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All Journal Hearty : Jurnal Kesehatan Masyarakat Jurnal Riset Kesehatan Poltekkes Depkes Bandung Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Jurnal Kesehatan Siliwangi Media Penelitian dan Pengembangan Kesehatan Folia Medica Indonesiana
Sofiyanti, Santi
Midwifery Department, Health Polytechnic, Ministry Of Health, Bandung
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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A COMPREHENSIVE REVIEW: DYSREGULATION OF GLUCOSE METABOLISM IN PREGNANCY AND INNOVATIVE STRATEGIES FOR PREVENTION-FOCUSED MIDWIFERY CARE: Tinjauan Komprehensif: Disregulasi Metabolisme Glukosa pada Kehamilan dan Strategi untuk Asuhan Kebidanan Preventif sofiyanti, santi
Jurnal Kesehatan Siliwangi Vol. 5 No. 3 (2025): JURNAL KESEHATAN SILIWANGI
Publisher : Politeknik Kesehatan Kemenkes Bandung

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Pregnancy triggers complex metabolic changes, particularly in glucose homeostasis. This vital adaptation, marked by physiological insulin resistance in the second and third trimesters, ensures an adequate glucose supply for the fetus. However, a failure of pancreatic beta-cell compensation can lead to Gestational Diabetes Mellitus (GDM), a significant obstetric complication. GDM shares pathophysiological similarities with type 2 diabetes (T2D) and poses substantial risks, including adverse perinatal outcomes (e.g., macrosomia and preeclampsia) and long-term consequences such as increased maternal T2D risk and offspring susceptibility to obesity via fetal programming. Despite these known impacts, GDM diagnosis remains challenging due to a lack of uniform diagnostic standards and often-delayed screening. This review, therefore, aims to comprehensively examine the physiological adaptations, factors influencing glucose dysregulation, and clinical implications of GDM. Furthermore, it evaluates current management strategies and identifies future research directions, emphasizing the crucial role of midwives in developing innovative, prevention-based approaches from preconception through the breastfeeding period to improve overall maternal and child health. Key words: Gestational Diabetes, Glucose Metabolism, Midwife, Prevention
The AKT Pathway and Satellite Cell Activation in Skeletal Muscle Mass Regulation Sofiyanti, Santi; Goenawan, Hanna; Lesmana, Ronny; Tarawan, Vita Murniati
Folia Medica Indonesiana Vol. 58, No. 1
Publisher : Folia Medica Indonesiana

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Highlight: • AKT or protein kinase B increase protein synthesis and control the degradation of proteins. • Satellite cells was provided remarkable ability to regenerate skeletal muscle. • Stimulation of protein synthesis is effective therapy to maintain muscle mass, prevent muscle wasting to reduce risk sarcopenia and improve quality of life in the elderly. Abstract: Muscles have an important role as a regulator of glucose and triglyceride metabolism. Some researches show the correlation between skeletal muscle mass and metabolic diseases, such as diabetes. Skeletal muscle mass decrease occurs due to chronic illness or physiological process of aging, thus increasing the risk of metabolic diseases as well as motion difficulty in the elderly. Skeletal muscle mass depends on balanced protein synthesis and degradation, controlled through a variety of signal transduction pathways including the AKT. AKT or protein kinase B increases protein synthesis through the mTOR and GSK3β and controls the degradation of proteins through FoxO transcription factors. Another factor that has an alleged role in the regulation of skeletal muscle is the satellite cells which provide remarkable ability to regenerate skeletal muscle. A comprehensive understanding of the biomolecular mechanism of muscle mass regulation is important to develop effective treatment or prevention of muscle atrophy in many cases, either caused by pathological conditions, such as chronic diseases, or the process of aging.
Co-Authors Amelia, Yulan Az-zahrah, Mulia citra, tiara Djudju Sriwenda Fadilah, Lola Noviani Ferina, Ferina Hanna Goenawan Hidayati, Desi Ida Widiawati, Ida Jen Astika Nuari Khoirul Barriyah, Jasmine Rachmatina, Marha Putri Ramadiyanti, Aliya Resmana, Rika Ronny Lesmana Salsabila, Alya Siti Patia, Siti Vita Murniati Tarawan Wanda Seviani, Riska Widaningsih, Neneng Yulinda