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All Journal Majalah Obstetri dan Ginekologi Homeostasis: Jurnal Mahasiswa Pendidikan Dokter Indonesian Journal of Case Reports
Yuseran, Hariadi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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PERBEDAAN NILAI MCV DAN MCHC PADA PASIEN KANKER OVARIUM DENGAN DAN TANPA KEMOTERAPI DI RSUD ULIN BANJARMASIN Putri, Ajeng Alifia; Yuseran, Hariadi; Aflanie, Iwan
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11444

Abstract

The ovary is one of the female reproductive organs which is where the egg or ovum is produced. Ovarian cancer is a gynecological malignancy that can arise from disorders of the ovarian epithelial cells. The treatment that is often used to treat ovarian cancer is chemotherapy. Chemotherapy can improve the clinical condition of ovarian cancer patients. Erythrocyte indices like Mean Corpuscular Volume (MCV) and Mean Corpuscular Hemoglobin Concentration (MCHC) can be used to examine anemia and chemotherapy. Between January and December 2021, the aim of this study was to compare the MCV and MCHC values of ovarian cancer patients receiving and not receiving chemotherapy at Ulin Banjarmasin General Hospital. An analytical observational study with a crosssectional design was used for the research design. According to the findings of the study, only 54 of the 110 study participants met the inclusion criteria at Ulin Hospital, Banjarmasin's medical record installation. The unpaired t-test was used for the analysis.  The results showed that the mean MCV values with and without chemotherapy were 86,8±3,8 fl and 81,4±7,5 fl (p<0,05), and the mean MCHC values without chemotherapy were 32,5±1,2 g/dl and 31,6±1,3 g/dl (p<0,05). It can be concluded that there are differences in MCV and MCHC values in ovarian cancer patients with and without chemotherapy.
PERBEDAAN KADAR UREUM DAN KREATININ PADA PREEKLAMPSIA DAN PREEKLAMPSIA BERAT Annisa, Haima; Yuseran, Hariadi; Hendriyono, Fransiskus Xaverius; Abimanyu, Bambang; Devi, Wivina Riza
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12379

Abstract

Abstract: Preeclampsia is pregnancy disorder (>20 weeks) characterized by hypertension with or without proteinuria. Failure trophoblast invasion in preeclampsia results impaired spiral artery remodeling, hypoxia, placental ischemia, endothelial dysfunction and kidney dysfunction. Kidney dysfunction cause urea and creatinine increase. This research aims determine the difference in urea and creatinine of preeclampsia versus severe preeclampsia at RSUD Ulin Banjarmasin 2020-2022. Analytical observational, retrospective cross-sectional. There were 60 preeclampsia and severe preeclampsia subjects at RSUD Ulin 2020-2022 according inclusion and exclusion criteria, non-probability sampling. Research results for median preeclampsia urea 13.0 mg/dL, minimum value 5.0 mg/dL, maximum value 75.0 mg/dL and median severe preeclampsia 30 mg/dL, minimum value 9.0 mg/dL, maximum value 100 mg/dL. Median preeclampsia creatinine 0.6 mg/dL, minimum value 0.14, maximum value 1.51 mg/dL and mean severe preeclampsia 1.0 mg/dL, standard deviation 0.41 mg/dL. There is significant difference in urea and creatinine in preeclampsia and severe preeclampsia, p=0.000 and p=0.001. Keywords: preeclampsia, severe preeclampsia, ureum, creatinine, RSUD Ulin Banjarmasin. Abstrak: Preeklampsia merupakan kelainan kehamilan (>20 minggu) ditandai hipertensi dengan atau tanpa proteinuria. Gagalnya invasi trofoblas pada preeklampsia mengakibatkan gangguan remodeling arteri spiralis, hipoksia, iskemia plasenta, disfungsi endotel dan berakhir pada disfungsi ginjal. Gangguan ginjal menyebabkan ureum dan kreatinin meningkat. Tujuan penelitian mengetahui perbedaan ureum dan kreatinin preeklampsia terhadap preeklampsia berat di RSUD Ulin Banjarmasin 2020-2022. Metode observasional analitik studi cross sectional retrospektif. Terdapat 60 subjek preeklampsia dan preeklampsia berat di RSUD Ulin Banjarmasin 2020-2022 sesuai kriteria inklusi dan eksklusi, teknik non-probability sampling. Hasil penelitian ureum preeklampsia median 13,0 mg/dL, nilai minimum 5,0 mg/dL, nilai maksimum 75,0 mg/dL dan preeklampsia berat median 30 mg/dL, nilai minimum 9,0 mg/dL, nilai maksimum 100 mg/dL. Kreatinin preeklampsia median 0,6 mg/dL, nilai minimum 0,14, nilai maksimum 1,51 mg/dL dan preeklampsia berat rerata 1,0 mg/dL, simpang baku 0,41 mg/dL. Kesimpulan: Terdapat perbedaan bermakna ureum dan kreatinin pada preeklampsia dan preeklampsia berat, nilai p=0,000 dan p=0,001. Kata-kata kunci: preeklampsia, preeklampsia berat, ureum, kreatinin, RSUD Ulin Banjarmasin
PERBEDAAN AKTIVITAS SGOT, SGPT DAN LDH PADA PREEKLAMPSIA DAN PREEKLAMPSIA BERAT Amelia, Fakhrina; Yuseran, Hariadi; Hendriyono, Fransiskus Xaverius; Abimanyu, Bambang; Devi, Wivina Riza
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12376

