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All Journal Hearty : Jurnal Kesehatan Masyarakat Jurnal Riset Kesehatan Poltekkes Depkes Bandung Women Midwives and Midwifery Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Jurnal Kesehatan Siliwangi Jakia : Jurnal Kesehatan Ibu dan Anak Media Penelitian dan Pengembangan Kesehatan Folia Medica Indonesiana
Sofiyanti, Santi
Midwifery Department, Health Polytechnic, Ministry Of Health, Bandung
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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A COMPREHENSIVE REVIEW: DYSREGULATION OF GLUCOSE METABOLISM IN PREGNANCY AND INNOVATIVE STRATEGIES FOR PREVENTION-FOCUSED MIDWIFERY CARE: Tinjauan Komprehensif: Disregulasi Metabolisme Glukosa pada Kehamilan dan Strategi untuk Asuhan Kebidanan Preventif sofiyanti, santi
Jurnal Kesehatan Siliwangi Vol. 5 No. 3 (2025): JURNAL KESEHATAN SILIWANGI
Publisher : Politeknik Kesehatan Kemenkes Bandung

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Abstract

Pregnancy triggers complex metabolic changes, particularly in glucose homeostasis. This vital adaptation, marked by physiological insulin resistance in the second and third trimesters, ensures an adequate glucose supply for the fetus. However, a failure of pancreatic beta-cell compensation can lead to Gestational Diabetes Mellitus (GDM), a significant obstetric complication. GDM shares pathophysiological similarities with type 2 diabetes (T2D) and poses substantial risks, including adverse perinatal outcomes (e.g., macrosomia and preeclampsia) and long-term consequences such as increased maternal T2D risk and offspring susceptibility to obesity via fetal programming. Despite these known impacts, GDM diagnosis remains challenging due to a lack of uniform diagnostic standards and often-delayed screening. This review, therefore, aims to comprehensively examine the physiological adaptations, factors influencing glucose dysregulation, and clinical implications of GDM. Furthermore, it evaluates current management strategies and identifies future research directions, emphasizing the crucial role of midwives in developing innovative, prevention-based approaches from preconception through the breastfeeding period to improve overall maternal and child health. Key words: Gestational Diabetes, Glucose Metabolism, Midwife, Prevention
The AKT Pathway and Satellite Cell Activation in Skeletal Muscle Mass Regulation Sofiyanti, Santi; Goenawan, Hanna; Lesmana, Ronny; Tarawan, Vita Murniati
Folia Medica Indonesiana Vol. 58, No. 1
Publisher : Folia Medica Indonesiana

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Highlight: • AKT or protein kinase B increase protein synthesis and control the degradation of proteins. • Satellite cells was provided remarkable ability to regenerate skeletal muscle. • Stimulation of protein synthesis is effective therapy to maintain muscle mass, prevent muscle wasting to reduce risk sarcopenia and improve quality of life in the elderly. Abstract: Muscles have an important role as a regulator of glucose and triglyceride metabolism. Some researches show the correlation between skeletal muscle mass and metabolic diseases, such as diabetes. Skeletal muscle mass decrease occurs due to chronic illness or physiological process of aging, thus increasing the risk of metabolic diseases as well as motion difficulty in the elderly. Skeletal muscle mass depends on balanced protein synthesis and degradation, controlled through a variety of signal transduction pathways including the AKT. AKT or protein kinase B increases protein synthesis through the mTOR and GSK3β and controls the degradation of proteins through FoxO transcription factors. Another factor that has an alleged role in the regulation of skeletal muscle is the satellite cells which provide remarkable ability to regenerate skeletal muscle. A comprehensive understanding of the biomolecular mechanism of muscle mass regulation is important to develop effective treatment or prevention of muscle atrophy in many cases, either caused by pathological conditions, such as chronic diseases, or the process of aging.
Yoga Exercises Have an Effect on Accelerating the Recovery of Diastasis Recti Abdominis Muscles in Postpartum Women Saraswati, Dewi Febriani; Widaningsih, Neneng; Sofiyanti, Santi; Indrayani, Diyan
Women, Midwives and Midwifery Vol. 6 No. 1 (2026): Women, Midwives and Midwifery journal
Publisher : Asosiasi Pendidikan Kebidanan Indonesia (AIPKIND)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36749/wmm.6.1.19-27.2026

