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All Journal International Journal of Public Health Science (IJPHS) Jurnal Keolahragaan Folia Medica Indonesiana Biomolecular and Health Science Journal CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL International Journal of Health and Medicine
Jongky Hendro Prajitno
Faculty Of Medicine, Universitas Airlangga
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Magnesium deficiency associated with diabetic retinopathy in type 2 diabetes mellitus: A meta-analysis Ronald Pratama Adiwinoto; Robert Dwitama Adiwinoto; Jongky Hendro Prajitno
International Journal of Public Health Science (IJPHS) Vol 10, No 3: September 2021
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v10i3.20916

Abstract

Diabetic retinopathy (DR) is the major cause of visual impairment in the working-age population with type 2 diabetes mellitus (T2DM). Magnesium (Mg) is involved in various metabolic processes and in experimental animal studies; Mg has shown essential roles in physiological eye function. Magnesium deficiency is common in T2DM; therefore we analyzed the association between serum Mg status and the presence of DR in T2DM patients. Systematic literature searching in several databases, from 1988 to September 2020, was performed using search terms: “serum magnesium” or “hypomagnesemia” and “diabetic retinopathy” or “retinopathy”. A total of 3,227 patients from 17 studies were included in this meta-analysis. Hypomagnesemia was associated with increased risk of developing DR (OR 4.52 [2.08, 9.81], p=0.0001) in T2DM patients. Serum Mg levels also lower in patients with DR than those without DR (MD –0.30 mg/dL [–0.44, –0.15], p<0.0001). Additionally, serum Mg levels were lower in patients with proliferative DR (PDR) than those with non-proliferative DR (NPDR) (MD-0.21 mg/dL [–0.34, –0.09], p=0.0009). Leave-one-out sensitivity analysis did not change the overall effect. Hypomagnesemia or low serum Mg levels in T2DM patients increased the risk of developing DR.
Poor Glycemic Control is Correlated with Reduced Cognitive Function in Type 2 Diabetes Mellitus Patients Archangela Olivia Eugenia; Achmad Firdaus Sani; Hermawan Susanto; Jongky Hendro Prajitno
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.31880

Abstract

Introduction: The prevalence of type 2 Diabetes Mellitus (T2DM) in Indonesia is increasing and is known to cause several complications related to the patient’s glycemic control. A chronic hyperglycemic state will lead to microvascular injury of the brain resulting in cognitive impairment as one of the complications of T2DM. Therefore, our present study observed the correlation between glycemic control and cognitive impairment in patients with T2DM.Methods: This was an observational study with a cross-sectional design of T2DM patients in endocrine outpatient clinics of Dr. Soetomo General Academic Hospital from October 2020 to March 2021. The subjects were recruited consecutively then categorized into groups with controlled (HbA1c < 7%) and uncontrolled (HbA1c ≥ 7%) blood glucose. The cognitive function was evaluated using the AD8 informant-based questionnaire.Results: A total of 43 adult T2DM patients aged < 65 years were recruited. The incidence of cognitive impairment was not significantly different (p=0.127) between controlled and uncontrolled blood glucose groups. However, HbA1c levels were positively and significantly correlated with AD8 scores (p=0.031, R=0.330). Moreover, the duration of T2DM was found to significantly affect cognitive abnormalities in these patients. (p=0.021).Conclusion: Poor glycemic control in T2DM patients increased the risk of developing reduced cognitive function.
The effect of diabetes exercise on the quality of life of type 2 diabetes mellitus patients Nur Rachmawati Maulida; Jongky Hendro Prajitno; Nuniek Nugraheny Sulistiawaty
Jurnal Keolahragaan Vol 10, No 1: April 2022
Publisher : Program Studi Ilmu Keolahragaan Program Pascasarjana Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jk.v10i1.46115

