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All Journal E-Jurnal Medika Udayana Cermin Dunia Kedokteran
Kesumaputri, Komang Diah Kurnia
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Health Professions Medicine & Pharmacology

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Hubungan Usia, Jenis Operasi, dan Waktu Operasi dengan Outcome Pasca Operasi Fraktur Tibia Terbuka Derajat III di RSUP Sanglah Denpasar pada Tahun 2018-2020 Kesumaputri, Komang Diah Kurnia; Subawa, I Wayan; Dewi, Kadek Ayu Candra; Meregawa, Putu Feryawan
E-Jurnal Medika Udayana Vol 12 No 10 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i10.P16

Abstract

Open tibial fracture is one of the most common lower extremity fractures in the world, especially in Denpasar City. Clinically, open tibial fracture grade III has higher risk of worse outcome, such as infection and bone healing complication than grades I and II, thus it should be evaluated further regarding risk factors affecting that occurrence. This research aims to know the relationship between several risk factors, those are age, surgery type, and time to surgery with postoperative outcomes in open tibial fractures grade III in terms of clinical, radiological, and functional based on Johner-Wruhs criteria. This research used cross-sectional method and used patients with open tibial fracture grade III who underwent surgery at RSUP Sanglah Denpasar in 2018-2020. Based on the data collection, there were 31 patients fulfilled the inclusion and exclusion criteria. The data collected were characteristics and postoperative outcome assessed using Johner-Wruhs criteria which consisted of 4 categories. From Kendall Tau correlation test, there was no significant relationship between age and outcome (p=0,215) and a significant relationship between time to surgery and outcome (p=0,021). Moreover, the results of Fisher’s Exact Test did not find significant relationship between surgery type and outcome (p=0,720). Based on the results, it can be concluded that time to surgery (debridement) has significant effect on postoperative outcome compared to age and surgery type. Time to debridement also has unidirectional relationship with outcome, which means the longer time to debridement, the worse outcome experienced by the patient. Keywords : open tibial fracture, surgery type, outcome, age, time to surgery
Hubungan Usia, Jenis Operasi, dan Waktu Operasi dengan Outcome Pasca Operasi Fraktur Tibia Terbuka Derajat III di RSUP Sanglah Denpasar pada Tahun 2018-2020 Kesumaputri, Komang Diah Kurnia; Subawa, I Wayan; Dewi, Kadek Ayu Candra; Meregawa, Putu Feryawan
E-Jurnal Medika Udayana Vol 11 No 10 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i10.P17

Abstract

Open tibial fracture is one of the most common lower extremity fractures in the world, especially in Denpasar City. Clinically, grade III open tibial fracture has higher risk of worse outcome, such as infection and bone healing complication than grade I and II, thus it should be evaluated further regarding risk factors affecting that occurrence. This research aims to know the relationship between several risk factors, those are age, surgery type, and time to surgery with postoperative outcomes in grade III open tibial fractures in terms of clinical, radiological, and functional based on Johner-Wruhs criteria. This research used cross-sectional method and used patients with grade III open tibial fracture who underwent surgery at Sanglah Denpasar General Hospital in 2018-2020. Based on the data collection, there were 31 patients fulfilled the inclusion and exclusion criteria. The data collected were characteristics and postoperative outcome assessed using Johner-Wruhs criteria which consisted of 4 categories. From Kendall Tau correlation test, there was no significant relationship between age and outcome (p=0,215) and a significant relationship between time to surgery and outcome (p=0,021). Moreover, the results of Fisher’s Exact Test did not find significant relationship between surgery type and outcome (p=0,720). Based on the results, it can be concluded that time to surgery (debridement) has significant effect on postoperative outcome compared to age and surgery type. Time to debridement also has unidirectional relationship with outcome, which means the longer time to debridement, the worse outcome experienced by the patient. Keywords: open tibial fracture, surgery type, outcome, age, time to surgery
Efektivitas Suplementasi Lutein dan Zeaxanthin terhadap Perkembangan Atrofi Geografis dan Ketajaman Penglihatan pada Degenerasi Makula Terkait Usia: Tinjauan Sistematis Berdasarkan Uji Klinis: Tinjauan Sistematik Kesumaputri, Komang Diah Kurnia; Dwipayani, Ni Made; Wibawa, I Made Dwi Surya; Agrasidi, Putu Anindya; -, Felicia
Cermin Dunia Kedokteran Vol 53 No 05 (2026): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i05.2155

Abstract

Introduction: Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration (AMD) that can cause severe central vision loss if its progression extends to the foveal area. Currently, therapeutic options for GA remain limited, with safety profiles requiring further evaluation. Lutein and zeaxanthin, as the main components of the Age-Related Eye Disease Study (AREDS2) formula, have become the focus of current research. Both are antioxidants concentrated in the macula, which exert protective effects on retinal structures and reduce oxidative stress. This systematic review aims to evaluate the effectiveness of oral lutein and zeaxanthin supplementation on GA progression and visual acuity in AMD patients. Methods: Literature searches were conducted across four biomedical databases based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. A total of four studies met the inclusion criteria and were analyzed qualitatively. Results: The analysis showed that oral supplementation of lutein (10 mg/day) and zeaxanthin (2 mg/day) may reduce the progression of non-central GA and stabilize or improve visual acuity in patients with AMD. Lutein at doses of 10 mg and 20 mg demonstrated similar effectiveness in improving visual acuity through an increase in macular pigment optical density (MPOD). Conclusion: Based on the findings of this systematic review, oral supplementation with lutein (10 mg/day) and zeaxanthin (2 mg/day), as incorporated in the AREDS2 formulation, appears to slow the progression of non-central GA and preserve foveal integrity (foveal sparing). Further long-term studies are required to confirm the clinical benefits and long-term safety.
Co-Authors -, Felicia Agrasidi, Putu Anindya Dewi, Kadek Ayu Candra I Wayan Subawa Meregawa, Putu Feryawan Ni Made Dwipayani, Ni Made Wibawa, I Made Dwi Surya