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THEEFFECTS OF CURCUMA RHIZOME EXTRACT (Curcuma xanthorrhiza Roxb.)TREATMENT USING VARIOUS DOSES TOWARDS ENDOMETRIAL THICKNESSIN MICE (Mus musculus) TREATED WITH MONOSODIUM GLUTAMATE (MSG) Inayatilah, Fidia Rizkiah
Journal of Islamic Pharmacy Vol 2, No 1 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i1.4250

Monosodium Glutamate (MSG) is a food seasoning that is widely used. Consumption of MSG in excessive doses can cause an excess of free radicals in the body that trigger oxidative stress and finally affect the reproductive system hormones. These free radicals can be suppressed by administration of antioxidants. Rhizomes of Curcuma xanthorrhiza extracts containantioxidants and they are widely grown. Theyare used as traditional medicine in Indonesia. This experiment was conducted to investigatewhether rhizomes of Curcuma xanthorrhiza extracts areable to inhibit decreasing endometrial thickness in female mice after receiving orally MSG-treatment.This research adoptedtrue experimental posttest only control group design. It includes 25 mice that were divided into 5 groups: control K1 (CMC) and K2 (MSG), treatment group (MSG and rhizomes of Curcuma xanthorrhiza extracts with dose of 0,4 mg/gBW, 0,8 mg/gBW, 1,2 mg/gBW).In addition, the miceâ€™s endometrium were removed to be subsequently stained using Hematoxillin-Eosin. Thickening of uterus was observed and measured with 40x magnitude using Microphoto Microscope Olympus. Data was analized using One Way ANOVA. The research finally comes with a result showing that there were not any significant differences discovered from the endometrium thickening from the five tested groups (p0,05). Therefore, it is implied that rhizomes of Curcuma xanthorrhiza extracts has no effect on endometrial thickness of uterus by oral MSG-treatment.Â Keywords: MSG, curcuma, endometrium

EVALUASI PENGGUNAAN ANTIBIOTIK PADA PASIEN PASCABEDAH APENDISITIS AKUT DI RSUD KABUPATEN PASURUAN TAHUN 2018 (Penelitian dilakukan di Instalasi Rawat Inap RSUD Kabupaten Pasuruan) Wirda, Wirda Anggraini; Wiraningtias, Novia Beta; Inayatilah, Fidia Rizkiah; Indrawijaya, Yen Yen Ari
Pharmaceutical Journal of Indonesia Vol 6, No 1 (2020)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Apendisitis akut adalah infeksi yang terjadi di apendiks vermiformis sehingga perlu segera dilakukan apendektomi. Apendektomi termasuk operasi kategori bersih kontaminasi yang memungkinkan terjadinya Infeksi Luka Operasi (ILO). Penggunaan antibiotik pada pasien pascabedah diharapkan untuk mencegah terjadinya infeksi tersebut. Penelitian ini bertujuan untuk mengidentifikasi profil penggunaan antibiotik dan mengetahui kuantitas serta kualitas penggunaan antibiotik. Penelitian ini menggunakan studi cross sectional yang dilakukan secara retrospektif menggunakan data rekam medis pasien pascabedah apendisitis akut Rumah Sakit Umum Daerah (RSUD) Kabupaten Pasuruan periode Januari-Desember 2018. Analisis data yang dilakukan pada penelitian ini secara deskriptif. Hasil dari penelitian ini menunjukkan bahwa profil penggunaan antibiotik terapeutik tertinggi untuk monoterapi adalah Sefuroksim (25,81%) dan untuk terapi kombinasi adalah Fosfomisin + Metronidazol (8,06%) dan Seftriakson + Metronidazol (8,06%). Kuantitas penggunaan antibiotik menggunakan metode Anatomical Therapeutic Chemical/ Defined Daily Dose (ATC/DDD) diperoleh nilai DDD total 52,01 DDD/100 patient-days dengan antibiotik tertinggi Metronidazol rute parenteral 14,00 DDD/100 patient-days. Antibiotik yang masuk dalam segmen Drug Utilization (DU) 90% adalah (Metronidazol, Seftriakson, Fosfomisin, Sefuroksim, Gentamisin) dengan rute parenteral. Kualitas penggunaan antibiotik berdasarkan pedoman Infectious Disease Society of America (IDSA) tepat indikasi (11,86%), tepat dosis (52,54%), tepat interval (22,03%), tepat lama pemberian (28,81%) dan tepat rute (96,61%).