Abstract

Physical inactivity and obesity are some of the main risk factors for diabetes mellitus (DM). The presence of DM might result in impaired quality of life (QoL). Our study aimed to firstly determine the association between diabetes exercise status and the QoL in type 2 Diabetes Mellitus (T2DM) patients and secondly to explore other factors associated with QoL among T2DM patients. This was an observational study with cross-sectional design of T2DM patients in dr. Trimurti primary health care (PHC) from January – December 2019. The subjects were recruited consecutively then categorized into treatment group (who performed diabetes exercise program) and control group (who did not perform diabetes exercise program).  then observed as in the exercise group (who performed diabetes exercise program) and in the non-exercise group (who did not perform diabetes exercise program). The dependent variable was the QoL and was collected through a modified questionnaire made from 30 questions. The maximum score for QoL was 120 (all 4 on the Likert scale) and the score results were categorized as poor if the score was 96.5 and good if the score was 96.5. Meanwhile, other data (comorbidities, exercise status, glycaemic status) were obtained through medical records. A total of 60 adult T2DM patients were recruited, consisting of 30 subjects each in the non-exercise and exercise groups. Male subjects, aged 65 years, had bachelor's degrees, retired, married, had very high income, had no comorbidities, and exercised independently every week tended to have good QoL. In the exercise group, the majority of subjects (60%) performed diabetes exercise every two weeks and the majority (90%) had random blood glucose levels 200 mg/dL. The chi-square test revealed a significant associaton between participation in diabetes exercise and QoL in T2DM subjects. Participation in diabetes exercise is associated with good QoL and better glycemic control in T2DM patients.
Correlation between Skinfold Thickness and Total Daily Dose of Insulin in Patient with Type 2 Diabetes Mellitus in Dr Soetomo General Hospital Larasati, Amilia Putri; Prajitno, Jongky Hendro; Purwanto, Bambang
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 2 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i2.49154

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) is a non-communicable disease with a high prevalence in Indonesia. T2DM is caused by insulin resistance and relative insulin deficiency. One of the therapy for T2DM is insulin administration which is injected into the subcutaneous tissue. The absorption of insulin in the subcutaneous tissue is influenced by many factors, one of which is the thickness of subcutaneous fat. This study aimed to determine the correlation between the skinfold thickness of T2DM patients with the total daily dose of insulin needed every day. Methods: This was an observational analytic study using a cross-sectional design to analyze the correlation between subcutaneous fat thickness represented by skinfold thickness and the total daily dose of insulin of T2DM patients. Measurement of skinfold thickness was carried out on the triceps using a skinfold caliper. Data on the patient's total daily dose of insulin were obtained from medical records.Results: A total of 53 patients were included in this study. The patient's mean triceps skinfold thickness was 26.29±8.72 mm. The mean total daily dose of insulin was 40.96±18.01 IU. The results of the Spearman Rank correlation test showed a significant correlation between skinfold thickness on the triceps and the patient's total daily dose of insulin (p<0.05). Conclusion: The higher the skinfold thickness, the greater the dose of insulin needed by the patient.
The Use of Canagliflozin in Diabetes Mellitus Type 2 on Renal Outcome: A Systematic Review Haikal, Vikri; Soelistijo, Soebagijo Adi; Puspa; Prajitno, Jongky Hendro
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 1 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i1.50710

Abstract

Introduction: One of the leading causes of death in patients with diabetes mellitus is Diabetic Kidney Disease (DKD). Canagliflozin is one of the therapeutic options that can be used to mitigate the progression of DKD. However, the limited existing studies have left the data regarding the effects of canagliflozin on the progression of DKD still unclear. Therefore, a comprehensive study on the efficacy and safety of using canagliflozin in patients with DKD is warranted.Methods: We performed a systematic search in the PubMed, Cochrane Library, ResearchGate, and Springer for randomized, placebo-controlled trials of the treatment of type 2 diabetes mellitus (T2DM) with canagliflozin that were published. A total of 25 journals were identified, and after excluding irrelevant studies, eighteen studies were ultimately included in this systematic review with total participants of 20,047.Results: Canagliflozin reduces the rate of estimated glomerular filtration rate (eGFR) decline in patients with diabetes mellitus. The reduction of urinary albumin-to-creatinine ratio (UACR) level was greater in canagliflozin group than in the control group, and the progression of albuminuria was slower in the canagliflozin group than in the control group.Conclusion: The use of Canagliflozin is considered to be one of the effective therapeutic options for kidney protection in patients with diabetes mellitus who are at risk of chronic kidney disease (CKD).
Profile of Education Level and Understanding of Insulin Therapy in Type 2 Diabetes Mellitus Patients With Insulin Therapy at RSUD dr. M. Soewandhi Surabaya Cintantya, Danastri Tiara; Prajitno, Jongky Hendro; Handayani, Samsriyaningsih
International Journal of Health and Medicine Vol. 2 No. 1 (2025): January : International Journal of Health and Medicine
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhm.v2i1.215

