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Penatalaksanaan Adenoma Pleomorfik Septum Nasal Muhammad Reko Danuwirya; Sukri Rahman; Aswiyanti Asri
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 2 No. 1 (2023)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v2i1.18

Pendahuluan: Tumor kelenjar liur minor pada sinonasal relatif jarang, dilaporkan hanya 4% sampai 8% dari semua tumor sinonasal. Adenoma Pleomorfik adalah tumor jinak campuran yang terdiri dari komponen sel epitel, mioepitel dan mesenkim yang tersusun dalam beberapa variasi komponen. Diagnosis tumor ini dapat ditegakkan dengan anamnesis, pemeriksaan fisik, pemeriksaan penunjang dan pemeriksaan histopatologi. Penatalaksanaan kasus adenoma pleomorfik adalah dengan eksisi per endoskopi serta perlu dilakukan follow up untuk mendeteksi kekambuhan dan kemungkinan transformasi menjadi keganasan. Laporan kasus: Dilaporkan seorang pasien perempuan umur 46 tahun dengan hidung tersumbat sebelah kiri sejak 2 bulan sebelum masuk rumah sakit. Pada pasien ini dilakukan eksisi per endoskopi dan diikuti dengan pemeriksaan histopatologi sebagai penatalaksanaan dan konfirmasi diagnosis. Kesimpulan: Tumor jinak di kavum nasal dapat berupa adenoma pleomorfik. Penatalaksanaan eksisi per endoskopi pada adenoma pleomorfik kavum nasal yang berasal dari septum memberikan hasil yang memuaskan.

Gambaran Hasil Biopsi Aspirasi Jarum Halus Massa Di Leher pada Pasien RSUP Dr. M. Djamil Padang Tahun 2019-2020 M. Adib Farhan; Sukri Rahman; Aswiyanti Asri
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 1 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v1i1.28

Pendahuluan: Massa di leher merupakan salah satu permasalahan kesehatan di seluruh dunia. Massa di leher dapat dijumpai di semua kelompok umur mulai dari anak anak hingga dewasa yang dapat berasal dari kelenjar getah bening, kelenjar tiroid, kelenjar saliva dan lain-lain. Salah satu metode diagnostik yang sangat bermanfaat untuk mengevaluasi dan menegakkan diagnosis massa di leher adalah pemeriksaan biopsy aspirasi jarum halus (BAJAH). Pemeriksaan BAJAH sederhana, akurat, cepat, dan ekonomis. Metode: Penelitian ini merupakan penelitian deskriptif dengan metode total sampling dilakukan untuk mengetahui distribusi frekuensi hasil BAJAH massa di leher pada pasien RSUP Dr. M. Djamil Padang periode 2019 – 2020. Hasil: Dari hasil penelitian ini jumlah sampel adalah 229 sampel. Hasil penelitian ini didapatkan massa di leher paling banyak terjadi pada usia >40 tahun yaitu 110 kasus (48%) dan lebih banyak terjadi pada laki-laki yaitu 131 kasus (57,2%). Massa di leher paling banyak berasal dari kelenjar getah bening yaitu sebanyak 170 kasus (74,2%), kemudian tiroid sebanyak 36 kasus (15,7%), kelenjar liur 14 kasus (6,3%), dan lain-lain 9 kasus (4,1%). Massa di leher paling banyak ditemukan pada lokasi anterior leher yaitu sebanyak 218 kasus (95,2%) dan berupa massa soliter 161 kasus (70,3%). Etiologi massa di leher yang paling banyak ditemukan merupakan infeksi/inflamasi 119 kasus (49,8%), neoplasma ganas 77 kasus (33,6%), dan neoplasma jinak yaitu 33 kasus (16,6%). Jenis sitopatologi massa di leher yang paling banyak ditemukan yaitu limfadenitis granulomatosa yaitu sebanyak 47 kasus (20,5%). Kesimpulan: Sehingga pada penelitian ini dapat disimpulkan bahwa massa di leher paling banyak terjadi berasal dari kelenjar getah bening dengan jenis sitopatologi terbanyak adalah limfadenitis granulomatosa.

Malignant Lesion on Intraoperative Frozen Section with Histopathology Feature Alveolar Soft Part Sarcoma: A Case Report Wildanur, Sri; Aswiyanti Asri; Pamelia Mayorita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 6 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i6.1003

Background: Alveolar soft part sarcoma (ASPS) are slow-growing inert soft tissue masses, but fast-growing masses are also reported. Because the cancer tissue is rich in blood vessels, distant metastasis is easy to occur through the blood tract, and lung metastasis is the most common. The diagnosis of ASPS should be combined with histopathology examination because of its rarity and often misdiagnosed, especially in unusual sites. Case presentation: A 22-year-old female came to the oncology surgery polyclinic at Dr. M. Djamil General Hospital Padang with a chief complaint of a lump in her left thigh since 1 year ago and has been getting enlarged in the last 6 months. The lump has been painful for the last 2 months. Upon an intraoperative frozen section examination, it was concluded that the lesion was malignant. Then, the tissue was prepared from formalin fixed paraffin embedded (FFPE), and the lesion was diagnosed as alveolar soft part sarcoma. Conclusion: In the case of ASPS, surgical management has an important role. The goal of the intraoperative frozen section of this patient is to determine whether the lesion is benign or malignant. There is a need for histological examination, collaboration, and optimal communication between pathologists and surgeons to avoid limitations and pitfalls examination.

