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All Journal MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB Pharmaceutical Sciences and Research (PSR) Journal of Community Health and Preventive Medicine (JOCHAPM)
Ardani Galih Prakosa, Ardani Galih
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Environmental Science Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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PENGARUH ANTOSIANIN UBI UNGU (Ipomoea batatas L.) KULTIVAR GUNUNG KAWI TERHADAP EKSPRESI CASPASE-3 PADA JARINGAN OTAK TIKUS MODEL DM TIPE 2 Prakosa, Ardani Galih; Ratnawati, Retty; Prabawati, Risma Karlina
Majalah Kesehatan FKUB Vol 4, No 2 (2017): MAJALAH KESEHATAN FAKULTAS KEDOKTERAN
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.081 KB) | DOI: 10.21776/ub.majalahkesehatan.2017.004.02.1

Abstract

Diabetes melitus (DM) merupakangangguan metabolism yang menyebabkan kondisi hiperglikemia. Hiperglikemia akan memicu pembentukan radikal bebas. Radikal bebas yang berlebihan dapat merusak sistem membran sel dan kematian sel di berbagai jaringan tubuh. Salah satu penanda terjadinya kematian sel pada suatu jaringan adalah caspase-3. Ubi ungu merupakan tanaman tradisional yang mengandung antosianin yang bermanfaat sebagai antiinflamasi, antioksidan, neuroprotektan, dan antidiabetik. Penelitian ini dilakukan untuk mengetahui pengaruh pemberian antosianin ubi ungu terhadap ekspresi caspase-3  pada jaringan otak tikus Wistar yang diinduksi DM tipe 2. Penelitian ini menggunakan desain eksperimental post-test only control group. Sampel penelitian terbagi menjadi 5 kelompok  yaitu kontrol negatif, kontrol positif, antosianin dosis 10 mg/kgBB, dosis 20 mg/kgBB, dan dosis 80 mg/kgBB selama 5 minggu. Kontrol positif adalah tikus yang dibuat DM tipe 2, sedangkan kontrol negatif adalah tikus sehat. Ekspresi caspase-3 diukur dengan metode imunohistokimia. Analisis statistik menunjukkan bahwa ekspresi caspase-3 berbeda secara bermakna pada semua kelompok perlakuan (ANOVA, p<0,05). Pemberian antosianin dosis 10 dan 20 mg/kgBB menurunkan ekspresi caspase-3 secara bermakna dibandingkan kontrol positif, sedangkan pemberian antosianindosis 80 mg/kgBB justru meningkatkan ekspresi caspase-3. Dapat disimpulkan bahwa pemberian antosianin dosis 10 dan 20 mg/kgBB menurunkan ekspresi caspase-3 pada jaringan otak tikus wistar model DM tipe 2. Kata kunci: antosianin, ekspresi caspase-3, hiperglikemia, jaringan otak
EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS Prabawati, Risma Karlina; Ratnawati, Retty; Rahayu, Masruroh; Prakosa, Ardani Galih
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.6

