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All Journal Stannum : Jurnal Sains dan Terapan Kimia MEDICINUS Pharmacon: Jurnal Farmasi Indonesia
Endah Dwijayanti
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Antioxidant Activity Testing Combination of Moringa Leaf (Moringa oleifera L.) and Bambian (Ocimum sanctum L.) Leaves Extract Using DPPH Method Endah Dwijayanti; Masli Nurcahya Zoraida; Siti Rahayu Kurnianingsih
Stannum : Jurnal Sains dan Terapan Kimia Vol 5 No 1 (2023): April 2023
Publisher : Department of Chemistry - Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/jstk.v5i1.3797

Abstract

Research on the antioxidant activity combination of the ethanol extract of Moringa (Moringa oleifera L.) and basil (Ocimim sanctum L.) leaves has been carried out. The purpose of this study was to identify the content of secondary metabolites and measure the value of antioxidant activity as well as the maximum ratio of the combination of ethanol extract of Moringa leaves and basil leaves. The research methods include maceration extraction using 70% ethanol as a solvent, phytochemical screening using specific reagents and antioxidant activity testing using the DPPH method. The results of the phytochemical screening test for Moringa leaf extract and basil leaves were positive for containing chemical compounds of the flavonoid and tannin groups. The antioxidant activity test of Moringa leaf ethanol extract obtained IC50 results of 69.474 ppm which was categorized as a strong antioxidant, while basil leaves of 34.663 ppm which was categorized as very strong antioxidant, while the results of the combined study of antioxidant activity test of Moringa leaf ethanol extract and basil leaves obtained IC50 results at the ratio of 25:25 mg is 51.589 ppm and the ratio of 35:15 mg is 57.009 ppm which was categorized as a strong antioxidant, while at 15:35 mg is the optimum ratio because the IC50 result is 42.714 ppm which was categorized as very strong.
Potensi farmakologi Kasumba Turatea (Carthamus tinctorius L.) sebagai antibakteri Lismayana Hansur; Ami Febriza; Dito Anurogo; Dara Ugi Aras; Endah Dwijayanti
MEDICINUS Vol. 37 No. 2 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/6zstjd88

Abstract

Kasumba turatea (Carthamus tinctorius L.) is a plant that has been used as traditional medicine in South Sulawesi. Themain component of C. tinctorius L. flowers is hydroxysafflor yellow A, which functions as an anti-inflammatory, antioxidant,and platelet aggregation inhibitor. This review highlights pharmacological potential of C. tinctorius L. as an antibacterialagent. The method involves a literature review from various databases such as PubMed, Google Scholar, and Scopus. Theresults show that C. tinctorius L. extracts are effective against various pathogenic bacteria such as Listeria monocytogenes,Streptococcus iniae, Staphylococcus aureus, and Escherichia coli. Bioactive compounds like carthamin, phenolics, and flavonoids exhibit significant antibacterial activity. Additionally, C. tinctorius L. extracts also show potential as anthelminticand antioxidant agents. Further research is required to isolate and characterize specific bioactive compounds, followed by in vivo validation and clinical study to confirm their efficacy as well as safety. 
Potential of Hydroxysafflor yellow A, the main compound of Kasumba Turate (Carthamus tinctorius ) as Anti-Inflammatory in Lung, Liver and Cardiac Tissues: A Literature Review Hansur, Lismayana; Aras, Dara Ugi; Endah Dwijayanti
Pharmacon: Jurnal Farmasi Indonesia Volume 21, No 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.4908

Abstract

Inflammation is the body's physiological response to stimuli such as infection, trauma and chronic disease. Its exacerbation can lead to deterioration in health and damage to tissues in organs such as the lungs, kidneys and liver. The drive behind the development of anti-inflammatory drugs is to improve treatment efficacy and reduce adverse effects. The primary aim of this article is to deliberate on the pharmacological properties of compound from C.tinctorius as an anti-inflammatory agent. Through an extensive study of data we made a literature review of 17 research conducted to unravel the potential of compound from C.tinctorius as an anti-inflammatory agent. The ability of Carthamus tinctorius to alleviate inflammation is demonstrated by its ability to inhibit the activation of the NF-κB pathway and suppress the binding of the TGF-β1 promoter. These molecular processes hold the promise of ameliorating lung injury by attenuating the inflammatory response through suppression of the TLR 4-dependent signalling pathway, thereby improving the health of rats suffering from pulmonary fibrosis, a condition characterised by inflammation and vascular tissue repair. In addition, compounds in C. tinctorius are effective in reducing T lymphocyte (CD4) apoptosis in sepsis through their anti-inflammatory and anti-apoptotic effects. The anti-inflammatory mechanism is also demonstrated by reducing inflammatory cytokines such as IL-6 in the lungs, kidneys and liver.
Co-Authors Ami Febriza Aras, Dara Ugi Dara Ugi Aras Dito Anurogo Hansur, Lismayana Lismayana hansur Masli Nurcahya Zoraida Siti Rahayu Kurnianingsih