The Effectivity of Murottal Al-Qurâ€™an Exposure to Spermatogenesis of Male Mice (Mus musculus) with stress Dianti, Meilina Ratna; Mazidah, Lilik Khoiriyatul; Ari Indrawijaya, Yen Yen; Inayatilah, Fidia Rizkiah
Journal of Islamic Medicine Vol 5, No 2 (2021): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2021
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v5i2.9886

Introduction: Stress is the body's reaction to pressure from stressors; one of the stressors that can trigger stress is a noise stressor. Stress can disrupt the body's homeostasis system, one of the cycles of spermatogenesis. Murottal Al-Qur'an therapy listening can produce a response of relaxation and peace of mind to increase healing. Methods: The study was conducted on 25 healthy male mice aged 8-12 weeks grouped randomly into five groups. The positive control group is the normal group. The negative control group is given a 12-hour stressor. The treatment groups are given 12 hours and 1, 2, and 4 hours therapy. The treatment for each group was carried out for 21 days. Spermatogenesis of mice was observed through the number of primary spermatocytes cells and spermatid cells. It takes place during the preparation of testicular histology with Hematoxylin Eosin staining. Primary spermatocyte and spermatid counts were examined under a 40x magnification microscope. Results: Murottal Al-Qur'an therapy can affect the amount of primary spermatocyte cells (p-value = 0.000) and spermatids (p-value = 0,000) that are very significant. Conclusion: Murottal Al-Qur'an therapy can be used to increase the spermatogenesis of mice with stress.Â Keywords: Stress, Noise, Spermatogenesis, Murottal Al-Qur'an.

The Effectiveness of Red Fruit Oil (Pandanus conideus Lamk.) Emulgel on the Acceleration of the Incision Wound Healing Process Fidia Rizkiah Inayatilah; Abdul Malik Guhir; Ria Ramadhani Dwi Atmaja
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.73135

Incision wounds have a fairly high prevalence in Indonesia. Chemical treatment of incision wounds has adverse side effects, therefore alternative treatment with natural ingredients is needed, namely using red fruit oil as the basic ingredient. The purpose of this study is to determine the effectiveness of red fruit oil (Pandanus conoideus Lamk.) gel emulsion on the healing process of incision wounds in males both macroscopically and microscopically. This is an experimental laboratory study. The study design used was true experimental with a post-test-only control group design approach. The population consisted of 25 male mice which were divided into 5 groups, namely: (1) K- was a control group where the incision wound on the back was given a gel emulsion base; (2) K+ was the control group where the incision wound on the back was given Iodine Povidone ; (3) P1 is the treatment group where the incision wound on the back is given a 5% red fruit oil gel emulsion (F1); (4) P2 is the treatment group where the incision wound on the back is given a red fruit oil gel emulsion 10% (F2); (5) P3 was the treatment group where the incision on the back was given a 15% red fruit oil gel emulsion (F3). The treatment was given for 14 days. The data were then analyzed using the ANOVA test. The result showed that the administration of red fruit oil emulgel had a significant effect on the size of the incision wound on the 7th day (p=0.035) and the 14th day (p=0.005). Giving red fruit oil emulgel also had a significant effect on the thickness of the epithelium (p=0.000) and the number of fibroblasts (p=0.000). It can be concluded that the administration of red fruit oil emulgel affects the healing process of the incision wound both macroscopically and microscopically.

The Influence of Murottal Al- Quran Exposure to Leydig Cell Of Stressed Male Mice (Mus Musculus) Meilina Ratna Dianti; Yen Yen Ari Indrawijaya; Fidia Rizkiah Inayatilah; Alifah Nurin Zuhdina
Journal of Islamic Medicine Vol 6, No 2 (2022): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2022
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v6i2.9888

