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All Journal Jurnal Kedokteran Brawijaya Universa Medicina Sebatik
Kridaningsih, Tri Nury
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Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Profile of HIV/AIDS Patients Coinfected with Tuberculosis in Bumi Wonorejo Health Centre and Santo Rafael Clinic Nabire, Papua Kridaningsih, Tri Nury; Widiyanti, Mirna; Adiningsih, Setyo; Hutapea, Hotma Martogi Lorensi; Fitriana, Eva; Natalia, Evi Iriani
Jurnal Kedokteran Brawijaya Vol 31, No 4 (2021)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2021.031.04.10

Abstract

HIV-TB co-infection still becomes a health problem in Indonesia, including in Nabire district, Papua province, which has the highest number of cases. HIV and TB infections are closely related and affect the epidemiology of one another. This study aims to determine the profile description of HIV-TB co-infected patients in Nabire. This research is a descriptive study with a cross-sectional design on 90 people with HIV/AIDS selected consecutively. Data were analyzed univariately and presented in the form of a frequency distribution table. The results showed that of 55 HIV/AIDS co-infected TB patients, almost all (90.9%) were Papuan ethnic, 70.9% were female and aged 30 to 49 years (50.9%) with a mean of 31.309.36 years. The majority of HIV-TB co-infected patients were married (63.6%), holding secondary education (58.2%), working (67.3%), engaging in sexual activity after 17 years of age, only having one sexual partner, and did not use drugs or obtain blood transfusions. The clinical profile of HIV-TB patients showed that 67.3% of the patients were with baseline CD4 count ≤350 cells/mm3, 64.8% had CD4 count at the time of study >350 cells/mm3, and viral load values fewer than 5000 copies/ml (87.3%). The therapy most widely received for patients with HIV-TB coinfection was the combination of ARV 3TC+EFV+TDF (76.4%). The most common clinical symptoms of HIV/AIDS patients were weight loss (56.4%), cough (40%), recurrent oral thrush (36.4%), chickenpox (32.7%), and tuberculosis lymph nodes (18.2%).
Viral load as a risk factor of reverse transcriptase inhibitor drug resistance mutation in antiretroviral-treated people living with HIV/AIDS Hutapea, Hotma Martogi Lorensi; Kridaningsih, Tri Nury; Prasetyo, Khoirul Huda; Antwi, Milton Boaheng
Universa Medicina Vol. 40 No. 3 (2021)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2021.v40.243-253

Abstract

Background The human immunodeficiency virus type 1 (HIV-1) is a major contagion faced by the population of Indonesia. The success of antiretroviral treatment (ART) is threatened by the emergence of drug resistance mutations (DRM). The aim of this study was to determine the association between CD4 count, CD4 count changes, viral load, adherence to therapy, and therapy history in the presence of DRM in people living with HIV/AIDS (PLWHA). MethodsThis was a cross-sectional study involving 269 adults who underwent antiretroviral (ARV) therapy for at least 6 months. The frequencies of DRM and polymorphisms were measured by partial amplification of the reverse transcriptase (RT) gene using RT-nested PCR on samples with viral loads of >1000 copies/mL. Sequencing was performed using the Sanger method, and edited by BioEdit. The edited sequences were submitted to http://hivdb.stanford.edu for DRM determination. Respondents’ medical data, CD4 count, viral load, and DRM were analyzed by simple and multiple logistic regression. ResultsThe multiple logistic regression analysis showed a significant association of CD4 count (aOR=12.47; 95% CI: 1.45 -107.39; p=0.023) and viral load at the time of study (aOR=29.56; 95% CI: 3.47-251.52; p=0.002) with the presence of DRM in respondents. ARV substitution history was not associated with the presence of DRM. There were 17 respondents (6.3%) carrying HIV-1 DRM, with M184V/I (11 sequences) as the most frequent pattern of NRTI resistance, and K103 (9 sequences) as that of NNRTI resistance. ConclusionThis study demonstrated that viral load at the time of the study was the most influential determinant factor for the presence of DRM in PLWHA.
IDENTIFIKASI ALASAN KESEDIAAN TES HIV DAN ANALISIS FAKTOR RISIKO PADA ORANG DENGAN HIV/AIDS DI PAPUA BARAT Adiningsih, Setyo; Widiyanti, Mirna; Rokhmad, Muhammad Fajri; Kridaningsih, Tri Nury
Sebatik Vol. 27 No. 2 (2023): Desember 2023
Publisher : STMIK Widya Cipta Dharma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46984/sebatik.v27i2.2285

Abstract

Tes diagnosis Human Immunodeficieny Virus (HIV) merupakan salah satu upaya pencegahan infeksi HIV dalam program Fast Track 95-95-95 yang ditargetkan tercapai pada tahun 2030. Sakit HIV stadium awal yang bersifat asimtomatis menyebabkan individu tidak menyadari telah terinfeksi. Studi ini bertujuan untuk mengidentifikasi alasan melakukan tes diagnosis HIV dan faktor risikonya oleh Orang Dengan HIV/AIDS (ODHA) di Papua Barat. Desain studi yang digunakan adalah cross-sectional dengan responden sebanyak 254 ODHA dari Manokwari, Kota Sorong, dan Fakfak. Data sekunder dikumpulkan dari rekam medis ODHA dan wawancara menggunakan kuesioner. Data kemudian dianalisis univariat untuk menggambarkan proporsi setiap variabel dan dianalisis bivariat dengan uji Chi-Square (Fisher's exact) pada nilai signifikan p < 0,05 untuk mengetahui faktor risiko alasan melakukan tes diagnosis HIV. Gambaran umum mayoritas ODHA adalah berusia dewasa 26-45 tahun sebanyak 70,1%, perempuan 54,7%, pendidikan dasar-menengah 66,5%, PNS;swasta/wiraswasta 66,9%, riwayat TB 52,4%, dan sakit HIV stadium III dan IV 68,1%. Alasan terbanyak untuk melakukan tes diagnosis HIV oleh ODHA adalah karena sakit sebanyak 64,2%. Variabel jenis kelamin, pekerjaan, riwayat TB, dan stadium sakit HIV menjadi faktor risiko yang berhubungan signifikan dengan alasan melakukan tes diagnosis HIV. Studi ini mengindikasikan adanya keterlambatan dalam diagnosis awal infeksi HIV pada ODHA di Papua Barat. Kedepannya perlu dilakukan studi komprehensif mengenai faktor yang memengaruhi ODHA untuk melakukan tes diagnosis HIV lebih awal sebagai informasi bagi pihak terkait dalam mengatasi permasalahan deteksi dini infeksi HIV.
Co-Authors Adiningsih, Setyo Adiningsih, Setyo Antwi, Milton Boaheng Eva Fitriana, Eva Hutapea, Hotma Martogi Lorensi Mirna Widiyanti Natalia, Evi Iriani Prasetyo, Khoirul Huda Rokhmad, Muhammad Fajri