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Pangestika, Intan Widya
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Prediksi In Silico Senyawa Berpotensi Anti-Kolesterol pada Kopi Robusta (Coffea canephora Pierre ex A. Froehner) Pangestika, Intan Widya; Aida Fasha, Gusti Nur
JNANALOKA Vol. 06 No. 01 Maret Tahun 2025
Publisher : Lentera Dua Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36802/jnanaloka.2025.v6-no01-%p

Abstract

Kopi robusta (Coffea canephora Pierre ex A. Froehner) merupakan salah satu komoditas penting di Indonesia yang memiliki potensi besar dalam bidang kesehatan, termasuk sebagai agen anti-kolesterol. Penelitian ini bertujuan untuk memprediksi senyawa dalam kopi robusta yang berpotensi sebagai anti-kolesterol menggunakan pendekatan in silico. Senyawa yang terkandung dalam kopi robusta diidentifikasi melalui basis data KNApSAcK, kemudian dianalisis menggunakan PASS Online untuk memprediksi aktivitasnya sebagai agen anti-kolesterol. Selanjutnya, prediksi target biologis dilakukan menggunakan SwissTargetPrediction, dan kecocokan farmakokinetik senyawa dianalisis berdasarkan Lipinski’s Rule melalui SwissADME. Hasil analisis menunjukkan bahwa beberapa senyawa memiliki potensi aktivitas tinggi sebagai agen anti-kolesterol, di antaranya delta7-Avenasterol, delta7-Stigmastenol, (3beta,5alpha)-Stigmastan-3-ol, (-)-beta-Sitosterol, dan Clerosterol, yang diprediksi berinteraksi dengan enzim sitokrom P450 dan reseptor nuklear yang berperan dalam regulasi kolesterol. Namun, senyawa ini memiliki nilai lipofilisitas tinggi, yang dapat mempengaruhi penyerapannya dalam tubuh. Sebaliknya, senyawa 2,3-Butanedione, Toluene, 2,3-Dimethylpyrazine, Phenol, dan Pyridine memenuhi semua kriteria Lipinski’s Rule, menunjukkan potensi lebih besar sebagai kandidat obat yang dapat dikembangkan lebih lanjut. Penelitian lanjutan diperlukan dalam bentuk uji in vitro dan in vivo guna mengonfirmasi efektivitas serta mekanisme kerja senyawa-senyawa ini dalam menurunkan kadar kolesterol. Selain itu, optimasi formulasi farmasi dan studi toksikologi perlu dilakukan untuk menjamin keamanan dan efektivitasnya sebagai agen terapi anti-kolesterol. Penelitian ini diharapkan dapat menjadi dasar dalam pengembangan obat berbasis senyawa alami dari kopi robusta, mendukung pemanfaatan komoditas lokal Indonesia dalam bidang kesehatan.
Relationship between altitudes, morphological traits, and biochemical compositions of Coffea canephora Pierre ex A. Froehner in Temanggung, Indonesia Pangestika, Intan Widya; Susilowati, Ari; Purwanto, Edi; Gunawan
Menara Perkebunan Vol. 93 No. 1 (2025): 93(1), 2025
Publisher : INDONESIAN OIL PALM RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/iribb.jur.mp.v93i1.621

Abstract

Among various edaphoclimatic factors influencing coffee bean quality, altitude is one of the primary factors that should be taken into account. This study aims to explore the relationship between altitude, morphological traits, and biochemical composition of robusta coffee in Temanggung Regency, the largest coffee-producing area in Central Java Province, Indonesia. Research sites were purposively selected and categorized into two altitude groups: GS, PS, and GN, located at circa 600 m a.s.l., and GT, WO, and TG, located at circa 900 m a.s.l. A total of 15 morphological traits were observed, consisting of eight vegetative and seven generative traits. Caffeine content was measured following the AOAC procedure using UV-Vis spectrophotometry, while brew acidity was evaluated using a pH meter. Several morphological traits of Temanggung robusta coffee demonstrated significant relationships with altitude. Canopy and stem diameter showed negative correlations with altitude, with correlation coefficients of -0.366 and  -0.408, respectively. Conversely, fruit width               (r = 0.041), bean length (r = 0.049), and bean thickness (r = 0.047) exhibited positive correlations. Regarding biochemical composition, caffeine content stood out by displaying a strong positive correlation with altitude (r = 0.816). Additionally, several morphological traits, including the number of primary branches, the number of productive branches, the number of fruits per bunch, and traits related to fruits and beans, appear to be advantageous for selection and breeding programs. Understanding these relationships provides valuable insights for developing superior Temanggung robusta coffee plants adapted to specific altitudinal conditions.
Co-Authors Aida Fasha, Gusti Nur ARI SUSILOWATI Edi Purwanto Gunawan