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All Journal Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Journal of Islamic Medicine Farmasis: Jurnal Sains Farmasi
Meilina Ratna Dianti
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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THE EFFECT OF GINGER RHIZOMES (Curcuma xanthorriza Roxb.) TOWARDS THE NUMBER OF OVARIAN FOLLICLES OF FEMALE MICE (Mus musculus) EXPOSED TO MONOSODIUM GLUTAMAT (MSG) Dianti, Meilina Ratna
Journal of Islamic Pharmacy Vol 2, No 1 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i1.4245

Abstract

Monosodium Glutamat activates an axis ablation in arcuate nucleus hypothalamus which happens to possibly initiate malfunctions in Hipothalamic Pituitary Adrenal axis. Yet, it is known that hypothalamus produces Gonadotropin Releasing Hormone which is able to stimulate the secretion of Gonadotropin Follicle Stimulating Hormon and Luteinizing Hormone from the anterior pituitary gland. These two hormones, however, are essentials for the development of gonad and during the cycles of oogenesis. Hence, any malfunctions resided in the human’s hypothalamus can possibly put endocrine gland into troubles, such as reproduction hormones which affect the workings of gonad. Therefore, the extract of Temulawak is promoted to be the attempt to resolve the issue for its antioxidant properties. Temulawak extract contains antioxidant, properties for as much as 87.01 ppm, according to Rosidi research’s result, analyzing the Temulawak’s potentials. The amount of antioxidant found Temulawak extract is categorized as active and applicable as natural antioxidant source. However, this research adopts true experimental post-test only control group design. It includes 5 (five) groups of female mice as which are K1 (CMC), K2 (CMC+MSG), P1 (MSG+0.4 mg Temulawak extract), P2 (MSG+0.8 MG Temulawak extract), P3 (MSG+1.2 mg Temulawak extract). In addition, the mice’s ovaries are removed to be subsequently tested using Hematoxillin-Eosin and the ovaries’ follicles quantity is observed and counted. The data is analyzed using One Way ANOVA. The research finally comes with a result showing that there are not any significant differences discovered from the ovaries’ follicles quantity from the five tested groups (p0.05). Therefore, it is implied that Temulawak extract does not provide any influential results to the house mice’s ovaries’ follicles quantity which has been exposed to MSG. Keywords: Monosodium Glutamate (MSG), Temulawak (Curcuma xanthorriza Roxb.), Ovarian follicles quantity 
IDENTIFICATION OF POTENTIAL DRUG RELATED PROBLEMS OF IMPROPER DOSAGE AND ADVERSE DRUG REACTIONS CATEGORIES IN OSTEOARTHRITIS OUTPATIENTS IN RSUD JOMBANG 2016 Muslim, Ayu Tria Nurjannah; Hakim, Abdul; Dianti, Meilina Ratna
Journal of Islamic Pharmacy Vol 3, No 1 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i1.4994

Abstract

Osteoarthritis is a chronic disorder of synovial joints, characterized by progressive softening and disintegration of cartilage in joints. This is the most common type of arthritis in Indonesia with prevalence about 23.6 to 31.3% and generally suffered by middle age patients. Drug therapy for treating osteoarthritis is NSAIDs, supplements and corticosteroids. The increasing number of available drugs, drug users and more complex drug regimens caused  more side effect and potential drug interaction and  lead to another problem, it is Drug Related Problems. The purpose of this study was to identify potential Drug Related Problem categories of improper dosage and Adverse Drug Reactions in osteoarthritis outpatient in RSUD Jombang during 2016. This research is a non-experimental descriptive study conducted retrospectively, carried out in March 2017 at RSUD Jombang.  Research sample is 87 respondents of osteoarthritis outpatient which taken by systematic random sampling method. The data presented in percentage of improper dosage and Adverse Drug reactions potential case. The result found potential of improper dosage in respondent about 82,76% and Adverse Drug Reactions about 20,69%.
The Effectivity of Murottal Al-Qur’an Exposure to Spermatogenesis of Male Mice (Mus musculus) with stress Dianti, Meilina Ratna; Mazidah, Lilik Khoiriyatul; Ari Indrawijaya, Yen Yen; Inayatilah, Fidia Rizkiah
Journal of Islamic Medicine Vol 5, No 2 (2021): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2021
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v5i2.9886