Abstract

Abstract: Preeclampsia is characterized by hypertension and proteinuria at gestational age >20 weeks. Preeclampsia occurs when endothelial dysfunction triggers organ damage, one of which is the liver. Cellular damage in the liver causes an increase in SGOT, SGPT and LDH. The research aims to determine whether there are differences in SGOT, SGPT and LDH activity in pregnant women with preeclampsia and severe preeclampsia. This type of research is an analytical observational, retrospective cross-sectional study. There were 60 subjects who met the inclusion criteria. Preeclampsia SGOT, SGPT and LDH activity had a median of 22 units/L, 12 units/L and 429 units/L, minimum values of 13 units/L, 3 units/L and 37 units/L, maximum values of 55 units/L, 53 units /L and 989 units/L. SGOT, SGPT and LDH activity in severe preeclampsia had a median of 61 units/L, 40 units/L and 811 units/L, minimum values of 41 units/L, 15 units/L and 402 units/L, maximum values of 1161 units/L, 977 units/L and 1756 units/L. Conclusion: There was a significant difference in SGOT, SGPT and LDH activity in preeclampsia and severe preeclampsia (p=0.000). Keywords: preeklampsia, severe preeklampsia, Serum Glutamic Oxaloacetic Transaminase, Serum Glutamic Pyruvic Transaminase, Lactate Dehydrogenase Abstrak: Preeklampsia ditandai hipertensi dan proteinuria pada usia kehamilan >20 minggu. Preeklampsia terjadi disfungsi endotel memicu terjadinya kerusakan organ salah satunya organ hati. Kerusakan seluler di hati menyebabkan peningkatan SGOT, SGPT dan LDH. Penelitian bertujuan mengetahui apakah terdapat perbedaan aktivitas SGOT, SGPT dan LDH pada ibu hamil preeklampsia dan preeklampsia berat. Jenis penelitian observasional analitik, studi cross sectional retrospektif. Didapatkan 60 subjek yang sesuai kriteria inklusi. Aktivitas SGOT, SGPT dan LDH preeklampsia mempunyai median 22 unit/L, 12 unit/L dan 429 unit/L, nilai minimum 13 unit/L, 3 unit/L dan 37 unit/L, nilai maksimum 55 unit/L, 53 unit/L dan 989 unit/L. Aktivitas SGOT, SGPT dan LDH preeklampsia berat mempunyai median 61 unit/L, 40 unit/L dan 811 unit/L, nilai minimum 41 unit/L, 15 unit/L dan 402 unit/L, nilai maksimum 1161 unit/L, 977 unit/L dan 1756 unit/L. Kesimpulan : didapatkan perbedaan bermakna aktivitas SGOT, SGPT dan LDH pada preeklampsia dan preeklampsia berat (p=0,000). Kata-kata kunci: preeklampsia, preeklampsia berat, Serum Glutamic Oxaloacetic Transaminase, Serum Glutamic Pyruvic Transaminase, Laktat Dehidrogenase
PERBEDAAN JUMLAH TROMBOSIT DAN PLR PADA PREEKLAMPSIA DAN PREEKLAMPSIA BERAT Dharagita, Putu Galuh; Yuseran, Hariadi; Hendriyono, Fransiskus Xaverius; Abimanyu, Bambang; Rosida, Azma
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12403

