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All Journal Jurnal Ilmu Alam dan Lingkungan Biosaintifika: Journal of Biology & Biology Education Jurnal Pembelajaran dan Biologi Nukleus Community Development Journal: Jurnal Pengabdian Masyarakat
Winanda, Witri
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Public Health Veterinary

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Pancreatic Lipase Inhibitory Activity of Endophytic Actinobacteria from Rhododendron spp. Winanda, Witri; Batubara, Irmanida; Lestari, Yulin
Biosaintifika: Journal of Biology & Biology Education Vol 13, No 2 (2021): August 2021
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v13i2.29981

Abstract

Antiobesity medication is available as therapeutic compounds that can reduce fat digestion by the inhibition of pancreatic lipase. Actinobacteria have the potency as source of bioactive compounds with various biological function including as pancreatic lipase inhibitor.  However, the potency of endophytic actinobacteria from Rhododendron spp. as source of pancreatic lipase inhibitor producer has not been reported yet. The aim of this study was to examine the potential of pancreatic lipase inhibitory activity of 23 endophytic actinobacteria from Rhododendron spp.; to characterize their colony based on morphology and molecular analysis. Screening test of pancreatic lipase inhibitor was conducted using the supernatant of endophytic actinobacteria, lipase pancreatic porcine (L3126) and p-nitrophenyl butyrate. The supernatant of selected isolates was extracted using ethyl acetate. The result showed that various inhibitory activities ranging between 0.00 until 91.69%. There were 11 out of 23 isolates that have potential as pancreatic inhibitor. Amongst them, the extract of four selected isolates, i.e. RZP 1.3, RSSB 3.2, RSS 2.1, and RJB F3.2 demonstrated inhibitory percentage of more than 80%. The RJB F3.2 extract showed to have IC50 value by 431.48 µg mL-1 compared to control, i.e. Xenical (89.07 µg mL-1). Phytochemical analysis exhibited that the extract of the selected isolates contained alkaloid which may function as pancreatic lipase inhibitor. Based on the morphological character, the selected isolates have various morphological colonies and 16S rRNA gene sequence revealed the sequence homology to Streptomyces spp. The data clearly indicate that endophytic actinobacteria from Rhododendron spp. have potency as pancreatic lipase inhibitor producer and further studies could be explored for the development of antiobesity agent.
The Potential of Various Matoa Plant (Pometia pinnata) Extracts as Antibacterial Agents: Systematic Literature Review Sarima, Sarima; Pistanty, Mingle A; Fathia, Mona; Winanda, Witri
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 2: Jurnal Pembelajaran Dan Biologi Nukleus June 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i2.7505

Abstract

Background: Bacteria in nature can have various effects on human life, including the development of diseases. Consequently, it is necessary to regulate or inhibit the growth of harmful bacteria. One method of doing so is through the use of natural ingredients, such as Matoa (Pometia pinnata). This study aims to provide a literature review on the potential of various Matoa plant extracts as antibacterials. Methodology: The investigation was conducted using the PRISMA approach, which involved the systematic literature review method. Electronic databases, including PubMed, ScienceDirect, Scopus, and Google Scholar, were searched from 2010 to 2024. "Pometia pinnata" is a search term that encompasses " Pometia pinnata as antibacterial" and "Antibacterial Activity of Pometia pinnata." A qualitative analysis was conducted on 22 articles that satisfied the inclusion criteria following the selection process. Findings: The review results indicated that the extracts of matoa's leaves, seeds, and bark contain active compounds, including flavonoids, tannins, saponins, alkaloids, and other phenolic compounds, which exhibit antibacterial activity. Despite the large potential, the majority of the research is still exploratory and has not yet progressed to the clinical trial stage. Consequently, additional, more intensive research is required to investigate the mechanism of action, toxicity, and potential clinical applications of herbal medicines derived from indigenous Indonesian plants. Contribution: This review highlights the antibacterial potential of matoa (Pometia pinnata) and underscores the need for further studies on its mechanism, toxicity, and clinical application, thereby guiding future research on Indonesian herbal medicine
Potensi Senyawa Bioaktif dari Bajakah Spatholobus littoralis Hassk. Sebagai Antikanker terhadap Sel MCF-7 secara In Vitro Habibi, Alif Rahman; Arfan, Alya Rahmaditya; Anwar, Khoirul; Azizah, Anggia; Fathia, Mona; Winanda, Witri; Berlyansyah, Azizul
Jurnal Ilmu Alam dan Lingkungan Vol. 16 No. 2 (2025): Jurnal Ilmu Alam dan Lingkungan
Publisher : Universitas Hasanuddin