Abstract

Introduction: Stress is the body's reaction to pressure from stressors; one of the stressors that can trigger stress is a noise stressor. Stress can disrupt the body's homeostasis system, one of the cycles of spermatogenesis. Murottal Al-Qur'an therapy listening can produce a response of relaxation and peace of mind to increase healing. Methods: The study was conducted on 25 healthy male mice aged 8-12 weeks grouped randomly into five groups. The positive control group is the normal group. The negative control group is given a 12-hour stressor. The treatment groups are given 12 hours and 1, 2, and 4 hours therapy. The treatment for each group was carried out for 21 days. Spermatogenesis of mice was observed through the number of primary spermatocytes cells and spermatid cells. It takes place during the preparation of testicular histology with Hematoxylin Eosin staining. Primary spermatocyte and spermatid counts were examined under a 40x magnification microscope. Results: Murottal Al-Qur'an therapy can affect the amount of primary spermatocyte cells (p-value = 0.000) and spermatids (p-value = 0,000) that are very significant. Conclusion: Murottal Al-Qur'an therapy can be used to increase the spermatogenesis of mice with stress. Keywords: Stress, Noise, Spermatogenesis, Murottal Al-Qur'an.
Efektifitas Terapi Murottal Al Qur’an terhadap Stres Mencit (Mus Musculus) Dianti, Meilina Ratna; Indrawijaya, Yen Yen Ari
Journal of Islamic Pharmacy Vol 6, No 1 (2021): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v6i1.10668

Abstract

Stres merupakan suatu keadaan tertekan baik secara fisik maupun secara psikologis. Suatu proses yang menilai suatu peristiwa sebagai sesuatu yg mengancam, ataupun membahayakan dan individu merespon peristiwa itu pada level fisiologis, emosional, kognitif, dan perilaku. Hormon kortisol adalah hormon stres, karena hormon ini akan diproduksi lebih banyak saat tubuh mengalami stres baik fisik maupun emosional. Terapi murottal Al-Qur’an merupakan salah satu terapi non farmakologis yang dapat digunakan untuk mempercepat proses penyembuhan. Lantunan Al-Qur’an secara fisik mengandung unsur suara manusia. Suara dapat menurunkan hormon stres, mengaktifkan hormon endorfin alami, meningkatkan perasaan rileks dan mengalihkan perhatian dari rasa takut, cemas, dan tegang, memperbaiki sistem kimia tubuh. Surat Ar-Rahman merupakan surat Makiyah yang mempunyai karakter ayat pendek  dan berulang sehingga dapat menimbulkan efek relaksasi bagi pendengar. Tujuan dari penelitian ini adalah Menganalisis efektifitas pemberian terapi Murottal Al Qur’an terhadap kadar hormon kortisol pada mencit yang mengalami stres. Metode penelitian ini adalah true experimental post-test only control group design. 35 mencit dibagi menjadi 5 kelompok, Kelompok K+: tidak diberi perlakuan  murottal QS. Ar-Rahman dan tidak diberi paparan stresor kebisingan; Kelompok Kontrol (-) diberi paparan stresor kebisingan 21 hari dan tidak diberi perlakuan murottal QS. Ar-Rahman; P1 diberi paparan stresor kebisingan 21 hari + murottal QS. Ar-Rahman 1 jam/hari; P2 diberi paparan stresor kebisingan 21 hari + murottal QS. Ar-Rahman 2 jam/hari; P3 diberi paparan stresor kebisingan 21 hari + murottal QS. Ar-Rahman 4 jam/hari. Analisis data menggunakan Median Test didapatkan nilai p value adalah 0,032 (p 0,05) menyatakan terdapat perbedaan yang signifikan kadar kortisol pada mencit dengan kontrol negatif, kontrol positif dan yang mendapat perlakuan 1, 2, dan 3. Kesimpulan penelitian ini adalah bahwa Terapi Murottal Al Quran dapat menurunkan kadar kortisol mencit yang dipapar stres kebisingan.Kata Kunci: Stres, Kebisingan, Murottal Al Quran, QS. Ar Rahman, Hormon, Kortisol 
Tingkat Kepuasan Pasien Terhadap Pelayanan Kefarmasian di Puskesmas Dinoyo Malang Siti Maimunah; Fitri Eka Utami; Meilina Ratna Dianti; Fidia Rizkiyah Inayatillah
Journal of Islamic Pharmacy Vol 7, No 1 (2022): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v7i1.14695

