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All Journal Jurnal Kedokteran Brawijaya Universa Medicina Folia Medica Indonesiana
Adiningsih, Setyo
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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RISIKO MALNUTRISI TERHADAP JUMLAH CD4⁺ ORANG DENGAN HIV/AIDS YANG MENJALANI TERAPI ANTIRETROVIRAL DI MIMIKA Adiningsih, Setyo; Widiyanti, Mirna
Jurnal Kedokteran Brawijaya Vol 30, No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.703 KB) | DOI: 10.21776/ub.jkb.2018.030.01.8

Abstract

Hubungan status gizi dengan Cluster of Differentiation 4 (CD4?) pada Orang Dengan HIV/AIDS (ODHA) yang menjalani terapi antiretroviral (ARV) di Papua belum banyak diketahui. Penelitian bertujuan menganalisis hubungan status gizi terhadap jumlah CD4? subjek penelitian. Parameter status gizi yang digunakan yaitu Indeks Massa Tubuh (IMT) dan anemia. Jenis penelitian adalah observasional deskriptif dengan desain cross-sectional. Inklusi yaitu pasien laki-laki dan perempuan sedang terapi ARV minimal 6 bulan, memiliki data CD4? dan rekam medis lengkap. Subjek penelitian yaitu 64 pasien HIV/AIDS yang menjalani terapi ARV di Rumah Sakit Mitra Masyarakat (RSMM) Mimika Papua bulan Januari sampai Oktober 2015, telah menyetujui inform consent dan memenuhi kriteria inklusi. Data dianalisis menggunakan statistik Fisher's Exact test dan Odds Ratio (OR). Mayoritas subjek penelitian adalah perempuan sebanyak 76,6%, kisaran umur 15-35 tahun sebanyak 60,9%, IMT >18,5 sebanyak 85,9%, kadar hemoglobin (Hb) <13g/dL sebanyak 73,4%, dan lama terapi ?60 bulan sebanyak 75%. Hasil Fisher's Exact test dan OR, ada hubungan signifikan IMT terhadap jumlah CD4? dengan nilai p?0,05=0,006 dan OR=13,867 serta 95% interval konvidensi (CI)=2,396-80,266. Hal ini menunjukkan subjek penelitian dengan IMT?18,5 atau malnutrisi berisiko 13,867 kali untuk memiliki jumlah CD4? ?200sel/ul dibandingkan subjek dengan IMT?18,5. Variabel jenis kelamin, umur, kadar Hb, dan lama terapi ARV tidak berhubungan signifikan dengan jumlah CD4?. IMT kurus (malnutrisi) berhubungan signifikan dengan jumlah CD4? rendah yaitu ?200sel/ul. Jumlah CD4? ?200sel/ul berisiko mempercepat status HIV menjadi stadium 4 atau sakit berat yang mengarah kepada AIDS. 
Body mass index increases CD4+ count in HIV/AIDS patients on first-line therapy Widiyanti, Mirna; Hadi, Moch Irfan; Kumalasari, Mei Lina Fitri; Natalia, Evi Iriani; Purba, Dedi Ananta; Adiningsih, Setyo
Universa Medicina Vol. 39 No. 2 (2020)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2020.v39.121-127

Abstract

BackgroundThe body mass index (BMI) may contribute somewhat to drug metabolism, thus affecting the efficacy of antiretroviral therapy (ART). CD4+ counts   in people infected with HIV are essential in determining the stage of the disease, initiation of antiretroviral therapy, opportunistic infections and evaluating treatment outcomes. The aim of this study was to determine the association of BMI and clinical stage with CD4+ counts in HIV patients seeking treatment using first-line antiretroviral therapy (ART).MethodsAn analytic study with a cross-sectional approach was conducted involving 251 HIV/AIDS patients who had received first-line antiretrovirals over six months. BMI, clinical staging according to WHO and CD4 + were collected. Multiple linear regression was used to evaluate the relationship between BMI, clinical stage and CD4+.ResultsAmong the enrolled patients, the median age was 36 years, 135 (55%) of the patients was female, 102 (40.6%) was overweight/obese, 161 (64.1%) was in stage 3 of the disease, and the median CD4+ count was 389 cells/mm3. Multiple linear regression test showed two variables with a significant effect on CD4+ count, namely BMI (B=69.247; 95 % CI : 42.886-95.608) and clinical stage (B=61.590; 28.910-94.270). BMI was the most influencing factor for CD4+ count (β=0.307) compared to clinical stage (β=0.216). ConclusionsBody mass index was the most influencing factor for CD4 + counts of HIV/AIDS patients. Regular ART can increase CD4+ counts and maintain the health of HIV/AIDS patients.
Profile of HIV/AIDS Patients Coinfected with Tuberculosis in Bumi Wonorejo Health Centre and Santo Rafael Clinic Nabire, Papua Kridaningsih, Tri Nury; Widiyanti, Mirna; Adiningsih, Setyo; Hutapea, Hotma Martogi Lorensi; Fitriana, Eva; Natalia, Evi Iriani
Jurnal Kedokteran Brawijaya Vol 31, No 4 (2021)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2021.031.04.10

