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All Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Kedokteran Ibnu Nafis
Mastari, Ekawaty Suryani
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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FAKTOR RISIKO ACUTE KIDNEY INJURY (AKI) PADA PASIEN DENGAN KEGANASAN: RISK FACTORS FOR ACUTE KIDNEY INJURY (AKI) IN PATIENTS WITH MALIGNANCY Agustiawan; Mastari, Ekawaty Suryani; Anggraini , Tivalen Dwirara; Saragih, Ulfah Octavia
Jurnal Kedokteran Ibnu Nafis Vol. 13 No. 2 (2024): Desember 2024
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/jkin.v13i2.662

Abstract

Acute kidney injury (AKI) merupakan kondisi dimana seseorang mengalami penurunan fungsi ginjal secara tiba-tiba (<48 jam). Mereka dengan AKI mengalami peningkatan kadar serum kreatinin >0.3 mg/dl, kenaikan presentasi kreatinin serum ≥50% (1,5 kali dari nilai awal/normal), atau penurunan urine output. Penelitian sebelumnya menunjukkan bahwa AKI merupakan komplikasi umum dari kanker, dimana hampir separuh pasien neoplastik mengalami AKI selama perjalanan penyakit mereka. Hal ini tentunya berdampak besar pada prognosis keseluruhan, lama rawat inap, dan biaya pengobatan. Kejadian AKI pada pasien kanker merupakan hal yang umum, dimana AKI seringkali ditemukan dalam perjalanan penyakit pasien dengan keganasan. AKI dapat disebabkan oleh karena faktor pasien, tumor, maupun pengobatan. Pencegahan dan antisipasi harus dilakukan untuk meningkatkan luaran pasien.
Comparison Of Reduction In Blood Pressure Between Sublingual and Oral Captopril Agustiawan, Agustiawan; Tabari, Muhammad Fadhlan La; Ilvira, Muhammad Natsir; Mastari, Ekawaty Suryani; Hardiyanti, Dwi
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 4 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i4.1794

Abstract

Background: Hypertensive crisis poses a high risk for long-term cardiovascular complications, and management focuses on controlled blood pressure (BP) reduction rather than immediate normalization. Objective: To compare the effectiveness of sublingual and oral captopril in reducing BP among patients with hypertensive urgency. Methods: A literature review was conducted using English-language studies published after 2012 that evaluated BP reduction outcomes of sublingual versus oral captopril. Results: Three relevant studies met the inclusion criteria, comparing both administration routes in hypertensive urgency management. All studies demonstrated that sublingual and oral captopril were similarly effective in lowering systolic and diastolic BP within the first few hours after administration. Sublingual captopril consistently produced a faster onset of action, with BP reduction observed within 15–30 minutes, whereas oral administration required 30–60 minutes to achieve comparable effects. None of the studies reported significant differences in adverse effects between the two routes. These findings suggest that while overall efficacy is comparable, the sublingual route provides more rapid BP control, which may be crucial in acute care settings. Conclusion: Both sublingual and oral captopril are effective options for hypertensive urgency, with the sublingual form offering a faster therapeutic response suitable for rapid BP reduction in emergency situations.
Co-Authors Agustiawan Agustiawan, Agustiawan Anggraini , Tivalen Dwirara Hardiyanti, Dwi Ilvira, Muhammad Natsir Saragih, Ulfah Octavia Tabari, Muhammad Fadhlan La