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All Journal Medicina journal of internal medicine E-Jurnal Medika Udayana Acta Interna : The Journal of Internal Medicine Indonesian Journal of Rheumatology Jurnal Penyakit Dalam Udayana Callosum Neurology Journal : Jurnal Berkala Neurologi Bali Oceana Biomedicina Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran Cermin Dunia Kedokteran COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Oceana Biomedicina Journal MEDICINUS Cermin Dunia Kedokteran

Gede Kambayana

Departemen Ilmu Penyakit Dalam, FK Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia

Author-ID : 207552

Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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KORELASI KADAR MATRIX METALLOPROTEINASES 3 (MMP-3) DENGAN DERAJAT BERATNYA OSTEOARTRITIS LUTUT Eka Imbawan, IGN; Raka Putra, Tjokorda; Kambayana, Gede
journal of internal medicine Vol. 12, No. 3 September 2011
Publisher : journal of internal medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (136.187 KB)

Osteoarthritis (OA) is one type of arthritis which commonly found especially in elderly and become the common cause ofdisability in elderly people. Recently known that immunologic respons and homeostasis of cartilage metabolism have animportant role, and MMP-3 as one of degradative enzyme which has a pivotal role in OA patogenesis. Aim of this studyis to determine correlation between level of MMP-3 and radiographic grading of knee OA, in Sanglah Hospital, DenpasarBali. An analytical cross sectional study was carried out in Policlinic Sanglah Hospital, enrolled 76 samples with kneeOA. Of all sample, 32 (42.1%) were males and 44 (57.9%) famales. The mean of MMP-3 serum level is 25.2 ± 20.7ng/ml. Radiographic grading of knee OA based on Kelgren and Lawrence criteria 4 (5.3%) grade 1,29 (38.3%) grade 2,28 (36.8%) grade 3 and 15 (19.7%) grade 4. The mean level of MMP-3 on grade 1 group is (24.7 ng/ml), grade 2 (17.8ng/ml), grade 3 (28.3 ng/ml) and grade 4 is 32.8 ng/ml. Using Spearman!s analyses, there were signiÞ cant correlationbetween MMP-3 and radiographic grading of knee OA (r = 0.25 and p = 0.03).There were signiÞ cant positive correlation between MMP-3 and radiographic grading of knee OA.

SEORANG PENDERITA SLE DENGAN EMBOLI PARU AKUT DAN HIPERTENSI PULMONAL (STUDI KASUS) Andisari, Hendrata Erry; Kambayana, Gede; Suega, Ketut
Oceana Biomedicina Journal Vol 3, No 1 (2020): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Kondisi Pulmonary embolism (PE) merupakan bagian dari spektrum penyakit yang disebut Venous thromboembolism (VTE). Seorang pasien dengan keluhan utama batuk yang mengeluarkan dahak berwarna keputihan datang ke RSUP Sanglah, Bali untuk mendapatkan terapi. Riwayat sebelumnya, pasien pernah dirawat inap di RSUP Sanglah tersebut.Saat ini diagnosis akhir pasien ini: SLE on treatment dengan moderate pulmonary hipertension dan suspek emboli paru, suspek pneumonia (HCAP) dengan severe sepsis dan syok sepsis, asidosis metabolik, observasi transaminitis ec reaktif dan hiponatremia kronik asimptomatik hipoosmoler euvolemic cb SIADH. Selanjutnya dilakukan tindakan terapi dan evaluasi terhadap terapi yang diberikan. Kata kunci: SLE, emboli paru akut, hipertensi, studi kasus

Prinsip Latihan Penderita Osteoartritis Nugraha, I.B. Aditya; Kambayana, Gede
Cermin Dunia Kedokteran Vol 44, No 2 (2017): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Osteoartritis (OA) lutut merupakan penyakit degeneratif kartilago sendi, prevalensinya meningkat pada usia >65 tahun. Penyakit ini dapat menimbulkan berbagai impairment, disability, serta handicap. Beberapa jenis latihan dapat dikembangkan untuk pasien OA seperti latihan stretching, strengthening, aerobik, dan fungsional. Semua latihan ini untuk mengurangi komplikasi imobilisasi dan membuat pasien lebih nyaman.Knee osteoarthritis is a cartilage degenerative disease, causing impairment, disability, and handicap. The management is pharmacological pain therapy. Exercises such as stretching, strengthening, aerobic, and functional exercises are to decrease the complication of immobilisation, and also to increase the quality of life.

