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The Economic Evaluation of Rare Disease Medicines Skarayadi, Oskar; Untari, Eka Kartika; Octaviani, Peppy; Larasati, Niken
Jurnal Kesehatan Masyarakat Vol 19, No 3 (2024)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v19i3.41661

Abstract

Economic evaluation of rare diseases and orphan drugs has gained prominence among scientists, managers, and the general public. This challenging problem requires evaluation and analysis from a variety of perspectives. Economic assessment of technologies can support decision-making and resource allocation. The research objective describes and discusses several important issues when addressing economic evaluation in rare diseases and orphan drugs. The method used in this article review is to search the Pubmed, Scopus, and ScienceDirect databases using specific keywords for research articles published in English between 2016 and 2021. We found 537 studies that economically evaluated the cost of treating rare diseases. The selected studies met the eligibility criteria that had been established. To assess the quality of the selected papers, we used a 10-point checklist derived from Drummond's criteria for economic evaluation. Seven papers were reviewed from the initial 20 articles that met the eligibility criteria, and 537 records were initially found across the three databases. The quality of the selected papers ranged from 70% to 100% in meeting Drummond's 10-point checklist. The conclusion of this research is to consistently and continuously identify cost-effective and cost-saving solutions that may help achieve good clinical outcomes and reduce the burden of disease. Future research should focus on the clinical implementation of interventions along with accompanying economic evaluations.
Pharmacogical Potential And Bioactivity Of Mangifera indica L.: A Scopus-Based Bibliometric Analysis Dwi Astuti, Niken; Octaviani, Peppy; Prabandari, Rani
Pharmacogenius Journal Vol 4 No 3 (2025): Pharmacy Genius
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/pharmgen.v4i3.855

Abstract

Introduction: Mangifera indica L. (mango) is a tropical plant valued in traditional medicine and rich in bioactive compounds such as mangiferin, quercetin, and catechin, known for antioxidant, anti-inflammatory, antimicrobial, antidiabetic, hepatoprotective, and immunomodulatory activities. Despite increasing research, no comprehensive bibliometric mapping of its pharmacological potential and bioactivity has been conducted. Objective: To analyze global research trends, influential contributors, and thematic foci on the pharmacological potential and bioactivity of Mangifera indica L.  using a Scopus-based bibliometric approach. Method: Publications from 2015–2024 were retrieved from Scopus using defined Boolean search terms. Only English-language journal articles in the final publication stage were included, resulting in 305 records. Data were analyzed using Microsoft Excel 2021, Bibliometrix/Biblioshiny, and VOSviewer to evaluate performance indicators, thematic evolution, and network visualization of co-authorship, co-citation, and keyword co-occurrence. Kesimpulan: Annual publications peaked in 2023 (n=50) and 2024 (n=54), showing growing scholarly interest. Industrial Crops and Products was the most influential journal, strongly linked to Molecules and Food Chemistry. CASAS L and MANTELL C were the most productive authors (7 articles each), while Ho Chi Minh City University of Technology led institutional output (47 articles). India was the most prolific country and a central hub for collaborations. Keyword mapping revealed two clusters: phytochemistry and bioactivity, and methodological advances. Research on Mangifera indica L.  has expanded significantly in the last decade, bridging pharmacognosy, food science, and nanotechnology. However, gaps remain in translational research and clinical application.