Edukasi Tentang Anemia dan Pemeriksaan Hb pada Ibu Hamil serta Pengobatan pada Masyarakat di Nagari Carocok Anau Kec.Tarusan Kab. Pesisir Selatan Elmatris Sy; Dessy Arisanti; Almurdi Almurdi; Endrinaldi Endrinaldi; Bobby Indra Utama; Dian Pertiwi; Rauza Sukma Rita; Zelly Dia Rofinda; Hasmiwati Hasmiwati; Aswiyanti Asri; Julizar Nazar; Mohamad Reza
Warta Pengabdian Andalas Vol 31 No 3 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.3.591-598.2024

The majority of people of Nagari Carocok Anau Kec. Tarusan Kab. Pesisir Selatan worked as a fisherman, farmer, a small number of civil servants and market traders, as well as a housewife. Pregnant women in Nagari Carocok Anau, most of whom are housewives, still do not receive health checks such as haemoglobin (Hb) checks. This activity aims to increase knowledge among the public and health cadres regarding anaemia and Hb examination in pregnant women, as well as treatment. The health of pregnant women is checked by checking blood pressure, Hb and medication. This Hb examination is an effort to minimize abnormalities that can occur in pregnant women and fetuses due to low Hb when the mother is pregnant. The examination results showed that more than half of the pregnant women (71.43%) who attended were in the age range 18 – 35 years. Nearly half (42.86%) of pregnant women had Hb levels below the normal limit (11 mg/dl). For a more valid diagnosis, it is necessary to carry out quantitative analysis from the hospital laboratory so that follow-up can be carried out. Education about anaemia and Hb examinations in pregnant women can increase people's knowledge so that preventive measures can be carried out early. Health checks on the general public (blood pressure, Hb) and treatment were also carried out, it was found that the Hb results were within normal limits.

ATYPICAL MICROGLANDULAR ADENOSIS MIMICKING INVASIVE TUBULAR CARCINOMA, A RARE CHALLENGING DIAGNOSIS Hera Novianti; Fitri Nur Handriyani; Aswiyanti Asri; Yenita Yenita; Noza Hilbertina; Pamelia Mayorita; Yessy Setiawati; Zulda Musyarifah; Meta Zulyati Oktora; Maisyah Nelzima
Nusantara Hasana Journal Vol. 4 No. 7 (2024): Nusantara Hasana Journal, December 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i7.1297

Background: Microglandular adenosis (MGA) is a rare breast lesion that poses diagnostic challenges due to its resemblance to invasive carcinoma, particularly invasive tubular carcinoma (ITC). Atypical MGA is of clinical concern because of its potential for malignant transformation. Accurate diagnosis relies on histopathological examination and immunohistochemical (IHC) analysis. Case Presentation: A 34-year-old woman presented with a painless lump in her left breast. Intraoperative frozen section analysis revealed small glandular structures with histological features mimicking ITC. Definitive diagnosis required further evaluation. Immunohistochemical analysis demonstrated S100 positivity, consistent with glandular differentiation, and negative p63 staining, indicating the absence of a myoepithelial layer. These findings, in the absence of definitive stromal invasion, supported a diagnosis of atypical MGA. Complete surgical excision was performed to ensure negative margins and exclude associated malignancy. Discussion: This case highlights the diagnostic complexity of atypical MGA, particularly in young patients. Frozen section analysis alone often fails to distinguish MGA from invasive carcinoma due to overlapping histological features. IHC markers, such as S100 and p63, are critical for differentiation. S100 positivity confirms glandular origin, while p63 negativity indicates the lack of a myoepithelial layer, distinguishing MGA from benign proliferative lesions. Accurate diagnosis is essential to avoid overtreatment, such as unnecessary chemotherapy or radical surgery, while ensuring appropriate management to mitigate malignant potential. Conclusion: This report underscores the importance of combining frozen section and IHC findings for rare breast lesions like atypical MGA. Increased awareness and careful evaluation are essential to achieve timely and precise diagnosis, enabling optimal surgical management and long-term outcomes.

p63 Expression in Ductal Carcinoma In Situ (DCIS) of the Breast and Its Correlation with Histopathological Grading and Morphological Variants Runky Pebranka; Aswiyanti Asri; Tofrizal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1178

