Article Per Year (5 Year)
p-Index From 2020 - 2025
0.817
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Plasma - Jurnal Kesehatan Folia Medica Indonesiana Universa Medicina Sebatik Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Mirna Widiyanti
Balai Litbang Biomedis Papua. Jl. Kesehatan No. 10 Dok II, Jayapura, Papua.
Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

Published : 10 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 10 Documents
Search

 1 
Dampak Perpaduan Obat ARV pada Pasien HIV/AIDS ditinjau dari Kenaikan Jumlah Limfosit CD4+ di RSUD Dok II Kota Jayapura Widiyanti, Mirna
JURNAL PLASMA Vol 1, No 2 Jun (2015)
Publisher : Balai Penelitian dan Pengembangan Biomedis Papua

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (66.06 KB)

Abstract

The purpose of ARV is reducing the rate of transmission, reducing morbidity and mortalityassociated with HIV, restoring and maintaining the immune system and suppressing the viralreplication maximal. Dok II Hospital is one of the hospitals that provide care and ARV therapy forpatients HIV. The number of patients increasing each year, it is necessary to evaluate the success ofARV drugs on a regular basis in order to achieve optimal outcomes. One way of monitoring is tolook at the efficacy of a combination of ARV drugs on the immune response of the increase is theincrease in Lymphocyte CD4+ cell count. To determine the efficacy of ARV combination based onthe increase in CD4 cell counts of patients after 6-12 months of ARV treatment in Dok II Hospital in2011-2012. The study was an observational. Data were collected retrospectively on secondary datafrom medical records of patients who met the inclusion criteria. Data were analyzed by ANOVA. Sixobtained the drug combination gave good efficacy based on a significant increase in LymphocyteCD4+ cell counts in patients with HIV/AIDS who receive ARV drugs in combination II and V (pvalue = 0.002) and the combination of III and V (p value = 0.033) while for other combinationsbetween no significant difference. The sixth best combination ARV efficacy there are 2 that thecombination II and V combination.
Low body mass index increases risk of anemia in patients with HIV-AIDS receiving antiretroviral therapy Widiyanti, Mirna; Ubra, Reynold; Fitriana, Eva
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.221-227

Abstract

BackgroundIn acquired immunodeficiency syndrome (AIDS) cases, cytopenias of all major blood cell lines were increasingly recognized in patients with HIV infection. Anemia commonly occurs during HIV infection and has been associated with increased progression to AIDS and decreased survival. The aim of this study was to determine the prevalence of anemia and associated risk factors in adults with HIV-AIDS receiving antiretroviral therapy (ART). MethodsA cross sectional study was conducted involving 90 adults with HIV-AIDS. Sociodemographic data were collected using a questionnaire. In all patients, CD4+ lymphocyte counts were performed by means of a PIMA analyzer, while hemoglobin was determined using a Sysmex hematology analyzer. The WHO cutoff value of hemoglobin was adjusted to altitude to define anemia. Mild to moderate anemia was defined as hemoglobin 8-13 g/dL for men and 8-12 g/dL for women. Severe anemia was defined as hemoglobin 8 g/dL. Data was analyzed by using logistic regression test.ResultsThere were 90 subjects with HIV-AIDS in this study. Anemia was found in 50 subjects (55.6%), consisting of 12.2% with mild anemia and 43.4% with moderate to severe anemia. Multiple logistic regression showed that an important risk factor for anemia was low body mass index (BMI) between <17-18.5 (OR=4.20; 95% CI=1.23-14.36). However, the CD4 <350 cells/mm3 was not a significant risk factor for anemia (OR=1.03; 95% CI=0.21-5.04).ConclusionsLow BMI increases the risk of anemia in subjects with HIV receiving ART. Better screening for anemia and infectious diseases, and modified harm reduction strategy for injection drug users are primary needs in HIV patients.
Habit of cooking pork on hot stones as main risk of cysticercosis Sandy, Semuel; Oktavian, Antonius; Kawulur, Hanna S; Widiyanti, Mirna; Sasto, Iman HS; Maladan, Yustinus
Universa Medicina Vol 37, No 2 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.88-96

