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All Journal Berkala Kedokteran Majalah Obstetri dan Ginekologi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Homeostasis: Jurnal Mahasiswa Pendidikan Dokter Indonesian Journal of Case Reports
Ferry Armanza, Ferry
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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PERBANDINGAN TINGKAT REPRESENTATIF PEMERIKSAAN PAP SMEAR METODE KOMBINASI SPATULA AYRE–CYTOBRUSH DENGAN METODE CERVEX BRUSH Kusumawati, Erika; Rahardja, Suka Dwi; Armanza, Ferry
Jurnal Berkala Kedokteran Vol 10, No 1 (2014): Februari 2014
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i1.395

Abstract

ABSTRACT: One way of early detection for cervix cancer is the Pap smear. This study aim is to compare the level of representative Pap smear method using combiation Ayre spatula-cytobrush with cervex brush method. This study is a descriptive analytic study with cross sectional approach. 47 pieces of preparat were selected according to inclusion criteria over the period of January-September 2013. Representative results of Pap smear using the combination of Ayre spatula-cytobrush and the used of brush cervex were 36 (76.60%) and 40 (85.10%). The results of data analysis using the Wilcoxon test with 95% confidence level indicates no statistically significant difference between the use of a combination of Ayre spatula-cytobrush methods with cervex brush method, the value of p = 0.157 (p> 0.05). It can be concluded that the representative rate of Pap smear using a combination of Ayre spatula-cytobrush method is not better than cervex brush method. Keywords: Pap smear, ayre spatula, cytobrush, cervex brush  ABSTRAK: Salah satu cara deteksi dini kanker servik adalah pemeriksaan Pap smear. Penelitian ini bertujuan untuk membandingkan tingkat representatif pemeriksaan Pap smear metode kombinasi spatula ayre-cytobrush dengan metode cervex brush. Penelitian ini adalah penelitian deskriptif analitik dengan pendekatan cross sectional. Preparat penelitian sebanyak 47 buah dipilih sesuai kriteria inklusi pada periode bulan Januari – September 2013. Hasil representatif Pap smear menggunakan kombinasi spatula ayre-cytobrush yakni 36 (76,60%) dan yang menggunakan cervex brush sebanyak 40 (85,10%). Hasil analisis data menggunakan uji wilcoxon dengan tingkat kepercayaan 95% , didapatkan hasil bahwa tidak terdapat perbedaan yang bermakna secara statistik antara penggunaan metode kombinasi spatula ayre-cytobrush dengan metode cervex brush yaitu dengan nilai  p = 0,157 (p > 0,05). Dapat disimpulkan bahwa tingkat representatif pemeriksaan Pap smear menggunakan metode kombinasi spatula ayre-cytobrush tidak lebih baik dibandingkan metode cervex brush. Kata-kata kunci: Pap smear, spatula ayre, cytobrush, cervex brush
Serum Level of Vascular Endothelial Growth Factor (VEGF) can be used to Assess Response of Radiation Therapy in Cervical Cancer Armanza, Ferry
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.533 KB)