Background: Ductal carcinoma in situ (DCIS) is a non-invasive breast cancer with varying potential for progression to invasive carcinoma. Myoepithelial cells (MECs) play a role in preventing this progression, and their absence is a hallmark of invasive disease. The p63 protein is a myoepithelial marker that can be assessed by immunohistochemistry (IHC). This study aimed to evaluate the relationship between p63 expression in MECs, the grade of DCIS, and the morphological subtype of DCIS. Methods: A cross-sectional study was conducted on 35 cases of DCIS diagnosed at the Anatomical Pathology Laboratory of Dr. M. Djamil General Hospital Padang. Paraffin blocks were collected, and Hematoxylin and Eosin (H&E) slides were reviewed to confirm the diagnosis and determine the histopathological grading (low, intermediate, and high) and morphological variants (comedo and non-comedo) of DCIS. Paraffin blocks were re-cut for p63 immunohistochemical staining. The extent of p63 expression was classified as complete or incomplete. Results: The majority of DCIS cases were high grade (54.3%) and of the non-comedo subtype (68.4%). All cases with complete p63 expression were of low histologic grade, while all cases with incomplete p63 expression were of high histologic grade. The results of the Chi-square test showed a statistically significant relationship between p63 expression and histopathological grading (p<0.001). There was no statistically significant relationship between p63 expression and morphological variant. Conclusion: The absence of p63 expression in DCIS is associated with high histologic grade. This finding suggests that p63 IHC may be a useful adjunct in evaluating DCIS.

The Significance of TGF-β Expression in Predicting Lymphovascular Invasion and Lymph Node Metastasis in Colorectal Cancer Aini, Julpa Nurul; Aswiyanti Asri; Noza Hilbertina; Tofrizal; Avit Suchitra; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1182

Background: Colorectal cancer (CRC) is a major health burden globally. The prognosis of CRC is strongly influenced by the presence of lymphovascular invasion (LVI) and lymph node (LN) metastasis. Transforming growth factor-beta (TGF-β) is a cytokine with a complex role in CRC progression. This study aimed to evaluate the significance of TGF-β expression in predicting LVI and LN metastasis in CRC. Methods: This cross-sectional study involved 50 patients diagnosed with CRC. The expression of TGF-β was assessed using immunohistochemical staining and the Allred scoring system. The relationship between TGF-β expression and the presence of LVI and LN metastasis was analyzed using the Chi-square test. Results: High TGF-β expression was significantly associated with both LVI (p = 0.011) and LN metastasis (p = 0.012) in CRC. Patients with high TGF-β expression had a higher risk of LVI and LN metastasis compared to those with low TGF-β expression. Conclusion: TGF-β expression is a significant predictor of LVI and LN metastasis in CRC. This finding has potential implications for risk stratification and treatment decisions in CRC patients.

Gambaran CT Scan Kepala Pasien Trauma Kepala di RSUP Dr. M Djamil Padang Tahun 2021 Hafizah Putri Tasyah; Avit Suchitra; Rina Gustia; Novita Ariani; Dina Arfiani Rusjdi; Aswiyanti Asri
Jurnal Kesehatan Masyarakat Indonesia (JKMI) Vol. 2 No. 4 (2025): Juli
Publisher : Publikasi Inspirasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62017/jkmi.v2i4.4799

Tujuan : mengetahui gambaran CT Scan kepala pasien trauma kepala di RSUP Dr. M. Djamil Padang pada tahun 2021. Metode : Penelitian ini adalah penelitian deskriptif retrospektif. Pengambilan data dilakukan di bagian Radiologi RSUP Dr. M Djamil Padang pada 8 Desember – 22 Desember 2022. Data diambil dalam periode bulan Januari – Desember 2021. Data dianalisis dengan menggunakan analisis univariat. Data dinyatakan dalam bentuk distribusi frekuensi. Hasil: Hasil penelitian ini adalah 357 sampel hasil CT Scan pasien yang memiliki diagnosis trauma kepala. sebanyak 72,5 % adalah laki-laki dan 27,5 % perempuan dari 357 sampel tersebut. Penderita trauma kepala paling banyak berusia 19-59 tahun (51,0 %). Gambaran lesi intrakranial yang terbanyak adalah lesi multipel ( 23,5 %). Kejadian fraktur maksilofasial ditemukan sebanyak 63 kejadian dari 357 pasien trauma kepala. Fraktur mandibular merupakan jenis fraktur yang banyak ditemukan yaitu 26 (7,2 %) kejadian. Fraktur calvaria ditemukan sebanyak 190 kejadian dari 357 pasien. Fraktur os frontal paling banyak ditemukan dengan 52 (14,6 5 %) kejadian Kesimpulan: penderita trauma kepala lebih banyak laki-laki dan lebih banyak pada usia 19-59 tahun. Gambaran lesi multipel paling banyak ditemukan pada gambaran Brain CT Scan. Kejadian fraktur mandibular yang paling banyak untuk fraktur maksilofasial. Fraktur frontal ditemukan paling banyak untuk fraktur calvaria.