Introduction: Stress is a body's response experienced by a person due to burdened feelings or oppressed in a particular event. Stress may interfere body's homeostasis. One of them is the spermatogenesis process. Healthy stress management is necessary, for example, by doing murottal Al-Qur'an. Reading Al-Qur'an with tartil delivers a beautiful tone and has a relaxing effect and stress release. This research aims to determine the effect of murottal Al-Qur'an on the amount of Leydig cells on male mice (Mus musculus) who are experiencing stress. The compressor used is noise from the road with an intensity of 85dB, given for 12 hours (18.00-06.00) for 21 days. The therapy used was murottal Al-Quran surah Ar-Rahman verses 1-78, which read by Shaykh Abdurrahman Sudais. In this research there were five categories, they are K+ (not given the stressor and murottal therapy), K- (given noise stressors and not given murottal therapy), P1 (given noise stressors for 12-hours and murottal therapy for 1-hour), P2 (given noise stressor for 12-hours and murottal therapy for 2-hours), P3 (given a stress stressor for 12-hours and murottal therapy for 4-hours). Moreover, observations were done on testicular histology preparations with Hematoxylin Eosin staining in olyvia (c) applications. The number of Leydig cells was examined with a 40x magnification microscope. Cell calculations are done manually with the image raster application. The results revealed that murottal Al-Quran is able to significantly affect the number of Leydig cells (p value = 0,000). Lastly, it can be concluded that there is an influence of murottal Al-Quran on the number of Leydig cells in male mice under stress. Keyword : Stress, Noice, Murottal Al-Aquran, Surah Ar-Rahman, Leydig Cell

Analysis of the relationship between knowledge, behaviour, prevention, and self-efficacy on the mental health of athletes during the COVID-19 pandemic Amiq, Fahrial; Inayatilah, Fidia Rizkiah; Angga, Prayogi Dwina
Indonesian Journal of Research in Physical Education, Sport, and Health Vol. 2 No. 1 (2024): Indonesian Journal of Research in Physical Education, Sport, and Health (IJRPES
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um086v2i12024p7-16

Background: Mental health has become a trending topic during the pandemic. Many athletes have experienced decreased performance during the pandemic, but not a few athletes are able to control their mental health. Objective: The purpose of this study was to examine the relationship between knowledge, preventive behaviour, and self-efficacy on mental health in professional football athletes during the COVID-19 pandemic. This research uses quantitative methods. Methods: This type of research is observational with a cross-sectional study. Eighty professional football athletes were involved in this research. The sampling technique was carried out using a proportional stratified simple random sampling technique. This research was conducted by distributing questionnaires consisting of 4 parts, namely knowledge level questionnaire sheets, preventive behaviour questionnaire sheets, self-efficacy questionnaire sheets, and mental health questionnaire sheets. The data obtained in this study were analyzed using the SPSS application with a descriptive test method to determine the min, max, average, and percentage. Furthermore, data analysis was carried out using the Spearman test method. Results: Based on the results of the study, The low p-value of 0.046 and the correlation coefficient of -0.224 suggest a meaningful negative correlation between self-efficacy and mental health. This indicates that as self-efficacy increases, mental health tends to decrease among the respondents. Conclusion: There is a significant relationship between self-efficacy and the mental health of the respondents. We provide recommendations for Psychologists to develop online interventions that aim to increase individual ability to cope with stressors during a pandemic and reduce excessive perceptions that have a negative impact on mental health.

Efek Induksi Proliferasi Sel Osteoblas Tulang Trabekular Mencit Jantan oleh Ekstrak Etanol 96% Daun Semanggi (Marsilea crenata Presl.): Induction Effect of Proliferation of Osteoblas Cells Trabecular Bone Male Mice by 96% Ethanol Extract of Semanggi Leaves (Marsilea crenata Presl.) Agnis Pondineka Ria Aditama; Faisal Akhmal Muslikh; Izza Nailia Shirvi; Firsta Roisatul Islamiyah; Kurniawan Hidayat Perdana Putra; Fidia Rizkiah Inayatilah; Weka Sidha Bhagawan; Burhan Ma’arif; Asri Wido Mukti; Asti Rahayu
Jurnal Sains dan Kesehatan Vol. 3 No. 4 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i4.634

Osteoporosis adalah kondisi penurunan kepadatan mineral tulang dan berisiko patah tulang yang disebabkan oleh defisiensi estrogen. Fitoestrogen adalah senyawa pada tanaman yang memiliki kemampuan berikatan dengan reseptor estrogen untuk menggantikan fungsi estrogen. Daun M. crenata Presl. diketahui mengandung senyawa fitoestrogen. Tujuan penelitian ini adalah untuk membuktikan ekstrak etanol 96% daun M. crenata Presl. dapat meningkatkan jumlah sel osteoblas tulang trabekular femur dan vertebra pada mencit yang mengalami osteoporosis. Penelitian ini dilakukan dengan pemberian ekstrak etanol 96% daun M. crenata Presl. dosis 1,2; 2,4; 4,8; dan 9,6/20 g BB mencit/hari. Analisis dilakukan dengan cara pemeriksaan histomorfometri menggunakan pewarnaan HE, dan pengamatan sel osteoblas menggunakan mikroskop cahaya Olympus dengan software optilab. Data dianalisis menggunakan metode one way ANOVA. Hasil yang didapat yaitu kelompok PIV dengan dosis 9,6/20g BB mencit/hari dapat meningkatkan jumlah rerata sel osteoblas dengan nilai tertinggi yaitu 224,60 pada tulang trabekular femur dan 540,11 pada trabekular vertebra. Nilai perhitungan ED50 ekstrak etanol 96% daun M. crenata Presl. yaitu 1,908 mg pada tulang trabekular femur dan 2,878 mg pada tulang trabekular vertebra

