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All Journal Medula Jurnal Ilmu Kedokteran dan Kesehatan MAHESA : Malahayati Health Student Journal AKADEMIK: Jurnal Mahasiswa Ekonomi & Bisnis
Prambudi Rukmono
Dr. H. Abdul Moeloek Hospital Faculty of Medicine, University of Lampung,
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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HUBUNGAN BAYI BERAT BADAN LAHIR RENDAH (BBLR) DENGAN TERJADINYA SEPSIS NEONATORUM DI RSUD DR. H. ABDUL MOELOEK PROVINSI LAMPUNG Firmansyah, Maulid Elang; Rukmono, Prambudi; Purwaningrum, Ratna; Octarianingsih, Fonda
Jurnal Ilmu Kedokteran dan Kesehatan Vol 10, No 8 (2023): Volume 10 Nomor 8
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v10i8.9715

Abstract

Abstrak : Hubungan Bayi Berat Badan Lahir Rendah (BBLR) Dengan Terjadinya Sepsis Neonatorum Di RSUD Dr. H. Abdul Moeloek Provinsi Lampung Tahun. Bayi berat badan lahir rendah (BBLR) adalah bayi dengan berat lahir kurang dari 2500 gram tanpa memandang masa kehamilan (gestasi). Berat lahir adalah berat bayi yang ditimbang dalam 1 (satu) jam setelah lahir (World Health Organization, 2020). Sepsis neonatorum adalah sindrom respon inflamasi sistemik disertai infeksi aliran darah pada usia 1 bulan pertama kehidupan. (dibuktikan dengan kultur) (Rukmono, 2020). bayi dengan berat badan lahir rendah memiliki banyak risiko mengalami permasalahan pada sistem tubuh, karena kondisi tubuh yang tidak stabil. Bayi berat lahir rendah berisiko tinggi mengalami infeksi atau sepsis neonatorum kemungkinan karena pematangan organ tubuhnya yang belum sempurna (hati, paru, pencernaan, otak, daya pertahanan tubuh dll) yang menyebabkan bayi lebih mudah terkena infeksi (Martua, 2021). Untuk mengetahui hubungan antara BBLR dengan kejadian sepsis neonatorum di RSUD Dr. H. Abdul Moeloek Provinsi Lampung. Metode deskriptif analitik dengan pendekatan cross sectional. Diolah dengan uji Chi-square. Jumlah subjek penelitian adalah 615 pasien bayi dengan prevalensi bayi yang lahir dengan berat badan lahir rendah sebanyak 267 (43,4%) dan bayi yang lahir dengan sepsis neonatorum sebanyak 59 (9,6%) setelah dilakukan uji hubungan antara sepsis neonatorum dengan berat badan lahir rendah menggunakan uji Chi-square didapatkan nilai p= 0,000, OR=3.983, CI=2.189 – 7.247. Dari hasil penelitian ini dapat disimpulkan bahwa terdapat hubungan yang signifikan antara bayi berat badan lahir rendah dengan terjadinya sepsis neonatorum.
HUBUNGAN KETUBAN PECAH DINI TERHADAP KEJADIAN SEPSIS NEONATORUM DI RUANG PERINATOLOGI RSUD Dr.H. ABDUL MOELOEK PROVINSI LAMPUNG Murtado, Ahmad; Rukmono, Prambudi; Hatta, Muhammad; Octarianingsih, Fonda
Jurnal Ilmu Kedokteran dan Kesehatan Vol 10, No 11 (2023): Volume 10 Nomor 11
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v10i11.10037

