis of CDC. CDC is described as a tumor that has a tubulopapillary architecture and forms a hobnail pattern along the glandular tube. Case presentation: A 56-year-old woman with the main complaint of a lump in the right abdomen for 1.5 months before entering the hospital. The lump in the stomach is getting bigger, complaints are accompanied by intermittent pain, nausea, vomiting, body feeling weak, and decreased appetite. The patient then underwent a CT-Scan examination of the abdomen and concluded that fluid/water was found next to the right kidney, and a hypodense lesion appeared in segment 6 of the right lobe of the liver. Histopathological examination of large tissue shows pieces of kidney tissue with a connective tissue capsule on the outside containing glomeruli and tubules lined by cuboidal epithelium as well as a proliferation of tumor cells that grow infiltratively in the connective tissue stroma which is partly desmoplastic and fatty tissue between the glomeruli and tubules. Tumor cells are arranged to form tubulopapillary and tubulocystic structures. These cells with pleomorphic nuclei, some hyperchromatic, some vesicular, coarse chromatin, clear nuclei, and atypical mitoses can be found and tumor cell embolism in the blood vessels and perineural invasion can be seen. There were spots and clusters of lymphocytes and plasma cells as well as areas of bleeding and necrosis. Conclusion: The patient was diagnosed with collecting duct carcinoma (CDC).

Title

Found 9 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 9 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 9 Documents
Search