Abstract

Abstract: Preeclampsia is hypertension in pregnancy >20 weeks with ≥140/90 mmHg and proteinuria. Preeclampsia when trophoblast invasion fails, causing ischemia, damage to placental endothelium that triggers platelet aggregation. Excessive platelet activity reduces systemic platelet counts. The PLR describes platelet to lymphocyte ratio. Placental ischemia causing chronic inflammation. The general objective determined the difference platelet count and PLR in preeclampsia and severe preeclampsia at RSUD Ulin Banjarmasin. This research is observational analytical, cross sectional, non-probability sampling techniques. The results is 70 subjects with preeclampsia and severe preeclampsia according the inclusion criteria. It was found the mean platelet in preeclampsia 294.82 ± 97.65 thousand/µL and severe preeclampsia 231.80 ± 75.99 thousand/µL. The mean PLR in preeclampsia 176.76 ± 79. The median PLR for severe pre-eclampsia is 74.92, the minimum value 23.16, the maximum value 195.56. Conclusion: There were significant differences in platelet count and PLR in preeclampsia and severe preeclampsia (p=0.004; p=0.000). Keywords: Preeclampsia, severe Preeclampsia, Trombosit, PLR, Pregnant woman.  Abstrak: Preeklampsia adalah hipertensi dalam kehamilan (>20 minggu) dengan tekanan darah ≥140/90 mmHg dan disertai proteinuria. Preeklampsia ketika invasi trofoblas ke plasenta gagal, menyebabkan iskemia dan kerusakan endotel plasenta yang memicu agregasi trombosit. Aktivitas trombosit berlebihan menurunkan jumlah trombosit di sistemik. Jumlah PLR menjelaskan rasio trombosit dan limfosit absolut. Iskemia plasenta menghasilakan ketidakseimbangan fungsi kekebalan menyebabkan peradangan kronis. Tujuan umum mengetahui perbedaan jumlah trombosit dan PLR pada preeklampsia dan preeklampsia berat di RSUD Ulin Banjarmasin. Penelitian ini observasional analitik dengan cross sectional menggunakan teknik non-probability sampling. Hasil penelitian didapatkan 70 subjek dengan preeklampsia dan preeklampsia berat sesuai kriteria inklusi dan ekslusi. Didapatkan rerata jumlah trombosit pada preeklampsia 294,82±97,65 ribu/µL dan preeklampsia berat 231,80±75,99 ribu/µL. Rerata jumlah PLR pada preeklampsia 176,76±79. PLR preeklampsia berat median 74,92, nilai minimum 23,16 dan nilai maksimum 195,56. Kesimpulan: Didapatkan perbedaan bermakna jumlah trombosit dan PLR pada preeklampsia dan preeklampsia berat (p=0,004;p=0,000). Kata-kata kunci: Preeklampsia, Preeklampsia berat, Trombosit, PLR, Ibu hamil.
PERBEDAAN HEMATOKRIT MCV DAN MCHC PADA PREEKLAMPSIA DAN PREEKLAMPSIA BERAT Asie, Gracia Chika Medylona Eka; Yuseran, Hariadi; Hendriyono, Fransiskus Xaverius; Abimanyu, Bambang; Rosida, Azma
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12378

Abstract

Abstract: Preeclampsia is a condition of hypertension and proteinuria at gestational age >20 weeks. Preeclampsia causes endothelial dysfunction resulting in plasma extravasation and hemoconcentration, characterized by an increase in hematocrit. Erythrocytes swell, causing an increase in MCV and a decrease in MCHC. The aim of the research was to determine the differences between hematocrit, MCV and MCHC in preeclampsia versus severe preeclampsia at Ulin Hospital, Banjarmasin. Analytical observational research method, retrospective cross-sectional research design. Purposive sampling for the 2020-2022 period, using 60 subjects according to inclusion and exclusion criteria. Analysis used unpaired T test and Mann Whitney. The results showed that the mean hematocrit for preeclampsia was 36.05 ± 3.64% and severe preeclampsia was 38.89 ± 2.83%. The median MCV for preeclampsia was 84.25 fL, the minimum value was 67.40 fL and the maximum value was 92.20 fL and the median for severe preeclampsia was 88.10 fL, the minimum value was 77.70 fL and the maximum value was 94.20 fL. The mean MCHC for preeclampsia was 33.53±1.38 g/dl and severe preeclampsia 34.16±0.88 g/dl. It can be concluded that there is a significant difference between hematocrit, MCV and MCHC in pregnant women with preeclampsia and severe preeclampsia (p<0.05). Keywords: preeclampsia, severe preeclampsia, hematocrit, MCV, MCHC Abstrak: Preeklampsia merupakan kondisi adanya hipertensi dan proteinuria pada usia kehamilan >20 minggu. Preeklampsia menyebabkan disfungsi endotel sehingga terjadi ekstravasasi plasma dan terjadi hemokonsentrasi, ditandai peningkatan hematokrit. Eritrosit membengkak, menyebabkan peningkatan MCV dan penurunan MCHC. Tujuan penelitian mengetahui perbedaan hematokrit, MCV dan MCHC pada preeklampsia terhadap preeklampsia berat di RSUD Ulin Banjarmasin. Metode penelitian observasional analitik, desain penelitian cross sectional retrospektif. Pengambilan sampel purposive sampling periode 2020-2022, menggunakan 60 subjek sesuai kriteria inklusi dan eksklusi. Analisis menggunakan uji t-tidak berpasangan dan Mann Whitney. Hasil penelitian menunjukan rerata hematokrit preeklampsia 36,05±3,64% dan preeklampsia berat 38,89±2,83%. Median MCV preeklampsia 84,25 fL, nilai minimum 67,40 fL dan nilai maksimum 92,20 fL serta median preeklampsia berat 88,10 fL, nilai minimum 77,70 fL dan nilai maksimum 94,20 fL. Rerata MCHC preeklampsia 33,53±1,38 g/dl dan preeklampsia berat 34,16±0,88 g/dl. Dapat disimpulkan adanya perbedaan bermakna antara hematokrit, MCV dan MCHC pada ibu hamil dengan preeklampsia dan preeklampsia berat (p < 0,05). Kata-kata kunci: preeklampsia, preeklampsia berat, hematokrit, MCV, MCHC
Early diagnosis and appropriate management of vaginal leiomyoma in rural areas Nizomy, Ihya Ridlo; Budinurdjaja, Pribakti; Armanza, Ferry; Yuseran, Hariadi; Joyce; Lahdimawan, Inas Tsurayya Fauziah
Majalah Obstetri & Ginekologi Vol. 32 No. 1 (2024): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V32I12024.60-67