Unraveling the Angiogenic Landscape in Endometrioid Endometrial Carcinoma: VEGF Expression, Histopathological Differentiation, and Lymphovascular Invasion as Key Players Mustika Sari; Aswiyanti Asri; Tofrizal; Henny Mulyani; Syamel Muhammad; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1340

Background: Endometrioid endometrial carcinoma (EEC) is a prevalent gynecological malignancy whose prognosis is influenced by factors including histopathological grade and lymphovascular invasion (LVI). Angiogenesis, crucial for tumor growth and metastasis, is significantly mediated by vascular endothelial growth factor (VEGF). This study aimed to investigate the expression of VEGF in EEC and its correlation with histopathological differentiation and LVI. Methods: This observational analytical study employed a cross-sectional design using 36 archival paraffin block samples of EEC diagnosed between January 2022 and December 2024 at the Anatomical Pathology Laboratory of Dr. M. Djamil General Hospital Padang. Cases were selected via simple random sampling from a population of 59. Histopathological grade (Grade 1, 2, or 3 based on FIGO architectural and nuclear criteria) and LVI (negative, focal, or substantial) were re-evaluated from Hematoxylin-Eosin (H&E) stained slides. VEGF expression was assessed by immunohistochemistry, scored semiquantitatively based on the percentage of positive tumor cells and staining intensity, and categorized as low or high. Data were analyzed using Chi-square tests, with p<0.05 considered statistically significant. Results: The mean age of patients was 54.36 years, with the highest prevalence in the 51-60 age group (41.7%). Grade 3 tumors were most common (38.9%), followed by Grade 2 (33.3%) and Grade 1 (27.8%). LVI was present in 47.2% of cases, predominantly focal (38.9%). High VEGF expression was observed in 58.3% of EEC cases. A statistically significant association was found between high VEGF expression and higher histopathological grade (p=0.000), with 66.7% of Grade 3 tumors showing high VEGF expression. No significant association was found between VEGF expression and LVI (p=0.080). Conclusion: High VEGF expression significantly correlated with higher histopathological grades in EEC, suggesting its role in tumor aggressiveness and dedifferentiation. However, a significant association with LVI was not established in this cohort. VEGF expression warrants further investigation as a potential prognostic biomarker and therapeutic target in EEC.

Unraveling the Angiogenic Landscape in Endometrioid Endometrial Carcinoma: VEGF Expression, Histopathological Differentiation, and Lymphovascular Invasion as Key Players Mustika Sari; Aswiyanti Asri; Tofrizal; Henny Mulyani; Syamel Muhammad; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1340

Background: Endometrioid endometrial carcinoma (EEC) is a prevalent gynecological malignancy whose prognosis is influenced by factors including histopathological grade and lymphovascular invasion (LVI). Angiogenesis, crucial for tumor growth and metastasis, is significantly mediated by vascular endothelial growth factor (VEGF). This study aimed to investigate the expression of VEGF in EEC and its correlation with histopathological differentiation and LVI. Methods: This observational analytical study employed a cross-sectional design using 36 archival paraffin block samples of EEC diagnosed between January 2022 and December 2024 at the Anatomical Pathology Laboratory of Dr. M. Djamil General Hospital Padang. Cases were selected via simple random sampling from a population of 59. Histopathological grade (Grade 1, 2, or 3 based on FIGO architectural and nuclear criteria) and LVI (negative, focal, or substantial) were re-evaluated from Hematoxylin-Eosin (H&E) stained slides. VEGF expression was assessed by immunohistochemistry, scored semiquantitatively based on the percentage of positive tumor cells and staining intensity, and categorized as low or high. Data were analyzed using Chi-square tests, with p<0.05 considered statistically significant. Results: The mean age of patients was 54.36 years, with the highest prevalence in the 51-60 age group (41.7%). Grade 3 tumors were most common (38.9%), followed by Grade 2 (33.3%) and Grade 1 (27.8%). LVI was present in 47.2% of cases, predominantly focal (38.9%). High VEGF expression was observed in 58.3% of EEC cases. A statistically significant association was found between high VEGF expression and higher histopathological grade (p=0.000), with 66.7% of Grade 3 tumors showing high VEGF expression. No significant association was found between VEGF expression and LVI (p=0.080). Conclusion: High VEGF expression significantly correlated with higher histopathological grades in EEC, suggesting its role in tumor aggressiveness and dedifferentiation. However, a significant association with LVI was not established in this cohort. VEGF expression warrants further investigation as a potential prognostic biomarker and therapeutic target in EEC.

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