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All Journal Majalah Patologi Indonesia Indian Journal of Forensic Medicine & Toxicology MEDICINUS The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Ambar Mudigdo
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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 1 
Peutz Jeghers Syndrome in 47 Years Old Woman (Histopathological Review) : Case Report Danu Yuliarto; Prasetyadi Mawardi; Ambar Mudigdo
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16835

Abstract

Background: Peutz-Jeghers syndrome (PJS) is an autosomal dominant inherited disorder, characterizedby intestinal hamartoma polyps in association with distinct patterns of skin and mucosal macular melanindeposition. Patients with PJS have a 15-fold increased risk of developing bowel cancer compared to thegeneral population.Case: A 47-year-old woman complained of black patches appearing on the lower and upper lips. Severalmonths ago, the patient said that black patches appeared on the gums and inner cheeks. Gastrointestinalcomplaints such as nausea or vomiting were previously denied. Dermatological examination in the oriset ginggiva et buccalis region showed multiple well-defined hyperpigmented macules. Histopathologicalexamination found an increase of melanocytes in the stratum basale with rows of melanocytes. Patienthad an endoscopy in the gastrointestinal tract and histopathological examination of the colonic mucosa, noabnormalities were found and no signs of malignancy were found on histopathological examination.Conclusion: Result of histopathological examination showed an increase in the number of melanocytesin the stratum basale with lined melanocytes. Based on histopathological examination in this patient moreleads to the diagnosis of PJS
Ekspresi Faktor Antiangiogenesis Thrombospondin-1 (TSP-1) dan Angiostatin Kanker Payudara Invasif Ambar Mudigdo; Dyah Ratna Budiani
Majalah Patologi Indonesia Vol 24 No 3 (2015): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.544 KB)

Abstract

Background Angiogenesis is one of the characteristics of malignant cancer cells. Angiogenesis activity considered as one of many determinants of prognosis of invasive breast cancer. The body has endogenous factors that act as antiangiogenesis, such as thrombospondin-1 (TSP1) and angiostatin. TSP1 is an antiangiogenesis factor that is dependent on wild-type p53. TSP-1 expression is induced by the transcription factor p53 WT. In some breast malignancies occurs mutations in the p53 gene, so TSP1 can not be expressed. The absence of TSP1 expected to bring a worse prognosis. Study of antiangiogenesis protein expression is expected to be used as an indicator of prognosis in breast cancer invasive ductal mammary carcinoma which divided into four sub-types: luminal A; luminal B; Her2 (over-expression) and triple negative/basal-like. This study is to analyzed TSP-1 and angiostatin of invasive breast cancer. Methods A total of 20 paraffin blocks of breast cancer tissue invasive ductal carcinoma from Pathology Anatomy RS Dr. Moewardi in 2013 were divided into four groups based on the expression status of estrogen receptors, progesterone receptors and Her2/neu as follows: luminal A subtype (ER+/PR+/Her2 negative); sub-type luminal B (ER-/PR and Her2 positive); Her2 over expression subtype (ER-/PR-/Her2 over-expression); and triple negative subtypes (basal-like tumors). Technique immunohistochemical ABC (avidin-biotin complex) used in special stains to measure the expression of TSP-1 and angiostatin, using monoclonal antibodies anti-human TSP-1 and anti-human angiostatin. Expression values are expressed in scale IDS, with a value range 0 to IDS 300. Analysis of the data used is difference test paired between groups (p
Histopathology of Helicobacter pylori in Chronic Dyspepsia Patients Wildan Nur; Paulus Kusnanto; Triyanta Yuli Pramana; Michael Tantoro Harnomo; Oyong Oyong; Ambar Mudigdo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 3, Desember 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (341.801 KB) | DOI: 10.24871/1332012161-165

Abstract

ABSTRACTBackground: Helicobacter pylori (H. pylori) are the most common infection found in dyspepsia cases. This infection is almost always found in digestive tract inflammation and commonly develops into chronic gastritis. Meanwhile, chronic gastritis is a condition assumed as the early event in pathological abnormalities of the stomach which finally may develop into carcinoma of the gaster. In Indonesia, data describing the incidence of H. pylori infection based on the histopathological appearance, location of specimen collection, inflammatory degree, and age of chronic dyspepsia patients is not yet available. The aim of this study is to determine the incidence of H. pylori based on histopathology appearance in chronic dyspepsia patients in Moewardi Hospital Surakarta.Method: This study is a cross sectional descriptive study by performing endoscopy-biopsy and histopathology examination to chronic dyspepsia patients who came to Gastroenterohepatology Clinic, Department of Internal Medicine, Moewardi Hospital, Surakarta on 1 January 2009 - 31 December 2010.Results: More than 90% subjects were 40 year old with the distribution of majority patients were 46-55 year old (32.43%). The most commonly found endoscopic appearance in subjects with positive H. pylori was superficial chronic gastritis (81.08%) with mild inflammatory degree (64.86%) and majority located in the antrum 97.3%.Conclusion: The proporsion of H. pylori infection in male and female was almost equal and was mostly found in the age group of 46-55 year old. This infection frequently happens in chronic dyspepsia who has histopathologic appearance of superficial chronic gastritis with mild inflammatory degree in the antrum area. Keywords: Helicobacter pylori, superficial chronic gastritis, age
Tinjauan Histopatologi pada Pyoderma Gangrenosum dengan Infeksi Sekunder Wibisono Nugraha; Danu Yuliarto; Eka Devinta Novi Diana; Alfina Rahma; Prasetyadi Mawardi; Frieda; Ambar Mudigdo
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.123

Abstract

Background: Pyoderma gangrenosum (PG) is a complex neutrophilic dermatosis, characterized by sterile, painful, necrotic ulcer, and is associated with systemic conditions. PG manifests as papules and vesicles that evolve into painful ulcers. Incidence of PG is relatively rare in Dr. Moewardi Hospital, so it is important to identify and correctly diagnose PG based on its’ histopathological features. Case A 54-year-old man complained of painful scab on several body parts. Hematoxylin and eosin staining in the epidermal layer showed a basket-weave orthokeratosis with necrotic tissue, acanthosis, and basal cell hypermelanosis. In the dermis layer there is a lymphocyte and neutrophil cell infiltrate with slight appearance of leukocytoclastic. Discussion: Pyoderma gangrenosum is a reactive, non-infectious inflammatory dermatosis (neutrophilic dermatoses). In this case, PG occurs in 54-year-old man as painful scab on back and legs. Classical PG characterized by papules, pustules, crusted or necrotic plaque, which typically have undermined, overhanging, dusky purple edges with surrounding induration and erythema. In this patient, the epidermal layer showed ulceration and slight appearance of leukocytoclastic vasculitis in the dermis area and lymphocyte infiltrate with slight neutrophil in the perivascular accompanied by erythrocyte extravasation, which support the diagnosis of PG.
Co-Authors Alfina Rahma Danu Yuliarto Dyah Ratna Budiani Eka Devinta Novi Diana Frieda Michael Tantoro Harnomo Oyong Oyong Paulus Kusnanto Prasetyadi Mawardi Triyanta Yuli Pramana Wibisono Nugraha Wildan Nur