Target Terapi Imunosupresan pada Lupus Eritematosus Sistemik Prisilia, Ni Ketut Donna; Kurniari, Pande Ketut; Kambayana, Gede
Cermin Dunia Kedokteran Vol 41, No 1 (2014): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Lupus eritematosus sistemik (Systemic Lupus Erythematosus / SLE) merupakan suatu kompleks penyakit melibatkan kelainan imun yang multipel meliputi fungsi abnormal sel B dan sel T, pembersihan abnormal kompleks imun berakibat penumpukan dalam jaringan, aktivasi komplemen dan apoptosis sel cacat menyebabkan penumpukan autoantigen yang potensial. Akibatnya terjadi induksi radang, gagal organ seperti pada ginjal, jantung, kulit dan sistem saraf. Terapi SLE berat antara lain imunosupresi dengan target sel B, sel T, menghambat sitokin, dan menghambat komplemen berfungsi menekan sistem imun (imunosupresif), efektif mengurangi gejala sisa SLE namun dapat meningkatkan risiko infeksi serius.Sytemic Lupus Erythematosus (SLE) is a complex of diseases involving multiple immune abnormality with abnormal cell T and cell B functions, abnormal immune complex clearance resulting accumulation in the tissue, complement activation and apoptosis of defective cell which caused potential autoantigen accumulation. The consequences are induction of inflammation, failure of organs such as kidney, heart, skin and nervous system. Immunosuppressive therapy targeted to B cell, T cell, the cytokines and complement is effective to reduce sequelae but increase the risk of serious infection.Â

Keganasan Kolorektal dengan Fenomena Raynaud Sekunder Adnyani, Ni Made Dwi; Nugraha, Ida Bagus Aditya; Kambayana, Gede
Cermin Dunia Kedokteran Vol 46, No 12 (2019): Kardiovaskular
Publisher : PT. Kalbe Farma Tbk.

Penyakit Raynaud adalah penyakit vaskular primer yang ditandai dengan spasme temporer arteri kecil dan arteriol, biasanya di jari tangan atau, yang lebih jarang, jari kaki. Penyebab penyakit Raynaud dapat primer atau sekunder; salah satu penyebab sekunder adalah proses malignansi. Dilaporkan kasus Fenomena Raynaud Sekunder diduga akibat kanker kororektal pada laki-laki, 46 tahun, suku Jawa.Raynaud's disease is a primary vascular disease characterized by temporary spasm of small arteries and arterioles, usually in fingers or, rarely, in toes. The cause of Raynaud's disease can be primary and secondary; one of the secondary causes is malignancy. This is a case of a 46 year-old Javanese male with secondary Raynaud's phenomenon associated with colorectal cancer.Â Â

CASE REPORT : OSTEOARTHRITIS Putu Imayati; Gede Kambayana
E-Jurnal Medika Udayana vol 2 no 7 (2013):e-jurnal medika udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (146.348 KB)

Osteoarthritis is a degenerative joint disease in which the affected joint is usually the large joint and unilateral. Prevalence of osteoarthritis in Indonesia, 15.5% in men and 12.7% in women, where the incidence is increasing with age. Osteoarthritis is more common an idiopathic disease or unknown cause although there is also a secondary cause such as trauma, infection, neurological or metabolic disorders. The usual complaints that perceived by osteoarthritis patients is pain in the affected joint, especially after the load on the joint. Therapy in osteoarthritis is usually symptomatic, which include the control of risk factors, physiotherapy and pharmacological.