Abstract

Objective: To compare the sensitivity and specificity of Squamous Cell Carcinoma (SCC) and Vascular Endothelial Growth Factor (VEGF) levels to assess the response of radiation therapy. Method: The study was conducted by the method of analytic observational cohort study in 24 patients with cervical cancer stage II-B and III-B in RSCM that met inclusion criteria. Examination of VEGF and SCC in serum samples was performed in the Prodia Laboratory Jakarta. The examination was conducted twice before and after radiation therapy. The subjects were treated by radiation therapy/chemoradiation according to standard procedures. After the completion of radiation was declared, the response of radiation therapy was conducted by clinical assessment. Result: Of the 24 subjects, we obtained a mean level of SCC pre-radiation was 23.43 ± 5.84 ng/ml and post-radiation was 2.19 ± 0.68 ng/ml. The mean VEGF pre-radiation was 790.41 ± 111.06 pg/ml and post-radiation was 497.47 ± 79.26 pg/ml. ROC curves of each tumor marker obtained SCC pre-radiation AUC 40%, p 0.53 (CI 0.18-0.68) and SCC post-radiation AUC 48.1%, p 0.91 (CI 0.21-0,75) can not be used as a diagnostic and prognostic factors of response to radiation therapy. VEGF pre-radiation produced an AUC of 17.5%, p 0.04 (CI 0.00-0.36), thus cannot be used as a prognostic factor for response to radiation therapy. VEGF after radiation produced an AUC of 92.5%, p 0.01 (CI 0.81-1.00), thus can be a diagnostic factor for response to radiation therapy. VEGF post-radiation with cut-off point 614.75 pg/ml had a sensitivity 80%, specificity 75%, NDP 94.12%, NDN 42.86%; RKP 3.2; RKN 0.26 and accuracy 79.16%. There is a significant correlation between the decrease of serum VEGF level post-radiation and a positive response of radiation therapy (p 0.01, CI 1.00-3.23). Conclusion: Examination of VEGF levels can be used to assess the response of radiation therapy with a sensitivity of 80% and specificity of 75%. [Indones J Obstet Gynecol 2014; 2-1: 40-45] Keywords: cervical cancer, SCC, therapeutic response, VEGF
Serum Level of Vascular Endothelial Growth Factor (VEGF) can be used to Assess Response of Radiation Therapy in Cervical Cancer Armanza, Ferry; Andrijono, Andrijono; Sutrisna, Bambang
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.533 KB) | DOI: 10.32771/inajog.v2i1.378

Abstract

Objective: To compare the sensitivity and specificity of Squamous Cell Carcinoma (SCC) and Vascular Endothelial Growth Factor (VEGF) levels to assess the response of radiation therapy. Method: The study was conducted by the method of analytic observational cohort study in 24 patients with cervical cancer stage II-B and III-B in RSCM that met inclusion criteria. Examination of VEGF and SCC in serum samples was performed in the Prodia Laboratory Jakarta. The examination was conducted twice before and after radiation therapy. The subjects were treated by radiation therapy/chemoradiation according to standard procedures. After the completion of radiation was declared, the response of radiation therapy was conducted by clinical assessment. Result: Of the 24 subjects, we obtained a mean level of SCC pre-radiation was 23.43 ± 5.84 ng/ml and post-radiation was 2.19 ± 0.68 ng/ml. The mean VEGF pre-radiation was 790.41 ± 111.06 pg/ml and post-radiation was 497.47 ± 79.26 pg/ml. ROC curves of each tumor marker obtained SCC pre-radiation AUC 40%, p 0.53 (CI 0.18-0.68) and SCC post-radiation AUC 48.1%, p 0.91 (CI 0.21-0,75) can not be used as a diagnostic and prognostic factors of response to radiation therapy. VEGF pre-radiation produced an AUC of 17.5%, p 0.04 (CI 0.00-0.36), thus cannot be used as a prognostic factor for response to radiation therapy. VEGF after radiation produced an AUC of 92.5%, p 0.01 (CI 0.81-1.00), thus can be a diagnostic factor for response to radiation therapy. VEGF post-radiation with cut-off point 614.75 pg/ml had a sensitivity 80%, specificity 75%, NDP 94.12%, NDN 42.86%; RKP 3.2; RKN 0.26 and accuracy 79.16%. There is a significant correlation between the decrease of serum VEGF level post-radiation and a positive response of radiation therapy (p 0.01, CI 1.00-3.23). Conclusion: Examination of VEGF levels can be used to assess the response of radiation therapy with a sensitivity of 80% and specificity of 75%.  Keywords: cervical cancer, SCC, therapeutic response, VEGF
PERBEDAAN KADAR FERITIN PADA IBU HAMIL DENGAN COVID-19 TANPA DAN DISERTAI PREEKLAMPSIA Penelitian di RSUD Ulin Banjarmasin Periode Maret 2020- Periode Maret 2020-Februari 2022 Rahmatullah, Muhammad Ikhsan; Armanza, Ferry; Hendriyono, Fransiskus Xaverius; Aditya, Renny; Rahmiati, Rahmiati
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11459