Abstract

BackgroundCysticercosis is an infectious disease caused by the larval form of Taenia solium (cysticercus cellulosae) and has been ranked as the most important food-borne parasite of humans in terms of public health, socioeconomic and trade impact. Cysticercosis is still a health problem in Papua and is inseparable from socio-cultural factors, hygiene and environmental sanitation. The aim of this study was to investigate the seroprevalence of cysticercosis and the risk factors that contribute to cysticercosis.MethodsA cross-sectional study was conducted in March-November 2016 involving 800 subjects. Demographic data and risk factors were collected using questionnaires. Cysticercosis serological examination was performed by means of the magnetic microsphere bead immunoassay technique coupled with rT24H recombinant protein to detect serum rT24H cysticercosis specific antibodies. The data obtained were analyzed by bivariate test (chi-square) and logistic regression.ResultsCysticercosis seroprevalence in Papua was 3.6% (284/7 874). The logistic regression analysis found that the risk factors playing the role of predictor were cooking pork with hot stones [OR=3.06; 95%CI: 2.19-4.28; p=0.000], nail hygiene [OR=2.05; 95%CI: 1.57-2.67; p=0.000], consumption of raw vegetables or salads [OR=0.52; 95%CI: 0.30-0.91; p=0.022], use of river water for washing foods [OR= 1.92; 95%CI: 1.39-2.64; p=0.000].ConclusionsCooking pork with hot stones was the main risk factor of cysticercosis. Suspected cases of T. solium in pigs should be confirmed by molecular methods. Both taeniasis and human cysticercosis should be notifiable and surveillance in animals should be improved.
RISIKO MALNUTRISI TERHADAP JUMLAH CD4⁺ ORANG DENGAN HIV/AIDS YANG MENJALANI TERAPI ANTIRETROVIRAL DI MIMIKA Adiningsih, Setyo; Widiyanti, Mirna
Jurnal Kedokteran Brawijaya Vol 30, No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.703 KB) | DOI: 10.21776/ub.jkb.2018.030.01.8

Abstract

Hubungan status gizi dengan Cluster of Differentiation 4 (CD4?) pada Orang Dengan HIV/AIDS (ODHA) yang menjalani terapi antiretroviral (ARV) di Papua belum banyak diketahui. Penelitian bertujuan menganalisis hubungan status gizi terhadap jumlah CD4? subjek penelitian. Parameter status gizi yang digunakan yaitu Indeks Massa Tubuh (IMT) dan anemia. Jenis penelitian adalah observasional deskriptif dengan desain cross-sectional. Inklusi yaitu pasien laki-laki dan perempuan sedang terapi ARV minimal 6 bulan, memiliki data CD4? dan rekam medis lengkap. Subjek penelitian yaitu 64 pasien HIV/AIDS yang menjalani terapi ARV di Rumah Sakit Mitra Masyarakat (RSMM) Mimika Papua bulan Januari sampai Oktober 2015, telah menyetujui inform consent dan memenuhi kriteria inklusi. Data dianalisis menggunakan statistik Fisher's Exact test dan Odds Ratio (OR). Mayoritas subjek penelitian adalah perempuan sebanyak 76,6%, kisaran umur 15-35 tahun sebanyak 60,9%, IMT >18,5 sebanyak 85,9%, kadar hemoglobin (Hb) <13g/dL sebanyak 73,4%, dan lama terapi ?60 bulan sebanyak 75%. Hasil Fisher's Exact test dan OR, ada hubungan signifikan IMT terhadap jumlah CD4? dengan nilai p?0,05=0,006 dan OR=13,867 serta 95% interval konvidensi (CI)=2,396-80,266. Hal ini menunjukkan subjek penelitian dengan IMT?18,5 atau malnutrisi berisiko 13,867 kali untuk memiliki jumlah CD4? ?200sel/ul dibandingkan subjek dengan IMT?18,5. Variabel jenis kelamin, umur, kadar Hb, dan lama terapi ARV tidak berhubungan signifikan dengan jumlah CD4?. IMT kurus (malnutrisi) berhubungan signifikan dengan jumlah CD4? rendah yaitu ?200sel/ul. Jumlah CD4? ?200sel/ul berisiko mempercepat status HIV menjadi stadium 4 atau sakit berat yang mengarah kepada AIDS. 
Gambaran Subtipe HIV-1 dengan Kadar CD4, Stadium Klinis, dan Infeksi Oportunistik Penderita HIV/AIDS di Kota dan Kabupaten Jayapura, Papua Widiyanti, Mirna; Sandy, Semuel
Majalah Kedokteran Bandung Vol 48, No 1 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (173.632 KB) | DOI: 10.15395/mkb.v48n1.738

