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All Journal Medula Indian Journal of Forensic Medicine & Toxicology
Retno Ariza Soeprihatini Soemarwoto
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Education Medicine & Pharmacology Neuroscience Public Health

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Significant Association of Adam 33 Polymorphism with COPD in Javanese Population of Indonesia Retno Ariza Soeprihatini Soemarwoto; Jamsari; Yanwirasti; Andika Chandra Putra; Syazili Mustofa; Wawan Abdullah Setiawan; Ifan Aulia Candra
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17045

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is one of World health cases that is commonlyknown, which is triggered by the combination of environmental factors especially cigarette smoking andgenetic factors. The association between A disintegrin and metalloprotease 33 (ADAM33) polymorphismsand COPD has been investigated and reported by other researchers. Objective: The main aim of this study isto identify the association between single nucleotide polymorphisms (SNPs) in ADAM 33 gene with COPDin the Javanese population in Lampung, Indonesia. Methods: A randomized cross-sectional study was usedin this research. PCR-Sequencing method was involved to analyze the polymorphic for three SNPs (T1, T2,and Q-1) of the ADAM33 gene. Statistical analysis data was performed in descriptive and comparative aswell as it was measured by parametric/non-parametric tests. Results: The results showed that the T2 GG,and T1AG genotypes in COPD group were significantly more frequent rather than in control group (p <0.05). In case of allele, it was found that the T1G and T2G was higher in COPD group rather than in thecontrol group (p = 0.440 and 0.131, respectively). Conclusion: The results clearly conclude that there wassignificant association between T1 and T2 polymorphisms of ADAM33 gene and COPD in the Javanesepopulation of Lampung, Indonesia.
The SNP rs13118928, rs1828591 and rs10519717 in the HHIP Gene are not Associated on COPD Susceptibility in Male Javanese Smokers Syazili Mustofa; Sutyarso; Muhartono; Yandri; Retno Ariza Soeprihatini Soemarwoto; Hendri Busman; Wawan Abdullah Setiawan
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17108

Abstract

Background: Hedgehog Interacting Protein (HHIP) gene polymorphisms have an association on COPDhas been carried out in Europe and Asia but in Indonesia there is still very limited study on this type andthe largest ethnic group in Indonesia is the Javanese. Objective: To analyze the association between theHHIP gene polymorphism and the incidence of COPD in male Javanese smokers in Lampung, Indonesia.Method: In a case-control study in Javanese male smokers, three single nucleotide polymorphism (SNPs)in the HHIP gene were analyzed by Sanger sequencing method. There were 110 participants in this studywhich were divided into 2 groups, such as COPD group (55 participants) and control group (55 participants).Three SNPs in the gene (rs13118928, rs1828591 and rs10519717) were selected for genotyping. Genotypedistributions were compared between patients and controls. The statistical analysis was carried out with theSPSS program with a chi-square test. Result: The genotypic frequency of the HHIP gene sequence at theSNP position rs1828591, such as AA (52.72%), GG (3.63%) and AG (43.63%) in COPD group, while inthe control group such as AA (38.18%), GG (9.09%) and GG (52.72%; p > 0.05). The genotypic frequencyof the HHIP gene sequence at the SNP position rs13118928 consisted of AA (47.27%) and AG (53.72%)in the control group, while the COPD group consisted of AA (52.72%), GG (1.81%) and AG (45.45%; p> 0.05). The genotypic frequency of the HHIP gene sequence at the SNP position rs10519717 consistedof TT (34.54%), CC (14.56%) and CT (50.90%) in COPD group, while controls group consisted of TT(23.63%), CC (16.37%) and CT (60.00%; p > 0.05). The genotypic analysis of Three SNPs in HHIP genewere observed but showed no significant difference between case and control groups. Conclusion: Singlenucleotidevariants in the HHIP gene are not associated with COPD susceptibility in Javanese male smokers.
GAMBARAN PENEGAKAN DIAGNOSIS DAN TATALAKSANA BERDASARKAN TINGKAT KEJADIAN TUMOR PARU DI RSUD DR. H. ABDUL MOELOEK PROVINSI LAMPUNG TAHUN 2018-2021 Vega Edelweis Veilana; Fransisca Tarida Yuniar Sinaga; Jordy Oktobiannobel; Retno Ariza Soeprihatini Soemarwoto
Medula Vol 12 No 2 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i2.365

Abstract

Tumors that occur in the lungs can be divided into several types, namely benign tumors, malignant tumors, primary tumors and tumors caused by metastases from malignancies originating from other organs. There are about 1 million deaths in the population each year, which are caused by lung cancer malignancies. The case of lung tumor malignancy is ranked 4th, from the total number of cancers that occur in Indonesia. The increase in mortality due to malignant lung tumors is most likely due to delays in diagnosis. According to the Ministry of Health of the Republic of Indonesia, lung tumors are the main cause of death in men with a percentage (21.8%) and in women with a percentage (9.1%). This research uses descriptive observational method with retrospective observation using purposive sampling technique. The data used in the form of medical records. There were 159 lung tumor patients studied, consisting of 77.4% of men, 44.0% of 41-60 years of age, 95.0% of no family history, 67.9% of shortness of breath, and 67.9% of smoking history. 79.2%, using FNAB as much as 37.7%, stage IVA as much as 25.8%, squamosa cell carcinoma as much as 50.3% and chemotherapy as much as 47.8%. Lung tumor patients were mostly found in men, with an age range of 41-60 years, tended to suffer from patients who did not have a family history, the most had symptoms of shortness of breath, were active smokers, the most were stage IVA, with the type of squamous cell carcinoma. FNAB samples were 50.3% and underwent chemotherapy.
Co-Authors Fransisca Tarida Yuniar Sinaga Hendri Busman Ifan Aulia Candra Jamsari Jamsari Jordy Oktobiannobel Muhartono Putra, Andika Chandra Sutyarso Syazili Mustofa Vega Edelweis Veilana Wawan Abdullah Setiawan Yandri Yanwirasti