KARAKTERISTIK PREVALENSI FINGERTIP INJURY DI RUMAH SAKIT UMUM PUSAT SANGLAH DENPASAR TAHUN 2012-2014 Try Parama Arthika; Aryana Wien IGN; Kambayana G
E-Jurnal Medika Udayana Vol 8 No 10 (2019): Vol 8 No 10 (2019): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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Setiap luka ataupun trauma area kuku, soft tissue, tulang distal dari insersi tendon musculus flexsor digit et pollicis longus dan ekstensor digitalis et pollicis longus merupakan definisi dari fingertip injury. Fingertip injury seperti subungual hematoma phalang (crush injury pada fingertip), laserasi nail bed, amputasi parsial atau komplit dari fingertip, amputasi pulp, dan fraktur pada area distal, mallet finger, avulsi flexor digitorum profundus, dan dislokasi pada sendi distal interphalang.Metode penelitian ini merupakan deskritif observasional dengan pendekatan cross-sectional untuk mengetahui gambaran epidemiologi fingertip Injury dan mengetahui jumlah kasus di RSUP Sanglah, Denpasar, Bali pada tahun 2012-2014 dimana diambil dari data sekunder catatan medik penderita di SMF Orthopaedi dan IGD RSUP Sanglah Denpasar sejak Juli 2015 sampai dengan Agustus 2015.Berdasarkan umur Fingertip Injury paling banyak pada kelompok umur 26-40 tahun sebesar 45% dan paling sedikit kelompok umur 71-85 sebesar 1,7%. Berdasarkan jenis kelamin dapat diketahui bahwa pasien yang mengalami Fingertip Injury paling banyak pada jenis kelamin laki-laki sebesar 85%. Kata Kunci: Fingertip Injury, Crush Injury, Digitalis et Pollicis Longus

Karakteristik pasien gout arthritis di Rumah Sakit Umum Pusat Sanglah Denpasar periode 2014-2015 Bagus Rhama; Gede Kambayana
E-Jurnal Medika Udayana Vol 7 No 2 (2018): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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Gout Arthritis is defined as one of a metabolic disorder called hyperuricaemia, where at any given moment to be blood consist some uric acid in the high levels. Associated with the presence of monosodium urate in leukocytes, usually found in the synovial joint fluid, monosodium urate crystals in the tissues (tophus), interstitial renal disease, gout and nephrolithiasis. Using a cross sectional design of Study for Gout Arthritis patients at General Hospital Sanglah period 2014-2015 which aims to find out the number of patient characteristics are gender, age, level of uric acid (hyperuricaemia Status), and the status of tophus. Gout Arthritis is obtained in 20 patients who were in Sanglah General Hospital, Denpasar. Of the 20 patients, the study sample obtained a total of 11 samples, 9 patients including exclusion criteria. Obtained a mean age of 57.18 + 2:27 years. Gout Arthritis patients male sex more that 10 (90.9%) than women 1 (9.1%). Comparison men: women is 10: 1. Age samples were in the range 42-65 years figures. A total of 4 samples (36.36%) stage Chronic Gout Arthritis and 7 other samples (63.63%) stage of Acute Gout Arthritis. Keywords: tophus, gout, metatarsalpalangeal

CASE REPORT : OSTEOARTHRITIS Putu Imayati; Gede Kambayana
E-Jurnal Medika Udayana vol 3 no 2 (2014):e-jurnal medika udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (115.579 KB)

Osteoarthritis is a degenerative joint disease in which the affected joint is usually the largejoint and unilateral. Prevalence of osteoarthritis in Indonesia, 15.5% in men and 12.7% inwomen, where the incidence is increasing with age. Osteoarthritis is more common anidiopathic disease or unknown cause although there is also a secondary cause such astrauma, infection, neurological or metabolic disorders. The usual complaints that perceivedby osteoarthritis patients is pain in the affected joint, especially after the load on the joint.Therapy in osteoarthritis is usually symptomatic, which include the control of risk factors,physiotherapy and pharmacological.