Abstract

Jumlah kasus HIV/AIDS di Indonesia akhir Maret 2013 tercatat 103.759 kasus dan 43.347 kasus AIDS yang tersebar di Indonesia. Papua merupakan provinsi ketiga yang memiliki jumlah kasus HIV/AIDS cukup tinggi, yaitu 10.881 kasus HIV dan 7.795 kasus AIDS. Tujuan penelitian ini melihat distribusi subtipe HIV-1 yang dominan di Papua dan mengetahui hubungan subtipe HIV-1 dengan kadar CD4, stadium klinis, dan infeksi oportunistik penderita HIV/AIDS. Penelitian menggunakan rancangan potong lintang. Pemeriksaan subtipe HIV-1 menggunakan RT-PCR dan sekuensing. Penelitian dilaksanakan di RSUD Dok II, RS Abepura, dan RSUD Yowari Kabupaten Jayapura pada bulan November–Desember 2012. Data CD4, stadium klinis, dan jenis infeksi oportunistik dicatat melalui rekam medis pasien. Data dianalisis menggunakan uji statistik chi-kuadrat. Subtipe HIV-1 yang dominan ditemukan, yaitu CRF01_AE sebanyak 51 orang (54%) dan subtipe B sebanyak 43 orang (46%). Dari 94 pasien HIV sebanyak 62 orang (66%) menderita infeksi oportunistik TB paru dan beberapa menderita lebih dari satu jenis infeksi oportunistik. Uji statistik menunjukkan tidak ada hubungan bermakna subtipe HIV-1 dengan kadar CD4 dan stadium klinis, tetapi menunjukkan korelasi bermakna terhadap infeksi oportunistik. Simpulan ditemukan subtipe HIV-1 yang dominan di Papua adalah CRF01_AE dan infeksi oportunistik terbanyak pada penderita adalah tuberkulosis. [MKB. 2016;48(1):1–6]Kata kunci: CD4, infeksi oportunistik, stadium klinis, subtipe HIV-1 Overview of HIV-1 Subtype with CD4 Levels, Clinical Stage and Opportunistic Infections HIV/AIDS in City and Regency of Jayapura-PapuaAbstractThe number of HIV/AIDS cases recorded in March 2013 in Indonesia is 103,759 HIV cases and 43,347 AIDS cases. Papua is the province that has the third highest number HIV/AIDS cases with 10,881 HIV cases and 7,795 AIDS cases. The aim of this study was to identify the distribution of HIV-1 subtypes which are dominant in Papua and to identify opportunistic infections related to HIV/AIDS and their relationship with HIV-1 subtypes. This study is a cross-sectional study. The identification of HIV-1 was performed using nested-PCR and sequencing to look for HIV-1 subtypes. The study was conducted in Dok II, Abepura and Yowari VCT Hospital in Jayapura District during the period of November–December 2012. CD4 and opportunistic infections were retrieved from patient medical records. Data were analyzed statistically using chi-square test. The dominant HIV-1 subtypes found were subtype CRF01-AE, which was found in 51 people (54%), and subtype B, which was found in 43 people (46%). Of 94 HIV patients, 62 (66%) respondents suffered from pulmonary tubeculosis opportunistic infection and some patients suffered more than one type of opportunistic infections. There was no significant difference found between the HIV-1 subtypes, CD4 level, and clinicial stage. However, a significant correlation with opportunistic infections was found. It is concluded that the dominant HIV-1 subtype in Papua is CRF01_AE with tuberculosis as the most frequent opportunistic infection. [MKB. 2016;48(1):1–6]Key words: CD4, clinical stage, HIV-1 subtypes, opportunistic infection 
Body mass index increases CD4+ count in HIV/AIDS patients on first-line therapy Widiyanti, Mirna; Hadi, Moch Irfan; Kumalasari, Mei Lina Fitri; Natalia, Evi Iriani; Purba, Dedi Ananta; Adiningsih, Setyo
Universa Medicina Vol. 39 No. 2 (2020)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2020.v39.121-127