Abstract

COVID-19 is an infectious disease which become a pandemic worldwide. Pregnant women are a vulnerable group infected with COVID-19. Ferritin is a marker of increased inflammation associated with the severity of COVID-19. Pregnant women with COVID-19 have a higher mortality than pregnant women without COVID-19. Low ferritin levels during 28-30 weeks of gestation are associated with a low incidence of preeclampsia. This study aims to determine whether there are significant feritin level difference in pregnant women with COVID-19 without and with preeclampsia. This type of research is analytic observational using a cross-sectional study design with retrospective data collection. The results of the study obtained 603 subjects, but only 63 subjects met the inclusion criteria. Pregnant women with COVID-19 without preeclampsia as 36 subjects were randomized thus obtained 27 subjects were pregnant women with COVID-19 without preeclampsia and 27 subjects were pregnant women with COVID-19 accompanied by preeclampsia. Pregnant women with COVID-19 without preeclampsia had a median 66 ng/mL with a minimum value 1 ng/mL and a maximum value 951 ng/mL and pregnant women with COVID-19 accompanied by preeclampsia had a median 55 ng/mL with a minimum value 2 ng/mL and a maximum value 1.112 ng/mL. The conclusion of this study was that there was no significant feritin level difference in pregnant women with COVID-19 without and with preeclampsia with p=0.924.
PROFIL URINALISIS PASIEN HIPERTENSI DALAM KEHAMILAN Di Bagian Obstetri dan Ginekologi RSUD Ulin Banjarmasin Periode Juni 2021-Mei 2022 Iman, Muhammad Nur; Nizomy, Ihya Ridlo; Rosida, Azma; Armanza, Ferry; Hendriyono, Franciscus Xaverius
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11460

Abstract

Hypertension disorders in pregnancy (HDP) is one of the most common complications in pregnancy forming a triad along with bleeding and infection which are the main causes of maternal and prenatal morbidity and mortality. Urinalysis examination is one of the important laboratory tests in the diagnosis of HDP, especially to identify the presence of preeclampsia which can lead to eclampsia. Through urinalysis it can be seen the presence of protein in the urine which is one of the diagnostic criteria for preeclampsia-eclampsia and assessing kidney function during pregnancy. The purpose of this study was to determine the urinalysis profile of hypertensive patients in pregnancy. This study used an observational research design with a cross-sectional approach, using secondary data from medical records. This study used the entire population according to the inclusion and exclusion criteria. The subjects of this study were 69 patients. The results showed that preeclampsia was the most common type of HDP, namely 122 people (59.2%). Based on the results of urinalysis in Preeclampsia, the results of urinalysis that showed the most positive results were proteinuria, namely Trace 4 people (9.8%), 1+ 10 people (24.4%), 2+ 10 people (24.4%), and 3+ 4 people (9.8%). Whereas in Preeclampsia Superimposed Hypertension showed the same results where proteinuria was the most positive, namely Trace 1 people (5.9%), 1+ 3 people (17.6%), and 2+ 8 people (47.1%).
PERBEDAAN RASIO NEUTROFIL-LIMFOSIT DAN C-REACTIVE PROTEIN PADA IBU HAMIL DENGAN COVID-19 TANPA DAN DISERTAI PREEKLAMPSIA Penelitian di RSUD Ulin Banjarmasin Periode Maret 2020 - Periode Maret 2020-Februari 2022 Qaedi, Muhammad Bari Nur; Armanza, Ferry; Hendriyono, Fransiskus Xaverius; Aditya, Renny; Rahmiati, Rahmiati
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11456

Abstract

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. Pregnant women are vulnerable to COVID-19. Preeclampsia is a complication in pregnant women characterized by hypertension at > 20 weeks of gestation and proteinuria. The Neutrophils Lymphocyte Ratio and C-Reactive Protein is a marker of inflammation related to disease severity. Elevated NLR and CRP are associated with COVID-19 and preeclampsia. The study aims to determine whether there are significant differences in NLR values or CRP levels for pregnant women with COVID-19 without and with preeclampsia. This type of research is analytic observational using a retrospective cross-sectional study. The results of the study were 603 subjects, 70 subjects met the inclusion criteria. Subjects of pregnant women with COVID-19 without preeclampsia were randomized, obtained 30 subjects of pregnant women with COVID-19 without preeclampsia and 30 subjects accompanied by preeclampsia. The NLR value of pregnant women with COVID-19 without preeclampsia had a median of 5.57, a minimum value of 1.90 and a maximum value of 30.38. Those accompanied by preeclampsia had a median of 5.13, a minimum value of 2.04 and a maximum value of 18.10. CRP levels of pregnant women with COVID-19 without preeclampsia had a median of 45.2 mg/L, a minimum value of 2.0 mg/L and a maximum value of 240.0 mg/L. Those accompanied by preeclampsia had a median of 50.4 mg/L, a minimum value of 2.6 mg/L and a maximum value of 318.1 mg/L. Conclusion: there was no significant difference in NLR values or CRP levels in pregnant women with COVID-19 without and with preeclampsia (p=0.631, p=0.478).
Early diagnosis and appropriate management of vaginal leiomyoma in rural areas Nizomy, Ihya Ridlo; Budinurdjaja, Pribakti; Armanza, Ferry; Yuseran, Hariadi; Joyce; Lahdimawan, Inas Tsurayya Fauziah
Majalah Obstetri & Ginekologi Vol. 32 No. 1 (2024): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V32I12024.60-67

