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All Journal Medula Jurnal Biomedika dan Kesehatan MAHESA : Malahayati Health Student Journal
Irawati, Nur Ayu Virginia
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Peran Intensitas Latihan dalam Hipertrofi Otot Skeletal Irawati, Nur Ayu Virginia; Sylviana, Nova; Lubis, Leonardo
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.124-132

Abstract

Endurance training, a form of physical activity that relies on continuous aerobic exercise and repetitive muscle contractions, is widely acknowledged for its positive effects on overall physical fitness. Aerobic exercise, an essential component of endurance training, has numerous benefits including improved cardiovascular and respiratory health, increased muscle endurance, and enhanced resistance against fatigue. It has also been found to contribute to skeletal muscles, potentially by stimulating the synthesis of proteins involved in muscle fiber formation. Although resistance exercise has been favored for promoting muscle growth, some suggests that aerobic exercise can also produce skeletal muscle hypertrophy comparable to that of resistance exercise if performed correctly. The duration, intensity, and specific type of aerobic exercise play important roles in determining skeletal muscle mass. The mammalian target of rapamycin (mTOR) known as a key regulator of muscle protein synthesis that associated with exercise activity. Several signaling pathways, such as Akt/mTOR and MAPK, are involved in controlling muscle protein synthesis during exercise. This review aimed to understand the impact of aerobic exercise intensity and other training parameters on skeletal muscle, to provide valuable insights for optimizing exercise programs and fostering muscle hypertrophy. In this review, we had systematically searched PubMed and Google Scholar from January 2013 to May 2023. Our result indicated that aerobic exercise can be expected to promote skeletal muscle hypertrophy and improve muscle mass and function. The regulation of skeletal muscle mass is complex, involving various signaling pathways such as mTOR, as well as the influence of hormones and growth factors.
Exploring Lactic Acid Bacteria and Metabolite-Target Interactions in Undernutrition Prevention: A Network Pharmacology and Molecular Docking Approach Prayogi, Norbertus Marcell; Berawi, Khairun Nisa; Irawati, Nur Ayu Virginia; Rukmono, Prambudi
MAHESA : Malahayati Health Student Journal Vol 5, No 11 (2025): Volume 5 Nomor 11 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i11.23016

Abstract

ABSTRACT Undernutrition is a major global issue, particularly in children, leading to stunting, wasting, and compromised immune function. Disruption of gut microbiota is a key factor in undernutrition, making probiotics, especially Lactic Acid Bacteria (LAB), a potential solution for improving nutritional status. This study explores the role of LAB and their metabolites in preventing undernutrition using network pharmacology and molecular docking approaches to identify potential molecular targets and related pathways. Network pharmacology tools like TargetNet, SEA, and SwissTargetPrediction were used to predict gene targets influenced by LAB metabolites. Cytoscape was used to build protein-protein interaction (PPI) networks, and molecular docking simulations evaluated the binding of LAB metabolites to key proteins associated with undernutrition. A total of 603 potential genes were identified, including human serum albumin (ALB), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α). Pathway analysis linked these proteins to immune response, nutrient absorption, and metabolic regulation. Molecular docking confirmed stable interactions with LAB metabolites. LAB and their metabolites show promise in managing undernutrition by modulating gut health and supporting nutrient absorption, providing a basis for future clinical applications. Keywords: Undernutrition, Lactic Acid Bacteria (LAB), Probiotics, Network Pharmacology, Molecular Docking
Peran Faktor Determinan Sosial Kesehatan, Personal Hygiene, dan Lingkungan dalam Penularan Protozoa Usus Khuluq, Muhammad Khusnul; Irawati, Nur Ayu Virginia; Mutiara, Hanna; Suwandi, Jhons Fatriyadi
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1406

Abstract

Intestinal protozoan infections are a significant health issue, particularly in developing countries with low socioeconomic conditions, poor sanitation, and inadequate personal hygiene practices. The transmission of intestinal protozoa is closely linked to various social determinants of health, including education level, occupation, and household income. Parents with lower education levels tend to have limited knowledge about hygiene and infection prevention, increasing the risk of transmission to children. Certain occupations, such as farming, are also associated with a higher risk of infection due to exposure to contaminated environments. Personal hygiene plays a crucial role in preventing intestinal protozoan infections. Habits such as washing hands before eating, after defecation, and maintaining overall cleanliness can reduce the risk of transmission through the fecal-oral route. Additionally, inadequate environmental sanitation, including the absence of toilets, poor waste management, and limited access to clean water, contributes to high infection rates. Several studies indicate that communities living in areas with poor sanitation are more vulnerable to infection, mainly due to high fecal contamination in water and soil. Beyond social and environmental factors, the presence of pets or livestock can also serve as a source of transmission. Animals exposed to intestinal protozoa pose a risk of spreading the infection if not properly managed. Therefore, preventing intestinal protozoan infections requires a comprehensive approach, including health education, increased awareness of personal hygiene, improved sanitation facilities, and access to safe drinking water for communities.
Co-Authors Hanna Mutiara, Hanna Jhons Fatriyadi Suwandi Khairun Nisa Khuluq, Muhammad Khusnul Leonardo Lubis Nova Sylviana Prambudi Rukmono Prayogi, Norbertus Marcell