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All Journal Majalah Obat Tradisional Acta Odontologica Indonesia
Kusuma, Ira Anggar
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Dentistry Health Professions Medicine & Pharmacology Public Health

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Antibacterial Activity of Euphorbia tirucalli against Lactobacillus acidophilus: An In Vitro Study Bang, Vania Christina Budiono; Hapsari, Rebriarina; Kusuma, Ira Anggar
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.86604

Abstract

Dental caries is a common oral disease that occurs due to excessive interaction between tooth structure, bacterial biofilm, and glucose. Lactobacillus acidophilus is the main cause of dentin dental caries, which can be prevented using anticaries agents. However, current anticaries agents may cause some side effects. Therefore, there is a need for natural anticaries agents with minimal side effects. Euphorbia tirucalli contains flavonoids, tannins, and saponins that contribute to its antibacterial activity. This study aimed to determine the antibacterial activity of E. tirucalli against L. acidophilus bacterial growth. This was an in-vitro study with a post-test-only control group design, divided into three groups. The positive control group received 0.2% chlorhexidine digluconate, the negative control group received aquadest, and the intervention groups received extracts with concentrations of 10 mg/mL, 20 mg/mL, 30 mg/mL, 40 mg/mL, and 100 mg/mL. Minimum Inhibitory Concentration (MIC) was examined post-treatment using the agar dilution method. The differences in colony growth were analyzed using Cramer's V and Fisher's Exact Test, with p<0.05 considered significant. E. tirucalli extracts showed antibacterial effects against L. acidophilus with a concentration of 40 mg/mL as the MIC. Extract groups with concentrations of 40 mg/mL and 100 mg/mL showed significant differences in L. acidophilus growth compared to the negative control group (p<0.001). The study concluded that E. tirucalli extract has antibacterial activity against the growth of L. acidophilus, with MIC of 40 mg/mL.
The Difference between Salivary Viscosity and Salivary Flow Rate on Nicotine Electric Smokers and Non-Smokers Difaputra, Syavergio Avia; Kusuma, Ira Anggar; Dewi, Dian Puspita; Retnoningrum, Dwi
Acta Odontologica Indonesia 2025: December (Article in Press)
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/actodont.27232

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Background: Electric cigarette which contained nicotine affected bad impact to oral cavity, since the nicotine contained on e-liquid electric cigarette could reduce function of salivary gland. This condition decreases the salivary flow rate and increase salivary viscosity. could impact to less activity of self-cleansing and antimicrobial of saliva. Objectives: To prove the difference of salivary viscosity and salivary flow rate on nicotine electric smokers and non-smokers. Methods: This research was an analytic descriptive research which exerted cross sectional research design. As many as 60 people were selected to be the research subjects who were then divided into 30 electric smokers and 30 non-smokers. The saliva on each subject was collected in a beaker cup stimulated for 8 minutes, and continued to the viscosity measurement to be valued both visually and subjectively. The data was analyzed through Mann-Whitney test to identify the difference between viscosity and salivary flow rate on nicotine electric smokers and non-smokers. Results: The result of Mann-Whitney test showed a significant difference between salivary flow rate (p<0,05) and salivary viscosity of nicotine electric smokers and non-smokers (p<0,05). Conclusion: This research indicated the difference of viscosity and salivary flow rate between electric smokers and non-smokers. The electric smokers have thicker viscosity and lower flow rate compared to the non-smokers.
The Effect of Bay Leaf Extract Gel on Increasing Fibroblasts in Traumatic Ulcers Healing Process Firawan, Kurnia Nisa Putri; Kusuma, Ira Anggar; Istiadi, Hermawan; Santoso, Oedijani
Acta Odontologica Indonesia Vol 1, No 1 (2025): June Edition
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/actodont.26204

Abstract

The wound healing process of traumatic injuries in the oral cavity involves four stage: hemostasis, inflammation, proliferation, and remodeling. Fibroblast cells are essential for the wound healing process, appearing on the 3rd day and reaching their peak on the 7th day after injury. This study reveals that bay leaf extract can accelerate wound healing process by mitigating inflammation and enhancing fibroblast cell activity. This research utilized a post-test only control group design. Fifteen male Wistar rats divided in 3 groups equally:  control group and 2 groups were given 5% and 10% of the bay leaf extract gel was applied twice a day until the 5th  day. The results indicated that the group treated with 10% bay leaf extract gel had significantly higher value compared to the control group and the group treated with 5% bay leaf extract gel. In this study, we can learn that bay leaf extract gel can increase of fibroblast cells in the ulcer healing process.
Sex Determination using Antegonial and Gonial Angle in Panoramic Radiographs: A Study on the Indonesian Population Jauza, Nadifa Zakin; Kusuma, Ira Anggar; Keshena, Jatu Rachel
Acta Odontologica Indonesia Vol 1, No 1 (2025): June Edition
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/actodont.27070

Abstract

Sex determination is a crucial aspect of forensic identification. This study investigates the capability of Sex determination is a crucial aspect of forensic identification. This study investigates the potential of antegonial (AGA) and gonial (GA) angle measurements on panoramic radiographs (PANs) for sex determination in an Indonesian population using logistic regression. A cross-sectional study was conducted on 300 PANs from individuals aged over 20 years, with measurements performed by two observers. Statistical analysis included independent sample t-test and logistic regression, with performance evaluated based on accuracy values. The t-test revealed significant differences in both AGA and GA between sexes. However, logistic regression yielded accuracy rates of 58% for AGA and 60.3% for GA, indicating that these variables alone are insufficient for reliable sex determination in the Indonesian population using PANs. Future studies should explore the inclusion of additional anthropometric variables from PANs to enhance the accuracy of mandibular-based sex determination methods.
Co-Authors Bang, Vania Christina Budiono Dewi, Dian Puspita Difaputra, Syavergio Avia Firawan, Kurnia Nisa Putri Hermawan Istiadi Jauza, Nadifa Zakin Keshena, Jatu Rachel Oedijani Santoso Rebriarina Hapsari Retnoningrum, Dwi