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All Journal Jurnal Mandala Pharmacon Indonesia Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Jurnal Farmasi dan Sains Indonesia (JFSI) INTERNATIONAL JOURNAL OF EDUCATION, INFORMATION TECHNOLOGY, AND OTHERS Kolaborasi Jurnal Pengabdian Masyarakat Pharmacy Genius
Prabandari, Rani
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Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Hubungan Pengetahuan dan Sikap Penyalahgunaan Misoprostol pada Mahasiswa Kesehatan dan Non Kesehatan Khisan, Gita Fitriatul; Prabandari, Rani; Kaaffah, Silma
Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Vol 15 No 1 (2025): Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal: Januari 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/pskm.v15i1.2224

Abstract

Misoprostol dalam beberapa tahun terakhir ini telah digunakan secara off-label sebagai penginduksi persalinan dan telah menjadi bagian dari “Daftar Model Obat Esensial” (WHO, 2015). Penelitian ini dilakukam kareana berdasarkan data Dinas Pendidikan Kabupaten Banyumas dengan kasus penyalahgunaan obat sampai dengan tahun 2020 terdapat sebanyak 138 kasus di Kabupaten Banyumas, dimana jumlah terbanyak pertama berada diWilayah Purwokerto Timur sebanyak (15,9%) dan kedua berada di Wilayah Purwokerto Selatan sebanyak (10,2%) (Sunarti, 2021). Tujuan penelitian ini untuk mengetahui hubungan pengetahuan dan sikap mahasiswa kesehatan dan non-kesehatan terhadap penyalahgunaan misoprostol. Sampel yang digunakan yaitu mahasiswa di bawah naungan Kementrian Riset Teknologi dan Pendidikan Tinggi menggunakan Platform Google Form dan bersedia mengikuti penelitian. Desain penelitian yang digunakan adalah study cross sectional dengan analisis bivariat. Hasil dari penelitian ini terdapat 166 mahasiswa kesehatan mempunyai pengetahuan tinggi 19,3%, sedang 70,5% rendah 10,2%. Mahasiswa non kesehatan sebanyak 238 mempunyai pengetahuan tinggi sebanyak 21% sedang 51,3% rendah 64%. Hasil sikap mahasiswa kesehatan sebanyak 166 responden dengan kategori tinggi sebanyak 56,0%, sedang 30,7 rendah 13,3. Sikap mahasiswa non kesehatan yang berjumlah 238 responden mempunyai kategori tinggi sebanyak 25,2% sedang 27,3% rendah 47,5%. Kesimpulan dari penelitian ini terdapat hubungan yang signifikan antara pengetahuan dan sikap dari mahasiswa kesehatan dan non kesehatan terhadap penyalahgunaan misoprostol.
Uji Aktivitas Antibakteri Sediaan Gel Facial-Wash Ekstrak Kayu Secang Dan Daun Belimbing Wuluh Terhadap Propionibacterium acnes Hamidah, Ai' Wikri; Samodra, Galih; Prabandari, Rani
Pharmacogenius Journal Vol 3 No 2 (2024): Pharmacy Genius
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/pharmgen.v3i2.336

Abstract

Pendahuluan: Ektrak kayu secang (Caesalpinia sappan L.) dan daun belimbing wuluh (Averrhoa bilimbi L.) memiliki senyawa metabolit sekunder yang berpotensi sebagai agen antibakteri terhadap Propionibacterium acnes. Tujuan: Penelitian ini bertujuan untuk memahami karakteristik fisik dan daya hambat bakteri sediaan gel facial-wash ekstrak kayu secang dan daun belimbing wuluh. Metode: metode penelitian adalah eksperimen. Ekstrak diformulasikan dalam bentuk sediaan gel facial-wash. F1 menggunakan konsentrasi ekstrak kayu secang 5% dan daun belimbing wuluh 10%, F2 menggunakan konsentrasi ekstrak kayu secang 7,5% dan daun belimbing wuluh 7,5%, F3 menggunakan konsentrasi ekstrak kayu secang 10% dan daun belimbing wuluh 5%. Hasil evaluasi sifat fisik mencangkup uji organoleptik, uji pH, uji daya sebar, uji viskositas, uji tinggi busa, dan uji antibakteri menggunakan metode sumuran. Hasil: Hasil pada F1, F2, dan F3 memenuhi persyaratan sediaan gel facial-wash.  Namun, uji pH dan daya sebar pada F3 tidak memenuhi kriteria sediaan gel facial-wash. Hasil uji antibakteri sediaan gel facial-wash esktrak kayu secang dan daun belimbing wuluh metode difusi sumuran, pada kontrol positif 19,07 mm, F1 sebesar 11,53 mm, F2 sebesar 17,07 mm, dan F3 sebesar 20 mm. Kesimpulan: Sediaan gel facial-wash ekstrak kayu secang dan daun belimbing wuluh menghasilkan zona hambat yang kuat terhadap bakteri Propionibacterium acnes.
Formulation of Scrub Preparations With Variations in the Concentration of Seagrass Leaf Ethanol Extract (Enhalus acoroides) Inayah, Somatul; Prabandari, Rani; Sunarti, Sunarti; Nawangsari, Desy
International Journal of Education, Information Technology, and Others Vol 7 No 2 (2024): International Journal of Education, information technology   and others (IJEIT)
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.10968299