Abstract

HIV-TB co-infection still becomes a health problem in Indonesia, including in Nabire district, Papua province, which has the highest number of cases. HIV and TB infections are closely related and affect the epidemiology of one another. This study aims to determine the profile description of HIV-TB co-infected patients in Nabire. This research is a descriptive study with a cross-sectional design on 90 people with HIV/AIDS selected consecutively. Data were analyzed univariately and presented in the form of a frequency distribution table. The results showed that of 55 HIV/AIDS co-infected TB patients, almost all (90.9%) were Papuan ethnic, 70.9% were female and aged 30 to 49 years (50.9%) with a mean of 31.309.36 years. The majority of HIV-TB co-infected patients were married (63.6%), holding secondary education (58.2%), working (67.3%), engaging in sexual activity after 17 years of age, only having one sexual partner, and did not use drugs or obtain blood transfusions. The clinical profile of HIV-TB patients showed that 67.3% of the patients were with baseline CD4 count ≤350 cells/mm3, 64.8% had CD4 count at the time of study >350 cells/mm3, and viral load values fewer than 5000 copies/ml (87.3%). The therapy most widely received for patients with HIV-TB coinfection was the combination of ARV 3TC+EFV+TDF (76.4%). The most common clinical symptoms of HIV/AIDS patients were weight loss (56.4%), cough (40%), recurrent oral thrush (36.4%), chickenpox (32.7%), and tuberculosis lymph nodes (18.2%).
Viral Load And Cd4+ among Hiv/Aids Patients Receiving Antiretroviral Therapy In Jayawijaya District, Papua Province, Indonesia Widiyanti, Mirna; Hadi, Moch. Irfan; Adiningsih, Setyo; Natalia, Evi Iriani; Purba, Dedi Ananta
Folia Medica Indonesiana Vol. 58, No. 1
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hightlight:• Clinical conditions, CD4+ cell counts, and the viral copies number in the blood for AIDS/HIV were given antiretroviral therapy. • The profile of CD4+ levels and plasma viral load in HIV patients receiving antiretroviral therapy • The lower CD4+ cell counts and higher viral loads happen in HIV-infected's men. Abstract: Highly active antiretroviral therapy (HAART) is expected to reduce human immunodeficiency virus (HIV) morbidity and mortality. Antiretroviral therapy in HIV patients is given based on clinical conditions, CD4+ cell counts, and the number of viral copies in the blood. This study aimed to determine the profile of CD4+ levels and plasma viral load in HIV patients receiving antiretroviral therapy. This was a cross-sectional study conducted within six months at Voluntary Counseling and Testing (VCT) in Jayawijaya Hospital, Papua, Indonesia. The CD4+ levels were measured using CD4+ counter and viral plasma was checked using Polymerase Chain Reaction (PCR) for 90 patients. The results showed more female patients had a CD4+ level <200 cells/mm3, a higher number of copies of the virus in the blood plasma, and stages of disease 3 and 4. Statistically, there was a significant relationship between CD4+ levels and gender with a p-value = 0.00. HIV-infected males were more likely to have lower CD4+ cell counts and higher viral loads than females.
Co-Authors Eva Fitriana, Eva Hutapea, Hotma Martogi Lorensi Kridaningsih, Tri Nury Mei Lina Fitri Kumalasari Mirna Widiyanti Moch. Irfan Hadi Natalia, Evi Iriani Purba, Dedi Ananta