Abstract

BackgroundThe body mass index (BMI) may contribute somewhat to drug metabolism, thus affecting the efficacy of antiretroviral therapy (ART). CD4+ counts   in people infected with HIV are essential in determining the stage of the disease, initiation of antiretroviral therapy, opportunistic infections and evaluating treatment outcomes. The aim of this study was to determine the association of BMI and clinical stage with CD4+ counts in HIV patients seeking treatment using first-line antiretroviral therapy (ART).MethodsAn analytic study with a cross-sectional approach was conducted involving 251 HIV/AIDS patients who had received first-line antiretrovirals over six months. BMI, clinical staging according to WHO and CD4 + were collected. Multiple linear regression was used to evaluate the relationship between BMI, clinical stage and CD4+.ResultsAmong the enrolled patients, the median age was 36 years, 135 (55%) of the patients was female, 102 (40.6%) was overweight/obese, 161 (64.1%) was in stage 3 of the disease, and the median CD4+ count was 389 cells/mm3. Multiple linear regression test showed two variables with a significant effect on CD4+ count, namely BMI (B=69.247; 95 % CI : 42.886-95.608) and clinical stage (B=61.590; 28.910-94.270). BMI was the most influencing factor for CD4+ count (β=0.307) compared to clinical stage (β=0.216). ConclusionsBody mass index was the most influencing factor for CD4 + counts of HIV/AIDS patients. Regular ART can increase CD4+ counts and maintain the health of HIV/AIDS patients.
Profile of HIV/AIDS Patients Coinfected with Tuberculosis in Bumi Wonorejo Health Centre and Santo Rafael Clinic Nabire, Papua Kridaningsih, Tri Nury; Widiyanti, Mirna; Adiningsih, Setyo; Hutapea, Hotma Martogi Lorensi; Fitriana, Eva; Natalia, Evi Iriani
Jurnal Kedokteran Brawijaya Vol 31, No 4 (2021)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2021.031.04.10

Abstract

HIV-TB co-infection still becomes a health problem in Indonesia, including in Nabire district, Papua province, which has the highest number of cases. HIV and TB infections are closely related and affect the epidemiology of one another. This study aims to determine the profile description of HIV-TB co-infected patients in Nabire. This research is a descriptive study with a cross-sectional design on 90 people with HIV/AIDS selected consecutively. Data were analyzed univariately and presented in the form of a frequency distribution table. The results showed that of 55 HIV/AIDS co-infected TB patients, almost all (90.9%) were Papuan ethnic, 70.9% were female and aged 30 to 49 years (50.9%) with a mean of 31.309.36 years. The majority of HIV-TB co-infected patients were married (63.6%), holding secondary education (58.2%), working (67.3%), engaging in sexual activity after 17 years of age, only having one sexual partner, and did not use drugs or obtain blood transfusions. The clinical profile of HIV-TB patients showed that 67.3% of the patients were with baseline CD4 count ≤350 cells/mm3, 64.8% had CD4 count at the time of study >350 cells/mm3, and viral load values fewer than 5000 copies/ml (87.3%). The therapy most widely received for patients with HIV-TB coinfection was the combination of ARV 3TC+EFV+TDF (76.4%). The most common clinical symptoms of HIV/AIDS patients were weight loss (56.4%), cough (40%), recurrent oral thrush (36.4%), chickenpox (32.7%), and tuberculosis lymph nodes (18.2%).
IDENTIFIKASI ALASAN KESEDIAAN TES HIV DAN ANALISIS FAKTOR RISIKO PADA ORANG DENGAN HIV/AIDS DI PAPUA BARAT Adiningsih, Setyo; Widiyanti, Mirna; Rokhmad, Muhammad Fajri; Kridaningsih, Tri Nury
Sebatik Vol. 27 No. 2 (2023): Desember 2023
Publisher : STMIK Widya Cipta Dharma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46984/sebatik.v27i2.2285

Abstract

Tes diagnosis Human Immunodeficieny Virus (HIV) merupakan salah satu upaya pencegahan infeksi HIV dalam program Fast Track 95-95-95 yang ditargetkan tercapai pada tahun 2030. Sakit HIV stadium awal yang bersifat asimtomatis menyebabkan individu tidak menyadari telah terinfeksi. Studi ini bertujuan untuk mengidentifikasi alasan melakukan tes diagnosis HIV dan faktor risikonya oleh Orang Dengan HIV/AIDS (ODHA) di Papua Barat. Desain studi yang digunakan adalah cross-sectional dengan responden sebanyak 254 ODHA dari Manokwari, Kota Sorong, dan Fakfak. Data sekunder dikumpulkan dari rekam medis ODHA dan wawancara menggunakan kuesioner. Data kemudian dianalisis univariat untuk menggambarkan proporsi setiap variabel dan dianalisis bivariat dengan uji Chi-Square (Fisher's exact) pada nilai signifikan p < 0,05 untuk mengetahui faktor risiko alasan melakukan tes diagnosis HIV. Gambaran umum mayoritas ODHA adalah berusia dewasa 26-45 tahun sebanyak 70,1%, perempuan 54,7%, pendidikan dasar-menengah 66,5%, PNS;swasta/wiraswasta 66,9%, riwayat TB 52,4%, dan sakit HIV stadium III dan IV 68,1%. Alasan terbanyak untuk melakukan tes diagnosis HIV oleh ODHA adalah karena sakit sebanyak 64,2%. Variabel jenis kelamin, pekerjaan, riwayat TB, dan stadium sakit HIV menjadi faktor risiko yang berhubungan signifikan dengan alasan melakukan tes diagnosis HIV. Studi ini mengindikasikan adanya keterlambatan dalam diagnosis awal infeksi HIV pada ODHA di Papua Barat. Kedepannya perlu dilakukan studi komprehensif mengenai faktor yang memengaruhi ODHA untuk melakukan tes diagnosis HIV lebih awal sebagai informasi bagi pihak terkait dalam mengatasi permasalahan deteksi dini infeksi HIV.
IDENTIFICATION OF ANTIRETROVIRAL MUTATION IN PROTEASE AND REVERSE TRANCRIPTASE INHIBITOR IN HUMAN IMMUNODEFICIENCY VIRUS-1 OF HIV/AIDS PATIENTS IN MIMIKA REGENCY, PAPUA Widiyanti, Mirna; Fitriana, Eva; Natalia, Evi Iriani; Wike, Irawati
Folia Medica Indonesiana Vol. 53 No. 1 (2017): JANUARY - MARCH 2017
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (434.509 KB) | DOI: 10.20473/fmi.v53i1.5491