Abstract

Kesehatan adalah hak asasi manusia yang harus di wujudkan. Puskesmas adalah fasilitas pelayanan kesehatan yang menyelenggarakan upaya kesehatan. Salah satu pelayanan di puskesmas yaitu Pelayanan Kefarmasian. Saat ini, orientasi Pelayanan Kefarmasian berubah menjadi pelayanan yang komprehensif yang bertujuan meningkatkan kualitas hidup pasien maka Apoteker dituntut untuk meningkatkan pengetahuan, keterampilan dan kemampuan agar dapat memberikan pelayanan yang baik dan bermutu sehingga dapat menimbulkan kepuasan pasien. Tujuan penelitian ini adalah untuk mengetahui tingkat kepuasan pasien terhadap pelayanan kefarmasian di Puskesmas Dinoyo Malang. Penelitian ini merupakan penelitian Deskriptif menggunakan metode non probability sampling. Sampel yang diperlukan sebanyak 100 sampel dan pengambilan data menggunakan kuesioner. Data dianalisis dengan metode pengolahan data Indeks Kepuasan Masyarakat (IKM) untuk mengetahui kualitas Pelayanan Kefarmasian. Hasil penelitian menyatakan bahwa pelayanan kefarmasian di Puskesmas Dinoyo Malang sudah baik. Dibuktikan dengan 49% responden Sangat Puas, 37% responden Puas, 12% responden Tidak Puas dan 2% responden Sangat Tidak Puas dengan nilai IKM sebesar 82.062 dengan kategori Mutu Pelayanan B dan dapat diartikan pelayanan kefarmasin di Puskesmas Dinoyo Malang Baik
The Influence of Murottal Al- Quran Exposure to Leydig Cell Of Stressed Male Mice (Mus Musculus) Meilina Ratna Dianti; Yen Yen Ari Indrawijaya; Fidia Rizkiah Inayatilah; Alifah Nurin Zuhdina
Journal of Islamic Medicine Vol 6, No 2 (2022): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2022
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v6i2.9888