Abstract

This study examines the relationship between education level and understanding of insulin therapy among type 2 diabetes mellitus patients undergoing insulin therapy at RSUD dr. M. Soewandhi Surabaya. Using a descriptive observational method with a cross-sectional design, data were collected from interviews and medical record observations from 100 patients aged 15-64. The findings reveal that most patients had low educational backgrounds, with 27% never attending school and 39% only completing high school. Regarding insulin therapy comprehension, 10% demonstrated good understanding, 55% moderate, and 35% poor. The highest comprehension was insulin usage rules, while the lowest was injection techniques. The study underscores the need for tailored health education to improve patient understanding, particularly for low-education groups. Limitations of the study include the single-site setting and potential response biases from interviews. Future research should expand to include diverse populations and examine non-educational factors influencing therapy comprehension, such as cultural and economic conditions.
DIABETES RISK FACTOR SCREENING IN ADULTS USING PERKENI QUESTIONNAIRE AND ORAL GLUCOSE TOLERANCE TEST IN SOCAH COUNTY, BANGKALAN Kamal, Radin H; Novendrianto, Dwiki; Chadijah, Faizah; Prasetya, Galan Budi; Pratama, Gilang Satria; Ariadnya, Mentari Octarina; Larasati, Nikita Gladys; Darain, Nur Lia F; Nanda, Ovitrani; Mavita, Silvi; Usamah, Usamah; Prajitno, Jongky Hendro
Folia Medica Indonesiana Vol. 53 No. 3 (2017): September 2017
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (55.924 KB) | DOI: 10.20473/fmi.v53i3.6448

Abstract

There are 8.4 million diabetes adult patients in Indonesia and most remained undiagnosed. Screening process for diabetes is very important. PERKENI has recommended the use of questionnaire and Oral Glucose Tolerance Test (OGTT) as risk factor screening tools. This study aimed to find out the use of PERKENI questionnaire and OGTT in adults as diabetes risk factor screening tools. This was a descriptive cross sectional study conducted in 2015 in Socah County Bangkalan. Participants (n=91) were interviewed regarding diabetes risk factor using PERKENI questionnaire. Anthropometric (height, weight, and abdominal circumference) measurements were also taken. The results were categorized into: very low risk, increased risk, moderate risk and high risk. Only those categorized as high risk were asked to take OGTT. Exclusion criteria were participants who had been diagnosed with diabetes by a physician and/or routinely taking anti diabetic medication, consumed drugs during the previous two weeks and does not finish the required procedures. From 91 eligible participants, only 9 (9.89%) were categorized as high risk. The result of OGTT were: 4 were within normal limit, 1 had impaired glucose tolerance (IGT) and 4 were newly diagnosed with diabetes. The use of PERKENI questionnaire and OGTT in high risk adult population as a diabetes risk factor screening tool increased new findings of diabetes cases. Our analysis may support the adoption of diabetes risk factor screening methods through questionnaires and OGTT in high risk adult population, especially in low resource setting.
Weight Gain in Type 2 Diabetes Mellitus Patients Receiving Sulfonylurea Medications at a Tertiary Hospital in Surabaya, Indonesia Respati, Ghagat Dresta Putra; Prajitno, Jongky Hendro; Setiawati, Rosy; Wironegoro, Rio
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 1 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i1.52126

