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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN The Indonesian Biomedical Journal Journal of Dedicators Community Medica Hospitalia Journal of Telenursing (JOTING) Acta Odontologica Indonesia

Retnoningrum, Dwi

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Author-ID : 1082552

Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

Published : 9 Documents Claim Missing Document

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Articles

The Immunomodulatory Effect of Cinnamon (Cinnamomum Burmanii) Bark Extract On the C-Reactive Protein (CRP) Level, Leukocyte Count and Leukocyte Type Count of Wistar Rats Exposed to Staphylococcus Aureus Utomo, Astika Widy; Retnoningrum, Dwi; Gumay, Ainun Rahmasari
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2020): June 2020
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Introduction: Bacterial infection induces inflammation in human body. This process produceshumoral and cellular immune responses. Cinnamomum burmaniigrows very vast in Indonesia and contains cinnamaldehyde known to have an anti-inflammatory effect.Objective: To prove the effect of C. burmanii bark extract on CRP level, leukocyte count and differential blood count.Methods:Â Aposttest-only controlled group design with 25 Wistar Rats divided into 5 groups was employed. The CN-G group was giventhe standard feed, the CP-G group was given the standard feed and levamisole 2.5 mg/KgBW, while the CBE-100, CBE-200, and CBE-400 groups were respectively given the standard feed and cinnamon bark extract 100 mg/kgBW, 200 mg/KgBW and 400 mg/KgBW. The treatmentswereconducted for 7 consecutive days.On day 8, all rats were injected with the suspense of S. aureus intraperitoneally. The blood wasthen drawn on day 9, followed with CRP level measurement using the ELISA method. The total leukocyte count and differential blood count weremanually measured.Results:Â There is no significant difference in the value of CRP level (One Way ANOVA; p = 0.749) with the total counts of leukocytes(p=0.685), monocytes (p=0.769), and eosinophil(p=0.123) between groups. The neutrophils and lymphocytes of CBE-100 group aresignificantly differentfrom the other groups.Conclusion:Â C. burmanii extract has a potential benefit as immunomodulator.Â

Pemberian Edukasi Berbasis Multimedia terhadap Kemampuan Perawatan Diri Pasien Kanker Kolorectal dengan Stoma Retnoningrum, Dwi; Dahlia, Debie
Journal of Telenursing (JOTING) Vol 6 No 1 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i1.9431

This study aims to determine the effectiveness of providing multimedia-based education on self-care of colorectal cancer patients with stomas. The research method used was a systematic review on four databases, namely Pubmed, Science Direct, ProQuest and Scopus with the keywords "colorectal cancer" OR "patient with stoma", AND "stoma education" OR "stoma management education", AND "self care", OR "self management" with the inclusion criteria of colorectal cancer patients, age> 18 years, from 2013 to 2023. The number of initial search articles was 4377 articles with 8 articles used. The results of the study obtained 8 articles which were then analyzed. In conclusion, the use of multimedia with OMRE, MELP, video (DVD), audiovisual, telehealth and mobile health applications to provide stoma care education can have an effective effect in increasing knowledge and self-care. In addition, it also has an effect on improving psychosocial adaptation and quality of life in colorectal cancer patients with stomas. Keywords: Education, Stoma Care, Multimedia, Self Care

Pengaruh Ekstrak Daun Wungu Terhadap Luas Islet Pankreas Tikus Wistar Diabetes Melitus Excelinda, Tifanni; Istiadi, Hermawan; Retnoningrum, Dwi; Hendrianingtyas, Meita
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar Belakang : Diabetes melitus merupakan kumpulan gejala gangguan metabolik dengan prevalensi penyandang yang masih terus meningkat. Faktor lingkungan, gaya hidup, maupun genetik dapat menyebabkan kerusakan sel pankreas maupun resistensi insulin yang kemudian bermanifestasi sebagai diabetes melitus. Daun wungu (Graphytophyllum pictum (L.) Griff) mengandung metabolit aktif seperti flavonoid yang merupakan antioksidan untuk mencegah destruksi dan meregenerasi sel pankreas penderita diabetes melitus. Tujuan : Membuktikan adanya perbedaan ukuran luas islet pankreas tikus Wistar diabetes melitus yang mendapatkan ekstrak daun wungu (Graphtophyllum pictum (L.) Griff) setelah perlakuan dengan kontrol. Metode : Penelitian true experimental dengan menggunakan desain Post-Test Only Control Group Design. Sampel 24 ekor tikus Wistar jantan dengan kriteria tertentu dibagi secara acak menjadi 4 kelompok. Kontrol negatif (K-1) diberikan aloksan dan kelompok perlakuan 1 (K-2), perlakuan 2 (K-3), dan perlakuan 3 (K-4) masing-masing diberikan aloksan dan ekstrak daun wungu 50 mg/kgBB, 100 mg/kgBB, dan 200 mg/kgBB. Glukosa darah diperiksa pada hari ke-4 untuk memastikan tikus sudah diabetes melitus dan dilanjutkan perlakuan selama 14 hari. Terminasi dan pengambilan organ dilakukan pada hari ke-15. Data berupa luas islet pankreas kemudian dianalisis menggunakan uji Kruskal-Wallis dan uji Mann-Whitney. Hasil: Berdasarkan uji Kruskal-Wallis didapatkan perbedaan luas islet pankreas yang bermakna (p = 0,000) antar kelompok. Pada uji Mann-Whitney didapatkan peningkatan luas islet pankreas yang signifikan (p = 0,000) pada seluruh kelompok perlakuan terhadap kontrol negatif. Rerata luas islet pankreas berbanding lurus dengan peningkatan dosis pemberian ekstrak daun wungu. Kesimpulan : Terdapat perbedaan ukuran luas islet pankreas yang signifikan pada seluruh kelompok perlakuan terhadap kontrol negatif. Kata Kunci : Daun wungu; luas islet pankreas; diabetes melitus