Abstract

Introduction:  Stress is a body's response experienced by a person due to burdened feelings or oppressed in a particular event. Stress may interfere body's homeostasis. One of them is the spermatogenesis process. Healthy stress management is necessary, for example, by doing murottal Al-Qur'an. Reading Al-Qur'an with tartil delivers a beautiful tone and has a relaxing effect and stress release. This research aims to determine the effect of murottal Al-Qur'an on the amount of Leydig cells on male mice (Mus musculus) who are experiencing stress. The compressor used is noise from the road with an intensity of 85dB, given for 12 hours (18.00-06.00) for 21 days. The therapy used was murottal Al-Quran surah Ar-Rahman verses 1-78, which read by Shaykh Abdurrahman Sudais. In this research there were five categories, they are K+ (not given the stressor and murottal therapy), K- (given noise stressors and not given murottal therapy), P1 (given noise stressors for 12-hours and murottal therapy for 1-hour), P2 (given noise stressor for 12-hours and murottal therapy for 2-hours), P3 (given a stress stressor for 12-hours and murottal therapy for 4-hours). Moreover, observations were done on testicular histology preparations with Hematoxylin Eosin staining in olyvia (c) applications. The number of Leydig cells was examined with a 40x magnification microscope. Cell calculations are done manually with the image raster application. The results revealed that murottal Al-Quran is able to significantly affect the number of Leydig cells (p value = 0,000). Lastly, it can be concluded that there is an influence of murottal Al-Quran on the number of Leydig cells in male mice under stress. Keyword : Stress, Noice, Murottal Al-Aquran, Surah Ar-Rahman, Leydig Cell
Uji Sitotoksistas Ekstrak Etanol 96% Daun Semanggi (Marsilea crenata Presl.) pada Sel hFOB 1.19 dengan Metode Microtetrazolium (MTT) Assay Burhan Ma'arif; Nabila Rosa; Meilina Ratna Dianti; Alif Firman Firdausy; Hening Laswati; Mangestuti Agil
FARMASIS: Jurnal Sains Farmasi Vol 1 No 1 (2020): Farmasis : Jurnal Sains Farmasi
Publisher : Universitas PGRI Adi Buana, Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Semanggi (Marsilea crenata Presl.) merupakan salah satu tanaman yang telah dimanfaatkan oleh masyarakat Indonesia, khususnya Jawa Timur, sebagai bahan makanan selama beberapa dekade. Marsilea crenata Presl. mengandung senyawa fitoestrogen memiliki struktur dan fungsi mirip estrogen dalam tubuh. Tujuan penelitian melakukan uji sitotoksisitas dan menentukan nilai IC50 dari ekstrak etanol 96 persen daun Marsilea crenata Presl. terhadap sel hFOB 1.19. Metode yang digunakan adalah microtetrazolium (MTT) assay dengan microplate reader. Sel dikultur pada microplate-96 well dan diberikan ekstrak dengan variasi dosis 62,5 ppm; 125 ppm; 250 ppm; 500 ppm; 1000 ppm; 2000 ppm dan 4000 ppm, kemudian ditambahkan reagen MTT 100μL, diinkubasi selama 2-4 jam dan ditambahkan SDS 10 persen sebagai stopper. Pembacaan hasil menggunakan microplate reader. Hasil dari pembacaan tersebut digunakan sebagai perhitungan nilai IC50 yang dapat menunjukkan tingkat sitotoksisitas ektrak etanol 96 persen Marsilea crenata Presl. Nilai IC50 yang didapatkan sebesar 2074,965 μg/ml. Berdasarkan hasil tersebut ekstrak etanol 96 persen Marsilea crenata Presl. dapat dikatakan aman dan tidak bersifat sitotoksik jika dikembangkan menjadi bahan obat.
Efek Antiinflamasi Ekstrak dan Tablet Daun Kenitu (Chrysophyllum cainito L. ) pada Tikus Wistar (Rattus norvegicus) Ma'arif , Burhan; Sholekhah, Syafirda Arma'atu; Fuadi, Muhammad Nauval Nadhirul; Dianti, Meilina Ratna; Suryadinata , Arief; Maulina, Novia
FARMASIS: Jurnal Sains Farmasi Vol 5 No 1 (2024): Farmasis: Jurnal Sains Farmasi Vol 5. No. 1 (2024)
Publisher : Universitas PGRI Adi Buana, Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/farmasis.v5i1.8614

Abstract

Pendahuluan : Inflamasi pada persendian akibat kerusakan tulang rawan merupakan ciri dari osteoarthritis (OA). Osteoarthtritis adalah suatu penyakit degeneratif terkait dengan rendahnya kadar estrogen dalam tubuh. Senyawa fitoestrogen memiliki struktur yang sama seperti estrogen, sehingga fitoestrogen dapat menjadi alternatif dalam meredakan inflamasi pada OA. Daun kenitu (Chrysophyllum cainito L.) salah satu tanaman yang memiliki kandungan senyawa fitoestrogen. Tujuan: Untuk membuktikan ekstrak etanol 70 persen (EDC) dan tablet (TDC) yang diformulasikan dari daun C. cainito  dapat mengurangi efek inflamasi pada tikus wistar jantan. Metode: Aktivitas antiinflamasi EDC dan TDC  kemudian diuji pada tikus menggunakan metode edema kaki tikus yang diinduksi karagenan dengan dosis 4,05, 8,1, dan 16,2 mg tiap 200gBB tikus per hari untuk EDC, sedangkan untuk TDC 24,3, 48,6, dan 97,2 mg tiap 200gBB tikus per hari. Setelah pemberian masing-masing sampel selama 30 menit, tikus diinduksi secara subplantar dengan karagenan 1 persen  kemudian diamati edema pada telapak kaki tikus selama 6 jam.  Hasil: EDC dan TDC menunjukkan aktivitas antiinflamasi, dengan dosis optimal untuk EDC adalah 4,05 mg tiap 200gBB sedangkan, dosis optimal untuk TDC adalah 48,6 mg tiap 200gBB, sehingga menghasilkan persentase penghambatan edema pada tikus. Kesimpulan: Hasil tersebut menunjukkan bahwa CLE dan CLT mempunyai efek anti inflamasi sehingga berpotensi untuk dikembangkan sebagai obat alternatif anti OA.
Effectiveness of 70% Ethanol Extract of Pomegranate (Punica granatum Linn) Against the Healing Process of Incisions and Burns in Mice Dianti, Meilina Ratna; Maimunah, Siti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006779