Abstract

Seagrass leaves (Enhalus acoroides) are known to contain antioxidants that can protect the skin from free radicals and keep the skin's pH stable. Group compounds found in seagrass leaf components are fernolics, tannins, flavonoids, and glycosides. To facilitate the application of seagrass leaf extract, it is necessary to formulate one of them, namely scrub preparations. Seagrass leaf ethanol extract formulation uses variations in concentrations of F1 20%, F2 30% and F3 40%. The purpose of the study was to determine physical properties tests, irritation tests and moisture tests on seagrass leaf ethanol extract scrub preparations. Seagrass leaf extract was extracted by remaceration method using 70% ethanol then formulated into scrub preparations. Scrub is a liquid or semisolid preparation in the form of an emulsion. The results of the physical properties test of scrub preparations showed semisolid preparations of green to dark green color, had a characteristic seagrass odor and were homogeneous because they did not show the presence of coarse grains. F1 viscosity results 39,260, F2 results 39,278, F3 results 39,385, dispersion tests obtained F1 7.93, F2 results 8 and F3 results 7.73, then F1 adhesion test results 5.63, F2 results 5.75, F3 results 7.14 and F1 pH test results of 5.7, F2 results 5.6 and F3 5.6. In the irritation test results, the three formulas showed no irritation and the moisture test of the three formulas was less moist. It can be concluded that the results of the physical properties test of viscosity, pH, adhesion and dispersion tests are in accordance with the range required, the irritation test in the three formulas does not occur irritation and in the moisture test the results obtained are moist.
Efektivitas Leaflet dalam Meningkatkan Pengetahuan Hipertensi pada Lansia di Desa Gandatapa Kusuma, Ikhwan Yuda; Nawangsari, Desi; Prabandari, Rani; Kurniasih, Khamdiyah Indah; Fauziah, Fauziah; Abely, Nastasya Anis; Safitri, Cindy Ade
Kolaborasi: Jurnal Pengabdian Masyarakat Vol 4 No 5 (2024): Kolaborasi: Jurnal Pengabdian Masyarakat
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/kolaborasi.v4i5.437

Abstract

Introduction:  Hypertension is a significant global health issue that often presents without symptoms, leaving many individuals unaware of their condition. Effective management and prevention of hypertension require increased awareness and education, particularly among the elderly population, who are at higher risk. Objective: This study aims to evaluate the effectiveness of health counseling using leaflets in improving hypertension knowledge among the elderly at Integrated service post (Posyandu) community association (RW) 4 Gandatapa. Method: This descriptive quantitative study employed a pre-post design. Health counseling was conducted using leaflets at  Integrated service post  (Posyandu) community association (RW) 4 Gandatapa on July 16, 2024, involving 44 elderly participants aged 65-70 years. Knowledge levels were assessed using pre-test and post-test questionnaires. The intervention included distributing leaflets and conducting a discussion session to reinforce the information provided. Result:The study observed a significant increase in participants' knowledge about hypertension, with average knowledge scores rising from 43% in the pre-test to 63% in the post-test. Conclusion: The findings suggest that health counseling using leaflets is an effective method for improving hypertension knowledge among the elderly. However, to optimize the impact, future interventions should consider additional support methods, especially for those with limited literacy or visual impairments.
Pelatihan Pembuatan Lilin Aromaterapi Antinyamuk Pada Anggota Fatayat Nu Ranting Purwosari Nawangsari, Desy; Kurniasih, Khamdiyah Indah; Prabandari, Rani; Fitri, Ely Nurul
Kolaborasi: Jurnal Pengabdian Masyarakat Vol 5 No 2 (2025): Kolaborasi: Jurnal Pengabdian Masyarakat
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/kolaborasi.v5i2.484

