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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Health and Medical Journal Andalas obstetrics and gynecology journal Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Science and Society (IJSOC) Scientific Journal Frontiers on Healthcare Research
Ariani, Tutty
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Mikosis Subkutan: Tinjauan Komprehensif Terkait Diagnosis, Tatalaksana, Serta Tantangan Diagnostik Ariani, Tutty
Health and Medical Journal Vol. 8 No. 1 (2026): HEME January 2026
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v8i1.1896

Abstract

Mikosis subkutan merupakan infeksi jamur yang terjadi akibat inokulasi jamur ke dalam jaringan dermis melalui trauma kulit, yang berpotensi menyebabkan infeksi sistemik, terutama pada individu dengan imunokompromais. Mikosis ini termasuk dalam kelompok mikosis profunda dan mencakup beberapa jenis, antara lain cutaneous sporotrichosis, chromoblastomycosis (jenis yang paling sering ditemukan), phaeohyphomycosis, mycetoma, dan basidiobolomycosis. Meskipun termasuk dalam sepuluh besar penyakit jamur yang paling umum di dunia, kasus mikosis subkutan sering kali tidak terdiagnosis secara tepat, terutama di daerah dengan fasilitas kesehatan terbatas dan kurangnya kesadaran klinis terhadap penyakit ini. Penelitian ini dilakukan dalam bentuk tinjauan pustaka dengan mengumpulkan dan menganalisis berbagai artikel ilmiah yang relevan guna memperoleh pemahaman yang komprehensif terkait aspek epidemiologi, manifestasi klinis, metode diagnostik, serta tatalaksana mikosis subkutan. Berdasarkan hasil analisis literatur, mikosis ini umumnya menyerang individu berusia 20–60 tahun, khususnya laki-laki yang bekerja di sektor pertanian atau yang sering terpapar lingkungan berjamur. Diagnosis yang akurat memerlukan pemeriksaan penunjang seperti kultur jamur, histopatologi jaringan, dan teknik diagnostik molekuler. Penatalaksanaan utamanya adalah pemberian antijamur sistemik, yang sering dikombinasikan untuk mencegah kekambuhan. Di samping itu, beberapa inovasi dalam bidang diagnostik dan terapeutik terus dikembangkan untuk meningkatkan efektivitas pengobatan. Mengingat masih rendahnya pencatatan dan pelaporan kasus serta seringnya terjadi salah diagnosis, diperlukan peningkatan pemahaman klinis dan penelitian lanjutan agar mikosis subkutan dapat dikenali secara dini dan ditangani secara optimal.
A Case of Onychomycosis with Nail Lichen Planus: The Importance of Supportive Examinations in Establishing a Diagnosis Ariani, Tutty; Farhanah, Nindya; Gustia, Rina
Scientific Journal Vol. 5 No. 1 (2026): SCIENA Volume V No 1, January 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v5i1.325

Abstract

Background: Onychomycosis and Nail Lichen Planus (NLP) are two conditions that cause nail damage and may sometimes present with overlapping clinical features, leading to difficulties in achieving an accurate diagnosis. Several ancillary examinations should be considered to avoid misdiagnosis of nail disorders. Case: A 64-year-old female patient presented to the Dermatology, Venereology, and Aesthetic Clinic at Dr. M. Djamil General Hospital Padang with complaints of progressive nail thickening and whitening affecting almost all nails, occasionally accompanied by itching, for the past 6 months. The patient had previously been diagnosed with onychomycosis and had regularly taken fluconazole 150 mg weekly for 6 months, but without improvement. Physical examination was within normal limits. Dermatological and onychoscopic examination revealed subungual hyperkeratosis, longitudinal ridging, onychotrophy, onychoschizia, trachyonychia, onycholysis, yellowish discoloration, melanonychia, and leukonychia, with an OSI score indicating severe involvement and a NALSI score of 100/120. KOH examination demonstrated the presence of hyphae, fungal culture revealed Aspergillus niger, PAS staining confirmed fungal elements, while biopsy results were consistent with NLP. The patient was diagnosed with onychomycosis with concomitant NLP and was treated with pulse itraconazole at a dose of 400 mg/day for one week each month for 2–3 months. Upon completion, treatment for NLP was initiated. Discussion: In this case, the absence of comprehensive ancillary examinations particularly biopsy, initially led to a diagnosis limited only to onychomycosis, without recognition of the coexisting NLP. This highlights the importance of thorough investigations to ensure an accurate and precise diagnosis.
Co-Authors Andani Eka Putra Andriani Fuji Lestari Anum, Qaira Asri, Ennesta Aulia , Salsabila Syafna Clarissa Maharani Putri Farhanah, Nindya Fonna, Nellia Kartika, Hersa Firda Kencana, Indah Rina Gustia Rizal, Yosse Satya Wydya Yenny Triani , Aisha