Abstract

Abstrak: Hubungan Ketuban Pecah Dini Terhadap Kejadian Sepsis Neonatorum Di Ruang Perinatologi Rsud Dr.H. Abdul Moeloek  Provinsi Lampung. Sepsis neonatorum adalah infeksi aliran darah yang bersifat invasif dan ditandai dengan ditemukannya bakteri dalam cairan tubuh seperti darah, cairan sumsum tulang atau air kemih. Ketuban Pecah Dini (KPD) atau ketuban pecah sebelum waktunya (KPSW), disebut juga dengan premature repture of the membrane (PROM) di definisikan sebagai pecahnya selaput ketuban sebelum waktunya melahirkan. Hal ini dapat terjadi pada kehamilan aterm maupun pada kehamilan preterm. Pada keadaan ini dimana risiko infeksi ibu dan anak meningkat. Ketuban pecah dini merupakan masalah penting dalam masalah obstetri yang juga dapat menyebabkan infeksi pada ibu dan bayi serta dapat meningkatkan kematian pada ibu dan bayi. Sepsis neonatorum sering dihubungkan dengan infeksi intra natal dan infeksi postnatal terutama nosocomial. Penelitian ini bertujuan untuk mengetahui apakah ada, hubungan antara ketuban pecah dini dengan kejadian sepsis neonatorum di Ruang Perinatalogi RSUD. H.Abdul Moeloek Provinsi Lampung Tahun 2022. Penelitian ini menggunakan metode deskriptif analitik dengan pendekatan cross sectional. Hasil Penelitian menunjukkan bahwa dari 406 sampel pasien sepsis neonatorum di RSUD Dr. H. Abdul Moeloek Bandar Lampung tahun 2022, didapatkan sebanyak 37 (9,0%) pasien ketuban pecah dini, sebanyak 39 orang (9,5%) pasien sepsis neonatorum. Ada hubungan ketuban pecah dini dengan sepsis neonatorum dengan (p value 0,005 OR 15,835). Hasil penelitian ini dapat disimpulkan bahwa terdapat hubungan yang signifikan antara bayi berat badan lahir rendah dengan terjadinya sepsis neonatorum.
Hubungan Waktu Tunggu dan Jenis Jaminan Kesehatan terhadap Tingkat Kepuasan Pasien Rawat Jalan di Rumah Sakit Lampung Eye Center Rukmono, Prambudi; Yuliaty, Farida; Rulia, Rulia
AKADEMIK: Jurnal Mahasiswa Ekonomi & Bisnis Vol. 5 No. 2 (2025): AKADEMIK: Jurnal Mahasiswa Ekonomi & Bisnis
Publisher : Perhimpunan Sarjana Ekonomi dan Bisnis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37481/jmeb.v5i2.1329

Abstract

This study aims to analyze the effect of waiting time and type of health insurance on patient satisfaction. Using a quantitative approach, research was conducted on outpatients at the Lampung Eye Center Hospital in Bandar Lampung, with a population of 7,998 people and a sample of 382 patients selected randomly. The independent variables in this study are waiting time and type of health insurance, while the dependent variable is patient satisfaction. Data was collected using a questionnaire and analyzed using multiple linear regression. The t test results show that waiting time (P Value = 0.000) and type of health insurance (P Value = 0.015) each have a significant effect on patient satisfaction. The F test also confirmed that these two variables jointly influence patient satisfaction (P Value = 0.000). Overall, both waiting time and type of health insurance have a significant effect on the level of patient satisfaction, both partially and simultaneously.
Exploring Lactic Acid Bacteria and Metabolite-Target Interactions in Undernutrition Prevention: A Network Pharmacology and Molecular Docking Approach Prayogi, Norbertus Marcell; Berawi, Khairun Nisa; Irawati, Nur Ayu Virginia; Rukmono, Prambudi
MAHESA : Malahayati Health Student Journal Vol 5, No 11 (2025): Volume 5 Nomor 11 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i11.23016