Abstract

Treatment with RT Inhibitors has been used as first line program in Mimika. Regular use of antiretroviral drugs can lower the amount of the virus, but after that HIV can become resistant to the drugs given. Viral resistance to the drugs can occur because of a mutation. If the resistance-associated mutations occur in the DNA of the virus, then the ARV provided will no longer be effective. The aim of this study was to identify the presence of resistance-associated mutations in DNA fragment that encodes the protease and reverse transcriptase. This study used cross sectional design with 84 subjects who had received antiretroviral for > 6 months. The study was conducted in Mitra Masyarakat Mimika Hospital. Laboratory process included extraction, RT-PCR, electrophoresis and sequencing. Data analysis used resistance interpretation algorithms in HIV Database. Results showed that 1 subject who did not receive protease therapy was identified as having minor mutation L10V, 1 subjects receiving NRTI inhibitors had mutation M184V motive and 1 subjects with M41L motive and 1 subjects who received NNRTI inhibitor therapy identified as having mutated Y181C and V108I motive. In conclusion, mutant HIV-1 related to ARV resistance has been identified in two subjects who had received antiretroviral therapy in Mitra Masyarakat Mimika Hospital.
Utilizing Rapid Molecular Tests (RMT/RIF) in Tuberculosis Drug-Sensitive/Resistant Discovery in Indonesia: A Pilot Study Herawati, Maria Holly; Dasuki, Dasuki; Lolong, Dina Bisara; Widiyanti, Mirna; Roosihermiatie, Betty; Permata, Ria Yuda; Raflizar, Raflizar; Ahmadi, Ferry; Supratikta, Hadi; Veruswati, Meita
Kesmas Vol. 18, No. 5
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The underdiagnosis and underreporting of tuberculosis (TB) indicators are unresolved problems. The rapid molecular test (RMT) is one of the breakthroughs for TB case finding by using safer and more sensitive equipment; it is even believed to help find drug-resistant TB. The results of several webinars held regularly by a TB program as well as its evaluation and the use of RMT formed the basis of this study. This initial pilot study aimed to provide an overview of case finding for both drug-sensitive and drug-resistant TB using RMT. A cross-sectional study was conducted on samples in several provinces in Indonesia that have used RMT, both in remote or non-remote island borders areas and fiscal capacity. Regarding the use of RMT for drug-sensitive TB case finding, the largest contributors were males aged above 15 years, while in the drug-resistant TB case finding group, the biggest contributor was the use of RMT in 2017 and 2018. Overall, the findings could only describe the situation in the study area. The use of RMT in drug-sensitive TB case finding would be maximized if the detected cases are males aged above 15 years, while RMT can help find cases of drug-resistant TB.
Co-Authors Adiningsih, Setyo Adiningsih, Setyo Ahmadi, Ferry Antonius Oktavian Betty Roosihermiatie DASUKI DASUKI Dina Bisara Lolong Eva Fitriana, Eva Holy A. Wibowo Hotma Hutapea, Hotma Hutapea, Hotma Martogi Lorensi Iman HS Sasto, Iman HS Kawulur, Hanna S Kridaningsih, Tri Nury Maladan, Yustinus Maria Holly Herawati Mei Lina Fitri Kumalasari Moch. Irfan Hadi Natalia, Evi Iriani Permata, Ria Yuda Purba, Dedi Ananta Raflizar Raflizar Reynold Ubra, Reynold Rokhmad, Muhammad Fajri Semuel Sandy Supratikta, Hadi Veruswati, Meita Wike, Irawati