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Abstract

Bajakah (Spatholobus littoralis Hassk.) is a plant from the Angiospermae group, belonging to the Leguminosae family, that grows in Kalimantan. This plant contains secondary metabolites with potential anticancer activity. Cancer is characterized by uncontrolled cell proliferation beyond normal mechanisms, leading to abnormal tissue growth and invasion. It is one of the leading causes of death worldwide, including breast cancer. In 2022, approximately 2.3 million women were diagnosed with breast cancer, with 670,000 deaths recorded globally, while around 1.63 million women were still living with the disease by the end of the year. This study aimed to evaluate the anticancer activity of Bajakah Spatholobus littoralis Hassk. against MCF-7 breast cancer cells using the MTS assay. The results showed that Bajakah extract exhibited low toxicity toward the MCF-7 cell line, with an IC50 value of 1,098.77 ppm. Therefore, it can be concluded that Bajakah Spatholobus littoralis Hassk., tested with the MTS method, is not cytotoxic to breast cancer cells. Further studies are recommended to investigate its potential effects on other cancer cell types
PELATIHAN PENGGUNAAN MIKROSKOP BINOKULER DAN TRINOKULER PADA SISWA SMA DI KOTA BATAM Azizah, Anggia; Anwar, Khoirul; Habibi, Alif Rahman; Fathi, Mona; Winanda, Witri; Berlyansah, Azizul
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 6 No. 4 (2025): Volume 6 No 4 Tahun 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v6i4.49129

Abstract

Keterampilan laboratorium merupakan kemampuan penting dalam pembelajaran biologi karena mendukung pemahaman konsep melalui pengalaman langsung. Kegiatan praktikum membantu siswa mengembangkan kemampuan observasi, berpikir kritis, dan ketertarikan terhadap sains. Permasalahan rendahnya literasi sains terutama biologi serta keterbatasan fasilitas laboratorium menyebabkan siswa jarang berinteraksi dengan alat-alat laboratorium terutama mikroskop. Kegiatan pengabdian ini bertujuan meningkatkan pemahaman dan keterampilan siswa SMA di kota Batam dalam penggunaan mikroskop binokuler dan trinokuler melalui pelatihan praktik langsung. Kegiatan meliputi sosialisasi tentang ilmu biologi, program studi biologi, pengenalan bagian dan fungsi mikroskop serta praktik pengamatan preparat jaringan otot manusia dan fungi mikroskopis yang diambil dari tempe dan roti berjamur. Pelatihan ini dilakukan secara interaktif dan partisipatif. Hasil menunjukkan peningkatan antusiasme, pemahaman, dan kemampuan siswa dalam menggunakan mikroskop. Kegiatan ini efektif meningkatkan ketertarikan dan minat siswa SMA terhadap ilmu biologi serta upaya mengaplikasikan pembelajaran teoritis. Pelatihan ini juga sebagai langkah awal yang potensial untuk dikembangkan lebih lanjut sebagai program berkelanjutan dalam membangun literasi mikroskopi dan minat siswa SMA terhadap ilmu biologi
Co-Authors Alya Rahmaditya Arfan Azizah, Anggia Berlyansah, Azizul Berlyansyah, Azizul Fathi, Mona Fathia, Mona Habibi, Alif Rahman Irmanida Batubara Khoirul Anwar Mingle A Pistanty, Mingle A Sarima, Sarima YULIN LESTARI