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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) EAJ (ECONOMICS AND ACCOUNTING JOURNAL) Jurnal Farmamedika (Pharmamedica Journal) Health & Medical Sciences
Nofriyanti
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Formulasi Dan Uji Aktivitas Emulgel Minyak Ikan Gabus (Channa striata) Sebagai Penyembuh Luka Bakar : Formulation and Activity Test of Snakehead (Channa striata) Oil as A Burns Healing Nofriyanti; Sinata, Novia; Mistawati, Aida
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2020.v6.i2.15013

Abstract

Burns often occur in various daily activities, second-degree burns are the most common. Snakehead oil (Channa striata) contains fatty acids such as omega-3 and omega-6 which can accelerate the wound healing process. This study aims to determine the physical stability and effectiveness of emulgel preparations containing snakehead oil for 8 weeks of storage of the wound healing process, which was given topically to 5 groups of treated mice.Second degree burns were made on the skin of mice, then the wound was smeared with emulgel preparations and the healing process was observed for 21 days. Cork fish oil was formulated in several concentrations; F1 (5%), F2 (10%) and F3 (15%). Organoleptic datas showed that all formulas formed as semisolid dosage form with a pale yellow color and distinctive smell of snakehead oil. The emulgel has homogenous state, not irritating effect and pH range of 5,7 to 5,3. The dosage which has a concentration of 15% gives the smallest spread but has the longest adhesion. In the Freeze and Thaw stability test conducted at 40C and 400C the dosage remains stable with an increase in globule size. Data analysis of the effectiveness of burn healing was done by two-way ANOVA statistical tests and continued with the Tukey test. The independent variable is the treatment group and the recovery time of mice while the dependent variable is the diameter of the burn. Statistical results showed that all formulas differed significantly (p <0.05) against negative controls indicating that they had effectiveness in wound healing. F3 has a better effectiveness of healing burns on the 15th day with 100% healing percent compared with F1 and F2 on the 21th day.
SINTESIS, KARAKTERISASI STRUKTUR, DAN KAJIAN MOLECULAR DOCKING SENYAWA 4’-METOKSI FLAVONOL SEBAGAI INHIBITOR MAIN PROTEASE (MPro) SARS-CoV-2 Ihsan Ikhtiarudin; Nesa Agistia; Neni Frimayanti; Enda Mora; Rahma Dona; Nofriyanti; Rosnita Dewi Rahmawati; Adel Zamri
Majalah Farmasi dan Farmakologi Vol. 26 No. 1 (2022): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v26i1.18652

Abstract

Main protease (MPro) merupakan salah satu protein yang memiliki peran penting dalam proses replikasi virus SARS-CoV-2. Beberapa studi in silico dan in vitro telah menunjukkan bahwa senyawa flavonoid baik alami maupun sintetis memiliki potensi yang menjanjikan untuk dikembangkan sebagai antivirus SARS-CoV-2. Penelitian ini bertujuan untuk mensintesis senyawa 4'-metoksi flavonol dan mengeksplorasi potensinya sebagai inhibitor MPro SARS-CoV-2. Sintesis dilakukan menggunakan senyawa awal 2'-hidroksi-4-metoksi kalkon melalui reaksi Algar-Flynn-Oyamada (AFO) dengan metode pengadukan (stirring method). Selanjutnya, kajian molecular docking dilakukan menggunakan struktur kristal MPro SARS-CoV-2 yang diunduh dari website RCSB Protein Data Bank (PDB ID: 6M2N). Hasil sintesis senyawa 4'-metoksi flavonol diperoleh rendemen produk sebesar 37,72 % dan struktur produk hasil sintesis telah dikonfirmasi melalui analisis spektroskopi UV-Vis, FT-IR, dan 1H NMR. Selanjutnya, hasil kajian molecular docking menunjukkan bahwa senyawa 4’-metoksi flavonol dapat membentuk ikatan hidrogen dengan dua residu penting pada sisi aktif 6M2N, yaitu Glu166 dan Gln189, dengan nilai energi bebas ikatan sebesar -7,13 kcal/mol dan nilai RMSD sebesar 1,45. Hasil kajian ini menunjukkan bahwa senyawa 4'-metoksi flavonol dapat terikat dengan lebih mudah pada sisi aktif MPro SARS-CoV-2 dibandingkan dengan baicalein sebagai senyawa flavonoid pembanding yang telah terbukti secara in vitro dapat menghambat aktivitas proteolitik MPro SARS-CoV-2.
EVALUASI SIFAT FISIK SUSPENSI REKONSTITUSI AMOKSISILIN GENERIK BERMEREK DI APOTEK KOTA BANGKINANG Nofriyanti; Agistia, Nesa; Pratiwi, Erniza
Jurnal Farmamedika (Pharmamedika Journal) Vol 9 No 2 (2024): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v9i2.344