Abstract

Introduction: Used cooking oil is oil that has been used repeatedly up to 3-4 times frying. The negative impact of used cooking oil if thrown away will become waste and damage the surrounding environment. One of the products of used cooking oil processing is aromatherapy candles and soap. Various forms of aromatherapy have sprung up such as essential oils, candles, incense, soaps and massage oils. People only use candles as a source of lighting when there is no electricity source. The function of candles is not only a lighting aid but is widely used as a room decorator and as a room fragrance, in this case what is commonly used is aromatherapy candles. Objective: The objectives of this activity are (1) Minimizing the disposal of used cooking oil (2) Changing the lifestyle of the community to process used cooking oil waste based on zero waste industry (3) Reducing the disposal of used cooking oil in any place can reduce the risk of groundwater pollution (4) Creating anti-mosquito aromatherapy candle products that have economic value. Method: The method of implementing the activity was carried out by providing material on the utilization of used cooking oil and training in making aromatherapy candle products for mosquitoes. Result: The outputs of this activity are increased knowledge related to products and the risk of contamination to the environment, increased knowledge and skills of partners in making aromatherapy candles. Conclusion: The training on making mosquito-repellent aromatherapy candles from used cooking oil successfully improved participants' knowledge and skills. It supports waste reduction and economic empowerment. Despite challenges in raw material consistency, the program holds potential for sustainability and commercialization.
UJI AKTIVITAS ANTIINFLAMASI KOMBINASI EKSTRAK DAUN SALAM (Syzygium polyanthum (Wight) Walp) dan EKSTRAK DAUN PEPAYA (Carica papaya L.) TERHADAP UDEMA KAKI TIKUS PUTIH JANTAN YANG DIINDUKSI KARAGENIN Syahputra, Dhika Adhil; Samodra, Galih; Prabandari, Rani
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p1-6

Abstract

Inflammation or inflammation is the body's normal response to tissue damage caused by physical trauma, chemical and microbial damage. Plants that are thought to have anti-inflammatory properties are bay leaves (Syzygium polyanthum (Wight) Walp). Which acts as an anti-inflammatory in bay leaves and papaya leaves are flavonoids. Bay leaf and papaya leaf extracts were extracted using 70% ethanol by maceration method. The test animals were divided into 7 groups, namely a negative control group (Na CMC), a positive group (Diclofenac Sodium 50 mg), a single dose group of 100 mg/kgBW bay leaf extract, a single dose group of 100 mg/kgBW papaya leaf extract, and a combination group of leaf extracts. salam and papaya leaf extract 50mg/kgBB: 50mg/kgBB, 150mg/kgBB: 100mg/kgBB, 250mg/kgBB: 200mg/kgBB. Treatment 1 hour after the hind legs of rats was induced by subplantar carrageenin. The results showed that the combination of bay leaf and papaya leaf extracts had anti-inflammatory activity. The results of the calculation of the inflammatory power in the combination group showed inflammatory activity.
Formulasi Antibakteri Mouthwash Ekstrak Etanol Daun Kirinyuh (Chromolaena odorata (L.) R.M.King & H.Rob.) Pada Bakteri Streptococcus mutans STCC 31987 Erdiyati, Esti; Prabandari, Rani; Sunarti, Sunarti; Nawangsari, Desi
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p17-27

Abstract

Kirinyuh leaves (Chromolaeina odorata (L.) R.M.King &; H.Rob.) contain secondary metabolites in the form of flavonoids, saponins, steiroids, tannins that can inhibit the growth of antibacterial growth. Based or its antibacterial properties, kirinyuh leaf extract can be developed into mouthwash to prevent dental plaque. The purpose of this study was to determine the physical stability test of the kirinyuh leaf ethanol extract mouthwash preparation and to determine the antibacterial activity of the kirinyuh leaf ethanol extract against Streptococcus mutans ATCC 31987 bacteria, so that a  formulation of the kirinyuh leaf ethanol extract mouthwash preparation could be made. Mouthwash is an antiseptic preparation that is used to clean the oral cavity and is used by gargling. The extraction used was remaceration method with 70% ethanol solvent, made in various extracts with concentrations of 10%, 20%, 30%. Further evaluation of the preparation includes : organoleptic test, pH test, viscosity test. The results of the One Way ANOVA analysis showed that there was no significant difference in the pH test, viscosity test with a p>0,05 value. Organoleptic test during 6 cycles of storage in a stable state during storage. The results showed that the ethanol extract of kirinyuh leaf mouthwash was able to inhibit the growth of Streptococcus mutans bacteria, namely in F1 the weak category was 2.43±0.81 mm, F2 was 10.21±3.56 mm the strong categori, F3 was 13.38±2.72 mm strong category.   Keywords : Antibacterial, Kirinyuh leaves, Mouthwash
AKTIVITAS EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) PADA SEDIAAN SALEP BASIS ABSORPSI TERHADAP BAKTERI Propionibacterium acne Maulana, Restu; Prabandari, Rani; Nawangsari, Desy
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p65-77