Pengaruh Ekstrak Daun Wungu Terhadap Kadar Malondialdehid Darah Pada Tikus Diabetes Militus Elnitiarta, Jasmine; Istiadi, Hermawan; Hendrianingtyas, Meita; Retnoningrum, Dwi
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar Belakang: Diabetes melitus (DM) merupakan penyakit kronik dengan gejala glukosa darah yang tinggi (hyperglycaemia) dimana terjadi peningkatan biomarker stress oksidatif yaitu MDA. Daun wungu (Graptophyllum pictum (L.) Griff) memiliki alkaloid dan flavonoid yang bersifat antioksidan untuk mengurangi radikal bebas.Tujuan: Mengetahui pengaruh ekstrak daun wungu (Graptophyllum pictum (L.) Griff) terhadap kadar malondialdehid darah pada tikus Wistar yang diinduksi aloksan.Metode: Desain percobaan menggunakan post-test only control group design. Penelitian ini menggunakan tikus wistar jantan sebanyak 24 ekor yang dibagi menjadi 6 tikus setiap kelompok. Kelompok kontrol negatif diberikan aloksan, kelompok perlakuan 1, kelompok perlakuan 2, dan kelompok perlakuan 3 diberikan ekstrak daun wungu dengan dosis 50, 100 dan 200 mg/kgBB peroral kemudian kadar glukosa darah diperiksa untuk memastikan bahwa tikus sudah diabetes melitus. Setelah tikus diabetes melitus, dilakukan tindakan tiap kelompok. Pada hari ke-14 tikus diambil data kadar malondialdehid darahnya. Data diuji dengan uji normalitas Saphiro-Wilk. Pada penelitian ini data terdistribusi normal (p>0.05) sehingga dilakukan uji ANOVA kemudian dilakukan uji post-hoc. Hasil: Didapatkan penurunan kadar MDA darah pada tikus yang diberikan daun wungu. Hasil signifikan didapatkan antara kelompok perlakuan 3 dengan kelompok kontrol negatif dan kelompok perlakuan lainnya. Kesimpulan: Daun wungu dengan berbagai dosis dapat menurunkan kadar malondialdehid darah pada tikus DM.

POLA PEMBERIAN ANTIBIOTIK DI ERA PANDEMI COVID-19 (STUDI KASUS DI RUMAH SAKIT NASIONAL DIPONEGORO) Putra, Dominikus Evano; Pramudo, Setyo Gundi; Arkhaesi, Nahwa; Retnoningrum, Dwi
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Background: Inappropriate use of antibiotics could increase the incidence of antibiotic resistance, hence increasing morbidity, mortality, and health cost. WHO has recommended to conduct a study of rational use of antibiotics in order to overcome this problem. Aim: To analyze the quality and quantity of antibiotic use in inpatient care facility at Diponegoro National Hospital (RSND). Methods: Quality and quantity assessment conducted by the use of DDD/100 patient–days and the Gyssens criteria. The study was conducted retrospectively at 86 patients’ medical records that were obtained by consecutive sampling method. Results: There were 141 antibiotics prescriptions from 86 medical records. Azithromycin, levofloxacin, and ceftriaxone were the most commonly used and had 48,12; 44,01; and 21,13 DDD/100 patient–days. By Gyssens crieteria, 35,4% of antibiotic usage was appropriate, 51,1% of antibiotic usage was inappropriate, and 13,5% no indication of the use of antibiotic. Based on the type of therapy, ADE 89,4% and ADET 10,6%. Conclusion: In terms of quantity, the most commonly used antibiotic was azithromycin. In terms of quality, 35,4% antibiotic were used appropriately according to Gyssens criteria. Keywords: Antibiotic usage; internal medicine; DDD/100 patient–days; Gyssens criteria

