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All Journal Indonesian Journal of Pharmaceutical Science and Technology Biosel: Biologi Science and Education
Sengka, Rani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Energy Environmental Science Medicine & Pharmacology

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Potential of Quercetin Compound from Guava Leaves (Psidium guajava L.) as a Inhibitor COVID-19 Sengka, Rani; Rompegading, Andi Badli; Irfandi, Rizal; Nur, Muhammad; Arafah, Muhammad; Yani, Ahmad
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.49666

Abstract

This research is a computer-based experimental study using the molecular docking method of quercetin compounds in the leaves of the guava plant (Psidium guajava L.) against the target protein (receptor), namely Mpro SARS-CoV-2 (PDB ID: 6M2N) using various softwares. consists of Chem Draw Ultra version 7.0, Marvin Sketch, PLANTS, Yasara, Discovery Studio Visualizer 2021, and pkCSM online tool and, protox online tool. This study aims to find out how the potential  of the quercetin compound from the leaves of the guava plant (Psidium guajava L.) has on its ability to inhibit the spread of Covid-19 by molecular docking. Data analysis in this study was carried out based on data obtained from the analysis of pharmacokinetic profiles, physicochemical properties, molecular docking, and predictions of toxicity to compounds that have potential as drug ingredients. Based on the results of molecular docking, it was shown that the quercetin compound has the potential to act as an inhibitor of the Mpro receptor (PDB ID: 6M2N) as evidenced by the docking score obtained which is smaller than the docking score obtained by the original ligand of the target receptor.
Eksplorasi Keanekaragaman Tumbuhan Tingkat Rendah sebagai Materi Pengembangan Modul Plantae Berbasis Kontekstual Sengka, Rani; Yani, Ahmad; Sahriah, Sahriah
Biosel Biology Science and Education Vol. 11 No. 1 (2022): BIOSEL (Biology Science and Education: Jurnal Penelitian Science dan Pendidika
Publisher : INSTITUT AGAMA ISLAM NEGERI AMBON

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (593.58 KB) | DOI: 10.33477/bs.v11i1.2697

Abstract

The diversity of low-level plants has been known for a long time and until now studies on lower-level plants are still being studied and increasingly being developed. Therefore, this study aims to identify the diversity of low-level plants in Labae village which can be used as a source of material for developing contextual-based modules in the village of Labae. plantae material in class X Senior High School (SHC). This study uses a survey method with exploratory techniques, namely research conducted by exploring areas where lower plants can be found by setting more thoroughly or thoroughly in a study. From the results of the study, it was found that there were 6 Thallophyta species from the fungal division, 3 Bryophyta species, and 8 Pteridophyta species. These low-level plant species will later be used in the development of contextual-based teaching materials in the form of modules for Plantae material in class X SHC. Keywords: Exploration, Module, Low Level Plants
Co-Authors ahmad yani Andi Badli Rompegading Irfandi, Rizal Muhammad Arafah Muhammad Nur Sahriah, Sahriah