Abstract

Moringa leaves contain flavonoids, alkaloids, saponins and tannins that can inhibit bacterial growth. In order to make the use of moringa leaves more practical, an absorption base ointment formulation was made. Ointment preparations were chosen because they are suitable for medicinal purposes on the skin because the drug contact with the skin is longer. This study aims to determine the physical properties, stability and antibacterial activity of absorption base ointment preparations of moringa leaf ethanol extract. The research method is experimental laboratory. The extract concentrations used were F0 (base), F1 (15%), F2 (20%) and F3 (25%). Physical quality testing is seen from organoleptic, homogeneity, pH, spreadability and stickiness. The pH test results were sequentially obtained as 6.33 ± 0.15, 5.9 ± 0.1, 5.6 ± 0.1 and 5.56 ± 0.15. The spreadability test sequentially obtained 2.87 ± 0.07, 2.9 ± 0.05, 3.05 ± 0.05 and 3.25 ± 0.1 cm. The stickiness test was 17.60 ± 0.60, 17.59 ± 0.46, 16.87 ± 0.47 and 16.18 ± 0.56 seconds. The results were analyzed using SPSS 26 with One Way ANOVA, there were significant differences in pH values, spreadability and adhesiveness with a significance value of <0.05. The results of the stability test with the Cycling test method analyzed by T-test there was no significant difference from each formula between day 0 and day 12 with a 2-tailed value >0.05 which means that the formulas made are all stable in the stability test. Formula 1, 2 and 3 can inhibit Propionibacterium acne bacteria with an average inhibition zone of F1 10.34 ± 1.86 mm, F2 13.77 ± 3.43 mm and F3 16.67 ± 0.97 mm. It can be concluded that the three formulas have strong inhibition.
Formulasi Sediaan Krim Ekstrak Daun Petai Cina (Leucaena leucocephala Lam) pada Proses Penyembuhan Luka Insisi terhadap Kelinci (Oryctolagus cuniculus Ningtyas, Ichi Aprilia; Prabandari, Rani; Nawangsari, Desy
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.521

Abstract

Chinese petai leaves (Leucaena leucocephala Lam) have metabolite compounds that can heal incisional wounds, namely flavonoid and saponin compounds which are made in cream dosage form. An incisional wound is a wound caused by a sharp instrument cutting the skin and underlying tissue. The aim of this research was to determine the physical properties of the cream and the percentage of treatment of incisional wounds by petai cina leaf extract cream. The method used was an experimental method with 6 test treatment groups. Group 1 was positive control (Povidone iodine ointment), group 2 was negative control (cream base), group 3 was 4% concentration, group 4 was 8% concentration, group 5 was 16% concentration, and group 6 was without treatment. The extraction method is by remaceration using 70% ethanol solvent. The results of the research show that the physical properties in the organoleptic test have a distinctive odor, brown color with a semi-solid shape. The homogeneity test shows that the cream is homogeneous with a spreadability of 5.48 cm ± 0.2, a sticking force of 12.56 seconds ± 0.19, pH range of 5.8 ± 0.12, and viscosity of 1293 ± 0.04 which meets the range test the physical properties of the cream preparation. The incision wound healing test showed that concentrations of 8% and 16% could provide a fast wound healing effect for 10 days with a wound healing percentage of 100%. It can be concluded that the formulated cream meets the requirements and the cream can heal incisional wounds with a percentage of 100% for 10 days.
Co-Authors Abely, Nastasya Anis Erdiyati, Esti Fauziah Fauziah Fitri, Ely Nurul Hamidah, Ai' Wikri Ikhwan Yuda Kusuma Inayah, Somatul Khisan, Gita Fitriatul Kurniasih, Khamdiyah Indah Maulana, Restu nawangsari, desi Nawangsari, Desy Ningtyas, Ichi Aprilia Safitri, Cindy Ade Samodra, Galih Silma Kaaffah Sunarti Syahputra, Dhika Adhil