Abstract

ABSTRACT Undernutrition is a major global issue, particularly in children, leading to stunting, wasting, and compromised immune function. Disruption of gut microbiota is a key factor in undernutrition, making probiotics, especially Lactic Acid Bacteria (LAB), a potential solution for improving nutritional status. This study explores the role of LAB and their metabolites in preventing undernutrition using network pharmacology and molecular docking approaches to identify potential molecular targets and related pathways. Network pharmacology tools like TargetNet, SEA, and SwissTargetPrediction were used to predict gene targets influenced by LAB metabolites. Cytoscape was used to build protein-protein interaction (PPI) networks, and molecular docking simulations evaluated the binding of LAB metabolites to key proteins associated with undernutrition. A total of 603 potential genes were identified, including human serum albumin (ALB), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α). Pathway analysis linked these proteins to immune response, nutrient absorption, and metabolic regulation. Molecular docking confirmed stable interactions with LAB metabolites. LAB and their metabolites show promise in managing undernutrition by modulating gut health and supporting nutrient absorption, providing a basis for future clinical applications. Keywords: Undernutrition, Lactic Acid Bacteria (LAB), Probiotics, Network Pharmacology, Molecular Docking
HUBUNGAN DIABETES MELITUS GESTASIONAL TERHADAP KEJADIAN BERAT BADAN LAHIR RENDAH DI RSUD DR H ABDUL MOELOEK TAHUN 2023 Suhaili, Gadis Bunga; Rukmono, Prambudi; Nareswari, Shinta; Sari, Ratna Dewi Puspita
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1304

Abstract

A low birth weight (LBW) infant is defined as an infant born weighing less than 2500 grams regardless of gestational age. The main factors causing LBW are maternal factors, fetal factors, and placental factors. Risk factors for LBW associated with maternal factors include a history of complications during pregnancy, one of which is gestational diabetes mellitus. This study used a cross-sectional design with Pearson Chi-Square statistical test conducted at Dr. H. Abdul Moeloek General Hospital, Lampung Province in October - November 2024. The study sample was infants born at Dr. H. Abdul Moeloek Hospital in the period January - December 2023. The results of this study indicate that 16% of infants born were extremely low birth weight (ELBW), 20% of infants born were very low birth weight (VLBW), and 64% of infants born were low birth weight (LBW). The results of the chi-square analysis showed that there was a relationship between gestational diabetes mellitus (p = 0.042) and low birth weight (LBW).  
Hubungan Prosedur Invasif dan Lama Rawat Inap Terhadap Kejadian Sepsis Neonatorum Awitan Lambat di RSUD Dr. H. Abdul Moeloek Tahun 2023 Putri Arafah, Aisyah; Rukmono, Prambudi; Nareswari, Shinta; Saputra, Oktadoni
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1310

Abstract

Infant Mortality Rate (IMR) in Indonesia is still dominated by neonatal deaths, accounting for 55% of all infant deaths. Neonatal sepsis is the third leading cause of neonatal deaths after low birth weight (LBW) and asphyxia. Late-onset neonatal sepsis (LONS) is a systemic response to infection when the neonate is more than 72 hours old, as evidenced by a positive blood culture. Currently, late-onset neonatal sepsis remains the third leading cause of neonatal deaths. Late-onset neonatal sepsis usually occurs through the transmission of pathogens from the environment (nosocomial). The difficulty of early diagnosis in late-onset neonatal sepsis necessitates a diagnosis based on nosocomial infection factors, such as the use of invasive procedures and prolonged hospital stays. This research employed a descriptive analytic method with a cross-sectional approach. The sample consisted of all neonates diagnosed with neonatal sepsis and recorded in medical records with positive blood culture results in the Perinatology ward of RSUD Dr. H. Abdul Moeloek Bandar Lampung in 2023. Data were analyzed univariately and bivariately using the Chi-square test with Fisher's exact test as an alternative. The data suggests a statistically significant correlation between invasive procedures (p= 0.043) and length of hospital stay (p= 0.012) with the development of late-onset neonatal sepsis (LONS).
Co-Authors Farida Yuliaty Firmansyah, Maulid Elang Irawati, Nur Ayu Virginia Khairun Nisa Muhammad Hatta Murtado, Ahmad Octarianingsih, Fonda Oktadoni Saputra, Oktadoni Prayogi, Norbertus Marcell Purwaningrum, Ratna Putri Arafah, Aisyah Ratna Dewi Puspita Sari Rulia, Rulia Shinta Nareswari, Shinta Suhaili, Gadis Bunga