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. The prevalence of diabetes in Indonesia is 1.5%, although East Java recorded a 2.1% rate in 2013. T2DM medications, such as sulfonylureas, may lead to hypoglycemia and weight gain. This study aimed to investigate the weight gain effects of sulfonylureas in T2DM patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Methods: This retrospective cross-sectional study used retrograde anamnesis on 41 T2DM patients receiving sulfonylurea medications for the preceding six months. The data were collected from medical records and interviews with the T2DM patients who received treatment at the Internal Medicine Clinic of Dr. Soetomo General Academic Hospital from January to June 2022. Results: Most patients were 46–65 years old (73.2%), female (51.2%), and had been diabetic for over 15 years (48.8%). The predominant medications administered to the patients were glimepiride (41.4%) and a combination of glibenclamide 5 mg, metformin 500 mg, and acarbose 100 mg (19.5%). Almost all patients took their medications in the morning before meals (92.6%). The average weight gain was 4.6 kg, with the glibenclamide and metformin combination resulting in a 17% incidence. Conclusion: T2DM patients who use sulfonylureas generally gain weight and exhibit specific traits, including being middle-aged, female, and diabetic for multiple years. The most commonly used sulfonylureas are glimepiride for monotherapy and glibenclamide for combination therapy with metformin and acarbose. Future research is required to understand weight gain in T2DM patients treated with sulfonylureas more comprehensively.   Highlights: 1. This study investigated weight changes in type 2 diabetes mellitus (T2DM) patients receiving sulfonylureas, with a special focus on the emergence of weight gain as a new problem in T2DM management. 2. The importance of this study pertains to its findings regarding weight gain in T2DM patients treated with sulfonylureas, offering additional data that aids in preventing adverse effects of the medications.
Effectiveness of Radioiodine Therapy for Graves' Hyperthyroidism: A Quality-of-Life Assessment Fauzi, Machfud; Prajitno, Jongky Hendro; Prabowo, Gwenny Ichsan; Novida, Hermina
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.53131

Abstract

Introduction: Graves' disease, an autoimmune disorder characterized by hyperthyroidism, is commonly managed through radioactive iodine therapy, antithyroid drugs, and thyroidectomy. Previous reports suggest that individuals undergoing radioactive iodine therapy exhibit superior overall quality of life and satisfaction compared to those opting for alternative therapeutic modalities. This study systematically reviewed evidence on the effectiveness of radioiodine therapy for Graves' hyperthyroidism, specifically emphasizing its impact on patients' quality of life. Methods: A systematic review was conducted on studies evaluating the quality of life of adult patients with Graves’ hyperthyroidism following radioiodine therapy. A literature search was carried out utilizing the PubMed, ScienceDirect, and Sage Journals online databases. The search results were screened according to the eligibility criteria for inclusion in a narrative synthesis. Results: The search yielded 203 items, of which four articles fulfilled the eligibility criteria and were included in the review. radioiodine therapy demonstrated improvements in the quality of life of patients with Graves' disease compared to other therapeutic modalities or no treatment at all. Enhancement in quality of life was observed across various scales, encompassing physical symptoms (goiter, hyperthyroidism, eye symptoms, and hypothyroidism), psychological symptoms (depression and anxiety), functioning and well-being (fatigue, cognitive impairment, and emotional vulnerability), and participation (social life disruptions, daily life interference, and cosmetic complaints). Conclusion: Findings concerning quality of life underscore the long-term effectiveness of radioiodine therapy as a preferred intervention for Graves' disease, contributing valuable insights for clinical decision-making.   Highlights: 1. This systematic review comprehensively synthesizes research findings regarding the impact of radioiodine therapy on the long-term quality of life of patients with Graves’ hyperthyroidism compared to surgery or antithyroid medication. 2. The findings suggest that radioiodine therapy offers improvement in the quality of life, which may be indicated by physical and psychological symptoms, functioning, well-being, and participation.
Co-Authors Achmad Firdaus Sani, Achmad Firdaus Archangela Olivia Eugenia Ariadnya, Mentari Octarina Bambang Purwanto Chadijah, Faizah Cintantya, Danastri Tiara Darain, Nur Lia F Fauzi, Machfud Haikal, Vikri Hermawan Susanto Hermina Novida, Hermina Kamal, Radin H Larasati, Amilia Putri Larasati, Nikita Gladys Mavita, Silvi Nanda, Ovitrani Novendrianto, Dwiki Nuniek Nugraheny Sulistiawaty Nur Rachmawati Maulida Prabowo, Gwenny Ichsan Prasetya, Galan Budi Pratama, Gilang Satria Puspa Respati, Ghagat Dresta Putra Robert Dwitama Adiwinoto Ronald Pratama Adiwinoto Samsriyaningsih Handayani Setiawati, Rosy Soelistijo, Soebagijo Adi Usamah Usamah, Usamah Wironegoro, Rio