Abstract

HIGHLIGHTS Extrauterine leiomyoma, including vaginal leiomyoma, is an exceedingly rare condition with complex pathogenesis and management. Clinical evaluation and high-quality imaging are required to confirm the diagnosis of vaginal tumor. If there are insufficient facilities, referrals must be made. Operative management using vaginal approach was described for treating vaginal leiomyoma.   ABSTRACT Objective: To describe the challenges of early diagnosis and appropriate management of vaginal leiomyoma in rural areas. Case Report: A 26-year-old woman, P1A0, was referred from a rural hospital and presented a chief complaint of vaginal mass. The patient was admitted to the tertiary hospital with suspected malignant vaginal tumor and underwent a biopsy, which revealed leiomyoma on pathological examination. Despite conservative treatment, the mass continued to grow, unaffected by the menstrual cycle, causing discomfort. Following a second hospital admission, the patient underwent surgical management of extirpation and vaginal reconstruction. The microscopic finding of the tumor showed myositis cell proliferation with hyperplastic growth, monotonous nuclei, and variable cell shapes, supporting the diagnosis of vaginal leiomyoma. During postoperative monitoring, there was no vaginal bleeding. Thereafter, on the day following surgery, it was found that the right labium major was swollen. This was treated with anticoagulants, topical NSAIDs, and a sitz bath. The patient was discharged from the hospital in good condition and had an uneventful postoperative recovery. Conclusion: Although the incidence of vaginal leiomyoma is uncommon, precise early diagnosis and appropriate management might improve outcomes, particularly in rural areas.
Hope After Cancer: Pregnancy Outcomes Following Fertility-Sparing Surgery – A Case Report Marpaung, Richardo; Armanza, Ferry; Yuseran, Hariadi; Waluyo, Setyo Teguh; Salan, Yosef Dwi Cahyadi
Indonesian Journal of Case Reports Vol. 3 No. 1 (2025): June 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v3i1.260

Abstract

Pregnancy after diagnosis of ovarian cancer is a rare event. Ovarian Cancer is associated with difficulty in achieving pregnancy. Little is known about the mechanism of this condition due to limited literature and studies. In this paper, the authors report a rare case of successful pregnancy in a patient with ovarian cancer. Patient initially diagnosed with cystadenocarcinoma mucinous of the ovary, two years prior to pregnancy, and later diagnosed with suspected ovarian cancer in the third trimester. The patient was then treated with optimal debulking surgery and cesarean section at 35 weeks of pregnancy. The patient delivered a healthy baby girl. Debulking surgery was carried out, and the patient was scheduled for chemotherapy. The findings from this case conclude that patients with ovarian cancer who receive conservative surgical treatment could have successful pregnancy outcomes. The quality of the patient’s life should be a priority, and follow-up for further treatment is essential.
Co-Authors Abimanyu, Bambang Amelia, Fakhrina Annisa, Haima Asie, Gracia Chika Medylona Eka Azma Rosida, Azma Budinurdjaja, Pribakti Devi, Wivina Riza Dharagita, Putu Galuh Ferry Armanza, Ferry Hendriyono, Fransiskus Xaverius Ihya Ridlo Nizomy, Ihya Ridlo Iwan Aflanie Joyce Lahdimawan, Inas Tsurayya Fauziah Marpaung, Richardo Putri, Ajeng Alifia Salan, Yosef Dwi Cahyadi Waluyo, Setyo Teguh