Abstract

A wound is a traumatic occurrence that damages the skin's and subcutaneous tissue's continuity. For the treatment of skin wounds, it is normal practice in the medical community to administer analgesics, anti-inflammatories, antibiotics, and antiseptics. Anti-inflammatory, antibacterial, and antioxidant properties are required, as well as assistance for cell proliferation in the production of protein and collagen for the regeneration process. Pomegranate is frequently used as herbal medicine and is thought to heal various diseases and ailments, including burns. This investigation will assess the effects of 70% ethanol extract from pomegranate fruit on mouse incisions and second-degree burns. To assess the effect of the extract on the healing of cuts and burns in mice, wounds and second-degree burns were made and treated with a 70% ethanol extract of pomegranate at doses of 7%, 14%, and 28%. Administration of pomegranate fruit extract in 70% ethanol at the optimum dose of 28% was shown to considerably boost wound healing activity and this finding demonstrates the ability of pomegranate extract to treat wounds.
The Influence of Murottal Al- Quran Exposure to Leydig Cell Of Stressed Male Mice (Mus Musculus) Dianti, Meilina Ratna; Indrawijaya, Yen Yen Ari; Inayatilah, Fidia Rizkiah; Zuhdina, Alifah Nurin
Journal of Islamic Medicine Vol 6, No 2 (2022): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2022
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v6i2.9888

Abstract

Introduction:  Stress is a body's response experienced by a person due to burdened feelings or oppressed in a particular event. Stress may interfere body's homeostasis. One of them is the spermatogenesis process. Healthy stress management is necessary, for example, by doing murottal Al-Qur'an. Reading Al-Qur'an with tartil delivers a beautiful tone and has a relaxing effect and stress release. This research aims to determine the effect of murottal Al-Qur'an on the amount of Leydig cells on male mice (Mus musculus) who are experiencing stress. The compressor used is noise from the road with an intensity of 85dB, given for 12 hours (18.00-06.00) for 21 days. The therapy used was murottal Al-Quran surah Ar-Rahman verses 1-78, which read by Shaykh Abdurrahman Sudais. In this research there were five categories, they are K+ (not given the stressor and murottal therapy), K- (given noise stressors and not given murottal therapy), P1 (given noise stressors for 12-hours and murottal therapy for 1-hour), P2 (given noise stressor for 12-hours and murottal therapy for 2-hours), P3 (given a stress stressor for 12-hours and murottal therapy for 4-hours). Moreover, observations were done on testicular histology preparations with Hematoxylin Eosin staining in olyvia (c) applications. The number of Leydig cells was examined with a 40x magnification microscope. Cell calculations are done manually with the image raster application. The results revealed that murottal Al-Quran is able to significantly affect the number of Leydig cells (p value = 0,000). Lastly, it can be concluded that there is an influence of murottal Al-Quran on the number of Leydig cells in male mice under stress. Keyword : Stress, Noice, Murottal Al-Aquran, Surah Ar-Rahman, Leydig Cell
Co-Authors Alifah Nurin Zuhdina Arief Suryadinata Burhan Ma'arif Fidia Rizkiah Inayatilah Fidia Rizkiyah Inayatillah Firdausy, Alif Firman Fitri Eka Utami Fuadi, Muhammad Nauval Nadhirul Hening Laswati Luky Adrianto Ma'arif , Burhan Mangestuti Agil Mazidah, Lilik Khoiriyatul Muslim, Ayu Tria Nurjannah Nabila Rosa Novia Maulina Sholekhah, Syafirda Arma'atu Siti Maimunah Siti Maimunah Yen Yen Ari Indrawijaya Zuhdina, Alifah Nurin