Abstract

Penyakit infeksi merupakan masalah kesehatan yang penting, obat andalan untuk mengatasinya adalah antibiotik. Amoksisilin merupakan antibiotik spektrum luas yang banyak digunakan pada infeksi yang disebabkan bakteri. Amoksisilin bersifat sukar larut di dalam air, sehingga dibuat dalam bentuk suspensi rekonstitusi. Penambahan volume cairan rekonstitusi yang tidak tepat dapat mempengaruhi efektivitas kerjanya. Penelitian ini bertujuan untuk mengetahui apakah sifat fisik sediaan suspensi rekonstitusi amoksisilin yang diambil di apotek di kota Bangkinang memenuhi persyaratan sesuai dengan yang tertera di dalam Farmakope Indonesia Edisi VI dan pustaka lainnya. 30 botol suspensi amoksisillin dengan nomor batch yang sama, ditambahkan air sesuai tanda batas yang tertera pada wadah dan kemudian dievaluasi sifat fisiknya, meliputi organoleptis, pH, bobot jenis, viskositas, volume sedimentasi, waktu redispersi dan volume terpindahkan yang diuji selama 7 hari penyimpanan. Diperoleh hasil uji organoleptik, pH, bobot jenis, viskositas, volume sedimentasi dan waktu redispersi yang memenuhi persyaratan selama penyimpanan 7 hari. Akan tetapi pada pegujian volume terpindahkan tidak sesuai dengan persyaratan pada Farmakope Indonesia edisi VI.
Evaluation of Good Distribution Practice (GDP) Implementation at the Provincial Pharmacy and Health Logistics Installation (IFLK) of Riau Nofriyanti; Devi Safitri; Nurzakyya Tinnisa; Ramona, Paula
Health & Medical Sciences Vol. 2 No. 4 (2025): August
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/phms.v2i4.495

Abstract

This study aimed to evaluate the implementation of Good Distribution Practice (GDP) at the Provincial Pharmacy and Health Logistics Installation (IFLK) of Riau. The research employed direct observation, document review, and active participation in pharmaceutical management activities, including planning, procurement, storage, distribution, recording, and monitoring. The evaluation focused on three key areas: general drug management, cold chain products, and controlled substances such as narcotics and psychotropics. The results showed that all assessed aspects of GDP were properly implemented at IFLK Riau, including the application of FIFO and FEFO principles, well-maintained cold chain facilities, secure storage for controlled drugs, and systematic stock documentation. Overall, the implementation of GDP at IFLK Riau was considered optimal and compliant with national standards, ensuring the quality, safety, and availability of medicines within the region. These findings emphasize the critical role of pharmacists in maintaining the integrity and sustainability of the pharmaceutical distribution system.
Fraud Analysis in the Corruption Case of PT. Waskita Karya Based on Ethical Principles and GCG Principles Kurnia Asih, Dea; Supriyatna, Dede; Andita Fitriannisa, Eka; Meisya, Eveline; Nofriyanti
EAJ (Economic and Accounting Journal) Vol. 8 No. 1 (2025): EAJ (Economics and Accounting Journal)
Publisher : Universitas Pamulang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32493/eaj.v8i1.y2025.p1-9

Abstract

This research aims to conduct a literature review of ethical principles and good corporate governance principles as well as business ethics regarding corruption cases at PT. Waskita Karya Tbk which has harmed many parties and also has an impact on public trust. Apart from that, this research also explains the factors that make this case possible. The research method used is a qualitative method and data collection is carried out through documentation from validated sources and literature studies. The results of this research conclude that in the literature, the fraud that occurred in this case was triggered by many things, such as fraud that was deliberately carried out and resulted in ethical issues and a lack of internal control. The solution offered is to strengthen the implementation of good corporate governance in company management and improve ethics from the lowest managerial level, up to the highest decision holders.
Co-Authors Adel Zamri Agistia, Nesa agistia, nesa Andita Fitriannisa, Eka Devi Safitri Enda Mora Ihsan Ikhtiarudin Kurnia Asih, Dea Meisya, Eveline Mistawati, Aida Neni Frimayanti Nurzakyya Tinnisa Pratiwi, Erniza Rahma Dona Ramona, Paula Rosnita Dewi Rahmawati Sinata, Novia Supriyatna, Dede