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All Journal Majalah Kesehatan FKUB Ina Kidney
Insanitaqwa, Aleyda Zahratunany
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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EVALUASI IN VITRO AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN SELADA AIR (Nasturtium officinale) TERHADAP BAKTERI METHICILLIN-RESISTANT Staphylococcus aureus Insanitaqwa, Aleyda Zahratunany; AS, Noorhamdani; Prasetyorini, Nugrahanti
Majalah Kesehatan FKUB Vol 8, No 3 (2021): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2021.008.03.2

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) adalah bakteri patogen penyebab infeksi nosokomial yang dapat menyerang beberapa sistem organ dan bersifat resisten terhadap beberapa antibiotik beta laktam seperti penisilin, sepalosporin, dan karbapenem. Prevalensi infeksi Staphylococcus aureus terus meningkat seiring dengan banyaknya prevalensi infeksi nosokomial dan meningkatnya tingkat resistensi Staphylococcus aureus terhadap beberapa antimikroba sehingga dibutuhkan suatu alternatif terapi yang dapat menggantikan atau meningkatkan efektivitas kerja antibakteri yang sudah ada. Ekstrak etanol daun selada air mengandung flavonoid, tannin, saponin, dan steroid yang dapat berperan sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri pada ekstrak etanol daun selada air (Nasturtium officinale) terhadap MRSA secara in vitro. Rancangan penelitian yang digunakan adalah experimental post test only control group design dengan metode uji aktivitas antibakteri difusi sumuran. Ekstrak etanol daun selada air yang digunakan yaitu ekstrak dengan konsentrasi 30%, 60%, 75%, 90%, 100%, dan 0% sebagai kontrol negatif dengan pengulangan sebanyak empat kali. Hasil penelitian menunjukkan perbedaan yang signifikan (p = 0,000) dengan diameter zona hambat terbesar dicapai pada aplikasi konsentrasi ekstrak 100% yaitu 9,88±0,27 mm, diikuti dengan konsentrasi ekstrak 90% sebesar  8,97±0,21 mm, konsentrasi ekstrak 75% sebesar 7,90±0,61 mm,  konsentrasi ekstrak 60% sebesar 7,19±0,13 mm, dan konsentrasi ekstrak 30% sebesar 6,16±0,12 mm. Oleh karena itu, dapat disimpulkan bahwa ekstrak etanol daun selada air memiliki aktivitas antibakteri terhadap MRSA secara in vitro.  
Characteristics and Clinical Outcomes of COVID-19 in ESRD Patients Undergoing Hemodialysis in Ngudi Waluyo Wlingi General Hospital in 2020-2022 Wijayanto, Fajar Hadi; Insanitaqwa, Aleyda Zahratunany; Mawaddah, Syarifiyana
Indonesian Journal of Kidney and Hypertension Vol 1 No 3 (2024): Volume 1 No. 3, December 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i3.156

Abstract

Background: The coronavirus disease (COVID-19) pandemic is a major threat to global health care. Comorbidities, including end-stage renal disease (ESRD), are related to an increased risk of severe infection and mortality. Objective: To assess determinants related to the clinical outcomes of COVID-19 in ESRD patients undergoing hemodialysis in Ngudi Waluyo Wlingi General Hospital in 2020-2022. Methods: This study included ESRD patients undergoing maintenance hemodialysis who were hospitalized at Ngudi Waluyo Wlingi General Hospital due to COVID-19 from May 2020 to February 2022. Clinical characteristics were investigated in relation to the severity and survival status. Results: A total of 26 patients (46.15% male) with a mean age of 52.27±13.65 years met the inclusion criteria. Of these, 42.3% had a mild infection, 23% had a moderate infection, 30.77% had a severe infection, and 3.8% had a critical infection. The mortality rate was 23.08%, with a mean length of stay of 15.19±7 days. Age, oxygen saturation, respiratory rate upon admission, lymphocyte and neutrophil levels, and neutrophil-to-lymphocyte ratio were significantly associated with COVID-19 severity. Length of stay was statistically influenced by respiratory rate upon admission. The mortality rate was correlated with the dialysis vintage, levels of hemoglobin, leukocytes, platelets, neutrophils, neutrophil-to-lymphocyte ratio, serum urea, serum creatinine, eGFR, and length of stay. Conclusion: COVID-19 in ESRD patients undergoing hemodialysis were more likely to have a poor prognosis. Identifying determinants is crucial for reducing morbidity and mortality.
Co-Authors Mawaddah, Syarifiyana Noorhamdani AS Nugrahanti Prasetyorini Wijayanto, Fajar Hadi