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All Journal Majalah Kesehatan FKUB Journal of Community Health and Preventive Medicine (JOCHAPM)
Insanitaqwa, Aleyda Zahratunany
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Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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EVALUASI IN VITRO AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN SELADA AIR (Nasturtium officinale) TERHADAP BAKTERI METHICILLIN-RESISTANT Staphylococcus aureus Insanitaqwa, Aleyda Zahratunany; AS, Noorhamdani; Prasetyorini, Nugrahanti
Majalah Kesehatan FKUB Vol 8, No 3 (2021): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2021.008.03.2

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) adalah bakteri patogen penyebab infeksi nosokomial yang dapat menyerang beberapa sistem organ dan bersifat resisten terhadap beberapa antibiotik beta laktam seperti penisilin, sepalosporin, dan karbapenem. Prevalensi infeksi Staphylococcus aureus terus meningkat seiring dengan banyaknya prevalensi infeksi nosokomial dan meningkatnya tingkat resistensi Staphylococcus aureus terhadap beberapa antimikroba sehingga dibutuhkan suatu alternatif terapi yang dapat menggantikan atau meningkatkan efektivitas kerja antibakteri yang sudah ada. Ekstrak etanol daun selada air mengandung flavonoid, tannin, saponin, dan steroid yang dapat berperan sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri pada ekstrak etanol daun selada air (Nasturtium officinale) terhadap MRSA secara in vitro. Rancangan penelitian yang digunakan adalah experimental post test only control group design dengan metode uji aktivitas antibakteri difusi sumuran. Ekstrak etanol daun selada air yang digunakan yaitu ekstrak dengan konsentrasi 30%, 60%, 75%, 90%, 100%, dan 0% sebagai kontrol negatif dengan pengulangan sebanyak empat kali. Hasil penelitian menunjukkan perbedaan yang signifikan (p = 0,000) dengan diameter zona hambat terbesar dicapai pada aplikasi konsentrasi ekstrak 100% yaitu 9,88±0,27 mm, diikuti dengan konsentrasi ekstrak 90% sebesar  8,97±0,21 mm, konsentrasi ekstrak 75% sebesar 7,90±0,61 mm,  konsentrasi ekstrak 60% sebesar 7,19±0,13 mm, dan konsentrasi ekstrak 30% sebesar 6,16±0,12 mm. Oleh karena itu, dapat disimpulkan bahwa ekstrak etanol daun selada air memiliki aktivitas antibakteri terhadap MRSA secara in vitro.  
BEYOND TRADITIONAL RISK FACTORS : A REVIEW OF ENVIRONMENTAL EXPOSURES IN CARDIOVASCULAR DISEASE Tjahjono, Cholid Tri; Arthamin, Maimun Zulhaidah; Prakosa, Ardani Galih; Insanitaqwa, Aleyda Zahratunany
Journal of Community Health and Preventive Medicine Vol. 5 No. 2 (2025): JOCHAPM Vol. 5 No. 2 2025
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jochapm.2025.005.02.5

Abstract

  Traditional cardiovascular disease (CVD) risk models frequently overlook environmental factors, despite increasing evidence that exposures such as air pollution, toxic chemicals, noise, and extreme temperatures markedly elevate CVD risk via common biological mechanisms. This review integrates contemporary evidence regarding the impact of environmental exposures on cardiovascular risk, exploring mechanistic insights, preventive strategies, and prospective research opportunities within the fields of environmental cardiology. We performed a narrative review of recent studies to assess environmental factors influencing cardiovascular health. Environmental exposures increases cardiovascular risk through oxidative stress, inflammation, autonomic imbalance, and endothelial dysfunction. Fine particulate matter (PM2.5), ozone, heavy metals, PFAS, noise pollution, and extreme temperatures are consistently linked to hypertension, arrhythmias, myocardial infarction, and stroke. People who work outside and older adults are more at risk than others. Urban redesign, monitoring of exposure, protective workplace interventions, and regulatory policies are all examples of preventive strategies. The exposome provides an effective framework for comprehensive exposure assessment. There are still big gaps in research, especially in low- and middle-income countries. This review underscore the imperative to underscore environmental risk factors in the prevention of CVD. Combining long-term research, data-driven policies, and personalized strategies is necessary to reduce the global burden of CVD and promote health equity.
Co-Authors Ardani Galih Prakosa, Ardani Galih Cholid Tri Tjahjono Maimun Zulhaidah Arthamin, Maimun Zulhaidah Noorhamdani AS Nugrahanti Prasetyorini