Abstract

Background: Hyperglycemia condition will decline cognitive function. No basic therapy has been 2 found for this. Purple potato anthocyanins are useful as anti-inflammatory, antioxidant, neuroprotectant, and antidiabetic.Objective: Evaluate effect of purple potato’s anthocyanins on MDA levels, brain’s caspase-3 expressiom, and spatial memory function in diabetic model of Wistar rats.Methods: This is an experimental study using diabetic model rats. The sample was divided into negative and positive control, anthocyanin dose of 10 mg/kg, 20 mg/kg, and 80 mg/kg groups. MDA levels were measured using spectrophotometer, caspase-3 expression with immunohistochemistry, and spatial memory function using Morris water maze test.Results: Tukey test showed that anthocyanin 10, 20, and 80 mg/kg lowering MDA levels, caspase-3 expression, and Morris water maze’s travel time compared to control positive (p = 0.000). But anthocyanin 80 mg/kg make a significant increase on these three variabels compared to 10 and 20mg/kg groups (p = 0.010). Pearson test showed that there no correlation between anthocyanin’s dose, MDA levels, caspase-3 expression, and Morris water maze test.Conclusion: Anthocyanin doses 10 and 20 mg/kg lowering MDA levels and caspase-3 expression, also improves spatial memory function on diabetic model of Wistar rats.
Anthocyanin-Rich Extract from Purple Sweet Potatoes Modified Body Weight, Visceral Fat and Circulatory IL-10 in Stressed-Mice Kurnianingsih, Nia; Rahma, Oktivani Adelathifa; Prayogo, Nabila Putri; Rayhanna, Qanitha Ailsya; Fahanani, Agwin Fahmi; Suprapto, Ratih Paramita; Prakosa, Ardani Galih; Ratnawati, Retty
Pharmaceutical Sciences and Research Vol. 11, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Stress-induced inflammation and oxidative stress mechanisms thus plant bioactive compounds as anti-inflammation and antioxidants are placed as novel strategies to resist the adverse effects of stress. Purple sweet potatoes (PSP) as a rich source of macronutrients and anthocyanin showed health benefits as neuroprotective and metabolic diseases. However, limited research explored the effect of PSP extract on stressed animal models. This study aimed to evaluate the bioactive compound analysis of PSP and the effect on body weight gain (BW), visceral fat (VF), and interleukin-10 (IL-10) of stressed model mice. Adult male BALB/c mice (6-8 weeks) were divided into control (CTRL), and stress (STR), stress+anthocyanin-rich extract (ANC) of PSP dose 10, 20, and 40 mg/kgBW. Stress was exposed as restraint stress for 2 hours/day for 14 days. The ANC was administered once a day orally. The IL-10 was measured by enzyme-linked immunosorbent assay (ELISA). Qualitative plant compound analysis showed the presence of flavonoids, alkaloids, phenolics, glycosides, and tannins in PSP extract. The PSP extract also contains a high level of total anthocyanin, 2468.9 ± 159.38 mg/l, and high antioxidant activity. This study observed tendencies to decrease BW and VF following ANC dose of 10 mg/kgBW treatment. The administration of ANC significantly increased the level of circulatory IL-10 cytokine. In conclusion, an anthocyanin-rich extract of PSP modified BW, VF, and IL-10 levels of restraint-stressed model mice.
BEYOND TRADITIONAL RISK FACTORS : A REVIEW OF ENVIRONMENTAL EXPOSURES IN CARDIOVASCULAR DISEASE Tjahjono, Cholid Tri; Arthamin, Maimun Zulhaidah; Prakosa, Ardani Galih; Insanitaqwa, Aleyda Zahratunany
Journal of Community Health and Preventive Medicine Vol. 5 No. 2 (2025): JOCHAPM Vol. 5 No. 2 2025
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jochapm.2025.005.02.5

Abstract

  Traditional cardiovascular disease (CVD) risk models frequently overlook environmental factors, despite increasing evidence that exposures such as air pollution, toxic chemicals, noise, and extreme temperatures markedly elevate CVD risk via common biological mechanisms. This review integrates contemporary evidence regarding the impact of environmental exposures on cardiovascular risk, exploring mechanistic insights, preventive strategies, and prospective research opportunities within the fields of environmental cardiology. We performed a narrative review of recent studies to assess environmental factors influencing cardiovascular health. Environmental exposures increases cardiovascular risk through oxidative stress, inflammation, autonomic imbalance, and endothelial dysfunction. Fine particulate matter (PM2.5), ozone, heavy metals, PFAS, noise pollution, and extreme temperatures are consistently linked to hypertension, arrhythmias, myocardial infarction, and stroke. People who work outside and older adults are more at risk than others. Urban redesign, monitoring of exposure, protective workplace interventions, and regulatory policies are all examples of preventive strategies. The exposome provides an effective framework for comprehensive exposure assessment. There are still big gaps in research, especially in low- and middle-income countries. This review underscore the imperative to underscore environmental risk factors in the prevention of CVD. Combining long-term research, data-driven policies, and personalized strategies is necessary to reduce the global burden of CVD and promote health equity.
Co-Authors Cholid Tri Tjahjono Fahanani, Agwin Fahmi Insanitaqwa, Aleyda Zahratunany Kurnianingsih, Nia Maimun Zulhaidah Arthamin, Maimun Zulhaidah Masruroh Rahayu, Masruroh Prayogo, Nabila Putri Rahma, Oktivani Adelathifa Rayhanna, Qanitha Ailsya Retty Ratnawati Risma Karlina Prabawati Suprapto, Ratih Paramita