Comparison of the prevalence of hyperuricemia in families of patients with and without gouty arthritis among Balinese people Gede Kambayana; T R Putra
Indonesian Journal of Rheumatology Vol. 3 No. 1 (2011): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Background: Gout is a metabolic disorder caused by hyperuricemia, which results from changes in uric acid metabolism. Both internal (e.g., genetics) and external factors (e.g., diet, habits, comorbidities) play role in the occurrence of hyperuricemia and the difference of hyperuricemia prevalence in different populations.Objective: To compare the prevalence of hyperuricemia in families of gout and non-gout patients among Balinese people.Methods: This cross-sectional study was carried out at the rheumatology clinic at Sanglah Hospital, Denpasar. Samples were collected using consecutive method and consisted of gout and non-gout patients. Several characteristics (alcohol and purine consumption,medications, blood pressure, body mass index, serum uric acid level, and serum creatinine) in both groups were collected and compared. Family members (fi rstdegree relatives) of patients in each group were also recruited and had their serum uric acid level measured and compared.Results: A total of 46 patients and 116 family members (23 patients and 58 family members in each group) were enrolled. Among gout patients, there was signifi cantlyhigher prevalence of hyperuricemia, serum uric acid level, blood pressure, and serum creatinine; and lower creatinine clearance compared with the non-gout patients. There was signifi cantly higher prevalence of hyperuricemia among families of gout patients comparedwith families of non-gout patients (60.3 vs. 29.3%, respectively; p = 0.001), with a prevalence ratio of 2.06. Mean serum uric acid level of the family members of gout patients were also signifi cantly higher than the family members of non-gout patients (7.24 (SD 1.74) vs. 5.92 (SD 1.63) mg/dL, respectively; p = 0.000).Conclusion: Among Balinese people in this study, significantly higher prevalence of hyperuricemia and mean serum uric acid level was observed in families of gout patients compared with families of non-gout patients.

Co-Authors A Halim Achadiono, Dedy Nurwachid Adnyani, Ni Made Dwi Ali Djamhuri Anak Agung Mas Putrawati Triningrat Andisari, Hendrata Erry Andriyasa Andriyasa Andriyasa, Andriyasa Anna Ariane Anwar Santoso Awalia Awalia Ayu Paramaiswari Bagus Rhama Dwi Budi Darmawati Dwijo Anargha Sindhughosa Faisal Parlindungan Gede Dilajaya Robin Gede Putu Arsana Govindha, I Putu Aris Harry Isbagio Hendrata Erry Andisari I Gusti Agung Friskha Surya Putra I Gusti Agung Indra Adi Kusuma I Gusti Ngurah Wien Aryana I K Rina I Ketut Suastika I Nyoman Suarjana I.B. Aditya Nugraha Ida Ayu Sri Indrayani Ida Bagus Aditya Nugraha IGN Eka Imbawan Indrawan, IGNM Budiana Ketut Suega Laniyati Hamijoyo, Laniyati Made Agus Kusumadjaja Made Paramita Wijayanti Manaek, Andi Ni Ketut Donna Prisilia Ni Made Dwi Adnyani Ni Made Dwi Adnyani Ni Putu Dewi Indriyani Nugraha, I.B. Aditya Nyoman Kertia Pande Ketut Kurniari Prisilia, Ni Ketut Donna Putra, T R Putu Imayati Rakhma Yanti Hellmi Rima Febry Lesmana Robin, Gede Dilajaya Rudy Hidayat T R Putra T R Putra Tejawati, Dewa Ayu Kartika Tjokorda Raka Putra Tonny, Tonny Try Parama Arthika Widhiarta, Putu Raka Wira Gotera Wiwekananda, Ketut Shri Satya Yenny Kandarini Yogiswara, Komang Satvika Yuliandari KK, Cok Istri

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