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All Journal AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Chemistry Indonesian Journal of Chemical Research IJCR (Indonesian Journal of Chemical Research) Dharma: Jurnal Pengabdian Masyarakat JURNAL INSAN CENDEKIA Paradigma: Jurnal Filsafat, Sains, Teknologi, dan Sosial Budaya
Qomariyah, Ani
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Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Pengembangan Metode Sensor Kolorimetri berbasis Nanopartikel Emas untuk Deteksi Dini Penyakit Kanker Badi'ah, Hanim Istatik; Qomariyah, Ani
INDONESIAN JOURNAL OF CHEMICAL RESEARCH Vol. 8 No. 2 (2023): Volume 8, ISSUE 2,2023
Publisher : Chemistry Department, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijcr.vol8.iss2.art5

Abstract

A gold nanoparticle as colorimetric sensor (AuNp) has been successfully developed for the detection of lactic acid, which is one of the biomarkers of cancer disease. The sensor is based on the presence of a color change in the AuNp solution when it reacts with dihydrogenic acid and is the result of the development of a simpler, faster, and more economical method for early detection and monitoring of cancer. The synthesis method of AuNp was reduced and characterized using UV-Vis and PSA spectrophotometers. Several optimizations were made to obtain AuNP in the best condition as a colorimetric sensor for the detection of lactic acid. The result of AuNp synthesis optimization with HAuCl4 concentration variation was obtained with a smallest size of 17.25 nm and a concentration of 1 mM. The optimum combustion time is 10 minutes, with a result of 17.05 nm. The AuNp colorimetric sensor undergoes a color change from grapefruit to purple when it reacts with fucking acid. The results of the validation of the methods carried out obtained a sensitivity value of 0.2212, a LOD value of 0.21 mM, a LOQ of 0.68 mM, a range of accuracy values of 94.72–106.66%, and % KV of <0.97.
Co-Authors Afifah Ainun Najib Badi'ah, Hanim Istatik Eko Sri Kunarti Faizah, Mamluatul Fisabilla, Adhinda Hakim, Ardhi Khoirul Hanifa, Nur Lailatul Kawitantri, Orchidara Herning Kusuma, Okta Nata Muhammad Afif Nurmazaya, Nufus Nuryono Nuryono Wijaya, Destia Kusuma Wulandari, Eka Yunita