Abstract

HIGHLIGHTS Extrauterine leiomyoma, including vaginal leiomyoma, is an exceedingly rare condition with complex pathogenesis and management. Clinical evaluation and high-quality imaging are required to confirm the diagnosis of vaginal tumor. If there are insufficient facilities, referrals must be made. Operative management using vaginal approach was described for treating vaginal leiomyoma.   ABSTRACT Objective: To describe the challenges of early diagnosis and appropriate management of vaginal leiomyoma in rural areas. Case Report: A 26-year-old woman, P1A0, was referred from a rural hospital and presented a chief complaint of vaginal mass. The patient was admitted to the tertiary hospital with suspected malignant vaginal tumor and underwent a biopsy, which revealed leiomyoma on pathological examination. Despite conservative treatment, the mass continued to grow, unaffected by the menstrual cycle, causing discomfort. Following a second hospital admission, the patient underwent surgical management of extirpation and vaginal reconstruction. The microscopic finding of the tumor showed myositis cell proliferation with hyperplastic growth, monotonous nuclei, and variable cell shapes, supporting the diagnosis of vaginal leiomyoma. During postoperative monitoring, there was no vaginal bleeding. Thereafter, on the day following surgery, it was found that the right labium major was swollen. This was treated with anticoagulants, topical NSAIDs, and a sitz bath. The patient was discharged from the hospital in good condition and had an uneventful postoperative recovery. Conclusion: Although the incidence of vaginal leiomyoma is uncommon, precise early diagnosis and appropriate management might improve outcomes, particularly in rural areas.
Hope After Cancer: Pregnancy Outcomes Following Fertility-Sparing Surgery – A Case Report Marpaung, Richardo; Armanza, Ferry; Yuseran, Hariadi; Waluyo, Setyo Teguh; Salan, Yosef Dwi Cahyadi
Indonesian Journal of Case Reports Vol. 3 No. 1 (2025): June 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v3i1.260

Abstract

Pregnancy after diagnosis of ovarian cancer is a rare event. Ovarian Cancer is associated with difficulty in achieving pregnancy. Little is known about the mechanism of this condition due to limited literature and studies. In this paper, the authors report a rare case of successful pregnancy in a patient with ovarian cancer. Patient initially diagnosed with cystadenocarcinoma mucinous of the ovary, two years prior to pregnancy, and later diagnosed with suspected ovarian cancer in the third trimester. The patient was then treated with optimal debulking surgery and cesarean section at 35 weeks of pregnancy. The patient delivered a healthy baby girl. Debulking surgery was carried out, and the patient was scheduled for chemotherapy. The findings from this case conclude that patients with ovarian cancer who receive conservative surgical treatment could have successful pregnancy outcomes. The quality of the patient’s life should be a priority, and follow-up for further treatment is essential.
Co-Authors Andrijono Andrijono Azma Rosida, Azma Bambang Sutrisna Budinurdjaja, Pribakti Erika Kusumawati Hendriyono, Franciscus Xaverius Hendriyono, Fransiskus Xaverius Ihya Ridlo Nizomy, Ihya Ridlo Iman, Muhammad Nur Joyce Lahdimawan, Inas Tsurayya Fauziah Marpaung, Richardo Qaedi, Muhammad Bari Nur Rahmatullah, Muhammad Ikhsan Rahmiati Rahmiati Renny Aditya Salan, Yosef Dwi Cahyadi Suka Dwi Rahardja, Suka Dwi Waluyo, Setyo Teguh Yuseran, Hariadi