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All Journal Folia Medica Indonesiana CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Wironegoro, Rio
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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EFFECTS OF EDAMAME (Glycine max) EXTRACTON POST-PRANDIAL SERUM TRIGLYCERIDE IN WISTAR RATS Kamal, Imran H; Dewanti, Linda; Wironegoro, Rio
Folia Medica Indonesiana Vol. 52 No. 1 (2016): JANUARY - MARCH 2016
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (164.142 KB) | DOI: 10.20473/fmi.v52i1.5211

Abstract

Edamame (Glycine max) is a preparation of immature soybeans in the pod, which is high in calcium and dietary fiber, two elements described in previous studies that could alter the level of post-prandial serum triglyceride.The purpose of this research is to analyze the effect of edamame (Glycine max) extract on post-prandial serum triglyceride in rats after intragastric administration of palm oil.The materials used in this study are palm oil, edamame extract, and ether. The design of this study is experimental post-test study design, which is a design to measure the serum triglyceride level after meal with and without Glycine max. Triglyceride is measured on each subject two times on total, first one after consumption of meal without Glycine max and the second one after consumption of meal with Glycine max. There is a washout period of 1 week between two times the samples were taken. Both results are then compared in every subject.The level of 2-hour post-prandial serum triglyceride in rats after palm oil without intragastric edamame (Glycine max) extract administration and with intragastric edamame (Glycine max) extract administration showed no significant difference. In conclusion, edamame (Glycine max) extract had no effect on 2-hour post-prandial serum triglyceride after palm oil administration via intragastric tube.
HIGH BLOOD GLUCOSE LEVEL INCREASE CARDIOVASCULAR DISEASE RISK IN TYPE 2 DIABETES MELLITUS Marchelia, Laili Zahrina; Purwati, Purwati; Wironegoro, Rio
Folia Medica Indonesiana Vol. 52 No. 2 (2016): APRIL - JUNE 2016
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.121 KB) | DOI: 10.20473/fmi.v52i2.5228

Abstract

Type 2 diabetes mellitus (DM) is the 10th leading cause of death in the world and had a risk 4.06 times greater to have cardiovascular disease (CVD). Fasting plasma glucose and 2-hours postprandial glucose level as diagnostic tests to evaluate DM and also as a predictive factors to CVD. This research uses descriptive analytic research with cross sectional design. The subject of this study is Type 2 DM patients came to Dr Soetomo hospital from January-October 2014. Data was recorded from medical records of patients and was analyzed with Chi Square test with p<0.05. As result, there is 102 Type 2 DM patients with 36 patients have CVD manifestation and 66 patients without complication. There is a significant association between fasting plasma glucose (FPG), 2-hours postprandial glucose (2hPPG) level, and CVD manifestation (p=0.00). So FPG and 2hPPG have a significant association with CVD manifestation. There are other factors that influencing the formation of CVD, hence, further research is needed.
Weight Gain in Type 2 Diabetes Mellitus Patients Receiving Sulfonylurea Medications at a Tertiary Hospital in Surabaya, Indonesia Respati, Ghagat Dresta Putra; Prajitno, Jongky Hendro; Setiawati, Rosy; Wironegoro, Rio
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 1 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i1.52126

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. The prevalence of diabetes in Indonesia is 1.5%, although East Java recorded a 2.1% rate in 2013. T2DM medications, such as sulfonylureas, may lead to hypoglycemia and weight gain. This study aimed to investigate the weight gain effects of sulfonylureas in T2DM patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Methods: This retrospective cross-sectional study used retrograde anamnesis on 41 T2DM patients receiving sulfonylurea medications for the preceding six months. The data were collected from medical records and interviews with the T2DM patients who received treatment at the Internal Medicine Clinic of Dr. Soetomo General Academic Hospital from January to June 2022. Results: Most patients were 46–65 years old (73.2%), female (51.2%), and had been diabetic for over 15 years (48.8%). The predominant medications administered to the patients were glimepiride (41.4%) and a combination of glibenclamide 5 mg, metformin 500 mg, and acarbose 100 mg (19.5%). Almost all patients took their medications in the morning before meals (92.6%). The average weight gain was 4.6 kg, with the glibenclamide and metformin combination resulting in a 17% incidence. Conclusion: T2DM patients who use sulfonylureas generally gain weight and exhibit specific traits, including being middle-aged, female, and diabetic for multiple years. The most commonly used sulfonylureas are glimepiride for monotherapy and glibenclamide for combination therapy with metformin and acarbose. Future research is required to understand weight gain in T2DM patients treated with sulfonylureas more comprehensively.   Highlights: 1. This study investigated weight changes in type 2 diabetes mellitus (T2DM) patients receiving sulfonylureas, with a special focus on the emergence of weight gain as a new problem in T2DM management. 2. The importance of this study pertains to its findings regarding weight gain in T2DM patients treated with sulfonylureas, offering additional data that aids in preventing adverse effects of the medications.
Co-Authors Jongky Hendro Prajitno Kamal, Imran H Linda Dewanti Marchelia, Laili Zahrina Purwati Purwati Respati, Ghagat Dresta Putra Setiawati, Rosy