Penyuluhan Osteoporosis dalam Upaya Pencegahan Komplikasi Tulang pada Pasien Talasemia Mayor di Kabupaten Rembang dan Grobogan Widyastiti, Nyoman Suci; Retnoningrum, Dwi; Ariosta, Ariosta; Nency, Yetty Movieta; Ngestiningsih, Dwi; Partiwi, Rina; Muniroh, Muflihatul; Naviati, Elsa; Afriana, Rizky Dyas
Journal of Dedicators Community Vol 7, No 3 (2023)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34001/jdc.v7i3.3577

Background Osteoporosis is a complication that often occurs in thalassemia major patients. This complication is still not widely known. This community service program aims to increase the knowledge of families of major thalassemia patients in Rembang Regency and Grobogan Regency regarding the complications of osteoporosis in thalassemia patients. Methods Education about osteoporosis, risk of osteoporosis in thalassemia patients, and prevention of osteoporosis. Extension method with presentation and discussion. The activity was attended by 20 thalassemia families in the Rembang Regency and 21 families of thalassemia patients in the Grobogan Regency. Before and after counseling, pretest and posttest questionnaires were completed to measure the knowledge of families of thalassemia major patients regarding bone complications in thalassemia patients. Results and Discussion Nearly half (46.34%) of respondents did not know the risk of osteoporosis in thalassemia. After counseling, 82.93% of respondents knew the risk of osteoporosis in thalassemia, but there were still 17.07% of respondents who still did not know this risk. Conclusion There is a significant increase in family knowledge of thalassemia major patients about the risk of osteoporosis in thalassemia. Further efforts to increase knowledge are needed with written information media (leaflets) given to families of thalassemia major patients

The Difference between Salivary Viscosity and Salivary Flow Rate on Nicotine Electric Smokers and Non-Smokers Difaputra, Syavergio Avia; Kusuma, Ira Anggar; Dewi, Dian Puspita; Retnoningrum, Dwi
Acta Odontologica Indonesia Vol 1, No 2 (2025): December Edition
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/actodont.27232

Background: Electric cigarette which contained nicotine affected bad impact to oral cavity, since the nicotine contained on e-liquid electric cigarette could reduce function of salivary gland. This condition decreases the salivary flow rate and increase salivary viscosity. could impact to less activity of self-cleansing and antimicrobial of saliva. Objectives: To prove the difference of salivary viscosity and salivary flow rate on nicotine electric smokers and non-smokers. Methods: This research was an analytic descriptive research which exerted cross sectional research design. As many as 60 people were selected to be the research subjects who were then divided into 30 electric smokers and 30 non-smokers. The saliva on each subject was collected in a beaker cup stimulated for 8 minutes, and continued to the viscosity measurement to be valued both visually and subjectively. The data was analyzed through Mann-Whitney test to identify the difference between viscosity and salivary flow rate on nicotine electric smokers and non-smokers. Results: The result of Mann-Whitney test showed a significant difference between salivary flow rate (p<0,05) and salivary viscosity of nicotine electric smokers and non-smokers (p<0,05). Conclusion: This research indicated the difference of viscosity and salivary flow rate between electric smokers and non-smokers. The electric smokers have thicker viscosity and lower flow rate compared to the non-smokers.

Insulin-like Growth Factor-1 and Calcium Ion Levels are Negatively Associated with Serum β-Cross Laps in Multi-transfused β-thalassemia Major Patients Widodo, Sabar; Widyastiti, Nyoman Suci; Limijadi, Edward Kurnia Setiawan; Hendrianingtyas, Meita; Retnoningrum, Dwi; Ariosta, Ariosta; Nency, Yetty Movieta
The Indonesian Biomedical Journal Vol 17, No 4 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i4.3706