Eksplorasi Hubungan Tingkat Pengetahuan Terhadap Kepatuhan Terapi Pasien Hipertensi di UPT Puskesmas Tanjung Batu Kabupaten Karimun Maulina, Novia; Luthfi, Fitrati Hasanah; Inayatilah, Fidia Rizkiah; muslikh, Faisal akhmal
Journal of Islamic Medicine Vol 9, No 1 (2025): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2025
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v9i1.25921

Background: Hypertension is a condition where blood pressure exceeds normal levels (120/80mmHg), with systolic blood pressure above 140 mmHg and diastolic blood pressure above 90mmHg. Termed as the "silent killer," hypertension often manifests without symptoms and is a leading cause of death in Indonesia. The prevalence of hypertension in the Riau Islands Province reached 25.85% in 2018, with Karimun Regency ranking second. Objectif: This study aims to assess the relationship between knowledge and adherence to antihypertensive medication among hypertensive patients at UPT Puskesmas Tanjung Batu, Karimun, in 2022. Methods: This observational study employs a Cross-sectional design. Data were collected from March to May 2022 from 90 respondents using a questionnaire. The sampling method used was consecutive sampling. Data analysis involved univariate and bivariate analyses with the Spearman rank test (significance level 0.005). Results: The majority of respondents were female (71%), aged 46-55 years (43%), with an educational background of elementary school (62%). On average, they had suffered from hypertension for less than 5 years (56%), and the primary source of information was from doctors (81%). Knowledge level was sufficient (49%), while medication adherence was low (83%). Statistical analysis indicated a significant relationship (p=0.001) and alignment between knowledge and adherence among hypertensive patients at UPT Puskesmas Tanjung Batu, Karimun, with a moderate correlation (r=0.343). Conclusion: There is a significant relationship between knowledge and adherence to antihypertensive medication among hypertensive patients.

The Influence of Murottal Al- Quran Exposure to Leydig Cell Of Stressed Male Mice (Mus Musculus) Dianti, Meilina Ratna; Indrawijaya, Yen Yen Ari; Inayatilah, Fidia Rizkiah; Zuhdina, Alifah Nurin
Journal of Islamic Medicine Vol 6, No 2 (2022): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2022
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v6i2.9888

Introduction: Stress is a body's response experienced by a person due to burdened feelings or oppressed in a particular event. Stress may interfere body's homeostasis. One of them is the spermatogenesis process. Healthy stress management is necessary, for example, by doing murottal Al-Qur'an. Reading Al-Qur'an with tartil delivers a beautiful tone and has a relaxing effect and stress release. This research aims to determine the effect of murottal Al-Qur'an on the amount of Leydig cells on male mice (Mus musculus) who are experiencing stress. The compressor used is noise from the road with an intensity of 85dB, given for 12 hours (18.00-06.00) for 21 days. The therapy used was murottal Al-Quran surah Ar-Rahman verses 1-78, which read by Shaykh Abdurrahman Sudais. In this research there were five categories, they are K+ (not given the stressor and murottal therapy), K- (given noise stressors and not given murottal therapy), P1 (given noise stressors for 12-hours and murottal therapy for 1-hour), P2 (given noise stressor for 12-hours and murottal therapy for 2-hours), P3 (given a stress stressor for 12-hours and murottal therapy for 4-hours). Moreover, observations were done on testicular histology preparations with Hematoxylin Eosin staining in olyvia (c) applications. The number of Leydig cells was examined with a 40x magnification microscope. Cell calculations are done manually with the image raster application. The results revealed that murottal Al-Quran is able to significantly affect the number of Leydig cells (p value = 0,000). Lastly, it can be concluded that there is an influence of murottal Al-Quran on the number of Leydig cells in male mice under stress. Keyword : Stress, Noice, Murottal Al-Aquran, Surah Ar-Rahman, Leydig Cell

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