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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara
Mukmin, Sugianto
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Humanities Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Egg White Extract Supplementation Improves Albumin and IGF-1 Levels in Malnourished Elderly Patients: A Randomized Controlled Trial Mukmin, Sugianto; Nur Riviati; Mgs Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i2.1188

Abstract

Background: Malnutrition is a prevalent issue among the elderly, often leading to hypoalbuminemia (low albumin levels) and decreased serum Insulin-like growth factor 1 (IGF-1) levels. These conditions are associated with increased morbidity and mortality. Egg white extract (EWE) supplementation has shown promise in improving hypoalbuminemia. This study investigated the effects of EWE supplementation on serum albumin and IGF-1 levels in malnourished elderly patients. Methods: A double-blind randomized controlled trial was conducted, involving 46 malnourished elderly inpatients with hypoalbuminemia. Participants were randomly assigned to receive either EWE (30 grams daily) or a placebo for two weeks. Serum albumin and IGF-1 levels were measured before and after the intervention. Results: After two weeks, the EWE group showed a significant increase in both serum albumin and IGF-1 levels compared to the placebo group. The mean serum albumin level in the EWE group increased from 2.80 g/dL to 3.7 g/dL, while the placebo group remained unchanged. The mean serum IGF-1 level in the EWE group increased from 1.74 ng/mL to 24.74 ng/mL, while the placebo group experienced a smaller increase. There was a moderate positive correlation between changes in albumin and IGF-1 levels. Conclusion: EWE supplementation effectively improves serum albumin and IGF-1 levels in malnourished elderly patients with hypoalbuminemia. This intervention may help reduce malnutrition-related complications and improve overall health outcomes in this vulnerable population.
Egg White Extract Supplementation Improves Albumin and IGF-1 Levels in Malnourished Elderly Patients: A Randomized Controlled Trial Mukmin, Sugianto; Nur Riviati; Mgs Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i2.1188

Abstract

Background: Malnutrition is a prevalent issue among the elderly, often leading to hypoalbuminemia (low albumin levels) and decreased serum Insulin-like growth factor 1 (IGF-1) levels. These conditions are associated with increased morbidity and mortality. Egg white extract (EWE) supplementation has shown promise in improving hypoalbuminemia. This study investigated the effects of EWE supplementation on serum albumin and IGF-1 levels in malnourished elderly patients. Methods: A double-blind randomized controlled trial was conducted, involving 46 malnourished elderly inpatients with hypoalbuminemia. Participants were randomly assigned to receive either EWE (30 grams daily) or a placebo for two weeks. Serum albumin and IGF-1 levels were measured before and after the intervention. Results: After two weeks, the EWE group showed a significant increase in both serum albumin and IGF-1 levels compared to the placebo group. The mean serum albumin level in the EWE group increased from 2.80 g/dL to 3.7 g/dL, while the placebo group remained unchanged. The mean serum IGF-1 level in the EWE group increased from 1.74 ng/mL to 24.74 ng/mL, while the placebo group experienced a smaller increase. There was a moderate positive correlation between changes in albumin and IGF-1 levels. Conclusion: EWE supplementation effectively improves serum albumin and IGF-1 levels in malnourished elderly patients with hypoalbuminemia. This intervention may help reduce malnutrition-related complications and improve overall health outcomes in this vulnerable population.
DETEKSI DINI GANGGUAN MINERAL TULANG PADA PENYAKIT GINJAL KRONIK: TINJAUAN SISTEMATIK: EARLY DETECTION OF BONE MINERAL DISORDERS IN CHRONIC KIDNEY DISEASE: A SYSTEMATIC REVIEW Agustiawan; Mukmin, Sugianto; Mastari, Ekawaty Suryani; Hardigaloeh, Amanda Trixie; Susanto, Denny
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 25 No. 1 (2026): Januari 2026
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v25i1.1052

Abstract

Gangguan metabolisme mineral dan tulang merupakan komplikasi penting pada pasien penyakit ginjal kronik yang berdampak pada meningkatnya morbiditas, mortalitas, dan risiko fraktur tulang. Tinjauan sistematik ini bertujuan untuk menganalisis bukti terkini mengenai peran biomarker biokimia dan pemeriksaan radiologis dalam deteksi dini CKD-MBD pada pasien CKD stadium 2–5. Pencarian literatur dilakukan melalui PubMed, Scopus, dan ScienceDirect untuk periode 2015–2025. Empat studi yang memenuhi kriteria inklusi berasal dari India, Italia, Tiongkok, dan Bangladesh, dengan desain potong lintang dan kohort prospektif. Bukti yang kami himpun menunjukkan bahwa peningkatan kadar parathyroid hormone (PTH), fosfat, alkaline phosphatase (ALP), dan fibroblast growth factor-23 (FGF-23) secara konsisten berhubungan dengan penurunan bone mineral density (BMD) serta progresivitas CKD. Kombinasi pemeriksaan biokimia dengan densitometri tulang (DXA) dan pendekatan berbasis machine learning terbukti meningkatkan akurasi diagnosis dini. Oleh karena itu, pemantauan biomarker tersebut dapat menjadi strategi penting dalam deteksi dan pencegahan CKD-MBD secara komprehensif.
Co-Authors Agustiawan Hardigaloeh, Amanda Trixie Mastari, Ekawaty Suryani Mgs Irsan Saleh Nur Riviati, Nur Susanto, Denny