BACKGROUND: Thalassemia patients with repeated transfusions (multi-transfusion) are often at risk of experiencing early osteoporosis. Several studies have demonstrated that osteoporosis in these individuals was associated with altered bone remodeling, characterized by decreased insulin-like growth factor-1 (IGF-1) and serum calcium ions, as well as increased serum β-Cross Laps (β-CTx) levels. Despite the prevalence of this condition, there is limited literature on the relationship between IGF-1 levels and calcium ions with β-CTx. Therefore, this study was conducted to examine the relationship between IGF-1 and calcium ions levels with serum β-CTx in multi-transfused β-thalassemia major patients.METHODS: A cross sectional study involved 29 thalassemia patients with multiple transfusions, aged 2-18 years, that were selected from the electronic medical records. Calcium ion levels were examined using ion selective electrode method. Subsequently, IGF-1 and serum β-CTx levels were examined by enzyme-linked immunosorbent assay (ELISA), and the data were analyzed using the Pearson correlation test.RESULTS: The results showed that the mean serum IGF-1 levels, calcium ion, and β-CTx were 20.11±20.763 ng/mL, 1.26±0.07 mmol/L, and 9330.40±1696.76 ng/mL, respectively. Statistical analysis showed a significant relationship between the levels of IGF-1 (r=-0.573; p=0.001) and calcium ion (r=-0.373; p=0.046) with serum β-CTx. A moderate negative relationship was found between IGF-1 levels and β-CTx, while calcium ion levels and β-CTx showed a weak negative relationship.CONCLUSION: A moderate negative correlation between IGF-1 and serum β-CTx, and a weak negative correlation between calcium ion and serum β-CTx suggest that IGF-1 and calcium ions may serve as potential indicators of bone turnover and osteoporosis risk in multi-transfused β-thalassemia major patients, underscoring their potential role in routine clinical evaluations.KEYWORDS: miR-200a expression, NO level, early-onset preeclampsia, late-onset preeclampsia

Lycopene Enhances the Beta Cell Capacity and Antihyperlipidemic Effects of Metformin on Type 2 Diabetic Rats Nugroho, Heri; Sianturi, Medina; Retnoningrum, Dwi; Susiloningsih, Neni
The Indonesian Biomedical Journal Vol 16, No 3 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i3.2989

BACKGROUND: Hyperglycemia causes dyslipidemia in type 2 diabetes mellitus (T2DM). Metformin monotherapy is known to be less effective at improving glycemic status, insulin function, and lipid profiles. Lycopene is a potential antioxidant and has been shown to be hypoglycemic and hypocholesterolemic. However, the effects lycopene and metformin combination are still up for debate. This study was conducted to determine the potential of lycopene in enhancing the ability of metformin to improve glycemic status, insulin resistance, beta cell capacity, and lipid profile of T2DM rats.METHODS: Thirty male Wistar rats were randomly divided into six groups: control (N), T2DM-untreated (D), T2DM + metformin (DM), T2DM + metformin + 10 mg/kgBW lycopene (DMLy-10), T2DM + metformin + 20 mg/kgBW lycopene (DMLy-20), and T2DM + metformin + 40 mg/kgBW lycopene (DMLy-40). The treatment was administered once daily through oral route and lasted for 28 days, before blood samples were collected. Fasting blood glucose (FBG) was assessed by oxidase-peroxidase method, fasting serum insulin and HbA1c were measured using enzyme-linked immunosorbent assay (ELISA), while lipid profile was determined using enzymatic methods. The homeostatic model assessment for insulin resistance (Homa-IR) as well as the homeostatic model evaluation of β-cell function (Homa-B) were then calculated.RESULTS: Fasting serum insulin levels increased significantly (p<10.05) in the DMLy-20 and DMLy-40 groups, but Homa-B or high-density lipoprotein (HDL) did not significantly increase. Additionally, the FBG, HbA1c, Homa-IR, total cholesterol, triglyceride, and low-density lipoprotein levels were not significantly decreased than in the group treated with metformin alone.CONCLUSION: Lycopene can enhance the ability of metformin to improve the glycemic status, insulin resistance, beta-cell capacity, and lipid profile of T2DM rats.KEYWORDS: dyslipidemia, Homa-B, insulin resistance, lycopene, metformin, type 2 diabetes mellitus

Co-Authors Afriana, Rizky Dyas Ainun Rahmasari Gumay, Ainun Rahmasari Ariosta Ariosta Astika Widy Utomo, Astika Widy Dahlia, Debie - Dewi, Dian Puspita Difaputra, Syavergio Avia Djuara P Lubis Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Elnitiarta, Jasmine Elsa Naviati Excelinda, Tifanni Heri Nugroho Hermawan Istiadi Kusuma, Ira Anggar Medina Sianturi Meita Hendrianingtyas Muniroh, Muflihatul Nahwa Arkhaesi Nyoman Suci Widyastiti Partiwi, Rina Pramudo, Setyo Gundi Putra, Dominikus Evano Susiloningsih, Neni Widodo, Sabar Yetty Movieta Nency, Yetty Movieta

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