Abstract

Background: diastasis Recti Abdominis Muscle (DRAM), a condition characterized by the separation of the rectus abdominis muscles along the linea alba, commonly occurs postpartum and may impair quality of life. Yoga has been proposed as a non-invasive intervention to address this issue through core muscle engagement and tissue remodeling. Purpose: this study aims to determine the effectiveness of yoga in accelerating the recovery of diastasis recti abdominis muscle in postpartum women. Methods: this quasi-experimental study employed a non-equivalent control group pretest-posttest design. Forty-eight postpartum women (4–10 days postpartum) were recruited, with 45 meeting the inclusion criteria and divided into intervention and control groups. The intervention group participated in structured yoga sessions (20 minutes/session, 4 times/week for 3 weeks), while the control group received routine postnatal exercise advice. The sampling technique used was simple random sampling. DRAM width was measured using a digital caliper. Data were analyzed using paired and independent t-tests. Results: data were analyzed using paired and independent t-tests. A significant reduction in DRAM was observed in the intervention group, with the mean width decreasing from 29.50 ± 3.39 mm to 9.38 ± 2.62 mm (p = 0.000), while the control group showed only a minor decrease (28.09 ± 3.05 mm to 26.03 ± 2.37 mm). Conclusion: the structured yoga intervention demonstrated consistent results with lower post-intervention variability. Yoga exercise significantly improves DRAM recovery in postpartum women by enhancing abdominal muscle strength and supporting tissue regeneration. Yoga is a safe, effective, and reproducible intervention for postpartum rehabilitation
Hubungan Dukungan Suami dengan Tingkat Kelelahan Ibu Postpartum di Wilayah Kerja Puskesmas Garuda Sintia Nurul Hikmah; Yanti, Yulidar; Yulia Ulfah; Santi Sofiyanti
JAKIA : Jurnal Kesehatan Ibu dan Anak Vol. 2 No. 1 (2026): JAKIA : Jurnal Kesehatan Ibu dan Anak
Publisher : Society of Visual Informatics

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62527/jakia.2.1.55

Abstract

Ibu postpartum memiliki peran baru sebagai seorang ibu yang mengalami perubahan fisik dan psikologis apabila tidak ditangani dapat menyebabkan terjadinya kelelahan postpartum. Salah satu faktor yang meningkatkan terjadinya kelelahan postpartum pada ibu yaitu kurangnya dukungan suami selama masa postpartum. Tujuan penelitian ini adalah untuk menganalisis hubungan dukungan suami dengan tingkat kelelahan pada ibu postpartum di Wilayah Kerja Puskesmas Garuda.  Metode penelitian yang digunakan analitik observasional dengan pendekatan crossectional. Pengambilan sampel menggunakan teknik non probability sampling jenis consecutive sampling sebanyak 50 sampel. Sampel tersebut adalah  ibu postpartum 3 hari sampai 1 bulan di Wilayah Kerja Puskesmas Garuda. Instrumen penelitian menggunakan kuesioner PFS dan PPSS. Analisis data yang digunakan yaitu uji analisis Chi Square. Hasil penelitian menunjukan bahwa sebagian besar ibu postpartum mendapatkan dukungan suami tinggi (52,0%) dan sebagian besar mengalami kelelahan ringan (60,0%). Terdapat hubungan antara dukungan suami dengan kelelahan ibu postpartum dengan nilai p <0,001. Ibu postpartum yang mendapat dukungan tinggi dari suami memiliki peluang 0,058 lebih rendah untuk mengalami kelelahan, dibandingkan ibu yang mendapat dukungan rendah.
Co-Authors Amelia, Yulan Az-zahrah, Mulia citra, tiara Fadilah, Lola Noviani Ferina, Ferina Hanna Goenawan Hidayati, Desi Ida Widiawati, Ida Indrayani, Diyan Jen Astika Nuari Khoirul Barriyah, Jasmine Rachmatina, Marha Putri Ramadiyanti, Aliya Resmana, Rika Ronny Lesmana Salsabila, Alya Saraswati, Dewi Febriani Sintia Nurul Hikmah Siti Patia, Siti Sriwenda, Djudju Vita Murniati Tarawan Wanda Seviani, Riska Widaningsih, Neneng Yanti, Yulidar Yulia Ulfah Yulinda